Of the various aspects of human nature, the biology of our knowledge systems is an area we struggle to grasp. The possibility that our knowledge might be predetermined by our organic makeup is something we find difficult to accept. This is not because we resist our condition as biological organisms – living breathing bodies whose design is shaped by natural laws and evolution. We rarely give a second thought to our lack of fur or our inability to fly and swim underwater. We are not even disturbed by many obvious shortcomings of our mental faculties – our inability to perceive infrared light, the fallibility of our memory, and the haphazard fleeting character of our attention. Those fickle quirks of our neural machinery are surely inconvenient, but they rarely leave us pondering the confinements of our fate.