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Heterogeneity of cognitive-neurobiological determinants of resilience

  • Erno J. Hermans (a1) and Guillén Fernández (a1)
Abstract

In their target article, Kalisch and colleagues advocate a paradigm shift in research on stress-related mental disorders away from vulnerability factors and toward determinants of resilience. We endorse this shift but argue that their focus on “appraisal style” as the ultimate path to resilience may be too narrow. We illustrate this point by examining recent literature on the role of corticosteroids in resilience.

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Amos, T., Stein, D. J. & Ipser, J. C. (2014) Pharmacological interventions for preventing post-traumatic stress disorder (PTSD). Cochrane Database of Systematic Reviews (7):166.
Arnsten, A. F. T. (2009) Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience 10(6):410–22. doi: 10.1038/nrn2648.
Beck, A. T. (2008) The evolution of the cognitive model of depression and its neurobiological correlates. The American Journal of Psychiatry 165(8):969–77. doi: 10.1176/appi.ajp.2008.08050721.
Bouton, M. E. (2004) Context and behavioral processes in extinction. Learning and Memory 11(5):485–94. doi: 10.1101/lm.78804.
Cousijn, H., Rijpkema, M., Qin, S., van Marle, H. J. F., Franke, B., Hermans, E. J., van Wingen, G. & Fernández, G. (2010) Acute stress modulates genotype effects on amygdala processing in humans. Proceedings of the National Academy of Sciences of the United States of America 107(21):9867–72. doi: 10.1073/pnas.1003514107.
de Kloet, E. R., Joëls, M. & Holsboer, F. (2005) Stress and the brain: From adaptation to disease. Nature Reviews Neuroscience 6(6):463–75. doi: 10.1038/nrn1683.
de Quervain, D. J.-F., Bentz, D., Michael, T., Bolt, O. C., Wiederhold, B. K., Margraf, J. & Wilhelm, F. H. (2011) Glucocorticoids enhance extinction-based psychotherapy. Proceedings of the National Academy of Sciences of the United States of America 108(16):6621–25. doi: 10.1073/pnas.1018214108.
Deschaux, O., Zheng, X., Lavigne, J., Nachon, O., Cleren, C., Moreau, J.-L. & Garcia, R. (2013) Post-extinction fluoxetine treatment prevents stress-induced reemergence of extinguished fear. Psychopharmacology 225(1):209–16. doi: 10.1007/s00213-012-2806-x.
Enman, N. M., Sabban, E. L., McGonigle, P. & Van Bockstaele, E. J. (2015) Targeting the neuropeptide Y system in stress-related psychiatric disorders. Neurobiology of Stress 1:3343. doi: 10.1016/j.ynstr.2014.09.007.
Feder, A., Nestler, E. J. & Charney, D. S. (2009) Psychobiology and molecular genetics of resilience. Nature Reviews Neuroscience 10(6):446–57. doi: 10.1038/nrn2649.
Henckens, M. J. A. G., van Wingen, G. A., Joëls, M. & Fernández, G. (2010) Time-dependent effects of corticosteroids on human amygdala processing. Journal of Neuroscience 30(38):12725–32. doi: 10.1523/JNEUROSCI.3112-10.2010.
Henckens, M. J. A. G., van Wingen, G. A., Joëls, M. & Fernández, G. (2011) Time-dependent corticosteroid modulation of prefrontal working memory processing. Proceedings of the National Academy of Sciences of the United States of America 108(14):58015806. doi: 10.1073/pnas.1019128108.
Hermans, E. J., Henckens, M. J. A. G., Joëls, M. & Fernández, G. (2014) Dynamic adaptation of large-scale brain networks in response to acute stressors. Trends in Neurosciences 37(6):304–14. doi: 10.1016/j.tins.2014.03.006.
Hermans, E. J., van Marle, H. J. F., Ossewaarde, L., Henckens, M. J. A. G., Qin, S., van Kesteren, M. T. R., Schoots, V. C., Cousijn, H., Rijpkema, M., Oostenveld, R. & Fernández, G. (2011) Stress-related noradrenergic activity prompts large-scale neural network reconfiguration. Science 334(6059):1151–53. doi: 10.1126/science.1209603.
Het, S. & Wolf, O. T. (2007) Mood changes in response to psychosocial stress in healthy young women: Effects of pretreatment with cortisol. Behavioral Neuroscience 121(1):1120. doi: 10.1037/0735-7044.121.1.11.
Joëls, M. & Baram, T. Z. (2009) The neuro-symphony of stress. Nature Reviews Neuroscience 10(6):459–66. doi: 10.1038/nrn2632.
Lazarus, R. S. (1993b) From psychological stress to the emotions: A history of changing outlooks. Annual Review of Psychology 44:121. doi: 10.1146/annurev.ps.44.020193.000245.
Malenka, R. C. & Deisseroth, K. (2014) Fix faulty circuits. Nature 515:200201.
McEwen, B. S., Gray, J. D. & Nasca, C. (2015) Recognizing resilience: Learning from the effects of stress on the brain. Neurobiology of Stress 1(C):111. doi: 10.1016/j.ynstr.2014.09.001.
Milad, M. R. & Quirk, G. J. (2012) Fear extinction as a model for translational neuroscience: Ten years of progress. Annual Review of Psychology 63:129–51. doi: 10.1146/annurev.psych.121208.131631.
Onur, O. A., Walter, H., Schlaepfer, T. E., Rehme, A. K., Schmidt, C., Keysers, C., Maier, W. & Hurlemann, R. (2009) Noradrenergic enhancement of amygdala responses to fear. Social Cognitive and Affective Neuroscience 4(2):119–26. doi: 10.1093/scan/nsn049.
Putman, P., Hermans, E. J., Koppeschaar, H., van Schijndel, A. & van Honk, J. (2007) A single administration of cortisol acutely reduces preconscious attention for fear in anxious young men. Psychoneuroendocrinology 32(7):793802. doi: 10.1016/j.psyneuen.2007.05.009.
Qin, S., Hermans, E. J., van Marle, H. J. F., Luo, J. & Fernández, G. (2009) Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex. Biological Psychiatry 66(1):2532. doi: 10.1016/j.biopsych.2009.03.006.
Raio, C. M., Brignoni-Perez, E., Goldman, R. & Phelps, E. A. (2014) Acute stress impairs the retrieval of extinction memory in humans. Neurobiology of Learning and Memory 112(C):212–21. doi: 10.1016/j.nlm.2014.01.015.
Raio, C. M., Orederu, T. A., Palazzolo, L., Shurick, A. A. & Phelps, E. A. (2013) Cognitive emotion regulation fails the stress test. Proceedings of the National Academy of Sciences of the United States of America 110(37):15139–44. doi: 10.1073/pnas.1305706110.
Schelling, G., Briegel, J., Roozendaal, B., Stoll, C., Rothenhäusler, H. B. & Kapfhammer, H. P. (2001) The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biological Psychiatry 50(12):978–85.
Scherer, K. R. (1994) Emotion serves to decouple stimulus and response. In: The nature of emotion: Fundamental questions, ed. Ekman, P. & Davidson, R. J., pp. 127–30. Oxford University Press.
Seery, M. D., Holman, E. A. & Silver, R. C. (2010) Whatever does not kill us: Cumulative lifetime adversity, vulnerability, and resilience. Journal of Personality and Social Psychology 99(6):1025–41. doi: 10.1037/a0021344.
Soravia, L. M., Heinrichs, M., Aerni, A., Maroni, C., Schelling, G., Ehlert, U., Roozendaal, B. & de Quervain, D. J.-F. (2006) Glucocorticoids reduce phobic fear in humans. Proceedings of the National Academy of Sciences of the United States of America 103(14):5585–90. doi: 10.1073/pnas.0509184103.
van Marle, H. J. F., Hermans, E. J., Qin, S. & Fernández, G. (2009) From specificity to sensitivity: How acute stress affects amygdala processing of biologically salient stimuli. Biological Psychiatry 66(7):649–55. doi: 10.1016/j.biopsych.2009.05.014.
Weis, F., Kilger, E., Roozendaal, B., de Quervain, D. J.-F., Lamm, P., Schmidt, M., Schmölz, M., Briegel, J. & Schelling, G. (2006) Stress doses of hydrocortisone reduce chronic stress symptoms and improve health-related quality of life in high-risk patients after cardiac surgery: A randomized study. The Journal of Thoracic and Cardiovascular Surgery 131(2):277–82. doi: 10.1016/j.jtcvs.2005.07.063.
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Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
  • URL: /core/journals/behavioral-and-brain-sciences
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