1Choi SW & Mason JB (2000) Folate and carcinogenesis: an integrated scheme. J Nutr 130, 129–132.
2Kuo CS, Lin CY, Wu MY, et al. (2008) Relationship between folate status and tumour progression in patients with hepatocellular carcinoma. Br J Nutr 100, 596–602.
3Welzel TM, Katki HA, Sakoda LC, et al. (2007) Blood folate levels and risk of liver damage and hepatocellular carcinoma in a prospective high-risk cohort. Cancer Epidemiol Biomarkers Prev 16, 1279–1282.
4Hirsch S, Sanchez H, Albala C, et al. (2009) Colon cancer in Chile before and after the start of the flour fortification program with folic acid. Eur J Gastroenterol Hepatol 21, 436–439.
5Mason JB, Dickstein A, Jacques PF, et al. (2007) A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev 16, 1325–1329.
6Sauer J, Mason JB & Choi SW (2009) Too much folate: a risk factor for cancer and cardiovascular disease? Curr Opin Clin Nutr Metab Care 12, 30–36.
7Cole BF, Baron JA, Sandler RS, et al. (2007) Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 297, 2351–2359.
8Jang H, Mason JB & Choi SW (2005) Genetic and epigenetic interactions between folate and aging in carcinogenesis. J Nutr 135, 2967S–2971S.
9Blount BC, Mack MM, Wehr CM, et al. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A 94, 3290–3295.
10Basten GP, Duthie SJ, Pirie L, et al. (2006) Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. Br J Cancer 94, 1942–1947.
11Choi SW, Friso S, Dolnikowski GG, et al. (2003) Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific. J Nutr 133, 1206–1212.
12Linhart HG, Troen A, Bell GW, et al. (2009) Folate deficiency induces genomic uracil misincorporation and hypomethylation but does not increase DNA point mutations. Gastroenterology 136, 227–235, .
13Blount BC & Ames BN (1995) DNA damage in folate deficiency. Baillieres Clin Haematol 8, 461–478.
14Fenech M, Aitken C & Rinaldi J (1998) Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 19, 1163–1171.
15Choi SW, Shane B & Selhub J (1996) Effect of methotrexate and 5-fluorouracil on de novo thymidylate synthesis in human colon carcinoma cell line, Caco-2. J Nutr Biochem 7, 35–44.
16Choi SW, Kim YI, Weitzel JN, et al. (1998) Folate depletion impairs DNA excision repair in the colon of the rat. Gut 43, 93–99.
17Adjei AA, Yamauchi K, Chan YC, et al. (1996) Comparative effects of dietary nucleoside–nucleotide mixture and its components on endotoxin induced bacterial translocation and small intestinal injury in protein deficient mice. Gut 38, 531–537.
18Walzem RL & Clifford AJ (1988) Folate deficiency in rats fed diets containing free amino acids or intact proteins. J Nutr 118, 1089–1096.
19Tamura T (1990) Microbiological assay of folate. In Folic Acid Metabolism in Health and Diseases, pp. 121–137 [Picciano MF, Stokstad ELR and Gregory JF III, editors]. New York: Wiley-Liss.
20van den Donk M, Pellis L, Crott JW, et al. (2007) Folic acid and vitamin B-12 supplementation does not favorably influence uracil incorporation and promoter methylation in rectal mucosa DNA of subjects with previous colorectal adenomas. J Nutr 137, 2114–2120.
21Hazra A, Selhub J, Chao WH, et al. (2010) Uracil misincorporation into DNA and folic acid supplementation. Am J Clin Nutr 91, 160–165.
22Kapiszewska M, Kalemba M, Wojciech U, et al. (2005) Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. A pilot study. J Nutr Biochem 16, 467–478.
23Bauchart-Thevret C, Stoll B & Burrin DG (2009) Intestinal metabolism of sulfur amino acids. Nutr Res Rev 22, 175–187.
24Chen H, Xia M, Lin M, et al. (2007) Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology 133, 207–218.
25Mikol YB, Hoover KL, Creasia D, et al. (1983) Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets. Carcinogenesis 4, 1619–1629.
26Zapisek WF, Cronin GM, Lyn-Cook BD, et al. (1992) The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diets. Carcinogenesis 13, 1869–1872.
27Yu MC, Yuan JM & Lu SC (2008) Alcohol, cofactors and the genetics of hepatocellular carcinoma. J Gastroenterol Hepatol 23, Suppl. 1, S92–S97.
28Kisliuk RL (2006) Invited article on ‘Thymidylate Synthesis’. In Encyclopedia of Life Sciences. Chichester: John Wiley & Sons, Ltd.
29Xu G, Herzig M, Rotrekl V, et al. (2008) Base excision repair, aging and health span. Mech Ageing Dev 129, 366–382.
30Duthie SJ, Grant G, Pirie LP, et al. (2010) Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prev Res (Phila Pa) 3, 92–100.