Africa has significant agriculture potential. The African Union (AU) Agenda 2063 and high-level AU heads of state decisions on food security and development – the Maputo and Malabo declarations – leverage this potential and underscore increased agriculture productivity as critical to poverty reduction and growth to accelerate socioeconomic transformation. However, efforts cannot be considered in isolation from combating climate change and safeguarding health of ecosystems. Climate change threatens to reduce crop yields by up to 40%. Healthy ecosystems will not be forthcoming with escalating land degradation. Going forward, Africa should synergize its effort at maximizing agriculture productivity with combating climate change and enhancing its ecosystems as called for under the global COP 21 Paris Agreement. Actualizing such an integrated solution will require inclusive partnerships among complementary actors to bridge requisite policy and nonpolicy gaps and foster practical means of implementation.