Skip to main content
×
×
Home

Controversy over exercise therapy for chronic fatigue syndrome: Continuing the debate

  • Trudie Chalder, Peter Denton White, Michael Sharpe and Alex J. Mitchell
Editor's summary

In a recent Round the Corner, Mitchell commented on a Cochrane Review of exercise therapy for chronic fatigue syndrome (CFS). One of the trials included in that review, and discussed by Mitchell, was the PACE trial. In this month's Round the Corner we are publishing a response we received from authors of the PACE trial (Chalder, White & Sharpe), together with Mitchell's reply. Ed.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Controversy over exercise therapy for chronic fatigue syndrome: Continuing the debate
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Controversy over exercise therapy for chronic fatigue syndrome: Continuing the debate
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Controversy over exercise therapy for chronic fatigue syndrome: Continuing the debate
      Available formats
      ×
Copyright
Corresponding author
Correspondence Professor Trudie Chalder, Department of Psychological Medicine, King's College London, Weston Education Centre, Cutcombe Road, London SE5 9RJ, UK. Email: c/o The Editor, apt@rcpsych.ac.uk
Correspondence Dr Alex J. Mitchell, Department of Psycho-Oncology, Hadley House, Leicester General Hospital, Leicester LE5 4PW, UK. Email ajm80@le.ac.uk
Footnotes
Hide All

In relation to this debate, the publishers would like to remind readers that, unless so stated, material in BJPsych Advances does not necessarily reflect the views of the Editor or the Royal College of Psychiatrists. The publishers are not responsible for any errors of omission or fact.

Declaration of Interest

T.C. and M.S. have received royalties from academic publishers. P.D.W. has done voluntary and paid consultancy work for the UK government and a reinsurance company.

Footnotes
References
Hide All
Castell, BD, Kazantzis, N, Moss-Morris, RE (2011) Cognitive behavioral therapy and graded exercise for chronic fatigue syndrome: a meta-analysis. Clinical Psychology: Science and Practice, 18: 311–24.
Goldsmith, KA, White, PD, Johnson, AL, et al (2016) The PACE trial: exploratory analysis of primary fatigue outcomes using bimodal rather than continuous Likert type scoring on the Chalder fatigue scale. Wolfson Institute of Preventive Medicine (http://www.wolfson.qmul.ac.uk/images/pdfs/pace/PACE_bimodal_CFQ_analysis_final_8_Sept_2016.pdf).
Hawkes, N (2011) Dangers of research into chronic fatigue syndrome. BMJ, 342: d3780.
International Consortium of Investigators for Fairness in Trial Data Sharing (2016) Toward fairness in data sharing. New England Journal of Medicine, 375: 405–7.
Lancet (2011) Editorial: Patients' power and PACE. Lancet, 377: 1808.
Larun, L, Brurberg, KG, Odgaard-Jensen, J, et al (2016) Exercise therapy for chronic fatigue syndrome. Cochrane Database of Systematic Reviews, 6: CD003200. doi: 10.1002/14651858.CD003200.pub6.
Mitchell, AJ (2017) Controversy over exercise therapy for chronic fatigue syndrome: key lessons for clinicians and academics. BJPsych Advances, 23: 145–8.
Sharpe, MC, Archard, LC, Banatvala, JE, et al (1991) A report – chronic fatigue syndrome: guidelines for research. Journal of the Royal Society of Medicine, 84: 118–21.
Sharpe, M, Goldsmith, KA, Johnson, AL, et al (2016) Patient reaction to the PACE trial - Authors' reply. Lancet Psychiatry, 3(2): e89.
Sharpe, M, Chalder, T, Johnson, AL, et al (2017) Do more people recover from chronic fatigue syndrome with cognitive behaviour therapy or graded exercise therapy than with other treatments? Fatigue: Biomedicine, Health & Behavior, 5: 5761.
Taichman, DB, Backus, J, Baethge, C, et al (2016) Sharing clinical trial data: a proposal from the International Committee of Medical Journal Editors. Annals of Internal Medicine, 357: 505–6.
Walwyn, R, Potts, L, McCrone, P, et al (2013) A randomised trial of adaptive pacing therapy, cognitive behaviour therapy, graded exercise, and specialist medical care for chronic fatigue syndrome (PACE): statistical analysis plan. Trials, 14: 386.
Wessely, S (2015) The PACE Trial for chronic fatigue syndrome: choppy seas but a prosperous voyage. National Elf Service (https://www.nationalelfservice.net/other-health-conditions/chronic-fatigue-syndrome/the-pace-trial-for-chronic-fatigue-syndrome-choppy-seas-but-a-prosperous-voyage/). Accessed 15 June 2017.
White, PD, Sharpe, MC, Chalder, T, et al (2007) Protocol for the PACE trial: a randomised controlled trial of adaptive pacing, cognitive behaviour therapy, and graded exercise, as supplements to standardised specialist medical care versus standardised specialist medical care alone for patients with the chronic fatigue syndrome/myalgic encephalomyelitis or encephalopathy. BMC Neurology, 7: 6.
White, PD, Goldsmith, KA, Johnson, AL, et al (2011) Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise Controversy over exercise therapy for CFS: continuing the debate therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial. Lancet, 377: 823–36.
White, PD, Johnson, AL, Goldsmith, K, et al (2013) Recovery from chronic fatigue syndrome after treatments given in the PACE trial. Psychological Medicine, 43: 2227–35.
White, PD, Chalder, T, Sharpe, M (2015) The planning, implementation and publication of a complex intervention trial for chronic fatigue syndrome: the PACE trial. BJPsych Bulletin, 39: 24–7.
White, PD, Chalder, T, Sharpe, M (2016) Releasing patient data from the PACE trial for chronic fatigue syndrome. BMJ Opinion, 22 September (http://blogs.bmj.com/bmj/2016/09/22/peter-white-et-al-releasing-patient-data-from-the-pace-trial-for-chronic-fatigue-syndrome/). Accessed 15 June 2017.
Wilshire, C, Kindlon, T, Matthees, A, et al (2017) Can patients with chronic fatigue syndrome really recover after graded exercise or cognitive behavioural therapy? A critical commentary and preliminary re-analysis of the PACE trial. Fatigue: Biomedicine, Health and Behavior, 5: 4356.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

BJPsych Advances
  • ISSN: 2056-4678
  • EISSN: 2056-4686
  • URL: /core/journals/bjpsych-advances
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Controversy over exercise therapy for chronic fatigue syndrome: Continuing the debate

  • Trudie Chalder, Peter Denton White, Michael Sharpe and Alex J. Mitchell
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *