Clinical Uses of Botulinum Toxins

doi:10.1017/CBO9780511544842

Botulinum toxins now play a very significant role in the management of a wide variety of medical conditions; from headaches to hypersalivation, and from spasticity to sweating. In this book, a strong, international team of experts outline the basic neurochemistry of botulinum toxins and chart the progress of the drug from laboratory to clinic. Then individual chapters summarize their use for the main clinical indications in the context of other available treatments. This book will be of interest to neuroscientists and practising clinicians working in a wide range of specialities, from neurology and dermatology to pediatrics, plastic surgery and rehabilitation medicine.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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List of Contributors
pp vii-x
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1 - Introduction
pp 1-8
- By Michael P. Barnes, Walkergate Park, International Centre for Neurorehabilitation and Neuropsychiatry, Newcastle upon Tyne, UK, Anthony B. Ward, North Staffordshire Rehabilitation Centre, Stoke-on-Trent, UK
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2 - Mechanistic basis for the therapeutic effectiveness of botulinum toxin A on over-active cholinergic nerves
pp 9-26
- By J. Oliver Dolly, International Centre for Neurotherapeutics, Dublin City University, Dublin, Ireland, Gary Lawrence, International Centre for Neurotherapeutics, Dublin City University, Dublin, Ireland
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3 - Botulinum toxin: from menace to medicine
pp 27-44
- By Peter Hambleton, Health Protection Agency, Porton Down, Salisbury, UK, Andrew M. Pickett, Ipsen Limited, 190 Bath Road, Slough, UK, Clifford C. Shone, Health Protection Agency, Porton Down, Salisbury, UK
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4 - Botulinum toxin: primary and secondary resistance
pp 45-57
- By Benjamin Anyanwu, New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ, USA; Seton Hall University School of Graduate Medical Education, South Orange, NJ, USA, Philip A. Hanna, New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ, USA; Seton Hall University School of Graduate Medical Education, South Orange, NJ, USA, Joseph Jankovic, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas, USA
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5 - Introduction to botulinum toxin in clinical practice
pp 58-79
- By Anthony B. Ward, North Staffordshire Rehabilitation Centre, Stoke-on-Trent, UK
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6 - Cervical dystonia
pp 80-110
- By Khalid Anwar, Hunters Moor Regional Neurological Rehabilitation Centre, Newcastle upon Tyne, UK
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7 - The use of botulinum toxin in otolaryngology
pp 111-121
- By Maurice Hawthorne, James Cook University Hospital, Middlesbrough, UK, Khalid Anwar, Hunters Moor Regional Neurological Rehabilitation Centre, Newcastle upon Tyne, UK
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8 - Spasticity
pp 122-174
- By Anthony B. Ward, North Staffordshire Rehabilitation Centre, Stoke-on-Trent, UK
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9 - Hyperhidrosis
pp 175-200
- By DeeAnna Glaser, Department of Dermatology, Saint Louis University School of Medicine, St Louis, MO, USA, Stephanie Benson, University of Colorado, School of Medicine, Denver
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10 - Hypersalivation
pp 201-228
- By M. Fiorella Contarino, Academic Medical Centre, Amsterdam, The Netherlands, Alberto Albanese, Istituto Nazionale Neurologico Carlo Besta, Università Cattolica del Sacro Cuore, Milano, Italy
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11 - Botulinum toxin type A for the prophylactic treatment of primary headache disorders
pp 229-242
- By David W. Dodick, Mayo Clinic College of Medicine, Scottsdale, Arizona, USA
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12 - Botulinum toxin in the management of back and neck pain
pp 243-261
- By Áine Carroll, The National Rehabilitation Hospital, Dun Laoghaire, Co. Dublin, Ireland
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13 - Clinical uses of botulinum toxin
pp 262-281
- By John Elston, Oxford Eye Infirmary, Radcliffe Infirmary, Oxford, UK
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14 - Bladder and bowel indications
pp 282-327
- By Giuseppe Brisinda, Department of Surgery, Catholic School of Medicine, University Hospital Agostino Gemelli, Rome, Italy, Federica Cadeddu, Department of Surgery, Catholic School of Medicine, University Hospital Agostino Gemelli, Rome, Italy, Giorgio Maria, Department of Surgery, Catholic School of Medicine, University Hospital Agostino Gemelli, Rome, Italy
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15 - Cosmetic uses of botulinum toxin A
pp 328-348
- By Kenneth Beer, Palm Beach Esthetic Center, West Palm Beach, Florida, USA, Joel L. Cohen, AboutSkin Dermatology and Dermsurgery, Englewood, Colorado, USA, Alastair Carruthers, Department of Dermatology, University of British Columbia, Vancouver BC, Canada
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16 - Other clinical neurological uses of botulinum toxin
pp 349-374
- By Michael P. Barnes, Walkergate Park, International Centre for Neurorehabilitation and Neuropsychiatry, Newcastle upon Tyne, UK
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Index
pp 375-384
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Plate section
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Clinical Uses of Botulinum Toxins

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Contents

Frontmatter
pp i-iv

Contents
pp v-vi

List of Contributors
pp vii-x

1 - Introduction
pp 1-8

2 - Mechanistic basis for the therapeutic effectiveness of botulinum toxin A on over-active cholinergic nerves
pp 9-26

3 - Botulinum toxin: from menace to medicine
pp 27-44

4 - Botulinum toxin: primary and secondary resistance
pp 45-57

5 - Introduction to botulinum toxin in clinical practice
pp 58-79

6 - Cervical dystonia
pp 80-110

7 - The use of botulinum toxin in otolaryngology
pp 111-121

8 - Spasticity
pp 122-174

9 - Hyperhidrosis
pp 175-200

10 - Hypersalivation
pp 201-228

11 - Botulinum toxin type A for the prophylactic treatment of primary headache disorders
pp 229-242

12 - Botulinum toxin in the management of back and neck pain
pp 243-261

13 - Clinical uses of botulinum toxin
pp 262-281

14 - Bladder and bowel indications
pp 282-327

15 - Cosmetic uses of botulinum toxin A
pp 328-348

16 - Other clinical neurological uses of botulinum toxin
pp 349-374

Index
pp 375-384

Plate section

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Clinical Uses of Botulinum Toxins

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