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The role of menaquinones (vitamin K2) in human health

  • Joline W. J. Beulens (a1), Sarah L. Booth (a2), Ellen G. H. M. van den Heuvel (a3) (a4), Elisabeth Stoecklin (a5), Athanasia Baka (a6) and Cees Vermeer (a7)...
Abstract

Recent reports have attributed the potential health benefits of vitamin K beyond its function to activate hepatic coagulation factors. Moreover, several studies have suggested that menaquinones, also known as vitamin K2, may be more effective in activating extra-hepatic vitamin K-dependent proteins than phylloquinone, also known as vitamin K1. Nevertheless, present dietary reference values (DRV) for vitamin K are exclusively based on phylloquinone, and its function in coagulation. The present review describes the current knowledge on menaquinones based on the following criteria for setting DRV: optimal dietary intake; nutrient amount required to prevent deficiency, maintain optimal body stores and/or prevent chronic disease; factors influencing requirements such as absorption, metabolism, age and sex. Dietary intake of menaquinones accounts for up to 25 % of total vitamin K intake and contributes to the biological functions of vitamin K. However, menaquinones are different from phylloquinone with respect to their chemical structure and pharmacokinetics, which affects bioavailability, metabolism and perhaps impact on health outcomes. There are significant gaps in the current knowledge on menaquinones based on the criteria for setting DRV. Therefore, we conclude that further investigations are needed to establish how differences among the vitamin K forms may influence tissue specificities and their role in human health. However, there is merit for considering both menaquinones and phylloquinone when developing future recommendations for vitamin K intake.

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Corresponding author
*Corresponding author: ILSI Europe a.i.s.b.l., Avenue E. Mounier 83, Box 6, 1200 Brussels, Belgium, fax +32 2 762 00 44, email publications@ilsieurope.be
References
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1Cockayne, S, Adamson, J, Lanham-New, S, et al. (2006) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 166, 12561261.
2Beulens, JW, Bots, ML, Atsma, F, et al. (2009) High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis 203, 489493.
3Geleijnse, JM, Vermeer, C, Grobbee, DE, et al. (2004) Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr 134, 31003105.
4Spronk, HM, Soute, BA, Schurgers, LJ, et al. (2003) Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats. J Vasc Res 40, 531537.
5Australian National Health and Medical Research Council, New Zealand Ministry of Health (2005) Vitamin K. Nutrient Reference Values for Australia and New Zealand, pp. 147151. Canberra: Commonwealth of Australia.
6FAO Rome Food and Nutrition Division (2001) Vitamin K. Human Vitamin and Mineral Requirements: Report of a Joint FAO/WHO Expert Consultation, Bangkok, Thailand, pp. 133150. Rome: FAO.
7National Research Council (2000) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press.
8EFSA Panel on Dietetic Products, Nutriton and Allergies (NDA) (2010) Scientific Opinion on principles for deriving and applying Dietary Reference Values. EFSA J 8, 1458.
9Shearer, MJ & Newman, P (2008) Metabolism and cell biology of vitamin K. Thromb Haemost 100, 530547.
10Collins, MD & Jones, D (1981) Distribution of isoprenoid quinone structural types in bacteria and their taxonomic implication. Microbiol Rev 45, 316354.
11Booth, SL & Suttie, JW (1998) Dietary intake and adequacy of vitamin K. J Nutr 128, 785788.
12Thijssen, HH, Vervoort, LM, Schurgers, LJ, et al. (2006) Menadione is a metabolite of oral vitamin K. Br J Nutr 95, 260266.
13Schurgers, LJ, Teunissen, KJ, Hamulyak, K, et al. (2007) Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 109, 32793283.
14Rishavy, MA & Berkner, KL (2012) Vitamin K oxygenation, glutamate carboxylation, and processivity: defining the three critical facets of catalysis by the vitamin K-dependent carboxylase. Adv Nutr 3, 135148.
15McCann, JC & Ames, BN (2009) Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging? Am J Clin Nutr 90, 889907.
16Schurgers, LJ & Vermeer, C (2000) Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. Haemostasis 30, 298307.
17Bolton-Smith, C, Price, RJ, Fenton, ST, et al. (2000) Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. Br J Nutr 83, 389399.
18Shearer, MJ & Bolton-Smith, C (2000) The UK food data-base for vitamin K and why we need it. Food Chem 68, 213218.
19Nimptsch, K, Rohrmann, S & Linseisen, J (2008) Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr 87, 985992.
20Kamao, M, Suhara, Y, Tsugawa, N, et al. (2007) Vitamin K content of foods and dietary vitamin K intake in Japanese young women. J Nutr Sci Vitaminol (Tokyo) 53, 464470.
21Fox, PF & McSweeney, PLH (2004) Cheese: an overview. In Cheese Chemistry, Physics and Microbiology, 1st vol., 3rd ed., pp. 1–18 [PF Fox, PLH McSweeney, TM Cogan and TP Guinee, editors]. London: Elsevier Academic Press.
22Beulens, JW, Van der, A D, Grobbee, DE, et al. (2010) Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. Diabetes Care 33, 16991705.
23Gast, GC, de Roos, NM, Sluijs, I, et al. (2009) A high menaquinone intake reduces the incidence of coronary heart disease. Nutr Metab Cardiovasc Dis 19, 504510.
24Elder, SJ, Haytowitz, DB, Howe, J, et al. (2006) Vitamin k contents of meat, dairy, and fast food in the U.S. Diet. J Agric Food Chem 54, 463467.
25Bresson, JL, Flynn, A, Heinonen, M, et al. (2008) Vitamin K2 added for nutritional purpose in foods for particular nutritional uses, food supplements and foods intended for the general population. EFSA J 822, 131.
26Gijsbers, BL, Jie, KS & Vermeer, C (1996) Effect of food composition on vitamin K absorption in human volunteers. Br J Nutr 76, 223229.
27Sato, T, Schurgers, LJ & Uenishi, K (2012) Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J 11, 93.
28Novotny, JA, Kurilich, AC, Britz, SJ, et al. (2010) Vitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kale. Br J Nutr 104, 858862.
29Schurgers, LJ & Vermeer, C (2002) Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim Biophys Acta 1570, 2732.
30AL Rajaba, A, Booth, SL, Peterson, JW, et al. (2012) Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats. J Nutr 142, 841845.
31Ronden, JE, Thijssen, HH & Vermeer, C (1998) Tissue distribution of K-vitamers under different nutritional regimens in the rat. Biochim Biophys Acta 1379, 1622.
32Thijssen, HH & Drittij-Reijnders, MJ (1994) Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. Br J Nutr 72, 415425.
33Fu, X, Peterson, JW, Hdeib, M, et al. (2009) Measurement of deuterium-labeled phylloquinone in plasma by high-performance liquid chromatography/mass spectrometry. Anal Chem 81, 54215425.
34Jones, KS, Bluck, LJ, Wang, LY, et al. (2008) A stable isotope method for the simultaneous measurement of vitamin K1 (phylloquinone) kinetics and absorption. Eur J Clin Nutr 62, 12731281.
35Jones, KS, Bluck, LJ, Wang, LY, et al. (2009) The effect of different meals on the absorption of stable isotope-labelled phylloquinone. Br J Nutr 102, 11951202.
36Nowicka, B & Kruk, J (2010) Occurrence, biosynthesis and function of isoprenoid quinones. Biochim Biophys Acta 1797, 15871605.
37Fernandez, F & Collins, MD (1987) Vitamin-K composition of anaerobic gut bacteria. FEMS Microbiol Lett 63, 175180.
38Hill, MJ (1997) Intestinal flora and endogenous vitamin synthesis. Eur J Cancer Prev 6, Suppl. 1, S43S45.
39Mathers, JC, Fernandez, F, Hill, MJ, et al. (1990) Dietary modification of potential vitamin K supply from enteric bacterial menaquinones in rats. Br J Nutr 63, 639652.
40Morishita, T, Tamura, N, Makino, T, et al. (1999) Production of menaquinones by lactic acid bacteria. J Dairy Sci 82, 18971903.
41Hojo, K, Watanabe, R, Mori, T, et al. (2007) Quantitative measurement of tetrahydromenaquinone-9 in cheese fermented by propionibacteria. J Dairy Sci 90, 40784083.
42Conly, JM & Stein, K (1992) The production of menaquinones (vitamin K2) by intestinal bacteria and their role in maintaining coagulation homeostasis. Prog Food Nutr Sci 16, 307343.
43Suttie, JW (1995) The importance of menaquinones in human nutrition. Annu Rev Nutr 15, 399417.
44Duello, TJ & Matschiner, JT (1972) Characterization of vitamin K from human liver. J Nutr 102, 331335.
45Usui, Y, Tanimura, H, Nishimura, N, et al. (1990) Vitamin K concentrations in the plasma and liver of surgical patients. Am J Clin Nutr 51, 846852.
46Olson, RE (1984) The function and metabolism of vitamin K. Annu Rev Nutr 4, 281337.
47Conly, JM & Stein, K (1992) Quantitative and qualitative measurements of K vitamins in human intestinal contents. Am J Gastroenterol 87, 311316.
48Ichihashi, T, Takagishi, Y, Uchida, K, et al. (1992) Colonic absorption of menaquinone-4 and menaquinone-9 in rats. J Nutr 122, 506512.
49Fujita, K, Kakuya, F & Ito, S (1993) Vitamin K1 and K2 status and faecal flora in breast fed and formula fed 1-month-old infants. Eur J Pediatr 152, 852855.
50Ramotar, K, Conly, JM, Chubb, H, et al. (1984) Production of menaquinones by intestinal anaerobes. J Infect Dis 150, 213218.
51Booth, SL & AL Rajaba, A (2008) Determinants of vitamin K status in humans. Vitam Horm 78, 122.
52AL Rajaba, A, Peterson, J, Choi, SW, et al. (2010) Measurement of menadione in urine by HPLC. J Chromatogr B Analyt Technol Biomed Life Sci 878, 24572460.
53Harrington, DJ, Booth, SL, Card, DJ, et al. (2007) Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes. J Nutr 137, 17631768.
54Bruge, F, Bacchetti, T, Principi, F, et al. (2011) Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation. Br J Nutr 106, 10581062.
55Harrington, DJ, Soper, R, Edwards, C, et al. (2005) Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection. J Lipid Res 46, 10531060.
56Suttie, JW (1992) Vitamin K and human nutrition. J Am Diet Assoc 92, 585590.
57Schurgers, LJ, Shearer, MJ, Hamulyak, K, et al. (2004) Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose–response relationships in healthy subjects. Blood 104, 26822689.
58Frick, PG, Riedler, G & Brogli, H (1967) Dose response and minimal daily requirement for vitamin K in man. J Appl Physiol 23, 387389.
59Suttie, JW, Mummah-Schendel, LL, Shah, DV, et al. (1988) Vitamin K deficiency from dietary vitamin K restriction in humans. Am J Clin Nutr 47, 475480.
60Udall, JA (1965) Human sources and absorption of vitamin K in relation to anticoagulation stability. JAMA 194, 127129.
61Booth, SL, Lichtenstein, AH, O'Brien-Morse, M, et al. (2001) Effects of a hydrogenated form of vitamin K on bone formation and resorption. Am J Clin Nutr 74, 783790.
62Booth, SL, Martini, L, Peterson, JW, et al. (2003) Dietary phylloquinone depletion and repletion in older women. J Nutr 133, 25652569.
63Furukawa, M, Nakanishi, T, Okuda, H, et al. (1992) Changes of plasma des-gamma-carboxy prothrombin levels in patients with hepatocellular carcinoma in response to vitamin K. Cancer 69, 3138.
64Emaus, N, Gjesdal, CG, Almas, B, et al. (2010) Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial. Osteoporos Int 21, 17311740.
65Tsukamoto, Y, Ichise, H, Kakuda, H, et al. (2000) Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and gamma-carboxylated osteocalcin concentration in normal individuals. J Bone Miner Metab 18, 216222.
66van Summeren, MJ, Braam, LA, Lilien, MR, et al. (2009) The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children. Br J Nutr 102, 11711178.
67Cranenburg, EC, Koos, R, Schurgers, LJ, et al. (2010) Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thromb Haemost 104, 811822.
68Dalmeijer, GW, van der Schouw, YT, Magdeleyns, E, et al. (2012) The effect of menaquinone-7 supplementation on circulating species of matrix Gla protein. Atherosclerosis 225, 397402.
69Theuwissen, E, Cranenburg, EC, Knapen, MH, et al. (2012) Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects. Br J Nutr 108, 16521657.
70Westenfeld, R, Krueger, T, Schlieper, G, et al. (2012) Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial. Am J Kidney Dis 59, 186195.
71Greenland, P, Bonow, RO, Brundage, BH, et al. (2007) ACCF/AHA clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol 49, 378402.
72Shanahan, CM, Proudfoot, D, Farzaneh-Far, A, et al. (1998) The role of Gla proteins in vascular calcification. Crit Rev Eukaryot Gene Expr 8, 357375.
73Maas, AH, van der Schouw, YT, Beijerinck, D, et al. (2007) Vitamin K intake and calcifications in breast arteries. Maturitas 56, 273279.
74Booth, SL (1997) Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore. Nutr Rev 55, 282284.
75Booth, SL, Tucker, KL, Chen, H, et al. (2000) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 71, 12011208.
76Jie, KG, Bots, ML, Vermeer, C, et al. (1996) Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 59, 352356.
77Kaneki, M, Hodges, SJ, Hosoi, T, et al. (2001) Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition 17, 315321.
78Knapen, MH, Nieuwenhuijzen Kruseman, AC, Wouters, RS, et al. (1998) Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int 63, 375379.
79Luukinen, H, Kakonen, SM, Pettersson, K, et al. (2000) Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J Bone Miner Res 15, 24732478.
80Schaafsma, A, Muskiet, FA, Storm, H, et al. (2000) Vitamin D(3) and vitamin K(1) supplementation of Dutch postmenopausal women with normal and low bone mineral densities: effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin. Eur J Clin Nutr 54, 626631.
81Sugiyama, T & Kawai, S (2001) Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K. J Bone Miner Metab 19, 146149.
82Szulc, P, Chapuy, MC, Meunier, PJ, et al. (1993) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 91, 17691774.
83Szulc, P, Arlot, M, Chapuy, MC, et al. (1994) Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res 9, 15911595.
84Szulc, P, Chapuy, MC, Meunier, PJ, et al. (1996) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 18, 487488.
85Vergnaud, P, Garnero, P, Meunier, PJ, et al. (1997) Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 82, 719724.
86Kalkwarf, HJ, Khoury, JC, Bean, J, et al. (2004) Vitamin K, bone turnover, and bone mass in girls. Am J Clin Nutr 80, 10751080.
87O'Connor, E, Molgaard, C, Michaelsen, KF, et al. (2007) Serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, and its relationship to bone health indices in Danish girls. Br J Nutr 97, 661666.
88van Summeren, M, van Coeverden, SC, Schurgers, LJ, et al. (2008) Vitamin K status is associated with childhood bone mineral content. Br J Nutr 100, 852858.
89van, SM, Braam, L, Noirt, F, et al. (2007) Pronounced elevation of undercarboxylated osteocalcin in healthy children. Pediatr Res 61, 366370.
90Hodges, SJ, Pilkington, MJ, Stamp, TC, et al. (1991) Depressed levels of circulating menaquinones in patients with osteoporotic fractures of the spine and femoral neck. Bone 12, 387389.
91Hodges, SJ, Akesson, K, Vergnaud, P, et al. (1993) Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res 8, 12411245.
92Kanai, T, Takagi, T, Masuhiro, K, et al. (1997) Serum vitamin K level and bone mineral density in post-menopausal women. Int J Gynaecol Obstet 56, 2530.
93Tamatani, M, Morimoto, S, Nakajima, M, et al. (1998) Decreased circulating levels of vitamin K and 25-hydroxyvitamin D in osteopenic elderly men. Metabolism 47, 195199.
94Tsugawa, N, Shiraki, M, Suhara, Y, et al. (2008) Low plasma phylloquinone concentration is associated with high incidence of vertebral fracture in Japanese women. J Bone Miner Metab 26, 7985.
95Katsuyama, H, Ideguchi, S, Fukunaga, M, et al. (2004) Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women. J Nutr Sci Vitaminol (Tokyo) 50, 114120.
96Kanellakis, S, Moschonis, G, Tenta, R, et al. (2012) Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II. Calcif Tissue Int 90, 251262.
97Katsuyama, H, Ideguchi, S, Fukunaga, M, et al. (2002) Usual dietary intake of fermented soybeans (Natto) is associated with bone mineral density in premenopausal women. J Nutr Sci Vitaminol (Tokyo) 48, 207215.
98Ikeda, Y, Iki, M, Morita, A, et al. (2006) Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study. J Nutr 136, 13231328.
99Apalset, EM, Gjesdal, CG, Eide, GE, et al. (2010) Dietary vitamins K1, K2 and bone mineral density: The Hordaland Health Study. Arch Osteopor 5, 7381.
100Lips, P (2010) Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol 121, 297300.
101Apalset, EM, Gjesdal, CG, Eide, GE, et al. (2011) Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study. Bone 49, 990995.
102Shearer, MJ (2009) Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev 23, 4959.
103Pucaj, K, Rasmussen, H, Moller, M, et al. (2011) Safety and toxicological evaluation of a synthetic vitamin K2, menaquinone-7. Toxicol Mech Methods 21, 520532.
104Ronden, JE, Groenen-van Dooren, MM, Hornstra, G, et al. (1997) Modulation of arterial thrombosis tendency in rats by vitamin K and its side chains. Atherosclerosis 132, 6167.
105Hemker, HC, AL Dieri, R, De Smeat, E, et al. (2006) Thrombin generation, a function test of the haemostatic–thrombotic system. Thromb Haemost 96, 553561.
106Holmes, MV, Hunt, BJ & Shearer, MJ (2012) The role of dietary vitamin K in the management of oral vitamin K antagonists. Blood Rev 26, 114.
107Bunyaratavej, N, Penkitti, P, Kittimanon, N, et al. (2001) Efficacy and safety of menatetrenone-4 postmenopausal Thai women. J Med Assoc Thai 84, Suppl. 2, S553S559.
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