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The development of resistance to glycarbylamide and 2-chloro-4-nitrobenzamide in Eimeria tenella in chicks *

Published online by Cambridge University Press:  06 April 2009

S. J. Ball
S. J. Ball
Affiliation:
Veterinary Research Station, May and Baker, Ltd., Ongar, Essex
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Extract

A twofold increase in resistance to glycarbylamide was induced in a strain of Eimeria tenella in chicks. This strain remained susceptible to amprolium, nicarbazin, nitrofurazone, zoalene, 3,5-dinitrobenzamide, 2-chloro-4-nitrobenzamide (M & B 5921) and spiramycin.

At least an eightfold resistance to 2-chloro-4-nitrobenzamide (M & B 5921) was developed in another strain of E. tenella. This strain was also resistant to nitrofurazone, zoalene and 3,5-dinitrobenzamide, but not to glycarbylamide, amprolium, nicarbazin and spiramycin.

A single test showed no transfer of drug-resistance when the two resistant strains were given simultaneously to the same birds.

When a small number of parasites of a glycarbylamide-resistant strain of E. tenella was introduced into a larger inoculum of the normal parent strain, the resistant individuals appeared to diminish in number during passages through untreated chicks.

I wish to thank Mrs B. M. Mitchell, Miss C. A. Hitchcock and Miss J. Watkins for technical assistance at various stages of the work.

Information

Type
Research Article
Information
Parasitology , Volume 56 , Issue 1 , February 1966 , pp. 25 - 37
Copyright
Copyright © Cambridge University Press 1966

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References

REFERENCES

Ball, S. J. (1959). Antibiotics in chemotherapy of caecal coccidiosis in chickens. J. comp. Path. Ther. 69, 327–33.CrossRefGoogle ScholarPubMed
Ball, S. J. (1964). Synergistic action of sulphaquinoxaline and 2-amino-4-dimethylamino-5-(4-chlorophenyl)-6-ethylpyrimidine in caecal coccidiosis in chickens. J. comp. Path. Ther. 74, 487–99.CrossRefGoogle ScholarPubMed
Ball, S. J. (1965). The chemotherapy of coccidiosis in the fowl and a study of the responses of different strains of Eimeria acervulina and E. tenella to medication. Ph.D. Thesis, University of London.Google Scholar
Cuckler, A. C. & Malanga, C. M. (1955). Studies on drug resistance in coccidia. J. Parasit. 41, 302–11.CrossRefGoogle ScholarPubMed
Gardiner, J. L. & McLoughlin, D. K. (1963). Drug resistance in Eimeria tenella. IV. The experimental development of a nitrofurazone-resistant strain. J. Parasit. 49, 947–50.CrossRefGoogle ScholarPubMed
Horton-Smith, C. (1962). Resistance to anticoccidial drugs experimentally induced in a laboratory strain of Eimeria tenella. Proc. 11th World's Poult. Congr., Mexico, pp. 483–9.Google Scholar
Joyner, L. P. (1957). Induced drug-fastness to nitrofurazone in a laboratory strain of Eimeria tenella. Vet. Rec. 69, 1415–18.Google Scholar
Kendall, S. B. & McCullough, F. S. (1952). Relationships between sulphamezathine therapy and the acquisition of immunity to Eimeria tenella. J. comp. Path. Ther. 62, 116–24.CrossRefGoogle ScholarPubMed
Long, P. L. & Rowell, J. G. (1958). Counting oocysts of chicken coccidia. Lab. Pract. 7, 515–19.Google Scholar
McLoughlin, D. K. & Gardiner, J. L. (1961). Drug, resistance in Eimeria tenella. I. The experimental development of a glycarbylamide-resistant strain. J. Parasit. 47, 1001–6.CrossRefGoogle Scholar
McLoughlin, D. K. & Gardiner, J. L. (1962). Drug resistance in Eimera tenella. II. The experimental development of a zoalene-resistant strain. J. Parasit. 48, 341–46.CrossRefGoogle Scholar