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Effects of whey protein isolate on body composition, lipids, insulin and glucose in overweight and obese individuals

  • Sebely Pal (a1), Vanessa Ellis (a1) and Satvinder Dhaliwal (a1)
  • DOI:
  • Published online: 09 April 2010

The health benefits currently associated with increased dairy intake may be attributable to the whey component of dairy proteins. The present study evaluated the effects of whey protein supplementation on body composition, lipids, insulin and glucose in comparison to casein and glucose (control) supplementation in overweight/obese individuals for 12 weeks. The subjects were randomised to whey protein, casein or glucose supplementation for 12 weeks according to a parallel design. Fasting blood samples and dual-energy X-ray absorptiometry measurements were taken. Seventy men and women with a mean age of 48·4 (sem 0·86) years and a mean BMI of 31·3 (sem 0·8) kg/m2 completed the study. Subjects supplemented with whey protein had no significant change in body composition or serum glucose at 12 weeks compared with the control or casein group. Fasting TAG levels were significantly lowered in the whey group compared with the control group at 6 weeks (P = 0·025) and 12 weeks (P = 0·035). There was a significant decrease in total cholesterol and LDL cholesterol at week 12 in the whey group compared with the casein (P = 0·026 and 0·045, respectively) and control groups (P < 0·001 and 0·003, respectively). Fasting insulin levels and homeostasis model assessment of insulin resistance scores were also significantly decreased in the whey group compared with the control group (P = 0·049 and P = 0·034, respectively). The present study demonstrated that supplementation with whey proteins improves fasting lipids and insulin levels in overweight and obese individuals.

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*Corresponding author: Dr Sebely Pal, fax +61 8 9266 2258, email
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1B Balkau , M Vernay , L Mhamdi , (2003) The incidence and persistence of the NCEP (National Cholesterol Education Program) metabolic syndrome. The French D.E.S.I.R. study. Diabetes Metab 29, 526532.

2S Golden , K Robinson , I Saldanha , (2009) Clinical review: prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review. J Clin Endocrinol Metab 94, 18531878.

3S Grundy , HJ Brewer , J Cleeman , (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109, 433438.

6M Pereira , D Jacobs , L Van Horn , (2002) Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA study. JAMA 287, 2081.

7P Huth , D DiRienzo & G Miller (2006) Major scientific advances with dairy foods in nutrition and health. J Dairy Sci 89, 12071221.

9J Bowen , M Noakes & P Clifton (2005) Effect of calcium and dairy foods in high protein, energy-restricted diets on weight loss and metabolicparameters in overweight adults. Int J Obes Relat Metab Disord 29, 957965.

21M Kawase , H Hashimoto , M Hosoda , (2000) Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J Dairy Sci 83, 255263.

25Y Zhang , K Guo , R LeBlanc , (2007) Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms. Diabetes 56, 16471654.

26E Bairaktari , K Hatzidimou , C Tzallas , (2000) Estimation of LDL cholesterol based on the Friedewald formula and on apo B levels. Clin Biochem 33, 549555.

27T Wallace , J Levy & D Matthews (2004) Use and abuse of HOMA modeling. Diabetes Care 27, 14871495.

28Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education (NCEP) Expert Panel on Detection Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285, 24862497.

30M Miller (2000) Current perspectives on the management of hypertriglyceridemia. Am Heart J 140, 232240.

32S Nagaoka , Y Kanamaru , Y Kuzuya , (1992) Comparative studies on the serum cholesterol lowering action of whey protein soybean protein in rats. Biosci Biotechnol Biochem 56, 14841485.

34Q Chen & R Reimer (2009) Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro. Nutrition 25, 340349.

36Y Boirie , M Dangin , P Gachon , (1997) Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci U S A 94, 1493014935.

37S Castiglioni , C Manzoni , A D'Uva , (2003) Soy proteins reduce progression of a focal lesion and lipoprotein oxidiability in rabbits fed a cholesterol-rich diet. Atherosclerosis 171, 163170.

39R Singh , B Martin , Y Hickey , (2009) Comparison of self-reported, measured, metabolizable energy intake with total energy expenditure in overweight teens. Am J Clin Nutr 89, 17441750.

40M Kretsch , A Fong & M Green (1999) Behavioral and body size correlates of energy intake underreporting by obese and normal-weight women. J Am Diet Assoc 99, 300306.

41S Voss , A Kroke , K Klipstein-Grobusch , (1997) Obesity as a major determinant of underreporting in a self-administered food frequency questionnaire: results from the EPIC-Potsdam Study. Z Ernahrungswiss 36, 229236.

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