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Soya isoflavone supplementation enhances spatial working memory in men

  • Alicia A. Thorp (a1) (a2), Natalie Sinn (a1), Jonathan D. Buckley (a1), Alison M. Coates (a1) and Peter R. C. Howe (a1)...
Abstract

Females perform better in certain memory-related tasks than males. Sex differences in cognitive performance may be attributable to differences in circulating oestrogen acting on oestrogen β receptors (ERβ) which are prevalent in brain regions such as the hippocampus, frontal lobe and cortex that mediate cognitive functions. Since soya isoflavones are known to activate ERβ, chronic isoflavone supplementation in males may improve cognitive performance in memory-related tasks. A 12-week double-blind, placebo-controlled cross-over trial was conducted in thirty-four healthy men to investigate the effect of isoflavone supplementation on cognitive function. Volunteers were randomised to take four capsules/d containing soya isoflavones (116 mg isoflavone equivalents/d: 68 mg daidzein, 12 mg genistein, 36 mg glycitin) or placebo for 6 weeks, and the alternate treatment during the following 6 weeks. Assessments of memory (verbal episodic, auditory and working), executive function (planning, attention, mental flexibility) and visual-spatial processing were performed at baseline and after each treatment period. Isoflavone supplementation significantly improved spatial working memory (P = 0·01), a test in which females consistently perform better than males. Compared with placebo supplementation, there were 18 % fewer attempts (P = 0·01), 23 % fewer errors (P = 0·02) and 17 % less time (P = 0·03) required to correctly identify the requisite information. Isoflavones did not affect auditory and episodic memory (Paired Associate Learning, Rey's Auditory Verbal Learning Task, Backward Digit Span and Letter-Number Sequencing), executive function (Trail Making and Initial Letter Fluency Task) or visual-spatial processing (Mental Rotation Task). Isoflavone supplementation in healthy males may enhance cognitive processes which appear dependent on oestrogen activation.

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Corresponding author
*Corresponding author: Professor Peter R. C. Howe, fax +61 8 8302 2178, email peter.howe@unisa.edu.au
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2VA Mann , S Sasanuma , N Sakuma , (1990) Sex differences in cognitive abilities: a cross-cultural perspective. Neuropsychologia 28, 10631077.

4ML Collaer & M Hines (1995) Human behavioral sex differences: a role for gonadal hormones during early development? Psychol Bull 118, 55107.

6PJ Shughrue , MV Lane & I Merchenthaler (1997) Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 388, 507525.

7MK Osterlund & YL Hurd (2001) Estrogen receptors in the human forebrain and the relation to neuropsychiatric disorders. Prog Neurobiol 64, 251267.

8CY Pau , KY Pau & HG Spies (1998) Putative estrogen receptor β and α mRNA expression in male and female rhesus macaques. Mol Cell Endocrinol 146, 5968.

9T Otto & H Eichenbaum (1992) Neuronal activity in the hippocampus during delayed non-match to sample performance in rats: evidence for hippocampal processing in recognition memory. Hippocampus 2, 323334.

11JA O'Keefe & RJ Handa (1990) Transient elevation of estrogen receptors in the neonatal rat hippocampus. Brain Res Dev Brain Res 57, 119127.

12SJ Duff & E Hampson (2000) A beneficial effect of estrogen on working memory in postmenopausal women taking hormone replacement therapy. Horm Behav 38, 262276.

13PM Maki , AB Zonderman & SM Resnick (2001) Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapy. Am J Psychiatry 158, 227233.

14C Miles , R Green , G Sanders , (1998) Estrogen and memory in a transsexual population. Horm Behav 34, 199208.

16SE File , DE Hartley , N Alom , (2003) Soya phytoestrogens change cortical and hippocampal expression of BDNF mRNA in male rats. Neurosci Lett 338, 135138.

17ED Lephart , TW West , KS Weber , (2002) Neurobehavioral effects of dietary soy phytoestrogens. Neurotoxicol Teratol 24, 516.

18SE File , DE Hartley , S Elsabagh , (2005) Cognitive improvement after 6 weeks of soya supplements in postmenopausal women is limited to frontal lobe function. Menopause 12, 193201.

19RH Duffy , H Wiseman & SE File (2003) Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones. Pharmacol Biochem Behav 75, 721729.

20D Kritz-Silverstein , D Von Mühlen , E Barrett-Connor , (2003) Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study. Menopause 10, 196202.

23LR White , H Petrovitch , GW Ross , (2000) Brain aging and midlife tofu consumption. J Am Coll Nutr 19, 242255.

24TD Lund , TW West , LY Tian , (2001) Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogens. BMC Neurosci 2, 20.

25P Celec , D Ostatníková , J Hodosy , (2007) Increased one week soybean consumption affects spatial abilities but not sex hormone status in men. Int J Food Sci Nutr 58, 424428.

26D Ostatníková , P Celec , J Hodosy , (2007) Short-term soybean intake and its effect on steroid sex hormones and cognitive abilities. Fertil Steril 88, 16321636.

27SE File , N Jarrett , E Fluck , (2001) Eating soya improves human memory. Psychopharmacology (Berl) 157, 430436.

28SJ Duff & E Hampson (2001) A sex difference on a novel spatial working memory task in humans. Brain Cogn 47, 470493.

29D Ivison (1977) The Wechsler Memory Scale: preliminary findings toward an Australian standardisation. Aust Psychol 12, 303312.

30ML Bleecker , K Bolla-Wilson , J Agnew , (1988) Age-related sex differences in verbal memory. J Clin Psychol 44, 403411.

31GM Geffen , KJ Moar , AP O'Hanlon , (1990) The Auditory Verbal Learning Test (Rey): performance of 16 to 86 year olds of average intelligence. Clin Neuropsychol 4, 4563.

32SA Berenbaum , L Baxter , M Seidenberg , (1997) Role of the hippocampus in sex differences in verbal memory: memory outcome following left anterior temporal lobectomy. Neuropsychology 11, 585591.

34E Hogervorst , T Sadjimin , A Yesufu , (2008) High tofu intake is associated with worse memory in elderly Indonesian men and women. Dement Geriatr Cogn Disord 26, 5057.

35SM Courtney , L Petit , JM Maisog , (1998) An area specialized for spatial working memory in human frontal cortex. Science 279, 13471351.

36RW Bonsall , D Zumpe & RP Michael (1990) Comparisons of the nuclear uptake of [3H]-testosterone and its metabolites by the brains of male and female macaque fetuses at 122 days of gestation. Neuroendocrinology 51, 474480.

37AS Clark , NJ MacLusky & PS Goldman-Rakic (1988) Androgen binding and metabolism in the cerebral cortex of the developing rhesus monkey. Endocrinology 123, 932940.

38NJ MacLusky , F Naftolin & PS Goldman-Rakic (1986) Estrogen formation and binding in the cerebral cortex of the developing rhesus monkey. Proc Natl Acad Sci U S A 83, 513516.

39M Bixo , T Bäckström , B Winblad , (1995) Estradiol and testosterone in specific regions of the human female brain in different endocrine states. J Steroid Biochem Mol Biol 55, 297303.

40KF Berman , PJ Schmidt , DR Rubinow , (1997) Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women. Proc Natl Acad Sci U S A 94, 88368841.

42ED Lephart , JM Thompson , KD Setchell , (2000) Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male rats. Brain Res 859, 123131.

43RE Passingham (1985) Memory of monkeys (Macaca mulatta) with lesions in prefrontal cortex. Behav Neurosci 99, 321.

44A Owen , JJ Downes , BJ Sahakian , (1990) Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28, 10211034.

45AM Owen , BJ Sahakian , J Semple , (1995) Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologia 33, 124.

46AM Owen , AC Evans & M Petrides (1996) Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study. Cereb Cortex 6, 3138.

47RM Ruff , RH Light , SB Parker , (1996) Benton Controlled Oral Word Association Test: reliability and updated norms. Arch Clin Neuropsychol 11, 329338.

48MT Sarno , A Buonaguro & E Levita (1985) Gender and recovery from aphasia after stroke. J Nerv Ment Dis 173, 605609.

50JE Blum , JL Fosshage & LF Jarvik (1972) Intellectual changes and sex differences in octogenarians: a twenty year longitudinal study of aging. Dev Psychol 7, 178187.

51S Kreijkamp-Kaspers , L Kok , DE Grobbee , (2004) Effect of soy protein containing isoflavones on cognitive function, bone mineral density, and plasma lipids in postmenopausal women: a randomized controlled trial. JAMA 292, 6574.

53RA Bornstein (1985) Normative data on selected neuropsychological measures from a non clinical sample. J Clin Psychol 41, 651659.

54KB Kortte , MD Horner & WK Windham (2002) The Trail Making Test, part B: cognitive flexibility or ability to maintain set? Appl Neuropsychol 9, 106109.

55EA Gaudino , MW Geisler & NK Squires (1995) Construct validity in the Trail Making Test: what makes part B harder? J Clin Exp Neuropsychol 17, 529535.

56VN Luine , ST Richards , VY Wu , (1998) Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters. Horm Behav 34, 149162.

57HA Bimonte & VH Denenberg (1999) Estradiol facilitates performance as working memory load increases. Psychoneuroendocrinology 24, 161173.

58B Berry , R McMahan & M Gallagher (1997) Spatial learning and memory at defined points of the estrous cycle: effects on performance of a hippocampal-dependent task. Behav Neurosci 111, 267274.

59CL Williams & WH Meck (1991) The organizational effects of gonadal steroids on sexually dimorphic spatial ability. Psychoneuroendocrinology 16, 155176.

60ED Lephart (1996) A review of brain aromatase cytochrome P450. Brain Res Brain Res Rev 22, 126.

61C Isgor & DR Sengelaub (1998) Prenatal gonadal steroids affect adult spatial behavior, CA1 and CA3 pyramidal cell morphology in rats. Horm Behav 34, 183198.

62RL Roof (1993) Neonatal exogenous testosterone modifies sex difference in radial arm and Morris water maze performance in prepubescent and adult rats. Behav Brain Res 53, 110.

63D Voyer , S Voyer & MP Bryden (1995) Magnitude of sex differences in spatial abilities: a meta-analysis and consideration of critical variables. Psychol Bull 117, 250270.

64SJ Fonda , R Bertrand , A O'Donnell , (2005) Age, hormones, and cognitive functioning among middle-aged and elderly men: cross-sectional evidence from the Massachusetts Male Aging Study. J Gerontol A Biol Sci Med Sci 60, 385390.

65SD Moffat , AB Zonderman , EJ Metter , (2002) Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. J Clin Endocrinol Metab 87, 50015007.

66K Yaffe , LY Liu , J Zmuda , (2002) Sex hormones and cognitive function in older men. J Am Geriatr Soc 50, 707712.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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