This chapter explores how policymakers and practitioners in settings beyond the sites of evaluation might make use of evidence from realist trials and systematic reviews, plus local needs assessment, to identify the best candidate interventions for their local contexts. To do this, local decision-makers need to assess how likely are interventions to achieve benefits in their contexts. This is partly a matter of assessing whether interventions are likely to be feasible, accessible and acceptable in their settings, which will be influenced by local capacity and norms. It is also a matter of assessing whether intervention mechanisms will be triggered and whether these are likely to generate beneficial outcomes. This will be influenced by what aetiological mechanisms are generating adverse outcomes in the context and hence what vulnerabilities exist which the intervention may be able to address. It will also be influenced by whether the local context provides affordances so that potential beneficiaries may be able to benefit from the intervention. Thinking through these issues should enable local policymakers and practitioners to decide whether such interventions could be delivered immediately at scale, be implementing but only within evaluated pilot studies or be rejected in favour of other interventions.