Biodesign has grown significantly in the last decade as an approach focused on designing with biological materials, processes, and systems. The inherent transdisciplinarity of biodesign enables it to cut across multiple fields. In this work, we look at how biodesign has recently been applied within Human-Computer Interaction (HCI), a disciplinary field that focuses on the design, development, and study of interactive technologies. Subsequently, Biological-HCI (Bio-HCI) has emerged as a rapidly growing and evolving area of research at the intersection of biodesign and HCI. To highlight the nascence of Bio-HCI, we examine three of our own Bio-HCI projects—SCOBY Breastplate, B10-PR1NT, and μMe—as case studies that exemplify how biodesign is being explored through specific, situated practices with a variety of interactive technologies. Through these cases, we identify potential themes and opportunities for Bio-HCI as it continues to push current understandings of computational interaction and promote more sustainable technological futures.