Skip to main content
×
Home

Strawberry anthocyanin and its association with postprandial inflammation and insulin

  • Indika Edirisinghe (a1), Katarzyna Banaszewski (a1), Jack Cappozzo (a1), Krishnankutty Sandhya (a1), Collin L. Ellis (a2) (a3), Ravi Tadapaneni (a1), Chulani T. Kappagoda (a3) and Britt M. Burton-Freeman (a1) (a2)...
Abstract

The present study investigates the effect of strawberry antioxidants in beverage form on meal-induced postprandial inflammatory and insulin responses in human subjects. Overweight adults (n 24) consumed a high-carbohydrate, moderate-fat meal (HCFM) accompanied by either a strawberry or a placebo beverage in a cross-over design. Postprandial changes in plasma anthocyanins, their metabolites, insulin, glucose and inflammatory markers were assessed for 6 h. The postprandial concentrations of pelargonidin sulfate and pelargonidin-3-O-glucoside were significantly increased when the strawberry beverage was consumed concurrently with the HCFM compared with the placebo beverage (P < 0·001). The strawberry beverage significantly attenuated the postprandial inflammatory response as measured by high-sensitivity C-reactive protein and IL-6 (P < 0·05) induced by the HCFM. It was also associated with a reduction in postprandial insulin response (P < 0·05). Collectively, these data provide evidence for favourable effects of strawberry antioxidants on postprandial inflammation and insulin sensitivity.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Strawberry anthocyanin and its association with postprandial inflammation and insulin
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Strawberry anthocyanin and its association with postprandial inflammation and insulin
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Strawberry anthocyanin and its association with postprandial inflammation and insulin
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: B. M. Burton-Freeman, fax +1 708 563 1873, email bburton@iit.edu
References
Hide All
1 Burton-Freeman B, Linares A, Hyson D, et al. (2010) Strawberry modulates LDL oxidation and postprandial lipemia in response to high-fat meal in overweight hyperlipidemic men and women. J Am Coll Nutr 29, 4654.
2 Burton-Freeman B (2010) Postprandial metabolic events and fruit-derived phenolics: a review of the science. Br J Nutr 104, Suppl. 3, S1S14.
3 Shoelson SE, Lee J & Goldfine AB (2006) Inflammation and insulin resistance. J Clin Invest 116, 7931801.
4 Halvorsen BL, Holte K, Myhrstad MC, et al. (2002) A systematic screening of total antioxidants in dietary plants. J Nutr 132, 461471.
5 Prior RL, Gu L, Wu X, et al. (2007) Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status. J Am Coll Nutr 26, 170181.
6 Aaby K, Skrede G & Wrolstad RE (2005) Phenolic composition and antioxidant activities in flesh and achenes of strawberries (Fragaria ananassa). J Agric Food Chem 53, 40324040.
7 Appel LJ, Moore TJ, Obarzanek E, et al. (1997) Clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336, 11171124.
8 Guo C, Cao G, Sofic E, et al. (1997) High-performance liquid chromatography coupled with coulometric array detection of electroactive components in fruits and vegetables. Relationship to oxygen radical absorbance capacity. J Agric Food Chem 45, 17871796.
9 Vinayagamoorthi R, Bobby Z & Sridhar MG (2008) Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistance. J Endocrinol 197, 287296.
10 Heilbronn LK & Campbell LV (2008) Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des 14, 12251230.
11 Burton-Freeman B, Davis PA & Schneeman BO (2004) Interaction of fat availability and sex on postprandial satiety and cholecystokinin after mixed-food meals. Am J Clin Nutr 80, 12071214.
12 Prior RL, Hoang H, Gu L, et al. (2003) Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORACFL)) of plasma and other biological and food samples. J Agric Food Chem 51, 32733279.
13 Seeram NP, Lee R, Scheuller S, et al. (2006) Identification of phenolic compounds in strawberries by liquid chromatography electrospray ionization mass spectroscopy. Food Chem 97, 111.
14 Aaby K, Ekeberg D & Skrede G (2007) Characterization of phenolic compounds in strawberry (Fragaria × ananassa) fruits by different HPLC detectors and contribution of individual compounds to total antioxidant capacity. J Agric Food Chem 55, 43954406.
15 Liang Wang & Morris ME (2005) Liquid chromatography-tandem mass spectroscopy assay for quercetin and conjugated quercetin metabolites in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci 821, 194201.
16 Appel LJ, Moore TJ, Obarzanek E, et al. (1997) The DCRG: a clinical trial of the effects of dietary patterns on blood pressure. N Engl J Med 336, 11171124.
17 Yusuf S, Hawken S, Ounpuu S, et al. (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case–control study. Lancet 364, 937952.
18 Liu RH (2003) Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 78, 517S520S.
19 Charlton AJ, Baxter NJ & Khan ML (2002) Polyphenol/peptide binding and precipitation. J Agric Food Chem 13, 15931601.
20 Luck G (1994) Polyphenols, astringency and proline-rich proteins. Phytochemistry 37, 357371.
21 Serafini M, Ghiselli A & Ferro-Luzzi A (1996) In vivo antioxidant effect of green and black tea in man. Eur J Clin Nutr 50, 2832.
22 Hollman PC, Van het Hof KH, Tijburg LB, et al. (2001) Addition of milk does not affect the absorption of flavonols from tea in man. Free Radic Res 34, 297300.
23 Handique JG & Baruah JB (2002) Polyphenolic compounds: an overview. React Funct Polym 52, 163188.
24 Williams RJ, Spencer JP & Rice-Evans C (2004) Flavonoids: antioxidants or signaling molecules? Free Radic Biol Med 36, 838849.
25 Virgili F & Marino M (2008) Regulation of cellular signals from nutritional molecules: a specific role for phytochemicals, beyond antioxidant activity. Free Radic Biol Med 45, 12051216.
26 Lapidot T, Harel S, Grani R, et al. (1998) Bioavailability of red wine anthocyanins as detected in human urine. J Agric Food Chem 46, 42974302.
27 Felgines C, Talavera S, Gonthier MP, et al. (2003) Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans. J Nutr 133, 12961301.
28 Franke EN, Waterhouse AL & Teissedre PL (1995) Principal phenolic phytochemicals in selected California wines and their antioxidant activity in inhibiting oxidation of human low-density lipoproteins. J Agric Food Chem 43, 890894.
29 Galvano F, La Fauci L, Vitaglione P, et al. (2007) Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides. Ann Ist Super Sanita 43, 382393.
30 Azzini E, Vitaglione P, Intorre F, et al. (2010) Bioavailability of strawberry antioxidants in human subjects. Br J Nutr 104, 11651173.
31 Borges G, Mullen W, Mullan A, et al. (2010) Bioavailability of multiple components following acute ingestion of a polyphenol-rich juice drink. Mol Nutr Food Res 54, S268S277.
32 Del Rio D, Borges G & Crozier A (2010) Berry flavonoids and phenolic: bioavailability and evidence of protective effects. Br J Nutr 104, S67S90.
33 Koli R, Erlund I, Jula A, et al. (2010) Bioavailability of various polyphenols from a diet containing moderate amounts of berries. J Agric Food Chem 58, 39273932.
34 Edirisinghe I, Burton-Freeman B, Varelis P, et al. (2008) Strawberry extract caused endothelium-dependent relaxation through the activation of PI3 kinase/Akt. J Agric Food Chem 56, 93839390.
35 Dresner A, Laurent D, Marcucci M, et al. (1999) Effects of free fatty acids on glucose transport and IRS-1 associated phosphatidylinositol 3-kinase activity. J Clin Invest 103, 253259.
36 Bloch-Damti A & Bashan N (2005) Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid Redox Signal 7, 15531567.
37 Lin CL & Lin JK (2008) Epigallocatechin gallate (EGCG) attenuates high glucose-induced insulin signaling blockade in human hepG2 hepatoma cells. Mol Nutr Food Res 52, 930939.
38 Sandhya K, Tadapaneni Ravi, Banaszewski Katie, et al. (2010) Strawberry extract attenuates oxidative stress-induced impaired insulin signaling in vitro in human skeletal muscle cells. FASEB J 24, 541.13.
39 Spranger J, Kroke A, Möhlig M, et al. (2003) Inflammatory cytokines and the risk to develop type 2 diabetes. Diabetes 52, 812817.
40 Lagathu C, Yvan-Charvet L, Bastard JP, et al. (2006) Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes. Diabetologia 49, 21622173.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 21
Total number of PDF views: 284 *
Loading metrics...

Abstract views

Total abstract views: 532 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 20th November 2017. This data will be updated every 24 hours.