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Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism

  • José Lopez-Miranda (a1), Christine Williams (a2) and Denis Lairon (a3)
Abstract

Most of diurnal time is spent in a postprandial state due to successive meal intakes during the day. As long as the meals contain enough fat, a transient increase in triacylglycerolaemia and a change in lipoprotein pattern occurs. The extent and kinetics of such postprandial changes are highly variable and are modulated by numerous factors. This review focuses on factors affecting postprandial lipoprotein metabolism and genes, their variability and their relationship with intermediate phenotypes and risk of CHD. Postprandial lipoprotein metabolism is modulated by background dietary pattern as well as meal composition (fat amount and type, carbohydrate, protein, fibre, alcohol) and several lifestyle conditions (physical activity, tobacco use), physiological factors (age, gender, menopausal status) and pathological conditions (obesity, insulin resistance, diabetes mellitus). The roles of many genes have been explored in order to establish the possible implications of their variability in lipid metabolism and CHD risk. The postprandial lipid response has been shown to be modified by polymorphisms within the genes for apo A-I, A-IV, A-V, E, B, C-I and C-III, lipoprotein lipase, hepatic lipase, fatty acid binding and transport proteins, microsomal triglyceride transfer protein and scavenger receptor class B type I. Overall, the variability in postprandial response is important and complex, and the interactions between nutrients or dietary or meal compositions and gene variants need further investigation. The extent of present knowledge and needs for future studies are discussed in light of ongoing developments in nutrigenetics.

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Corresponding author
*Corresponding author: Dr Denis Lairon, fax +33 4 91 78 21 01, email denis.lairon@medecine.univ-mrs.fr.
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2 DB Zilversmit (1979) Atherogenesis: a postprandial phenomenon. Circulation 60, 473485.

3 PH Groot , WA van Stiphout , XH Krauss , (1991) Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease. Arterioscler Thromb 11, 653662.

4 JR Patsch , G Miesenbock , T Hopferwieser , V Muhlberger , E Knapp , JK Dunn , AM Gotto Jr & W Patsch (1992) Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arterioscler Thromb 12, 13361345.

5 F Karpe , P Tornvall , T Olivecrona , G Steiner , LA Carlson & A Hamsten (1993) Composition of human low density lipoprotein: effects of postprandial triglyceride-rich lipoproteins, lipoprotein lipase, hepatic lipase and cholesteryl ester transfer protein. Atherosclerosis 98, 3349.

6 E Meyer , HT Westerveld , FC de Ruyter-Meijstek , MM van Greevenbroek , R Rienks , HJ van Rijn , DW Erkelens & TW de Bruin (1996) Abnormal postprandial apolipoprotein B-48 and triglyceride responses in normolipidemic women with greater than 70 % stenotic coronary artery disease: a case-control study. Atherosclerosis 124, 221235.

7 HN Ginsberg , J Jones , WS Blaner , A Thomas , W Karmally , L Fields , D Blood & MD Begg (1995) Association of postprandial triglyceride and retinyl palmitate responses with newly diagnosed exercise-induced myocardial ischemia in middle-aged men and women. Arterioscler Thromb Vasc Biol 15, 18291838.

8 JE Ryu , G Howard , TE Craven , MG Bond , AP Hagaman & JR Crouse 3rd (1992) Postprandial triglyceridemia and carotid atherosclerosis in middle-aged subjects. Stroke 23, 823828.

9 F Karpe , U de Faire , M Mercuri , MG Bond , ML Hellenius & A Hamsten (1998) Magnitude of alimentary lipemia is related to intima-media thickness of the common carotid artery in middle-aged men. Atherosclerosis 141, 307314.

10 S Boquist , G Ruotolo , R Tang , J Bjorkegren , MG Bond , U de Faire , F Karpe & A Hamsten (1999) Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation 100, 723728.

11 A Hamsten , A Silveira , S Boquist , R Tang , MG Bond , U de Faire & J Bjorkegren (2005) The apolipoprotein CI content of triglyceride-rich lipoproteins independently predicts early atherosclerosis in healthy middle-aged men. J Am Coll Cardiol 45, 10131017.

12 CS Uiterwaal , DE Grobbee , JC Witteman , WA van Stiphout , XH Krauss , LM Havekes , AM de Bruijn , A van Tol & A Hofman (1994) Postprandial triglyceride response in young adult men and familial risk for coronary atherosclerosis. Ann Intern Med 121, 576583.

13 L Tiret , C Gerdes , MJ Murphy , J Dallongeville , V Nicaud , DS O'Reilly , U Beisiegel & G De Backer (2000) Postprandial response to a fat tolerance test in young adults with a paternal history of premature coronary heart disease – the EARS II study (European Atherosclerosis Research Study). Eur J Clin Invest 30, 578585.

14 NR Phillips , D Waters & RJ Havel (1993) Plasma lipoproteins and progression of coronary artery disease evaluated by angiography and clinical events. Circulation 88, 27622770.

15 F Karpe (1999) Postprandial lipoprotein metabolism and atherosclerosis. J Intern Med 246, 341355.

16 MT Speidel , FM Booyse , A Abrams , MA Moore & BH Chung (1990) Lipolyzed hypertriglyceridemic serum and triglyceride-rich lipoprotein cause lipid accumulation in and are cytotoxic to cultured human endothelial cells. High density lipoproteins inhibit this cytotoxicity. Thromb Res 58, 251264.

17 RA Vogel , MC Corretti & GD Plotnick (1997) Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol 79, 350354.

18 H Doi , K Kugiyama , H Oka , S Sugiyama , N Ogata , SI Koide , SI Nakamura & H Yasue (2000) Remnant lipoproteins induce proatherothrombogenic molecules in endothelial cells through a redox-sensitive mechanism. Circulation 102, 670676.

20 GJ Miller (1998) Postprandial lipaemia and haemostatic factors. Atherosclerosis 141, Suppl. 1, S47S51.

23 A Broijersen , F Karpe , A Hamsten , AH Goodall & P Hjemdahl (1998) Alimentary lipemia enhances the membrane expression of platelet P-selectin without affecting other markers of platelet activation. Atherosclerosis 137, 107113.

24 DA Hyson , TAG Paglieroni , T Wun & JC Rutledge (2002) Postprandial lipemia is associated with platelet and monocyte activation and increased monocyte cytokine expression in normolipemic men. Clin Appl Thromb Hemost 8, 147155.

26 A van Tol , MS van der Gaag , LM Scheek , T van Gent & HF Hendriks (1998) Changes in postprandial lipoproteins of low and high density caused by moderate alcohol consumption with dinner. Atherosclerosis 141, Suppl. 1, S101S103.

27 CM Williams (1998) Dietary interventions affecting chylomicron and chylomicron remnant clearance. Atherosclerosis 141, Suppl. 1, S87S92.

40 MC Cabezas , TW de Bruin , H Jansen , LA Kock , W Kortlandt & DW Erkelens (1993) Impaired chylomicron remnant clearance in familial combined hyperlipidemia. Arterioscler Thromb 13, 804814.

41 AH Lichtenstein , LM Ausman , W Carrasco , JL Jenner , LJ Gualtieri , BR Goldin , JM Ordovas & EJ Schaefer (1993) Effects of canola, corn, and olive oils on fasting and postprandial plasma lipoproteins in humans as part of a National Cholesterol Education Program Step 2 diet. Arterioscler Thromb 13, 15331542.

45 B Vessby , M Unsitupa , K Hermansen , (2001) Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU Study. Diabetologia 44, 312319.

47 MM Jensen , MS Christensen & CE Hoy (1994) Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. Ann Nutr Metab 38, 104116.

48 TA Sanders , T de Grassi , GJ Miller & JH Morrissey (2000) Influence of fatty acid chain length and cis/trans isomerization on postprandial lipemia and factor VII in healthy subjects (postprandial lipids and factor VII). Atherosclerosis 149, 413420.

54 MS Weintraub , R Zechner , A Brown , S Eisenberg & JL Breslow (1988) Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism. J Clin Invest 82, 18841893.

55 A Zampelas , H Roche , JM Knapper , (1998) Differences in postprandial lipaemic response between Northern and Southern Europeans. Atherosclerosis 139, 8393.

56 KD Silva , CN Kelly , AE Jones , RD Smith , SA Wootton , GJ Miller & CM Williams (2003) Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids. Atherosclerosis 166, 7384.

57 AA Rivellese , A Maffettone , B Vessby , M Uusitupa , K Hermansen , L Berglund , A Louheranta , BJ Meyer & G Riccardi (2003) Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects. Atherosclerosis 167, 149158.

61 Y Park & WS Harris (2003) Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance. J Lipid Res 44, 455463.

68 EJ Parks , RM Krauss , MP Christiansen , RA Neese & MK Hellerstein (1999) Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance. J Clin Invest 104, 10871096.

71 A Harbis , C Defoort , H Narbonne , (2001) Acute hyperinsulinism modulates plasma apolipoprotein B-48 triglyceride-rich lipoproteins in healthy subjects during the postprandial period. Diabetes 50, 462469.

75 K Higashi , S Abata , N Iwamoto , M Ogura , T Yamashita , O Ishikawa , F Ohslzu & H Nakamura (2001) Effects of soy protein on levels of remnant-like particles cholesterol and vitamin E in healthy men. J Nutr Sci Vitaminol (Tokyo) 47, 283288.

76 S Westphal , E Taneva , S Kastner , J Martens-Lobenhoffer , S Bode-Boger , S Kropf , J Dierkes & C Luley (2006) Endothelial dysfunction induced by postprandial lipemia is neutralized by addition of proteins to the fatty meal. Atherosclerosis 185, 313319.

77 JC Mamo , AP James , MJ Soares , DG Griffiths , K Purcell & JL Schwenke (2005) A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet. Eur J Clin Nutr 59, 11421148.

78 AE Hardman & HE Aldred (1995) Walking during the postprandial period decreases alimentary lipaemia. J Cardiovasc Risk 2, 7178.

79 NV Tsetsonis & AE Hardman (1996) Reduction in postprandial lipemia after walking: influence of exercise intensity. Med Sci Sports Exerc 28, 12351242.

80 NV Tsetsonis & AE Hardman (1996) Effects of low and moderate intensity treadmill walking on postprandial lipaemia in healthy young adults. Eur J Appl Physiol Occup Physiol 73, 419426.

81 AE Hardman (1998) The influence of exercise on postprandial triacylglycerol metabolism. Atherosclerosis 141, Suppl. 1, S93S100.

83 SP Sady , PD Thompson , EM Cullinane , MA Kantor , E Domagala & PN Herbert (1986) Prolonged exercise augments plasma triglyceride clearance. JAMA 256, 25522555.

85 JQ Zhang , B Smith , MM Langdon , HL Messimer , GY Sun , RH Cox , M James-Kracke & TR Thomas (2002) Changes in LPLa and reverse cholesterol transport variables during 24-h postexercise period. Am J Physiol Endocrinol Metab 283, E267E274.

86 DS Petitt & KJ Cureton (2003) Effects of prior exercise on postprandial lipemia: a quantitative review. Metabolism 52, 418424.

87 JM Gill , GP Mees , KN Frayn & AE Hardman (2001) Moderate exercise, postprandial lipaemia and triacylglycerol clearance. Eur J Clin Invest 31, 201207.

88 BK Smith , GY Sun , OM Donahue & TR Thomas (2004) Exercise plus n-3 fatty acids: additive effect on postprandial lipemia. Metabolism 53, 13651371.

89 M Axelsen , B Eliasson , E Joheim , RA Lenner , MR Taskinen & U Smith (1995) Lipid intolerance in smokers. J Intern Med 237, 449455.

90 N Mero , M Syvanne , B Eliasson , U Smith & MR Taskinen (1997) Postprandial elevation of ApoB-48-containing triglyceride-rich particles and retinyl esters in normolipemic males who smoke. Arterioscler Thromb Vasc Biol 17, 20962102.

91 AR Sharrett , G Heiss , LE Chambless , E Boerwinkle , SA Coady , AR Folsom & W Patsch (2001) Metabolic and lifestyle determinants of postprandial lipemia differ from those of fasting triglycerides: the Atherosclerosis Risk In Communities (ARIC) study. Arterioscler Thromb Vasc Biol 21, 275281.

94 HJ Pownall , CM Ballantyne , KT Kimball , SL Simpson , D Yeshurun & AM Gotto Jr (1999) Effect of moderate alcohol consumption on hypertriglyceridemia: a study in the fasting state. Arch Intern Med 159, 981987.

96 KG Jackson , JM Knapper-Francis , LM Morgan , DH Webb , A Zampelas & CM Williams (2003) Exaggerated postprandial lipaemia and lower post-heparin lipoprotein lipase activity in middle-aged men. Clin Sci (Lond) 105, 457466.

97 AP van Beek , FC de Ruijter-Heijstek , DW Erkelens & TW de Bruin (1999) Menopause is associated with reduced protection from postprandial lipemia. Arterioscler Thromb Vasc Biol 19, 27372741.

98 ME Ossewaarde , GM Dallinga-Thie , ML Bots , YT van der Schouw , TJ Rabelink , DE Grobbee & HT Westerveld (2003) Treatment with hormone replacement therapy lowers remnant lipoprotein particles in healthy postmenopausal women: results from a randomized trial. Eur J Clin Invest 33, 376382.

99 GF Lewis , NM O'Meara , PA Soltys , JD Blackman , PH Iverius , AF Druetzler , GS Getz & KS Polonsky (1990) Postprandial lipoprotein metabolism in normal and obese subjects: comparison after the vitamin A fat-loading test. J Clin Endocrinol Metab 71, 10411050.

100 C Couillard , N Bergeron , D Prud'homme , J Bergeron , A Tremblay , C Bouchard , P Mauriege & JP Despres (1998) Postprandial triglyceride response in visceral obesity in men. Diabetes 47, 953960.

102 N Mekki , MA Christofilis , M Charbonnier , (1999) Influence of obesity and body fat distribution on postprandial lipemia and triglyceride-rich lipoproteins in adult women. J Clin Endocrinol Metab 84, 184191.

103 IJ Goldberg , T Vanni-Reyes , S Ramakrishnan , S Holleran & HN Ginsberg (2000) Circulating lipoprotein profiles are modulated differently by lipoprotein lipase in obese humans. J Cardiovasc Risk 7, 4147.

104 AP James , GF Watts , PH Barrett , D Smith , S Pal , DC Chan & JC Mamo (2003) Effect of weight loss on postprandial lipemia and low-density lipoprotein receptor binding in overweight men. Metabolism 52, 136141.

105 G Reaven (2002) Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation 106, 286288.

106 MR Taskinen (2002) Diabetic dyslipidemia. Atheroscler Suppl 3, 4751.

107 J Jeppesen , CB Hollenbeck , MY Zhou , AM Coulston , C Jones , YD Chen & GM Reaven (1995) Relation between insulin resistance, hyperinsulinemia, postheparin plasma lipoprotein lipase activity, and postprandial lipemia. Arterioscler Thromb Vasc Biol 15, 320324.

108 S Boquist , A Hamsten , F Karpe & G Ruotolo (2000) Insulin and non-esterified fatty acid relations to alimentary lipaemia and plasma concentrations of postprandial triglyceride-rich lipoproteins in healthy middle-aged men. Diabetologia 43, 185193.

109 SM Haffner (2002) Lipoprotein disorders associated with type 2 diabetes mellitus and insulin resistance. Am J Cardiol 90, 55i61i.

111 T Hirano , G Yoshino , K Kashiwazaki & M Adachi (2001) Doxazosin reduces prevalence of small dense low density lipoprotein and remnant-like particle cholesterol levels in nondiabetic and diabetic hypertensive patients. Am J Hypertens 14, 908913.

112 BV Howard , DC Robbins , ML Sievers , (2000) LDL cholesterol as a strong predictor of coronary heart disease in diabetic individuals with insulin resistance and low LDL: the Strong Heart Study. Arterioscler Thromb Vasc Biol 20, 830835.

113 M Guerin , W Le Goff , TS Lassel , A Van Tol , G Steiner & MJ Chapman (2001) Atherogenic role of elevated CE transfer from HDL to VLDL(1) and dense LDL in type 2 diabetes: impact of the degree of triglyceridemia. Arterioscler Thromb Vasc Biol 21, 282288.

114 EJ Schaefer , JR McNamara , PK Shah , K Nakajima , LA Cupples , JM Ordovas & PW Wilson (2002) Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study. Diabetes Care 25, 989994.

115 MG Masding , AJ Stears , GC Burdge , SA Wootton & DD Sandeman (2003) Premenopausal advantages in postprandial lipid metabolism are lost in women with type 2 diabetes. Diabetes Care 26, 32433249.

116 MG Masding , AJ Stears , GC Burdge , SA Wootton & DD Sandeman (2006) The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with type 2 diabetes. Diabet Med 23, 768774.

117 CJ Fielding , VG Shore & PE Fielding (1972) A protein cofactor of lecithin:cholesterol acyltransferase. Biochem Biophys Res Commun 46, 14931498.

118 D Reichl & NE Miller (1989) Pathophysiology of reverse cholesterol transport. Insights from inherited disorders of lipoprotein metabolism. Arteriosclerosis 9, 785797.

119 L Calabresi , M Cassinotti , G Gianfranceschi , O Safa , T Murakami , CR Sirtori & G Franceschini (1993) Increased postprandial lipemia in Apo A-IMilano carriers. Arterioscler Thromb 13, 521528.

124 HJ Menzel , G Sigurdsson , E Boerwinkle , S Schrangl-Will , H Dieplinger & G Utermann (1990) Frequency and effect of human apolipoprotein A-IV polymorphism on lipid and lipoprotein levels in an Icelandic population. Hum Genet 84, 344346.

125 P de Knijff , LG Johansen , M Rosseneu , RR Frants , J Jespersen & LM Havekes (1992) Lipoprotein profile of a Greenland Inuit population. Influence of anthropometric variables, apo E and A4 polymorphism, and lifestyle. Arterioscler Thromb 12, 13711379.

126 MA Ostos , J Lopez-Miranda , C Marin , P Castro , P Gomez , E Paz , JA Jimenez Pereperez , JM Ordovas & F Perez-Jimenez (2000) The apolipoprotein A-IV-360His polymorphism determines the dietary fat clearance in normal subjects. Atherosclerosis 153, 209217.

128 RB Weinberg , VR Cook , JA Beckstead , DD Martin , JW Gallagher , GS Shelness & RO Ryan (2003) Structure and interfacial properties of human apolipoprotein A-V. J Biol Chem 278, 3443834444.

130 M Vrablik , A Horinek , R Ceska , V Adamkova , R Poledne & JA Hubacek (2003) Ser19 → Trp polymorphism within the apolipoprotein AV gene in hypertriglyceridaemic people. J Med Genet 40, e105.

131 L Masana , J Ribalta , J Salazar , J Fernandez-Ballart , J Joven & MC Cabezas (2003) The apolipoprotein AV gene and diurnal triglyceridaemia in normolipidaemic subjects. Clin Chem Lab Med 41, 517521.

133 R Moreno , F Perez-Jimenez , C Marin , (2006) A single nucleotide polymorphism of the apolipoprotein A-V gene − 1131T>C modulates postprandial lipoprotein metabolism. Atherosclerosis 189, 163–168.

134 P Carlsson , C Darnfors , SO Olofsson & G Bjursell (1986) Analysis of the human apolipoprotein B gene; complete structure of the B-74 region. Gene 49, 29–51.

135 J Lopez-Miranda , JM Ordovas , MA Ostos , (1997) Dietary fat clearance in normal subjects is modulated by genetic variation at the apolipoprotein B gene locus. Arterioscler Thromb Vasc Biol 17, 17651773.

136 E Boerwinkle & L Chan (1989) A three codon insertion/deletion polymorphism in the signal peptide region of the human apolipoprotein B (APOB) gene directly typed by the polymerase chain reaction. Nucleic Acids Res 17, 4003.

137 CD Byrne , NJ Wareham , PK Mistry , DI Phillips , ND Martensz , D Halsall , PJ Talmud , SE Humphries & CN Hales (1996) The association between free fatty acid concentrations and triglyceride-rich lipoproteins in the post-prandial state is altered by a common deletion polymorphism of the apo B signal peptide. Atherosclerosis 127, 35–42.

138 A Regis-Bailly , B Fournier , J Steinmetz , R Gueguen , G Siest & S Visvikis (1995) Apo B signal peptide insertion/deletion polymorphism is involved in postprandial lipoparticles' responses. Atherosclerosis 118, 23–34.

141 MC Jong , MH Hofker & LM Havekes (1999) Role of apoCs in lipoprotein metabolism: functional differences between apoC1, apoC2, and apoC3. Arterioscler Thromb Vasc Biol 19, 472–484.

143 SK Woo & HS Kang (2003) The apolipoprotein CIII T2854G variants are associated with postprandial triacylglycerol concentrations in normolipidemic Korean men. J Hum Genet 48, 551555.

144 U Beisiegel , W Weber , G Ihrke , J Herz & KK Stanley (1989) The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature 341, 162–164.

145 H Gylling , M Hallikainen , J Pihlajamaki , J Agren , M Laakso , RA Rajaratnam , R Rauramaa & TA Miettinen (2004) Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. J Lipid Res 45, 16601665.

146 RW Mahley (1988) Apolipoprotein E:cholesterol transport protein with expanding role in cell biology. Science 240, 622630.

148 MS Weintraub , S Eisenberg & JL Breslow (1987) Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. J Clin Invest 80, 15711577.

149 A Dart , B Sherrard & H Simpson (1997) Influence of apo E phenotype on postprandial triglyceride and glucose responses in subjects with and without coronary heart disease. Atherosclerosis 130, 161–170.

150 J Dallongeville , L Tiret , S Visvikis , (1999) Effect of apo E phenotype on plasma postprandial triglyceride levels in young male adults with and without a familial history of myocardial infarction: the EARS II study. European Atherosclerosis Research Study. Atherosclerosis 145, 381–388.

151 F Cardona , S Morcillo , M Gonzalo-Marin & FJ Tinahones (2005) The apolipoprotein E genotype predicts postprandial hypertriglyceridemia in patients with the metabolic syndrome. J Clin Endocrinol Metab 90, 29722975.

152 S Mui , M Briggs , H Chung , RB Wallace , T Gomez-Isla , GW Rebeck & BT Hyman (1996) A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele. Neurology 47, 196–201.

153 MJ Artiga , MJ Bullido , I Sastre , M Recuero , MA Garcia , J Aldudo , J Vazquez & F Valdivieso (1998) Allelic polymorphisms in the transcriptional regulatory region of apolipoprotein E gene. FEBS Lett 421, 105–108.

154 E Boisfer , G Lambert , V Atger , (1999) Overexpression of human apolipoprotein A-II in mice induces hypertriglyceridemia due to defective very low density lipoprotein hydrolysis. J Biol Chem 274, 1156411572.

155 L Viitanen , J Pihlajamaki , R Miettinen , P Karkkainen , I Vauhkonen , P Halonen , A Kareinen , S Lehto & M Laakso (2001) Apolipoprotein E gene promoter ( − 219G/T) polymorphism is associated with premature coronary heart disease. J Mol Med 79, 732737.

156 JA Moreno , J Lopez-Miranda , C Marin , (2003) The influence of the apolipoprotein E gene promoter ( − 219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males. J Lipid Res 44, 2059–2064.

157 V Matarese , RL Stone , DW Waggoner & DA Bernlohr (1989) Intracellular fatty acid trafficking and the role of cytosolic lipid binding proteins. Prog Lipid Res 28, 245–272.

158 LJ Baier , JC Sacchettini , WC Knowler , (1995) An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 95, 1281–1287.

159 RA Hegele , SB Harris , AJ Hanley , S Sadikian , PW Connelly & B Zinman (1996) Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians. J Clin Endocrinol Metab 81, 43344337.

160 K Yamada , X Yuan , S Ishiyama , K Koyama , F Ichikawa , A Koyanagi , W Koyama & K Nonaka (1997) Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men. Diabetologia 40, 706–710.

161 JJ Agren , R Valve , H Vidgren , M Laakso & M Uusitupa (1998) Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene. Arterioscler Thromb Vasc Biol 18, 1606–1610.

162 A Georgopoulos , O Aras & MY Tsai (2000) Codon-54 polymorphism of the fatty acid-binding protein 2 gene is associated with elevation of fasting and postprandial triglyceride in type 2 diabetes. J Clin Endocrinol Metab 85, 31553160.

163 E Tahvanainen , M Molin , S Vainio , L Tiret , V Nicaud , E Farinaro , L Masana & C Ehnholm (2000) Intestinal fatty acid binding protein polymorphism at codon 54 is not associated with postprandial responses to fat and glucose tolerance tests in healthy young Europeans. Results from EARS II participants. Atherosclerosis 152, 317–325.

165 K Gertow , C Skoglund-Andersson , P Eriksson , S Boquist , K Orth-Gomer , K Schenck-Gustafsson , A Hamsten & RM Fisher (2003) A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. Atherosclerosis 167, 265–273.

166 U Beisiegel , W Weber & G Bengtsson-Olivecrona (1991) Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A 88, 83428346.

168 RM Fisher , SE Humphries & PJ Talmud (1997) Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis. Atherosclerosis 135, 145–159.

169 C Gerdes , RM Fisher , V Nicaud , J Boer , SE Humphries , PJ Talmud & O Faergeman (1997) Lipoprotein lipase variants D9N and N291S are associated with increased plasma triglyceride and lower high-density lipoprotein cholesterol concentrations: studies in the fasting and postprandial states: the European Atherosclerosis Research Studies. Circulation 96, 733–740.

171 J Lopez-Miranda , G Cruz , P Gomez , C Marin , E Paz , P Perez-Martinez , FJ Fuentes , JM Ordovas & F Perez-Jimenez (2004) The influence of lipoprotein lipase gene variation on postprandial lipoprotein metabolism. J Clin Endocrinol Metab 89, 47214728.

172 FM van't Hooft , B Lundahl , F Ragogna , F Karpe , G Olivecrona & A Hamsten (2000) Functional characterization of 4 polymorphisms in promoter region of hepatic lipase gene. Arterioscler Thromb Vasc Biol 20, 1335–1339.

173 H Jansen , G Chu , C Ehnholm , J Dallongeville , V Nicaud & PJ Talmud (1999) The T allele of the hepatic lipase promoter variant C-480T is associated with increased fasting lipids and HDL and increased preprandial and postprandial LpCIII:B: European Atherosclerosis Research Study (EARS) II. Arterioscler Thromb Vasc Biol 19, 303–308.

174 P Gomez , JL Miranda , C Marin , C Bellido , JA Moreno , R Moreno , P Perez-Martinez & F Perez-Jimenez (2004) Influence of the -514C/T polymorphism in the promoter of the hepatic lipase gene on postprandial lipoprotein metabolism. Atherosclerosis 174, 73–79.

175 F Karpe , B Lundahl , E Ehrenborg , P Eriksson & A Hamsten (1998) A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels. Arterioscler Thromb Vasc Biol 18, 756761.

176 B Lundahl , A Hamsten & F Karpe (2002) Postprandial plasma ApoB-48 levels are influenced by a polymorphism in the promoter of the microsomal triglyceride transfer protein gene. Arterioscler Thromb Vasc Biol 22, 289293.

177 H Hauser , JH Dyer , A Nandy , (1998) Identification of a receptor mediating absorption of dietary cholesterol in the intestine. Biochemistry 37, 1784317850.

178 F Bietrix , D Yan , M Nauze , (2006) Accelerated lipid absorption in mice overexpressing intestinal SR-BI. J Biol Chem 281, 72147219.

179 P Perez-Martinez , J Lopez-Miranda , JM Ordovas , (2004) Postprandial lipemia is modified by the presence of the polymorphism present in the exon 1 variant at the SR-BI gene locus. J Mol Endocrinol 32, 237–245.

180 D Corella , L Qi , ES Tai , M Deurenberg-Yap , CE Tan , SK Chew & JM Ordovas (2006) Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet. Diabetes Care 29, 1313–1319.

181 C Phillips , K Mullan , D Owens & GH Tomkin (2004) Microsomal triglyceride transfer protein polymorphisms and lipoprotein levels in type 2 diabetes. QJM 97, 211–218.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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