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22 - Severe Local Anaesthetic Toxicity in Labour

from Scenario Section 4 - Neuraxial Analgesia

Published online by Cambridge University Press:  25 March 2019

Kirsty MacLennan
Affiliation:
Manchester University Hospitals NHS Trust
Catherine Robinson
Affiliation:
Manchester University Hospitals NHS Trust
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Publisher: Cambridge University Press
Print publication year: 2019

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References

Further Reading

www.lipidrescue.org for up-to-date reviews and articles on the use of lipid emulsion.Google Scholar

Bibliography

AAGBI Working Party. (2010). Guidelines for the Management of Severe Local Anaesthetic Toxicity. London: AAGBI. Available from: www.aagbi.org/sites/default/files/la_toxicity_2010_0.pdf (accessed March 16, 2017).Google Scholar
Bern, S. and Weinberg, G. (2011). Local anesthetic toxicity and lipid resuscitation in pregnancy. Current Opinion in Anesthesiology, 24, 262267.CrossRefGoogle ScholarPubMed
Cook, T. (2009). The 3rd National Audit of The Royal College of Anaesthetists: Major Complications of Central Neuraxial Block in the United Kingdom. Available from: www.rcoa.ac.uk/nap3 (accessed March 16, 2017).Google Scholar
Guay, J. (2006). The epidural test dose: a review. Anaesthesia and Analgesia, 102, 921929.CrossRefGoogle ScholarPubMed
Hayes, B. D., Gosselin, S., Calello, D. P., et al. (2016). Lipid Emulsion Workgroup. Systematic review of clinical adverse events reported after acute intravenous lipid emulsion administration. Clinical Toxicology (Philadelphia), 54(5), 365404.CrossRefGoogle ScholarPubMed
Huang, Y., Pryor, M., Mather, L., et al. (1998). Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. Anesthesia and Analgesia, 86, 797804.Google ScholarPubMed
Levine, M., Hoffman, R. S., Lavergne, V., et al. (2016). Lipid Emulsion Workgroup. Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity. Clinical Toxicology (Philadelphia), 54(3), 194221.CrossRefGoogle ScholarPubMed
Mazoit, J., Boico, O. and Samii, K. (1993). Myocardial uptake of bupivacaine: II. Pharmacokinetics and pharmacodynamics of bupivacaine enantiomers in the isolated perfused rabbit heart. Anesthesia and Analgesia, 77, 477482.CrossRefGoogle ScholarPubMed
Mulroy, M. F. (2002). Systemic toxicity and cardiotoxicity from local anesthetics: incidence and preventive measures. Regional Anesthesia and Pain Medicine, 27, 556561.Google ScholarPubMed
Nightingale, C., Margarson, M. P., Shearer, E., et al. (2015). Peri-operative Management of the Obese Surgical Patient. London: AAGBI: Society for Obesity and Bariatric Anaesthesia. Available from: www.aagbi.org/sites/default/files/Peri_operative_management_obese_patientWEB.pdf (accessed March 29, 2017).Google ScholarPubMed
Rajan, N. (2009). Management of severe local anaesthetic toxicity. Updates in Anaesthesia. Available from: www.anaesthesiologists.org (accessed March 16, 2017).Google Scholar
Weinberg, G. (2012). Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose. Anesthesiology, 117(1): 180187.CrossRefGoogle ScholarPubMed

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