Published online by Cambridge University Press: 28 February 2020
Uterine fibroids (or leiomyomas) are the most common benign gynaecological tumours, formed by smooth muscle and connective tissue. Most are asymptomatic, but sometimes may cause pain, pressure symptoms, metrorrhagia, infertility due to implantation failure, miscarriage, preterm delivery, and puerperal haemorrhage. Fibroids can be single or multiple. Their size and location vary and they may undergo benign degenerative changes: atrophic and hyaline degeneration, calcification, infection, and infarction. Malignant degeneration towards leiomyosarcoma is extremely rare, occurring in less than 0.2 per cent of cases.
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