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Phenotypic programming as a distal cause of resilience

  • Esther Nederhof (a1)

During early childhood, individuals with high sensitivity to early programming adjust their phenotype in a way that is expected to be adaptive in their later environment. These adaptations are hypothesized to result in resilience in environments that match the early environment. As appraisal style is a putative target of adaptive programming, early experiences could be a distal cause of resilience.

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Andersen, S. L. (2003) Trajectories of brain development: Point of vulnerability or window of opportunity? Neuroscience and Biobehavioral Reviews 27(1–2):318. doi: 10.1016/S0149-7634(03)00005-8.
Belsky, J., Bakermans-Kranenburg, M. J. & van IJzendoorn, M. H. (2007) For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science 16(6):300304.
Biggio, F., Pisu, M. G., Garau, A., Boero, G., Locci, V., Mostallino, M. C., Olla, P., Utzeri, C. & Serra, M. (2014) Maternal separation attenuates the effect of adolescent social isolation on HPA axis responsiveness in adult rats. European Neuropsychopharmacology 24(7):1152–61. doi: 10.1016/j.euroneuro.2014.03.009.
Boyce, W. T. & Ellis, B. J. (2005) Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Development and Psychopathology 17(2):271301. doi: 10.1017/S0954579405050145.
Brody, G. H., Yu, T., Chen, E., Miller, G. E., Kogan, S. M. & Beach, S. R. H. (2013) Is resilience only skin deep? Rural African Americans' socioeconomic status-related risk and competence in preadolescence and psychological adjustment and allostatic load at age 19. Psychological Science 24(7):1285–93. doi: 10.1177/0956797612471954.
Champagne, D. L., Bagot, R. C., van Hasselt, F., Ramakers, G., Meaney, M. J., de Kloet, E. R., Joëls, M. & Krugers, H. (2008) Maternal care and hippocampal plasticity: Evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress. Journal of Neuroscience 28(23):6037–45. doi: 10.1523/JNEUROSCI.0526-08.2008.
Daskalakis, N. P., Oitzl, M. S., Schachinger, H., Champagne, D. L. & de Kloet, E. R. (2012) Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiology and Behavior 106(5):707–21. doi: 10.1016/j.physbeh.2012.01.015.
Del Giudice, M., Ellis, B. J. & Shirtcliff, E. A. (2011) The adaptive calibration model of stress responsivity. Neuroscience and Biobehavioral Reviews 35:1562–92.
Ellis, B. J., Boyce, W. T., Belsky, J., Bakermans-Kranenburg, M. J. & van Ijzendoorn, M. H. (2011) Differential susceptibility to the environment: An evolutionary-neurodevelopmental theory. Development and Psychopathology 23(1):728.
Ellis, B. J. & Del Giudice, M. (2014) Beyond allostatic load: Rethinking the role of stress in regulating human development. Development and Psychopathology 26(1):120. doi: 10.1017/S0954579413000849.
Frankenhuis, W. E. & Del Giudice, M. (2012) When do adaptive developmental mechanisms yield maladaptive outcomes? Developmental Psychology 48(3):628–42. doi: 10.1037/a0025629; 10.1037/a0025629.
Frankenhuis, W. E. & Panchanathan, K. (2011) Balancing sampling and specialization: An adaptationist model of incremental development. Proceedings of the Royal Society B – Biological Sciences 278(1724):3558–65. doi: 10.1098/rspb.2011.0055.
Gluckman, P. D., Hanson, M. A. & Beedle, A. S. (2007) Early life events and their consequences for later disease: A life history and evolutionary perspective. American Journal of Human Biology 19(1):119.
Ivy, A. S., Brunson, K. L., Sandman, C. & Baram, T. Z. (2008) Dysfunctional nurturing behavior in rat dams with limited access to nesting material: A clinically relevant model for early-life stress. Neuroscience 154(3):1132–42. doi: 10.1016/j.neuroscience.2008.04.019.
Kuzawa, C. W. (2005) Fetal origins of developmental plasticity: Are fetal cues reliable predictors of future nutritional environments? American Journal of Human Biology 17(1):521.
Lupien, S. J., McEwen, B. S., Gunnar, M. R. & Heim, C. (2009) Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nature Reviews Neuroscience 10(6):434–45.
Nederhof, E., Ormel, J. & Oldehinkel, A. J. (2014) Mismatch or cumulative stress: The pathway to depression is conditional on attention style. Psychological Science 25(3):684–92. doi: 10.1177/0956797613513473.
Nederhof, E. & Schmidt, M. V. (2012) Mismatch or cumulative stress: Toward an integrated hypothesis of programming effects. Physiology and Behavior 106(5):691700. doi: 10.1016/j.physbeh.2011.12.008.
Oldehinkel, A. J., Ormel, J., Verhulst, F. C. & Nederhof, E. (2014) Childhood adversities and adolescent depression: A matter of both risk and resilience. Development and Psychopathology 26(4, Pt.1) 1067–75. doi: 10.1017/S0954579414000534.
Santarelli, S., Lesuis, S. L., Wang, X., Wagner, K. V., Hartmann, J., Labermaier, C., Scharf, S. H., Müller, M. B., Holsboer, F. & Schmidt, M. V. (2014) Evidence supporting the match/mismatch hypothesis of psychiatric disorders. European Neuropsychopharmacology 24(6):907–18. doi: 10.1016/j.euroneuro.2014.02.002.
Van den Hove, D. L. A., Leibold, N. K., Strackx, E., Martinez-Claros, M., Lesch, K. P., Steinbusch, H. W. M., Schruers, K. R. J. & Prickaerts, J. (2014) Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system. European Neuropsychopharmacology 24(4):595607. doi: 10.1016/j.euroneuro.2013.09.006.
Zalosnik, M. I., Pollano, A., Trujillo, V., Suarez, M. M. & Durando, P. E. (2014) Effect of maternal separation and chronic stress on hippocampal-dependent memory in young adult rats: Evidence for the match-mismatch hypothesis. Stress: The International Journal on the Biology of Stress 17(5):445–50. doi: 10.3109/10253890.2014.936005.
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Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
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