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Acute effects of whey protein isolate on blood pressure, vascular function and inflammatory markers in overweight postmenopausal women

  • Sebely Pal (a1) and Vanessa Ellis (a1)

Abstract

Previous evidence indicates that chronic consumption of dairy whey proteins has beneficial effects on CVD risk factors. The present study investigated the postprandial effects of whey protein isolate on blood pressure, vascular function and inflammatory markers in overweight and obese postmenopausal women. This was a randomised, three-way cross-over design study where twenty overweight and obese postmenopausal women consumed a breakfast meal in conjunction with one of three supplements: 45 g whey protein isolate, 45 g sodium caseinate or 45 g of a glucose control. Fasting and postprandial blood samples, blood pressure and pulse wave analysis readings were taken for up to 6 h. After consumption of the meal, both systolic and diastolic blood pressure, and augmentation index (AI) decreased initially for all interventions and gradually returned to baseline levels by 6 h. However, there were no significant differences in AI, systolic or diastolic blood pressure within or between the glucose control, casein or whey groups. There were also no significant group effects on plasma inflammatory markers (IL-6, TNF-α and C-reactive protein). The health effects previously seen with chronic whey protein ingestion were not seen in the acute 6 h postprandial period in relation to blood pressure, vascular function or inflammatory markers when compared with casein and a glucose control. This suggests that such effects are better observed from the long-term consumption of whey proteins.

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Corresponding author

*Corresponding author: Associate Professor S. Pal, fax +61 8 9266 2258, email s.pal@curtin.edu.au

References

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1 Kochanek, K, Murphy, S, Anderson, R, et al. (2004) Deaths: final data for 2002. Natl Vital Stat Rep 53, 1115.
2 Australian Bureau of Statistics (2009) Causes of Death, Australia 2007. Canberra, ACT: ABS Publication. http://www.abs.gov.au/ausstats/abs@.nsf/Products/9982A795F3C13BE2CA25757C001EF4D9?opendocument (updated 22 January 2010).
3 Australian Bureau of Statistics (2006) Cardiovascular Disease in Australia: A Snapshot, 2004–05. Canberra, ACT: ABS Publication. http://www.abs.gov.au/ausstats/abs@.nsf/mf/4821.0.55.001 (updated 22 January 2010).
4 Appel, L, Brands, M, Daniels, S, et al. (2006) Dietary approaches to prevent and treat hypertension. A scientific statement from the American Heart Association. Hypertension 47, 296308.
5 van Trijp, M, Bos, W, Uiterwaal, C, et al. (2004) Determinants of augmentation index in young men: the ARYA study. Eur J Clin Invest. 34, 825830.
6 Wilkinson, I & McEniery, C (2004) Arterial stiffness, endothelial function and novel pharmacological approaches. Clin Exp Pharmacol Physiol 31, 795799.
7 Schiffrin, E (2004) Vascular stiffening and arterial compliance: implications for systolic blood pressure. Am J Hypertens 17, 39S48S.
8 Ross, R (1999) Atherosclerosis – an inflammatory disease. N Engl J Med 340, 115126.
9 Gaspard, U, Gottal, J & van den Brule, F (1995) Postmenopausal changes of lipid and glucose metabolism: a review of their main aspects. Maturitas 21, 171178.
10 Bechlioulis, A, Naka, K, Papanikolaou, O, et al. (2009) Menopause and hormone therapy: from vascular endothelial function to cardiovascular disease. Hellenic J Cardiol 50, 303315.
11 Abbott, R, Curb, J & Rodriguez, B (1996) Effect of dietary calcium and milk consumption on the risk of thrombolic stroke in older middle-aged men. The Honolulu Heart Program. Stroke 27, 813818.
12 Doulton, T (2006) ACE inhibitor-angiotensin receptor blocker combinations: a clinician's perspective. Mini Rev Med Chem 6, 491497.
13 Prasad, K (2006) C-reeactive protein (CRP)-lowering agents. Cardiovasc Drug Rev 24, 3350.
14 Andrzejczak, D, Górska, D & Czarnecka, E (2007) Influence of enalapril, quinapril and losartan on lipopolysaccharide (LPS)-induced serum concentrations of TNF-alpha, IL-1 beta, IL-6 in spontaneously hypertensive rats (SHR). Pharmacol Rep 59, 437446.
15 FitzGerald, R & Meisel, H (1999) Lactokinins: whey protein-derived ACE inhibitory peptides. Nahrung 3, 165167.
16 Kawase, M, Hashimoto, H, Hosoda, M, et al. (2000) Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J Dairy Sci 83, 255263.
17 Mullaly, M, Meisel, H & FitzGerald, R (1997) Angiotensin-I-converting enzyme inhibitory activities of gastric and pancreatic proteinase digest of whey proteins. Int Dairy 7, 299303.
18 Seppo, L, Jauhiainen, T, Poussa, T, et al. (2003) A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr 77, 326330.
19 Lee, Y, Skurk, T, Hennig, M, et al. (2007) Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. Eur J Nutr 46, 2127.
20 Pal, S & Ellis, V (2009) The chronic effects of whey proteins on blood pressure, vascular function and inflammatory markers in overweight individuals. Obesity 18, 13541359.
21 Craig, C, Marshall, A, Sjöström, M, et al. (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35, 13811395.
22 Arya, F, Egger, S, Colquhoun, D, et al. (2010) Differences in postprandial inflammatory responses to a ‘modern’ v. traditional meat meal: a preliminary study. Br J Nutr 104, 724728.
23 Janner, J, Godtfredsen, N, Ladelund, S, et al. (2010) Aortic augmentation index: reference values in a large unselected population by means of the SphygmoCor device. Am J Hypertens 23, 180185.
24 van Trijp, M, Bos, W, van der Schouw, Y, et al. (2005) Alcohol and arterial wave reflections in middle aged and elderly men. Eur J Clin Invest 35, 615621.
25 Naissides, M, Mamo, J, James, T, et al. (2006) The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women. Eur J Clin Nutr 60, 740745.
26 Takano, T (1998) Milk derived peptides and hypertension reduction. Int Dairy J 8, 375381.
27 FitzGerald, R & Meisel, H (2000) Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr 84, S33S37.
28 Abubakar, A, Tadao, S, Kitazawa, H, et al. (1998) Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J Dairy Sci 81, 31313138.
29 Nurminen, M, Sipola, M, Kaarto, H, et al. (2000) Lactorphin lowers blood pressure measured by radiotelemetry in normotensive and spontaneously hypertensive rats. Life Sci 66, 535543.
30 Hata, Y, Yamamoto, M, Ohni, M, et al. (1996) A study on the effect of sour milk on blood pressure in hypertensive patients. Am J Clin Nutr 64, 767771.
31 Qureshi, G, Brown, R, Salciccioli, L, et al. (2007) Relationship between aortic atherosclerosis and non-invasive measures of arterial stiffness. Atherosclerosis 195, e190e194.
32 Greenwald, S (2007) Ageing of the conduit arteries. J Pathol 211, 157172.
33 Benetos, A, Waeber, B, Izzo, J, et al. (2002) Influence of age, risk factors and cardiovascular and renal disease on arterial stiffness: clinical applications. Am J Hypertens 15, 11011108.
34 Blacher, J & Safar, M (2005) Large-artery stiffness, hypertension and cardiovascular risk in older patients. Nat Clin Pract Cardiovasc Med 2, 450455.
35 Safar, M (2001) Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors. Curr Opin Nephrol Hypertens 10, 257261.
36 Tomiyama, H, Hashimoto, H, Hirayama, Y, et al. (2006) Synergistic acceleration of arterial stiffening in the presence of raised blood pressure and raised plasma glucose. Hypertension 47, 180188.
37 Sekiya, S, Kobayashi, Y, Kita, E, et al. (1992) Antihypertensive effects of tryptic hydrolysate of casein on normotensive and hypertensive volunteers (in Japanese). J Jap Soc Nutr Food Sci 45, 513517.
38 Bastian, E & Harper, W (2003) Emerging health benefits of whey. Dairy Council Digest 74, 3136.
39 Boirie, Y, Dangin, M, Gachon, P, et al. (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci U S A 94, 1493014935.
40 Ballard, K, Bruno, R, Seip, R, et al. (2009) Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial. Nutr J 8, 34.
41 Humbert, M, Monti, G, Brenot, F, et al. (1995) Increased interleukin-1 and interleukin-6 serum concentrations in severe primary pulmonary hypertension. Am J Respir Crit Care Med 151, 16281631.

Keywords

Acute effects of whey protein isolate on blood pressure, vascular function and inflammatory markers in overweight postmenopausal women

  • Sebely Pal (a1) and Vanessa Ellis (a1)

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