Skip to main content Accessibility help

Quantifying resilience: Theoretical or pragmatic for translational research?

  • Gleb P. Shumyatsky (a1), Tanja Jovanovic (a2) and Talma Handler (a3)

Quantifying resilience allows for several testable hypotheses, such as that resilience is equal to the number of mental health problems given a known quantity of stressor load. The proposed model lends itself well to prospective studies with data collection pre- and post-adversity; however, prestressor assessments are not always available. Challenges remain for adapting quantifying resilience to animal research, even if the idea of its translation value is significant.

Hide All
Admon, R., Milad, M. R. & Hendler, T. (2013) A causal model of post-traumatic stress disorder: Disentangling predisposed from acquired neural abnormalities. Trends in Cognitive Sciences 17(7):337–47. doi: 10.1016/j.tics.2013.05.005.
Binder, E. B., Bradley, R. G., Liu, W., Epstein, M. P., Deveau, T. C., Mercer, K. B., Tang, Y., Gillespie, C. F., Heim, C. M., Nemeroff, C. B., Schwartz, A. C., Cubells, J. F. & Ressler, K. J. (2008) Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. Journal of the American Medical Association 299(11):1291–305. doi: 10.1001/jama.299.11.1291.
Bremner, J. D., Southwick, S. M., Darnell, A. & Charney, D. S. (1996) Chronic PTSD in Vietnam combat veterans: Course of illness and substance abuse. American Journal of Psychiatry 153:369–75.
Cuthbert, B. N. (2014a) The RDoC framework: Facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry 13(1):2835. doi: 10.1002/wps.20087.
Elhai, J. D., Gray, M. J., Kashdan, T. B. & Franklin, C. L. (2005) Which instruments are most commonly used to assess traumatic event exposure and posttraumatic effects? A survey of traumatic stress professionals. Journal of Traumatic Stress 18(5):541–45. doi: 10.1002/jts.20062.
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R. & Hirsch, J. (2006) Resolving emotional conflict: A role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 51(6):871–82.
Etkin, A. & Wager, T. (2007) Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry 164(10):1476–88. doi: 10.1176/appi.ajp.2007.07030504.
Feder, A., Ahmad, S., Lee, E. J., Morgan, J. E., Singh, R., Smith, B. W., Southwick, S. M. & Charney, D. S. (2013) Coping and PTSD symptoms in Pakistani earthquake survivors: Purpose in life, religious coping and social support. Journal of Affective Disorders 147(1–3):156–63. doi: 10.1016/j.jad.2012.10.027.
Glover, E. M., Jovanovic, T., Mercer, K. B., Kerley, K., Bradley, B., Ressler, K. J. & Norrholm, S. D. (2012) Estrogen levels are associated with extinction deficits in women with posttraumatic stress disorder. Biological Psychiatry 72(1):1924. doi: 10.1016/j.biopsych.2012.02.031.
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C. & Wang, P. (2010) Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. American Journal of Psychiatry 167(7):748–51.
Milad, M. R., Pitman, R. K., Ellis, C. B., Gold, A. L., Shin, L. M., Lasko, N.. B., Zeidan, M. A., Handwerger, K., Orr, S. P. & Rauch, S. L. (2009) Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. Biological Psychiatry 66(12):1075–82.
Morgan, C. A., III., Wang, S., Southwick, S. M., Rasmusson, A., Hazlett, G., Hauger, R. L. & Charney, D. S. (2000) Plasma neuropeptide-Y concentrations in humans exposed to military survival training. Biological Psychiatry 47(10):902909. doi: 10.1016/S0006-3223(99)00239-5.
Norrholm, S. D., Jovanovic, T., Smith, A., Binder, E. B., Klengel, T., Conneely, K., Mercer, K. B., Davis, J. S., Kerley, K., Winkler, J., Gillespie, C. F., Bradley, B. & Ressler, K. J. (2013) Differential genetic and epigenetic regulation of catechol-O-methyl-transferase is associated with impaired fear inhibition in posttraumatic stress disorder. Frontiers in Behavioral Neuroscience 7:30. doi: 10.3389/fnbeh.2013.00030.
Rauch, S. L., Whalen, P. J., Shin, L. M., McInerney, S. C., Macklin, M. L., Lasko, N. B., Orr, S. P. & Pitman, R. K. (2000) Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: A functional MRI study. Biological Psychiatry 47(9):769–76.
Reul, J. M. (2014) Making memories of stressful events: A journey along epigenetic, gene transcription, and signaling pathways. Frontiers in Psychiatry 5:111.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Behavioral and Brain Sciences
  • ISSN: 0140-525X
  • EISSN: 1469-1825
  • URL: /core/journals/behavioral-and-brain-sciences
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed