Since the escalation of hostilities in Gaza in October 2023, the health care system has been overwhelmed by mass casualties, infrastructure damage, and supply shortages. Amid these conditions, septic amputations have emerged as a desperate, life-saving measure for patients with severe limb wound infections. This article examines the rise of such procedures, drawing from contextual analysis and firsthand cases at Al-Aqsa Martyrs’ Hospital. It also highlights doctors’ observation of how delayed access to care, lack of sterile tools, antibiotic shortages, and multidrug-resistant infections have often made limb salvage impossible. These amputations, while medically necessary, reflect the collapse of trauma care and underscore the urgent need for adaptable humanitarian intervention, standards, and call for the protection of health care facilities and services continuity.