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The problem of drug resistance in malaria

Published online by Cambridge University Press:  06 April 2009

W. Peters
W. Peters
Affiliation:
Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
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Extract

The resistance in human malaria is mainly of practical importance in relation to Plasmodium falciparum. Strains resistant not only to chloroquine but also to dihydrofolate reductase inhibitors, and even to potentiating combinations of these with sulphonamides or sulphones, are appearing in an ever increasing geographical area which now includes tropical Africa and India. Few new drugs are available or foreseen for the near future, mefloquine and artemisinine being the leading contenders. It is vital that all measures possible should be taken to protect such new compounds, their deployment in the form of judiciously selected combinations with other antimalarials being an essential procedure that should be followed. Drugs in new chemical classes and with different modes of action are still urgently needed. Reliance should not be placed on drugs alone to control malaria on a community basis.

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Type
Research Article
Information
Parasitology , Volume 90 , Issue 4 , April 1985 , pp. 705 - 715
Copyright
Copyright © Cambridge University Press 1985

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References

REFERENCES

Anon. (1978). Chloroquine-resistant malaria acquired in Kenya and Tanzania. Denmark, Georgia, New York. Morbidity Mortality Weekly Report No. 47, 27, 463–4.Google Scholar
Boudreau, E. F., Webster, H. K., Pavanand, K., & Thosingha, L., (1982). Type II mefloquine resistance in Thailand. Lancet 2, 1335.CrossRefGoogle ScholarPubMed
Brockelman, C. R., Monkolkeha, S., & Tanariya, P., (1981). Decrease in susceptibility of Plasmodium falciparum to mefloquine in continuous culture. Bulletin of the World Health Organization 59, 249–52.Google ScholarPubMed
Bruce-Chwatt, L. J., Black, R. H., Canfield, C. J., Clyde, D. F., Peters, W., & Wernsdorfer, W. H., (1981). Chemotherapy of Malaria, 2nd edn.Geneva: World Health Organization.Google Scholar
Bygbjerg, I. C., Schapira, A., Flachs, H., Gomme, G., & Jepsen, S., (1983). Mefloquine resistance of falciparum malaria from Tanzania enhanced by treatment. Lancet 1, 774–5.CrossRefGoogle ScholarPubMed
Campbell, C. C., Payne, D., Schwartz, I. K., & Khatib, O. J., (1983). Evaluation of amodiaquine treatment of chloroquine-resistant Plasmodium falciparum malaria on Zanzibar, 1982. American Journal of Tropical Medicine and Hygiene 32, 1216–20.CrossRefGoogle ScholarPubMed
Canfield, C. J., & Heiffer, M. H., (1978). The US Army drug development program. In Advances in Pharmacology and Therapeutics, vol. 10. Chemotherapy (ed. Adolphe, M.), pp. 99–108. Oxford and New York.Google Scholar
Chawira, A. N., Robinson, B. L., Warhurst, D. C., & Peters, W., (1984). Drug combination studies with qinghaosu (artemisinine) against rodent malaria. Journal of Protozoology 31, 47A.Google Scholar
Chongsuphajaisiddhi, T., Sabchareon, A., & Attanath, P., (1981). In vivo and in vitro sensitivity of falciparum malaria to quinine in Thai children. Annals of Tropical Paediatrics 1, 21–6.CrossRefGoogle ScholarPubMed
Choudhury, D. S., Ghosh, S. K., Devi, C. U., & Malhotra, M. S., (1983). Response of Plasmodium falciparum to chloroquine in Delhi, Sonepat District of Haryana and Terai Region of Uttar Pradesh. Indian Journal of Malariology 20, 63–70.Google Scholar
Cosgriff, T. M., Boudreau, E. F., Pamplin, C. L., Doberstyn, E. B., Desjardins, R. E., & Canfield, C., (1982). Evaluation of the antimalarial activity of the phenanthrenemethanol halofantrine (WR 171,669). American Journal of Tropical Medicine and Hygiene 31, 1075–9.CrossRefGoogle ScholarPubMed
Darlow, B., Vrobova, H., Gibney, S., Joley, D., Stace, J., & Alpers, M., (1982). Sulfadoxine-pyrimethamine for the treatment of acute malaria in children in Papua New Guinea. I. Plasmodium falciparum. American Journal of Tropical Medicine and Hygiene 31, 1–9.CrossRefGoogle ScholarPubMed
de Souza, J.-M., (1983). A phase II clinical trial of mefloquine in Brazilian male subjects. Bulletin of the World Health OrganizatiOn 61, 815–20.Google ScholarPubMed
Deloron, P., Le Bras, J., & Ramanamirija, J. A., (1984). Amodiaquine and chloroquine efficacy against Plasmodium falciparum in Madagascar. Lancet 1, 1303–4.CrossRefGoogle ScholarPubMed
Ellis, D. S., Li, Z. L., Gu, H. M., Peters, W., Robinson, B. L., Tovie, G., & Warhurst, D. C., (1985). The chemotherapy of rodent malaria. XXXIX. Ultrastructural changes following treatment with artemisinine of Plasmodium berghei infection in mice, with observations of the localisation of [3H]dehydroartemisinine in P. falciparum in vitro. Annals of Tropical Medicine and Parasitology (in the Press.)CrossRefGoogle ScholarPubMed
Ferraroni, J. J., Speer, C. A., Hayes, J., & Suzuki, M., (1981). Prevalence of chloroquine-resistant falciparum malaria in the Brazilian Amazon. American Journal of Tropical Medicine and Hygiene 30, 526–30.CrossRefGoogle ScholarPubMed
Geary, T. G., & Jensen, J. B., (1983). Lack of cross-resistance to 4-aminoquinolines in chloroquine-resistant Plasmodium falciparum in vitro. Journal of Parasitology 69, 97–105.CrossRefGoogle ScholarPubMed
Gu, H. M., Lu, B. F., & Qu, Z. X., (1980). Activities of 25 derivatives of artemisinine against chloroquine-resistant Plasmodium berghei. Ada Pharmaclogica Sinica 1, 48–50.Google ScholarPubMed
Gu, H. M., Warhurst, D. C., & Peters, W., (1983). Rapid action of qinghaosu and related drugs on incorporation of [3H ]isoleucine by Plasmodium falciparum in vitro. Biochemical Pharmacology 32, 2563–6.CrossRefGoogle ScholarPubMed
Gu, H. M., Warhurst, D. C., & Peters, W., (1984). Uptake of [3H ]dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene 78, 265–70.CrossRefGoogle ScholarPubMed
Heiffer, M. H., Davidson, E. E. Jr, & Korte, D. W. Jr. (1984). Preclinical testing. In Antimalarial Drugs. I. Biological Background, Experimental Methods and Drug Resistance (ed. Peters, W. and Richards, W. H. G.), pp. 341–73. Berlin, Heidelberg, New York and Tokyo: Springer-Verlag.Google Scholar
Hurly, M. G. D., (1959). Potentiation of pyrimethamine by sulphadiazine in human malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene 53, 412–13.CrossRefGoogle ScholarPubMed
Jiang, J. B., Li, G. Q., Guo, X. B., Kong, Y. C., & Arnold, K., (1982). Antimalarial activity of mefloquine and Qinghaosu. Lancet 2, 285–7.CrossRefGoogle ScholarPubMed
Johnson, D. E., Roendej, P., & Williams, R. G., (1982). Falciparum malaria acquired in the area of the Thai–Khmer border resistant to treatment with Fansidar. American Journal of Tropical Medicine and Hygiene 31, 907–12.CrossRefGoogle ScholarPubMed
Kihamia, C. M., & Gill, H. S., (1982). Chloroquine-resistant falciparum malaria in semi-immune native African Tanzanians. Lancet 2, 43.CrossRefGoogle Scholar
Kyrönseppä, H., Lumio, J., Ukkonen, R., & Pettersson, T., (1984). Chloroquine-resistant malaria from Angola. Lancet 1, 1244.CrossRefGoogle ScholarPubMed
Lambros, C., & Notsch, J. D., (1983). Mefloquine resistance in Plasmodium falciparum. Journal of Protozoology 30, iii: 8A.Google Scholar
Lanners, H. N., & Trager, W., (1984). Intranuclear structures in pyrimethamine-resistant isolates of the malaria parasite Plasmodium falciparum. Cell Biology International Reports 8, 221–5.CrossRefGoogle ScholarPubMed
Lapierre, J., Devant, J., Coquelin, B., Faurant, C., & Galal, A. A., (1983). Bilan d'une éxperience de chimioprophylaxie du paludisme par la mefloquine au Cambodge. Bulletin de la Société de Pathologic Éxotique 76, 357–63.Google Scholar
Latter, V. S., Dalton, L., & Hickmott, E., (1984). The antimalarial activity of the hydroxynaphthoquinone BW58C,2–4′-T'butylcyclohexyl-3-hydroxy-l,4-naphthoquinone. Abstract in the 11th International Congress for Tropical Medicine and Malaria,Calgary, Canada,16–22 September 1984, p. 82.Google Scholar
Le Bras, J., Deloron, P., Charmot, G., Savel, J., Coulanges, P., & Coulaud, J. P., (1983). Can 4-aminoquinolines be used against chloroquine-resistant falciparum malaria? Proceedings of the 13th International Congress of Chemotherapy,Vienna,28 August–2 September 1983,Part 76, pp. 39–42.Google Scholar
Li, G., Guo, X., Jin, R., Wang, Z., Jian, H., & Li, Z., (1982). Clinical studies on treatment of cerebral malaria with qinghaosu and its derivatives. Journal of Traditional Chinese Medicine 2, 125–30.Google ScholarPubMed
Li, Y., Qin, Y., Qu, Y., & Kung, C. C., (1981). Hydroxypiperaquine phosphate in treating chloroquine resistant falciparum malaria. Chinese Medical Journal 94, 303–4.Google ScholarPubMed
Li, Z. L., Gu, H. M., Warhurst, D. C., & Peters, W., (1983). Effects of qinghaosu and related compounds on incorporation of [G-3H]hypoxanthine by Plasmodium falciparum in vitro. Transactions of the Royal Society of Tropical Medicine and Hygiene 77, 522–3.CrossRefGoogle ScholarPubMed
Merkli, B., Richle, R., & Peters, W., (1980). The inhibitory effect of a drug combination on the development of mefloquine resistance in Plasmodium berghei. Annals of Tropical Medicine and Parasitology 74, 1–9.CrossRefGoogle ScholarPubMed
Moore, D. V., & Lanier, J. E., (1961). Observations on two Plasmodium falciparum infections with an abnormal response to chloroquine. American Journal of Tropical Medicine and Hygiene 10, 5–9.CrossRefGoogle ScholarPubMed
Neiva, A., (1910). Ueber die Bildung einer chininresistent Rasse des Malariaparasiten. Memorias do Instituto Oswaldo Cruz (Rio de Janeiro) 2, 131–40.CrossRefGoogle Scholar
Nocht, B., & Werner, H., (1910). Beobachtungen über relative Chininresistenz bei Malaria aus Brasilien. Deutsche Medizinischer Wochenschrift 36, 1557–60.Google Scholar
Olsen, V. V., Jensen, T., & Jorgensen, M., (1984). Chloroquine-resistant Plasmodium falciparum malaria from Angola. Lancet 1, 1462–3.CrossRefGoogle ScholarPubMed
Onori, E., Payne, D., Grab, B., Horst, H. I., Franco, J. A., & Joia, H., (1982). Incipient resistance of Plasmodium falciparum to chloroquine among a semi-immune population of the United Republic of Tanzania. Bulletin of the World Health Organization 60, 77–87.Google ScholarPubMed
Patchen, L. C., Mount, D. L., Schwartz, I. K., & Frederick, C. C., (1983). Analysis of filterpaper-absorbed, finger-stick blood samples for chloroquine and its major metabolite using high-performance liquid chromatography with fluorescence detection. Journal of Chromatography 278, 81–9.CrossRefGoogle ScholarPubMed
Peters, W., (1970). Chemotherapy and Drug Resistance in Malaria. London and New York: Academic Press.Google Scholar
Peters, W., (1982). Future deployment of mefloquine and essential measures for protecting mefloquine against resistance. In Drug-resistant Malaria, (ed. Wernsdorfer, W.), pp. 123–8. Geneva: UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.Google Scholar
Peters, W., (1984 a). History and current status of drug resistance. In Antimalarial Drugs. I. Biological Background, Experimental Methods, and Drug Resistance (ed. Peters, W. and Richards, W. H. G.), pp. 423–45. Berlin, Heidelberg, New York and Tokyo: Springer-Verlag.Google Scholar
Peters, W., (1984 b). Use of drug combinations. In Antimalarial Drugs. II. Current Antimalarials and New Drug Developments (ed. Peters, W. and Richards, W. H. G.), pp. 499–50. Berlin, Heidelberg, New York and Tokyo: Springer-Verlag.Google Scholar
Peters, W., (1984 c). Resistance to antiparasitic drugs and its prevention. Paper presented at 4th. European Colloquium of Parasitology,Izmir, Turkey,14–19 October, 1984 (in the Press).Google Scholar
Peters, W., Portus, J. H., & Robinson, B. L., (1977). The chemotherapy of rodent malaria. XXVIII. The development of resistance to mefloquine (WR 142,490). Annals of Tropical Medicine and Parasitology 71, 419–27.CrossRefGoogle ScholarPubMed
Peters, W., & Robinson, B. L., (1984 a). The chemotherapy of rodent malaria. XXXV. Further studies on the retardation of drug resistance by the use of a triple combination of mefloquine, pyrimethamine and sulfadoxine in mice infected with P. berghei and ‘P. berghei NS’. Annals of Tropical Medicine and Parasitology 78, 459–66.CrossRefGoogle Scholar
Peters, W., & Robinson, B. L., (1984 b). The chemotherapy of rodent malaria. XXXVII. The in vivo action of two Mannich bases, WR 194,965 and WR 228,258 and an 8-aminoquinoline WR 225,448. Annals of Tropical Medicine and Parasitology 78, 561–5.CrossRefGoogle Scholar
Pinichpongse, S., Doberstyn, E. B., Cullen, J. R., Yisunsri, L., Thongsombun, Y., & Thimasarn, K., (1982). An evaluation of five regimens for the outpatient therapy of falciparum malaria in Thailand 1980–1981. Bulletin of the World Health Organization 60, 907–12.Google Scholar
Pribadi, W., Dakung, L. S., Gandahusada, S., & Daldyono, , (1981). Chloroquine resistant Plasmodium falciparum infection from Lampung and South Sumatra, Indonesia. Southeast Asian Journal of Tropical Medicine and Public Health 12, 69–73.Google ScholarPubMed
Qinghaosu Antimalaria Coordinating Research Group. (1979). Antimalaria studies on qinghaosu. Chinese Medical Journal 92, 811–16.Google Scholar
Reacher, M., Campbell, C. C., Freeman, J., Doberstyn, E. B., & Brandling-Bennett, A. D., (1981). Drug therapy for Plasmodium falciparum resistant to pyrimethamine-sulfadoxine (Fansidar). Lancet 2, 1066–9.CrossRefGoogle ScholarPubMed
Rieckmann, K. H., McNamara, J. V., Frischer, H., Stockert, T. A., Carson, P., & Powell, R. D., (1968). Effects of chloroquine, quinine and cycloguanil upon the maturation of asexual erthrocytic forms of two strains of Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene 17, 661–71.CrossRefGoogle Scholar
Rieckmann, K. H., Sax, L. J., Campbell, G. H., & Mrema, J. E., (1978). Drug sensitivity of Plasmodium falciparum. An in vitro microtechnique. Lancet 1, 22–3.Google Scholar
Schapira, A., (1984). Concomitant resistance to pyrimethamine and cycloguanil of chloroquineresistant falciparum malaria from East Africa: an in vitro study of 12 isolates. Transactions of the Royal Society of Tropical Medicine and Hygiene 78, 359–62.CrossRefGoogle Scholar
Schmidt, L. H., Vaughan, D., Mueller, D., Crosby, R., & Hamilton, R., (1977). Activities of various 4-aminoquinolines against infections with chloroquine-resistant strains of Plasmodium falciparum. Antimicrobial Agents and Chemotherapy 11, 826–43.CrossRefGoogle ScholarPubMed
Smrkovski, L. L., Buck, R. L., Alcantara, A. K., Rodriguez, C. S., & Uylanco, C. V., (1982). In vitro mefloquine resistant Plasmodium falciparum from the Philippines. Lancet 2, 322.CrossRefGoogle ScholarPubMed
Spencer, H. C., Kaseje, D. C. O., & Koech, D. K., (1984). The Kenyan Saradidi community malaria project. I. Sensitivity of Plasmodium falciparum isolates to chloroquine in 1981 and 1982. Transactions of the Royal Society of Tropical Medicine and Hygiene (in the Press).Google Scholar
Sweeney, T. R., (1984). Drugs with quinine-like action. In Antimalarial Drugs. II. Current Antimalarials and New Drug Developments (ed. Peters, W. and Richards, W. H. G.), pp. 267–324. Berlin, Heidelberg, New York and Tokyo: Springer-Verlag.Google Scholar
Sweeney, T. R., & Pick, R. O., (1984). 4-aminoquinolines and Mannich bases. In Antimalarial Drugs. II. Current Antimalarials and New Drug Developments (ed. Peters, W. and Richards, W. H. G.), pp. 363–85. Berlin, Heidelberg, New York and Tokyo: Springer-Verlag.Google Scholar
Tan-Ariya, P., & Brockelman, C. R., (1983). The inhibitory activity of mefloquine in combination with sulfadoxine-pyrimethamine against Plasmodium falciparum in continuous culture. Malaria Research, Thailand, 1983.A Conference Sponsored by the Malaria Division25–27 April 1983,Ministry of Health, Bangkok p. 53.Google Scholar
Uprety, H. C., Gupta, V. K., & Sharma, V. P., (1982). Modified plan of operation and its impact on malaria. Indian Journal of Malariology 19, 137–8.Google Scholar
Vleugels, M. P. H., Wetsteyn, J. C. F. M., & Meuwissen, J. H. E. Th., (1982). Fansidar-resistant Plasmodium falciparum infection from Tanzania. Tropical and Geographical Medicine 34, 263–5.Google ScholarPubMed
Wernsdorfer, W., (1982). Drug-Resistant Malaria. Geneva: UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.Google Scholar
Wernsdorfer, W. H., (1983). Known geographical distribution, frequency and intensity of drugresistant malaria. (Cyclostyled report) MAP/SGCM/WP/83.10, Geneva: World Health Organization.Google Scholar
Wernsdorfer, W., & Trigg, P., (1983). Modern Design of Antimalarial Drugs. Geneva: UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases.Google Scholar
World Health Organization. (1981). The development of qinghaosu and its derivatives as antimalarial drugs. (Cyclostyled report) TDR/CHEMAL-SWO(4)/(QHS)/81.3, Geneva: World Health Organization.Google Scholar
World Health Organization. (1983). Development of mefloquine as an antimalarial drug. Bulletin of the World Health Organization 61, 169–78.Google Scholar
Zheng, X., Xia, Y., Gao, F., Guo, H., & Chen, C., (1979). Synthesis of 7351, a new antimalarial drug. Ada Pharmaceutica Sinica 14, 736–7.Google ScholarPubMed