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Effects of pre- and postnatal maternal stress on infant temperament and autonomic nervous system reactivity and regulation in a diverse, low-income population

  • Nicole R. Bush (a1), Karen Jones-Mason (a1), Michael Coccia (a1), Zoe Caron (a1), Abbey Alkon (a1), Melanie Thomas (a2), Kim Coleman-Phox (a1), Pathik D. Wadhwa (a3), Barbara A. Laraia (a4), Nancy E. Adler (a1) and Elissa S. Epel (a1)...

We examined the prospective associations of objective and subjective measures of stress during pregnancy with infant stress reactivity and regulation, an early-life predictor of psychopathology. In a racially and ethnically diverse low-income sample of 151 mother–infant dyads, maternal reports of stressful life events (SLE) and perceived stress (PS) were collected serially over gestation and the early postpartum period. Infant reactivity and regulation at 6 months of age was assessed via maternal report of temperament (negativity, surgency, and regulation) and infant parasympathetic nervous system physiology (respiratory sinus arrhythmia [RSA]) during the Still Face Paradigm. Regression models predicting infant temperament showed higher maternal prenatal PS predicted lower surgency and self-regulation but not negativity. Regression models predicting infant physiology showed higher numbers of SLE during gestation predicted greater RSA reactivity and weaker recovery. Tests of interactions revealed SLE predicted RSA reactivity only at moderate to high levels of PS. Thus, findings suggest objective and subjective measures of maternal prenatal stress uniquely predict infant behavior and physiology, adjusting for key pre- and postnatal covariates, and advance the limited evidence for such prenatal programming within high-risk populations. Assessing multiple levels of maternal stress and offspring stress reactivity and regulation provides a richer picture of intergenerational transmission of adversity.

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Corresponding author
Address correspondence and reprint requests to: Nicole R. Bush, Psychiatry and Pediatrics, University of California, San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118; E-mail:
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This research was supported by NIH Grants 1 U01 HL097973 and NHLBI 5 R01 HL116511, the Robert Wood Johnson Health and Society Scholars Program, and the Lisa and John Pritzker Family Foundation. The authors also acknowledge Michelle Stephens for her assistance with scoring the autonomic nervous system data; Vanessa Tearnan, Marialma Gonzales-Cruz, Yurivia Cervantes, and Amy Engler for their assistance in collecting the autonomic nervous system data; and Holly Wing, Gwen Valencia-Moscoso, Amber Benson, Samantha Schilf, and Danielle Emmet for their assistance with the MAMAS data collection. We are also thankful to the families for their generous participation in this research.

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Aiken L. S., & West S. G. (1991). Multiple regression: Testing and interpreting interactions. Newbury Park, CA: Sage.
Alkon A., Boyce W. T., Tran L., Harley K. G., Neuhaus J., & Eskenazi B. (2014). Prenatal adversities and Latino children's autonomic nervous system reactivity trajectories from 6 months to 5 years of age. PLOS ONE, 9, e86283. doi:10.1371/journal.pone.0086283
Alkon A., Lippert S., Vujan N., Rodriquez M. E., Boyce W. T., & Eskenazi B. (2006). The ontogeny of autonomic measures in 6- and 12-month-old infants. Developmental Psychobiology, 48, 197208. doi:10.1002/dev.20129
American College of Obstetrics and Gynecologists Committee on Health Care for Undeserved Women. (2006). ACOG Committee Opinion No. 343: Psychosocial risk factors: Perinatal screening and intervention. Obstetrics and Gynecology, 108, 469477.
Bakermans-Kranenburg M. J., & van IJzendoorn M. H. (2009). The first 10,000 Adult Attachment Interviews: Distributions of adult attachment representations in clinical and non-clinical groups. Attachment and Human Development, 11, 223263. doi:10.1080/14616730902814762
Bar-Haim Y., Marshall P., & Fox N. (2000). Developmental changes in heart period and high-frequency heart period variability from 4 months to 4 years of age. Developmental Psychobiology, 37, 4456. doi:10.1002/1098-2302(200007)37:1<44::AID-DEV6>3.0.CO;2-7
Barker D. J. (1998). In utero programming of chronic disease. Clinical Science, 95, 115128.
Barker D. J. (2007). The origins of the developmental origins theory. Journal of Internal Medicine, 261, 412417. doi:10.1111/j.1365-2796.2007.01809.x
Bates D., Mächler M., Bolker B., & Walker S. (2015). Fitting linear mixed-effects models using lme4. Journal of Statistical Software, 67, 151. doi:10.18637/jss.v067.i01
Beauchaine T. P. (2001). Vagal tone, development, and Gray's motivational theory: Toward an integrated model of autonomic nervous system functioning in psychopathology. Development and Psychopathology, 13, 183214.
Beauchaine T. P. (2015). Respiratory sinus arrhythmia: A transdiagnostic biomarker of emotion dysregulation and psychopathology. Current Opinion in Psychology, 3, 4347. doi:10.1016/j.copsyc.2015.01.017
Beauchaine T. P., Gatzke-Kopp L., & Mead H. (2007). Polyvagal theory and developmental psychopathology: Emotion dysregulation and conduct problems from preschool to adolescence. Biological Psychology, 74, 174184. doi:10.1016/j.biopsycho.2005.08.008
Belsky J., & Pluess M. (2009). Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885908. doi:10.1037/a0017376
Berntson G. G., Cacioppo J. T., & Quigley K. S. (1994). Autonomic cardiac control: I. Estimation and validation from pharmacological blockades. Psychophysiology, 31, 572585. doi:10.1111/j.1469-8986.1994.tb02350.x
Berston G. G., Quigley K. S., & Lozano D. (2007). Cardiovascular psychophysiology. In Cacioppo J. T., Tassinary L. G., & Berntson G. G. (Eds.), Handbook of psychophysiology (pp. 182210). Cambridge: Cambridge University Press.
Borders A. E., Wolfe K., Qadir S., Kim K. Y., Holl J., & Grobman W. (2015). Racial/ethnic differences in self-reported and biologic measures of chronic stress in pregnancy. Journal of Perinatology, 35, 580584. doi:10.1038/jp.2015.18
Bosquet Enlow M., King L., Schreier H. M., Howard J. M., Rosenfield D., Ritz T., & Wright R. J. (2014). Maternal sensitivity and infant autonomic and endocrine stress responses. Early Human Development, 90, 377385. doi:10.1016/j.earlhumdev.2014.04.007
Bosquet Enlow M., Kullowatz A., Staudenmayer J., Spasojevic J., Ritz T., & Wright R. J. (2009). Associations of maternal lifetime trauma and perinatal traumatic stress symptoms with infant cardiorespiratory reactivity to psychological challenge. Psychosomatic Medicine, 71, 607614. doi:10.1097/PSY.0b013e3181ad1c8b
Boyce W. T., Quas J., Alkon A., Smider N., Essex M., & Kupfer D. J. (2001). Autonomic reactivity and psychopathology in middle childhood. British Journal of Psychiatry, 179, 144150. doi:10.1192/bjp.179.2.144
Bradley R. H., & Corwyn R. F. (2002). Socioeconomic status and child development. Annual Review of Psychology, 53, 371399. doi:10.1146/annurev.psych.53.100901.135233
Braveman P., Marchi K., Egerter S., Kim S., Metzler M., Stancil T., & Libet M. (2010). Poverty, near-poverty, and hardship around the time of pregnancy. Maternal and Child Health Journal, 14, 2035. doi:10.1007/s10995-008-0427-0
Burns E., Farr S. L., & Howards P. P. (2015). Stressful life events experienced by women in the year before their infants’ birth—United States, 2000–2010. Morbidity and Mortality Weekly Report, 64, 247251.
Bush N. R., & Boyce W. T. (2016). Differential sensitivity to context: Implications for developmental psychopathology. In Cicchetti D. (Ed.), Developmental psychopathology. Hoboken, NJ: Wiley.
Bush N. R., Caron Z. K., Blackburn K. S., & Alkon A. (2016). Measuring cardiac autonomic nervous system (ANS) activity in toddlers—Resting and developmental challenges. Journal of Visualized Experiments, 108, e53652. doi:10.3791/53652
Bush N. R., Lane R. D., & McLaughlin K. A. (2016). Mechanisms underlying the association between early-life adversity and physical health: Charting a course for the future. Psychosomatic Medicine, 78, 11141119. doi:10.1097/psy.0000000000000421
Buss C., Davis E. P., Muftuler L. T., Head K., & Sandman C. (2010). High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6–9-year-old children. Psychoneuroendocrinology, 35, 141153. doi:10.1016/j.psyneuen.2009.07.010
Buss C., Davis E. P., Shahbaba B., Pruessner J. C., Head K., & Sandman C. A. (2012). Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proceedings of the National Academy of Sciences, 109, E1312E1319. doi:10.1073/pnas.1201295109
Calkins S. D., & Keane S. P. (2004). Cardiac vagal regulation across the preschool period: Stability, continuity, and implications for childhood adjustment. Developmental Psychobiology, 45, 101112. doi:10.1002/dev.20020
Calkins S. D., & Perry N. B. (2016). The development of emotion regulation: Implications for child adjustment. In Cicchetti D. (Ed.), Developmental psychopathology. Hoboken, NJ: Wiley.
Cassidy J., Jones J. D., & Shaver P. R. (2013). Contributions of attachment theory and research: A framework for future research, translation, and policy. Developmental Psychobiology, 25, 14151434. doi:10.1017/s0954579413000692
Centers for Disease Control and Prevention. (2005). Phase 5 Core Questionnaire—Pregnancy stressful life events. Pregnancy Risk Assessment Monitoring System (PRAMS). Washington, DC: Author. Retrieved from
Cicchetti D. (2011). Allostatic load. Development and Psychopathology, 23, 723724. doi:10.1017/S0954579411000277
Cicchetti D., & Dawson G. (2002). Multiple levels of analysis. Development and Psychopathology, 14, 417420. doi:10.1017/S0954579402003012
Cicchetti D., & Gunnar M. (2008). Integrating biological measures into the design and evaluation of preventative interventions. Development and Psychopathology, 20, 737743. doi:10.1017/S0954579408000357
Cicchetti D., Rogosch F. A, Toth S. L., & Sturge-Apple M. L. (2011). Normalizing the development of cortisol regulation in maltreated infants through preventative interventions. Development and Psychopathology, 23, 789800. doi:10.1017/S0954579411000307
Cohen S., Kamarck T., & Mermelstein R. (1983). A global measure of perceived stress. Journal of Health and Social Behavior, 24, 385396.
Cohen S., & Williamson G. M. (1988). Perceived stress in a probability sample of the United States. Newbury Park, CA: Sage.
Coleman-Phox K., Laraia B. A., Adler N., Vieten C., Thomas M., & Epel E. (2013). Recruitment and retention of pregnant women for a behavioral intervention: Lessons from the maternal adiposity, metabolism, and stress (MAMAS) study. Preventing Chronic Disease, 10, 17. doi:10.5888/pcd10.120096
Committee on Obstetric Practice. (2015). Committee opinion No. 630: Screening for perinatal depression. Obstetrics and Gynecology, 125, 12681271.
Conradt E., & Ablow J. (2010). Infant physiological response to the still-face paradigm: Contributions of maternal sensitivity and infants’ early regulatory behavior. Infant Behavior and Development, 33, 251265. doi:10.1016/j.infbeh.2010.01.001
Davis E. P., Glynn L. M., Schetter C. D., Hobel C., Chicz-Demet A., & Sandman C. A. (2005). Corticotropin-releasing hormone during pregnancy is associated with infant temperament. Developmental Neuroscience, 27, 299305. doi:10.1159/000086709
Davis E. P., Glynn L. M., Waffarn F., & Sandman C. A. (2011). Prenatal maternal stress programs infant stress regulation. Journal of Child Psychology and Psychiatry, 52, 119129. doi:10.1111/j.1469-7610.2010.02314.x
Dierckx B., Tulen J. H., van den Berg M. P., Tharner A., Jaddoe V. W., Moll H. A., … Tiemeier H. (2009). Maternal psychopathology influences infant heart rate variability: Generation R study. Psychosomatic Medicine, 71, 313321. doi:10.1097/psy.0b013e318198a82c
DiPietro J. A. (2004). The role of prenatal maternal stress in child development. Current Directions in Psychological Science, 13, 7174. doi:10.1111/j.0963-7214.2004.00277.x
DiPietro J. A. (2012). Maternal stress in pregnancy: Considerations for fetal development. Journal of Adolescent Health, 51(Suppl. 2), S3S8. doi:10.1016/j.jadohealth.2012.04.008
DiPietro J. A., Bornstein M. H., Hahn C. S., Costigan K., & Achy-Brou A. (2007). Fetal heart rate and variability: Stability and prediction to developmental outcomes in early childhood. Child Development, 78, 17881798. doi:10.1111/j.1467-8624.2007.01099.x
DiPietro J. A., Costigan K. A., & Gurewitsch E. D. (2003). Fetal response to induced maternal stress. Early Human Development, 74, 125138. doi:10.1016/j.earlhumdev.2003.07.001
DiPietro J. A., Novak M. F., Costigan K. A., Atella L. D., & Reusing S. P. (2006). Maternal psychological distress during pregnancy in relation to child development at age two. Child Development, 77, 573587. doi:10.1111/j.1467-8624.2006.00891.x
Doom J. R., & Gunnar M. R. (2013). Stress physiology and developmental psychopathology: Past, present, and future. Development and Psychopathology, 25. doi:10.1017/S0954579413000667
Duncan G. J., & Brooks-Gunn J. (1997). Consequences of growing up poor. New York: Russell Sage Foundation.
Dunkel Schetter C. (2011). Psychological science on pregnancy: Stress processes, biopsychosocial models, and emerging research issues. Annual Review of Psychology, 62, 531558. doi:10.1146/annurev.psych.031809.130727
Eisenberg N., Sadovsky A., Spinrad T. L., Fabes R. A., Losoya S. H., Valiente C., … Shepard S. A. (2005). The relations of problem behavior status to children's negative emotionality, effortful control, and impulsivity: Concurrent relations and prediction of change. Developmental Psychology, 41, 193211. doi:10.1037/0012-1649.41.1.193
Ellis B. J., & Del Giudice M. (2014). Beyond allostatic load: Rethinking the role of stress in regulating human development. Development and Psychopathology, 26, 120. doi:10.1017/S0954579413000849
Entringer S., Buss C., Swanson J. D., Cooper D. M., Wing D. A., Waffarn F., & Wadhwa P. D. (2012). Fetal programming of body composition, obesity and metabolic function: The role of intrauterine stress and stress biology. Journal of Nutrition and Metabolism, 2012, 116. doi:10.1155/2012/632548
Entringer S., Buss C., & Wadhwa P. D. (2015). Prenatal stress, development, health and disease risk: A psychobiological perspective—2015 Curt Richter Award Paper. Psychoneuroendocrinology, 62, 366375. doi:10.1016/j.psyneuen.2015.08.019
Epel E., Laraia B., Coleman-Phox K., Leung C., Vieten C., Mellin L., … Adler N. E. (2017). Effects of a mindfulness-based intervention on distress, weight gain, and glucose control for pregnant low-income women: A controlled trial. Unpublished manuscript.
Feldman R., Singer M., & Zagoory O. (2010). Touch attenuates infants’ physiological reactivity to stress. Developmental Science, 13, 271278. doi:10.1111/j.1467-7687.2009.00890.x
Ferreira A. J. (1965). Emotional factors in prenatal environment: A review. Journal of Nervous and Mental Disease, 141, 108118.
Field T., Diego M., Dieter J., Hernandez-Reif M., Schanberg S., Kuhn C., … Bendell D. (2001). Depressed, withdrawn, and instrusive mothers’ effects on their fetuses and neonates. Infant Behavior and Development, 24, 2739. doi:10.1016/S0163-6383(01)00066-2
Field T., Diego M., Dieter J., Hernandez-Reif M., Schanberg S., Kuhn C., … Bendell D. (2004). Prenatal depression effects on the fetus and the newborn. Infant Behavior and Development, 27, 216229. doi:10.1016/j.infbeh.2003.09.010
Field T., Diego M., Hernandez-Reif M., Schanberg S., Kuhn C., Yando R., & Bendell D. (2003). Pregnancy anxiety and comorbid depression and anger: Effects on the fetus and neonate. Depression and Anxiety, 17, 140151. doi:10.1002/da.10071
Fox N. A., Henderson H. A., Rubin K. H., Calkins S. D., & Schmidt L. A. (2001). Continuity and discontinuity of behavioral inhibition and exuberance: Psychophysiological and behavioral influences across the first four years of life. Child Development, 72, 121.
Gartstein M. A., & Rothbart M. K. (2003). Studying infant temperament via the Revised Infant Behavior Questionnaire. Infant Behavior and Development, 26, 6486.
Gibson E. L. (2006). Emotional influences on food choice: Sensory, physiological and psychological pathways. Physiology & Behavior, 89, 5361. doi:10.1016/j.physbeh.2006.01.02
Gluckman P. D., & Hanson M. A. (2004). The developmental origins of the metabolic syndrome. Trends in Endocrinology and Metabolism, 15, 183187. doi:10.1016/j.tem.2004.03.002
Gluckman P. D., Low F. M., Buklijas T., Hanson M. A., & Beedle A. S. (2011). How evolutionary principles improve the understanding of human health and disease. Evolutionary Applications, 4, 249263. doi:10.1111/j.1752-4571.2010.00164.x
Glynn L. M., & Sandman C. A. (2011). Prenatal origins of neurological development: A critical period for fetus and mother. Current Directions in Psychological Science, 20, 384389. doi:10.1177/0963721411422056
Gold P. W., & Chrousos G. P. (2002). Organization of the stress system and its dysregulation in melancholic and atypical depression: High vs low CRH/NE states. Molecular Psychiatry, 7, 254275. doi:10.1038/sj/mp/4001032
Graignic-Philippe R., Dayan J., Chokron S., Jacquet A. Y., & Tordjman S. (2014). Effects of prenatal stress on fetal and child development: A critical literature review. Neuroscience & Biobehavioral Reviews, 43, 137162. doi:10.1016/j.neubiorev.2014.03.022
Graziano P., & Derefinko K. (2013). Cardiac vagal control and children's adaptive functioning: A meta-analysis. Biological Psychology, 94, 2237. doi:10.1016/j.biopsycho.2013.04.011
Grobman W. A., Parker C., Wadhwa P. D., Willinger M., Simhan H., Silver B., … Reddy U. M. (2016). Racial/ethnic disparities in measures of self-reported psychosocial states and traits during pregnancy. American Journal of Perinatology. Advance online publication. doi:10.1055/s-0036-1586510
Guardino C. M., & Schetter C. D. (2014). Coping during pregnancy: A systematic review and recommendations. Health Psychology Review, 8, 7094. doi:10.1080/17437199.2012.752659
Gunnar M. R., Sebanc A. M., Tout K., Donzella B., & van Dulmen M. H. (2003). Peer rejection, temperament, and cortisol activity in preschoolers. Developmental Psychobiology, 43, 346358. doi:10.1002/dev.10144
Haley D. W., Handmaker N. S., & Lowe J. (2006). Infant stress reactivity and prenatal alcohol exposure. Alcoholism: Clinical and Experimental Research, 30, 20552064. doi:10.1111/j.1530-0277.2006.00251.x
Haley D. W., & Stansbury K. (2003). Infant stress and parent responsiveness: Regulation of physiology and behavior during still-face and reunion. Child Development, 74, 15341546. doi:10.1111/1467-8624.00621
Hanson M., Godfrey K. M., Lillycrop K. A., Burdge G. C., & Gluckman P. D. (2011). Developmental plasticity and developmental origins of non-communicable disease: Theoretical considerations and epigenetic mechanisms. Progress in Biophysics and Molecular Biology, 106, 272280. doi:10.1016/j.pbiomolbio.2010.12.008
Hertzman C. (1999). The biological embedding of early experience and its effects on health in adulthood. Annals of the New York Academy of Sciences, 896, 8595.
Hertzman C., & Boyce W. T. (2010). How experience gets under the skin to create gradients in developmental health. Annual Review of Public Health, 31, 329347. doi:10.1146/annurev.publhealth.012809.103538
Holochwost S. J., Gariepy J. L., Propper C. B., Mills-Koonce W. R., & Moore G. A. (2014). Parenting behaviors and vagal tone at six months predict attachment disorganization at twelve months. Developmental Psychobiology, 56, 14231430. doi:10.1002/dev.21221
Jacob S., Byrne M., & Keenan K. (2009). Neonatal physiological regulation is associated with perinatal factors: A study of neonates born to healthy African American women living in poverty. Infant Mental Health Journal, 30, 8294. doi:10.1002/imhj.20204
Jones N. A., Fox N., Davalos M., Lundy B., & Hart S. (1998). Newborns of mothers with depressive symptoms are physiologically less developed. Infant Behavior and Development, 21, 537541.
Jones-Mason K., Allen I. E., Bush N., & Hamilton S. (2016). Epigenetic marks as the link between environment and development: Examination of the associations between attachment, socioeconomic status, and methylation of the SLC6A4 gene. Brain and Behavior, 6, e00480. doi:10.1002/brb3.480
Kaplan L. A., Evans L., & Monk C. (2008). Effects of mothers’ prenatal psychiatric status and postnatal caregiving on infant biobehavioral regulation: Can prenatal programming be modified? Early Human Development, 84, 249256. doi:10.1016/j.earlhumdev.2007.06.004
Knight A. K., Craig J. M., Theda C., Bækvad-Hansen M., Bybjerg-Grauholm J., Hansen C. S., … Smith A. K. (2016). An epigenetic clock for gestational age at birth based on blood methylation data. Genome Biology, 17, 206. doi:10.1186/s13059-016-1068-z
Krinsley K. E., Gallagher J. G., Weathers F. W., Kutter C. J., & Kaloupek D. G. (2003). Consistency of retrospective reporting about exposure to traumatic events. Journal of Traumatic Stress, 16, 399409. doi:10.1023/a:1024474204233
Kroenke K., Spitzer R. L., & Williams J. B. (2001). The PHQ-9: Validity of a brief depression severity measure. Journal of General Internal Medicine, 16, 606613. doi:10.1046/j.1525-1497.2001.016009606.x
Kuo B. C. H. (2014). Coping, acculturation, and psychological adaptation among migrants: A theoretical and empirical review and synthesis of the literature. Health Psychology and Behavioral Medicine, 2, 1633. doi:10.1080/21642850.2013.843459
McLaughlin K. A., Sheridan M. A., Tibu F., Fox N. A., Zeanah C. H., & Nelson C. A. III. (2015). Causal effects of the early caregiving environment on development of stress response systems in children. Proceedings of the National Academy of Sciences, 112, 56375642. doi:10.1073/pnas.1423363112
Mesman J., van Ijzendoorn M. H., & Bakermans-Kranenburg M. J. (2009). The many faces of the Still-Face Paradigm: A review and meta-analysis. Developmental Review, 29, 120162. doi:10.1016/j.dr.2009.02.001
Moisiadis V. G., & Matthews S. G. (2014a). Glucocorticoids and fetal programming: Part 1. Outcomes. Nature Reviews Endocrinology, 10, 391402. doi:10.1038/nrendo.2014.73
Moisiadis V. G., & Matthews S. G. (2014b). Glucocorticoids and fetal programming: Part 2. Mechanisms. Nature Reviews Endocrinology, 10, 403411. doi:10.1038/nrendo.2014.74
Monk C., Spicer J., & Champagne F. A. (2012). Linking prenatal maternal adversity to developmental outcomes in infants: The role of epigenetic pathways. Development and Psychopathology, 24, 13611376. doi:10.1017/S0954579412000764
Moore G. A. (2010). Parent conflict predicts infants’ vagal regulation in social interaction. Development and Psychopathology, 22, 2333. doi:10.1017/S095457940999023X
Moore G. A., Hill-Soderlund A. L., Propper C. B., Calkins S. D., Mills-Koonce W. R., & Cox M. J. (2009). Mother-infant vagal regulation in the face-to-face still-face paradigm is moderated by maternal sensitivity. Child Development, 80, 209223. doi:10.1111/j.1467-8624.2008.01255.x
Nast I., Bolten M., Meinlschmidt G., & Hellhammer D. H. (2013). How to measure prenatal stress? A systematic review of psychometric instruments to assess psychosocial stress during pregnancy. Paediatric and Perinatal Epidemiology, 27, 313322. doi:10.1111/ppe.12051
Nolvi S., Karlsson L., Bridgett D. J., Korja R., Huizink A. C., Kataja E. L., & Karlsson H. (2016). Maternal prenatal stress and infant emotional reactivity six months postpartum. Journal of Affective Disorders, 199, 163170. doi:10.1016/j.jad.2016.04.020
Oldehinkel A. J., Hartman C. A., De Winter A. F., Veenstra R., & Ormel J. (2004). Temperament profiles associated with internalizing and externalizing problems in preadolescence. Development and Psychopathology, 16, 421440. doi:10.1017/S0954579404044591
Pluess M., & Belsky J. (2011). Prenatal programming of postnatal plasticity? Development and Psychopathology, 23, 2938. doi:10.1017/S0954579410000623
Ponirakis A., Susman E. J., & Stifter C. A. (1998). Negative emotionality and cortisol during adolescent pregnancy and its effects on infant health and autonomic nervous system reactivity. Developmental Psychobiology, 33, 163174.
Posner M. I., & Rothbart M. K. (2000). Developing mechanisms of self-regulation. Development and Psychopathology, 12, 427441.
Preacher K. J., Curran P. J., & Bauer D. J. (2006). Computational tools for probing interactions in multiple linear regression, multilevel modeling, and latent curve analysis. Journal of Educational and Behavioral Statistics, 31, 437448. doi:10.3102/10769986031004437
Propper C. B., & Holochwost S. J. (2013). The influence of proximal risk on the early development of the autonomic nervous system. Developmental Review, 33, 151167. doi:10.1016/j.dr.2013.05.001
Provenzi L., Olson K. L., Montirosso R., & Tronick E. (2016). Infants, mothers, and dyadic contributions to stability and prediction of social stress response at 6 months. Developmental Psychology, 52, 18. doi:10.1037/dev0000072
Pruessner J. C., Hellhammer D. H., & Kirschbaum C. (1999). Burnout, perceived stress, and cortisol responses to awakening. Psychosomatic Medicine, 61, 197204.
Rash J. A., Campbell T. S., Letourneau N., & Giesbrecht G. F. (2015). Maternal cortisol during pregnancy is related to infant cardiac vagal control. Psychoneuroendocrinology, 54, 7889. doi:10.1016/j.psyneuen.2015.01.024
Rash J. A., Thomas J. C., Campbell T. S., Letourneau N., Granger D. A., Giesbrecht G. F., & Team A. S. (2016). Developmental origins of infant stress reactivity profiles: A multi-system approach. Developmental Psychobiology, 58, 578599. doi:10.1002/dev.21403
Ritz T., Bosquet Enlow M., Schulz S. M., Kitts R., Staudenmayer J., & Wright R. J. (2012). Respiratory sinus arrhythmia as an index of vagal activity during stress in infants: Respiratory influences and their control. PLOS ONE, 7, e52729. doi:10.1371/journal.pone.0052729
Sandman C. A., Davis E. P., Buss C., & Glynn L. M. (2011). Prenatal programming of human neurological function. International Journal of Peptides, 2011, 9. doi:10.1155/2011/837596
Sandman C. A., Davis E. P., Buss C., & Glynn L. M. (2012). Exposure to prenatal psychobiological stress exerts programming influences on the mother and her fetus. Neuroendocrinology, 95, 721. doi:10.1159/000327017
Sandman C. A., Davis E. P., & Glynn L. M. (2012). Prescient human fetuses thrive. Psychological Science, 23, 93100. doi:10.1177/0956797611422073
Sandman C. A., Glynn L., Wadhwa P. D., Chicz-DeMet A., Porto M., & Garite T. (2003). Maternal hypothalamic-pituitary-adrenal disregulation during the third trimester influences human fetal responses. Developmental Neuroscience, 25, 4149. doi:10.1159/000071467
Sherwood A., Allen M. T., Obrist P. A., & Langer A. W. (1986). Evaluation of beta-adrenergic influences on cardiovascular and metabolic adjustments to physical and psychological stress. Psychophysiology, 23, 89104.
Shiner R. L., Buss K. A., McClowry S. G., Putnam S. P., Saudino K. J., & Zentner M. (2012). What is temperament now? Assessing progress in temperament research on the twenty-fifth anniversary of Goldsmith et al. (1987). Child Development Perspectives, 6, 436444. doi:10.1111/j.1750-8606.2012.00254.x
Sidebottom A. C., Harrison P. A., Godecker A., & Kim H. (2012). Validation of the Patient Health Questionnaire (PHQ)-9 for prenatal depression screening. Archives of Women's Mental Health, 15, 367374. doi:10.1007/s00737-012-0295-x
Siu A. L., US Preventive Services Task Force, Bibbins-Domingo K., Grossman D. C., Baumann L. C., Davidson K. W., … Pignone M. P. (2016). Screening for depression in adults: US Preventive Services Task Force recommendation statement. Journal of the American Medical Association, 315, 380387. doi:10.1001/jama.2015.18392
Sontag L. W., & Richards T. (1938). Studies in fetal behavior: I. Fetal heart rate as a behavioral indicator. Monographs of the Society for Research in Child Development, 3(4, Serial No. 17).
Stifter C., & Dollar J. (2016). Temperament and developmental psychopathology. In Cicchetti D. (Ed.), Developmental psychopathology. Hoboken, NJ: Wiley.
Suurland J., van der Heijden K. B., Smaling H. J., Huijbregts S. C., van Goozen S. H., & Swaab H. (2016). Infant autonomic nervous system response and recovery: Associations with maternal risk status and infant emotion regulation. Development and Psychopathology. Advance online publication. doi:10.1017/S0954579416000456
Tackett J. L., Kushner S. C., Herzhoff K., Smack A. J., & Reardon K. W. (2014). Viewing relational aggression through multiple lenses: Temperament, personality, and personality pathology. Development and Psychopathology, 26, 863877. doi:10.1017/s0954579414000443
Toth S. L., Sturge-Apple M. L., Rogosch F. A., & Cicchetti D. (2015). Mechanisms of change: Testing how preventative interventions impact psychological and physiological stress functioning in mothers in neglectful families. Development and Psychopathology, 27, 16611674. doi:10.1017/S0954579415001017
Tronick E., Als H., Adamson L., Wise S., & Brazelton T. B. (1978). The infant's response to entrapment between contradictory messages in face-to-face interaction. Journal of the American Academy of Child & Adolescent Psychiatry, 17, 113.
US Department of Health and Human Services. (2011). The 2011 HHS poverty guidelines (DOCID:fr20ja11-76) . Washington, DC: Author. Retrieved from
Vaughn B. E., Bost K. K., & van IJzendoorn M. H. (2008). Attachment and temperament: Additive and interactive influences on behavior, affect, and cognition during infancy and childhood. In Cassidy J. & Shaver P. R. (Eds.), Handbook of attachment: Theory, research, and clinical applications (pp. 192216). New York: Guilford Press.
Wadhwa P. D., Buss C., Entringer S., & Swanson J. M. (2009). Developmental origins of health and disease: Brief history of the approach and current focus on epigenetic mechanisms. Seminars in Reproductive Medicine, 27, 358368. doi:10.1055/s-0029-1237424
Wadhwa P. D., Dunkel-Schetter C., Chicz-DeMet A., & Sandman C. A. (1999). The psychobiology of stress in human pregnancy. Psychosomatic Medicine, 61, 9696.
Wadhwa P. D., Entringer S., Buss C., & Lu M. C. (2011). The contribution of maternal stress to preterm birth: Issues and considerations. Clinics in Perinatology, 38, 351384. doi:10.1016/j.clp.2011.06.007
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Development and Psychopathology
  • ISSN: 0954-5794
  • EISSN: 1469-2198
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