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Improvements in LDL particle size and distribution by short-term alternate day modified fasting in obese adults

  • Krista A. Varady (a1), Surabhi Bhutani (a1), Monica C. Klempel (a1) and Benoît Lamarche (a2)
  • DOI: http://dx.doi.org/10.1017/S0007114510003788
  • Published online: 30 September 2010
Abstract

Alternate day modified fasting (ADMF) beneficially modulates several indicators of CHD risk, but its effects on LDL particle size have never been tested. Accordingly, we examined the effects of ADMF on LDL particle size and distribution in obese adults. Sixteen obese subjects participated in a 10-week trial with three consecutive phases: (1) 2-week control phase; (2) 4-week ADMF controlled feeding phase; (3) 4-week ADMF self-selected feeding phase. After 8 weeks of diet, body weight and waist circumference were reduced (P < 0·05) by 5·6 (sem 0·9) kg and 4·0 (sem 0·9) cm, respectively. LDL-cholesterol and TAG concentrations decreased (P < 0·05) by 25 (sem 10) % and 32 (sem 6) %, respectively. Peak LDL particle size increased (P < 0·05) from 266 (sem 1) to 268 (sem 1) Å. Additionally, the proportion of small LDL particles decreased (P < 0·05) from 13 (sem 2) % to 9 (sem 3) %, while the proportion of large LDL particles increased (P < 0·05) from 68 (sem 4) % to 76 (sem 4) % post-treatment. These findings suggest that ADMF is an effective diet strategy for increasing LDL particle size and decreasing the proportion of small, dense LDL particles in obese adults.

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*Corresponding author: K. A. Varady, fax +1 312 413 0319, email varady@uic.edu
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1BA Griffin , DJ Freeman , GW Tait , (1994) Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis 106, 241253.

2HR Superko & RR Gadesam (2008) Is it LDL particle size or number that correlates with risk for cardiovascular disease? Curr Atheroscler Rep 10, 377385.

3JP Despres (2007) Cardiovascular disease under the influence of excess visceral fat. Crit Pathw Cardiol 6, 5159.

6EC Westman , WS Yancy Jr, MK Olsen , (2006) Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses. Int J Cardiol 110, 212216.

7KA Varady , S Bhutani , EC Church , (2009) Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. Am J Clin Nutr 90, 11381143.

8JB Johnson , W Summer , RG Cutler , (2007) Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med 42, 665674.

11AC St-Pierre , IL Ruel , B Cantin , (2001) Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease. Circulation 104, 22952299.

12A Tchernof , B Lamarche , D Prud'Homme , (1996) The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care 19, 629637.

14NL Harman , AR Leeds & BA Griffin (2008) Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss. Eur J Nutr 47, 287293.

15T Tzotzas , TD Filippatos , A Triantos , (2008) Effects of a low-calorie diet associated with weight loss on lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in healthy obese women. Nutr Metab Cardiovasc Dis 18, 477482.

16DL Rainwater , BD Mitchell , AG Comuzzie , (1999) Relationship of low-density lipoprotein particle size and measures of adiposity. Int J Obes Relat Metab Disord 23, 180189.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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