What evidence is there for and against unified schemes for active galactic nuclei (AGN)? How do the AGN populations evolve over cosmological timescales? And what can the variability of their UV and X-ray emission tell us? These are just some of the exciting issues addressed in this volume of papers collected from the 33rd Herstmonceux conference in Cambridge. AGN are among the most spectacular objects known to astronomy. Yet, despite years of intense and wide-ranging research, the debate continues - what is their fundamental source of power? Rapid progress has been made towards answering this question by a variety of large-scale, multi-wavelength monitoring campaigns and the latest generation of satellite-borne observations. This volume provides a valuable overview and timely update of the exciting and rapidly developing field of AGN research - essential reading for graduate students and researchers.