Social isolation refers to the lack of objective social contact and is one of the health risk factors. Previous studies have shown that social isolation is associated with several physical and mental disorders. However, the relationship between social isolation and schizophrenia remains unclear.

This study aimed to investigate whether there is a potentially causal association between social isolation and schizophrenia.

The UK Biobank (UKB) is a large population-based cohort study. In this study, social isolation was assessed using self-reported questionnaires. Participants were categorized into socially isolated and non-isolated groups based on the scores. We identified cases of schizophrenia through hospitalization records and death registrations in the UKB. Propensity score matching was used to reduce the influence of confounding factors. We estimated the hazard ratios (HRs) of social isolation to schizophrenia using Cox regression. In addition, we estimated the causal association between social isolation and schizophrenia by two-sample Mendelian randomization analysis. Genetic data for social isolation and schizophrenia were extracted from the UKB and the Psychiatric Genomics Consortium, respectively.

315 cases of schizophrenia were documented during a mean follow-up of 12.3 years. After adjusting for demographic, socioeconomic, and lifestyle factors, the risk of schizophrenia in the socially isolated group was 1.73 times higher than that in the non-socially isolated group (95% CI, 1.37-2.18). Results from two-sample Mendelian randomization analysis showed that participating in more other group activities was associated with a reduced risk of schizophrenia (OR, 0.49; 95% CI, 0.31-0.77).

Social isolation was potentially causally associated with an increased risk of schizophrenia. The results of this study emphasize the importance of reducing the risk of developing schizophrenia through initiatives to reduce social isolation and increase social activities.

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Mining work and environment are the hardest and most difficult jobs in the labor market, increasing the risk of physical and mental illness. A study was conducted to determine the level of stress in mine workers and evaluate the relationship between depression and stress.

To determine the level of stress in mine workers and evaluate the relationship between depression and stress.

Questionnaires were collected from mine workers using the stress detection test (SRQ) and depression detection test (PHQ9) developed by the World Health Organization for doctors.

2.2% (95) of the respondents are male and 7.8% (8) are female workers. Of these, 70.9% work night shifts, 24.3% do not work night shifts, and 4.8% occasionally work night shifts. Comparing the stress levels of the respondents by age, 1.9% (2) of 20-24-year-olds are moderately stressed, 3.9% (4) of 25-29-year-olds are moderately stressed, and 4.8% (5) are stressed. 30-34-year-olds have moderate stress, 1.9% (2) have high stress, 1% (1) of 35-39-year-olds have moderate stress, 1.9% (2) have high stress, and 1% (1) have high stress. 40-44 have moderate, 1% (1) high, and 1% (1) 45-49 have moderate stress. The depression status of the participants compared to the 20-24-year-olds was 1% (1) transient mood depression, 1% (1) moderate depression, and 25-29-year-olds self-correcting transient mood 4.8% depression (5), 4.8% moderate depression (5), 1% (1) moderate depression, 1% (1) severe depression, 5.8% (6) depressed, 4.8% ((5)) moderate depression, 1.9% (2) moderate depression, 35-39-year-old spontaneous self-correction (68%). 7) with depression, 1.9% (2) with moderate depression, temporary self-correction at the age of 40-44 1.9% (2) with depression, 1% (1) with severe depression, temporary at the age of 45-49 2.9% (3) have depression. According to this, it can be considered that 25-44-year-olds are at risk of depression with a high depression index.

The study concluded that 25-44-year-olds are at risk of depression with a high depression index, indicating that they are at risk of depression.

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Charles Bonnet syndrome (CBS) is a condition in which patients with a free psychiatric history manifest visual hallucinations on the basis of a diagnosed ophthalmic disease (brain disease or optic nerve damage), which causes severe vision loss (partial or total).

Hypothesis testing: “Administration of low doses of typical and atypical antipsychotics is the more effective pharmacological treatment for visual hallucinations of CBS”.

Patients underwent pathological, psychiatric and ophthalmological assessment, resulting in a complete study-appropriate medical history.

The sample consisted of ten female patients and eight male patients. The median age of the sample was 84 years. None of the patients was diagnosed with major psychopathology and in no clinical case was an individual medical history of dependence on alcohol or other psychotropic substances recorded. A common cause of the dysfunctional vision of the entire sample of patients was the visual deficit due to a diagnosed cataract condition. During the examination of each patient, it was found that a significant number of predisposing factors for CBS, as described in the literature, were detected. Increased stress levels, depressed mood, cognitive deficits, damage at the level of brain tissue, living conditions of the patient in environments with insufficient light intensity, social withdrawal or poor interaction with others contributed to the vulnerability of visual hallucinations. The administration of broad-spectrum medicines of Internal Medicine was also recorded as a covariate for the triggering of visual hallucinations. As demonstrated by the majority of patients, the administration of a low dose of a typical antipsychotic led to effective treatment of the syndrome.

Based on the present study, in patients of both sexes (men and women), aged 73-98 years, haloperidol and risperidone in low doses of 1-2 mg and olanzapine in low doses of 2.5-5 mg appear to be more effective options in treating with optical hallucinations in CBS.

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Psychiatry trainees in Ireland are categorised as Non-Consultant Hospital Doctors (NCHD). Research into the wellbeing of NCHD’s has consistently highlighted difficult working conditions with the majority reporting they have been told by others they neglect their own health. The learning outcomes of the College of Psychiatrists of Ireland are majority clinical, professional and academic based with only a small focus on outcomes related to trainee wellbeing. Therefore, local and creative initiatives to support psychiatry trainee health and wellbeing are warranted.

To conduct a needs analysis amongst psychiatry trainees in the Sligo/Leitrim Mental Health Service to inform the development of a NCHD Wellness at Work Committee and assess its impact over over a six month period from January 2024 – July 2024.

Following Clinical Director ethical approval, an anonymous online survey was shared with NCHD’s through email to assess their workplace wellbeing needs. Results were collected and analysed using Microsoft Excel leading to the creation and implementation of an action plan. At the end of the period, another anonymous online survey was shared through email to assess the usefulness of the project.

16 out of 23 local NCHD’s responded to the needs analysis.

88% identified ‘Physical Health’ as the top priority for the committee, while 75% endorsed the ‘Psychosocial work Environment’ and ‘Mental Health and Wellbeing’. The ‘Physical Work Environment’ and ‘Healthy Eating’ were chosen by 44%.

In terms of a wellness at work development program, the most frequently requested item was ‘Activities to support mental health’ (69%), followed by ‘Corporate Leisure Centre discounts’ at 63%, ‘Stress Management’ and ‘Exercise/physical activity classes’ both at 56% and ‘Access to healthy food’ and ‘Sports participation’ options both at 50%.

‘Not enough time’ was identified as the greatest barrier to participation by 69% with equal variations across preferred timing of activities.

The action plan included the improvement of the physical work environment along with the arrangement of a financial planning webinar, Human Resources Coaching, Occupational Health and Health Promotion sessions. Information was shared by email on the Cycle to Work scheme and the Living Well stress reduction program along with social events including a breakfast club, provision of time and facilitites pre-trainee teaching for social interaction and a regular social dinner.

An impact assessment survey provided 12 responses from a total requested of 16 with all 12 responding indicating a positive impact. The missing 4 responses were due to trainees moving location.

This is, to our knowledge, the first quality improvement project to date involving the creation of an NCHD Wellness at Work Committee in Ireland.

The results will be used to inform and encourage the development of similar initiatives Deanery wide.

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Growing evidence suggests that inflammation plays a critical role in the early stages of psychosis, potentially contributing to disease onset and progression. Several studies have identified elevated levels of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in individuals at clinical high risk (CHR) for psychosis and in those with first-episode psychosis (FEP). However, inconsistencies across studies highlight the need for further research to clarify the relationship between immune dysregulation and psychosis onset.

This talk reviews the current literature on inflammatory markers in early psychosis and their potential implications for pathophysiology, early detection, and treatment strategies. Notably, inflammation may serve as a promising biomarker for identifying individuals at risk and monitoring disease progression. Additionally, anti-inflammatory interventions are being explored as potential adjunctive treatments for psychosis.

Beyond the review of existing evidence, we will present original data from the PREGAP study conducted at the Early Intervention \Service (EIS) of Basurto University Hospital. This dataset includes inflammatory marker assessments in CHR and FEP individuals, providing novel insights into immune alterations in early psychosis.

Understanding the role of inflammation in psychosis could open new avenues for personalized medicine, early intervention, and improved treatment outcomes. Future research should focus on large-scale longitudinal studies to confirm the clinical utility of inflammatory markers and identify potential therapeutic targets.

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Psychosocial treatment is a crucial component of the rehabilitation process for individuals with serious mental illness (SMI). However, adherence to these interventions is often low, with high dropout rates posing challenges to successful outcomes. Understanding the factors that influence patient adherence, and dropout is essential for improving program efficacy and patient well-being.

This study aims to analyze the demographic, clinical, and motivational factors that contribute to adherence or dropout from the “Programa Mais de Perto” (PMDP), a psychosocial rehabilitation initiative for individuals with SMI, in order to enhance patient retention and optimize therapeutic outcomes.

The study included all patients with SMI enrolled in the PMDP activities until December 2023. Data were collected through clinical file reviews and telephone interviews using a structured questionnaire, including the World Health Organization Disability Assessment Schedule (WHODAS 2.0). Demographic and clinical variables, as well as patient-reported experiences, were analyzed to identify factors associated with continued participation or dropout.

The study initially included 87 patients, of whom 41 adhered to the program and 46 dropped out. However, after further filtering and questionnaire analysis, a subset of 36 patients was evaluated in detail (22 in the adherence group and 14 in the dropout group). The adherence group had lower disability scores on WHODAS 2.0 and reported higher intrinsic motivation, such as improving physical and mental well-being. In contrast, the dropout group highlighted external pressures from mental health professionals as reasons for initial participation and cited fatigue, lack of integration, and distance from the program as reasons for discontinuation. Tai Chi Chuan was the most popular activity (39% participation), while the Book Club had the lowest engagement (3%).

Intrinsic motivation is a key predictor of adherence to psychosocial rehabilitation programs, while external pressures may increase dropout risk. Enhancing flexibility, offering a wider range of activities, and fostering peer support systems could improve retention rates. These findings reinforce the importance of adapting psychosocial interventions to the needs and motivations of individuals with SMI for better long-term outcomes.

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Personal recovery in psychosis is one of the fields where research and clinical activities are growing faster. But the concept lacks conceptual clarity and internal consistency. As a result, most of the studies evaluating its efectiveness may be biased. As in any other intervention, great improvement in clinical evolution of the users has been claimed. And so, neurobiological changes should be described.

This study finds to develop a systematic review of studies describing changes surrounding the recovery process from a neurobiological level.

Keywords hev been selected in order to find all studies focussing on personal recovery in psychosis from its neurobiological basis. Qualitative studies of personal recovery will be excluded. Cross-sectional, longitudinal as well as intervention studies will be included.

The systematic review is underway. The study protocol will be registered at PROSPERO database.

Most studies researching about personal recovery have been developed taking “personal recovery” as an outcome marker. But this is not enough. We need to clarify the neurobiological basis underlying this concept.

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Procrastionation is commonly conceptualized as an irrational, conscious, and sometimes intentional tendency to delay the start or to complete tasks or decisions, despite consequences. The behavior may be present in several psychiatric disorders, especially OCD, ADHD and anxiety disorders However, there is no consensus definition of procrastination, nor established pathophysiology or motivation.

To analyze the descriptive psychopathology as well as the presence or absence of associated symptoms, motivations, and consequences of procrastination. In sequence, to conceptualize the construct of “procrastination” based on the literature published and define the motivations and consequences of the behavior for the individuals.

The scoping review complies with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and included articles published English, Spanish and Portuguese, between 1973-2023 and indexed in PubMed/MEDLINE, LILACS, Scielo, EMBASE, Scopus, Web of Science, and PsycINFO database. Research conducted in animals, poster publications, conferences in scientific conclaves, and letters to the author were excluded.

We found 387 studies with different designs (295 [76,2%] were cross-sectional, 12 [3,1%] systematic reviews and 5 [1,3%] were meta-analysis) and published in English (86,6%), Spanish (9,3%) and Portuguese (3,9%). Only 5 studies (1.3%) used populations with AHDH and 1 study (0.02%) used a population with OCD, 7 studies (1.8%) used populations with other disorders (Depression, Anxiety) and 374 studies (96.4%) involved students (mainly university students), workers, or the general population. Of the population the majority was female (63,98%), single, young and has some occupation. In 323 articles, at least one scale was used to assess procrastination, with a total of 40 different ones. Furthermore, 337 studies define procrastination and 305 use the definition of other authors.

Procrastination is a complex event, so far without a defined concept. More investigation is necessary for a more comprehensive understanding of this phenomenon.

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There are clear unmet medical needs in the treatment of Cocaine Use Disorder (CUD), since there are no pharmacological treatments approved. The neurobiological circuitry of addiction has been described in recent years, and it provides a solid rationale to target specific brain regions to treat addictive behaviors, including CUD. The stimulation of the left Dorsolateral Prefrontal Cortex (DLPFC) with repetitive transcranial magnetic stimulation (rTMS) has proved to reduce craving for various drugs, including cocaine.

We present the results of a retrospective study performed in a private setting with 93 patients with CUD, who were treated with rTMS following the protocol from Terraneo et al. In 12 weeks patients received 32 sessions of 2400 pulses (100% MT; 10 Hz; 60 pulses per train, 15 seconds interval; 40 trains per session), for a total of 76800 pulses.

The main outcome was total abstinence of cocaine (self-reported plus urinalysis). Abstinence rates at days 30, 60 and 90 were 55,9%; 40,8%; and 34,4% respectively.

Psychiatric comorbidities (insomnia, depression and anxiety) were also assessed with validated questionnaires. Drop-out was directly related to recent cocaine use, but initial levels of psychological distress did not predict drop-out.

No relevant side effects were reported. Mild and transient headache was reported by a few patients after the first session.

In conclusion rTMS was well tolerated, drop out rates were high and 34% of the patients remained abstinent after the 90 days treatment period.

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Rates of mental health disorders in resettled refugees surpass those of the host population (Hameed et al, KJM 2018;11 20-23). However, most studies suggest heterogenicity between populations, suggesting a need for a non-generalized approach to resettled-refugee mental health (Silove et al, World Psychiatry 2017;16 130-139). Since the Taliban assumed control in August 2021, the United States has taken in about 90,000 Afghan refugees (Green, Wilson Center 2023), 15,000 have settled in Houston, Texas (Schneider, Texas Standard 2023).

This study investigates factors that may predict higher rates of distress and symptoms of PTSD and depression within an Afghan refugee community resettled in Houston, Texas.

Seventy-four Afghan refugees located in Houston, Texas were surveyed for demographic information and physical or emotional symptoms as directed by the Refugee Health Screener-15 (RHS-15). An average score of ≥ 12 on the RHS-15 or a self-reported distress score ≥5 indicated a positive result on the screening tool. Mann-Whitney and Fisher’s exact tests were used to compare differences in patient baseline characteristics and responses stratified by a positive RHS-15 or distress screen. Spearman’s Rank Correlation Coefficient was used to assess the correlation between selected response variables and outcomes as well as between the RHS-15 and distress scores.

40% of subjects scored ≥12 on the RHS-15 and 35% indicated a distress score ≥ 5. Income differed significantly between the RHS <12 group and the RHS ≥12 group (p=.02). The RHS <12 group had a higher proportion of individuals in the lowest income bracket, < $10,000, and a greater proportion in the $20,000-$30,000 bracket. Meanwhile, the RHS ≥12 group had a higher proportion in the $10,000-20,000 income bracket. There was a negative correlation between self-reported health scores with both RHS-15 score (ρ=-.508, p<.001) and distress score (ρ=-.423, p=.001) as well as between neighborhood support levels and distress scores(ρ=-.314, p=.018).

This Afghan refugee cohort shows theoretical rates of PTSD and MDD higher than the average American (40.3% RHS-15 score vs. 3.6% PTSD and 8.3% MDD) (NIH 2023). The increased risk of mental disorder may be attributed to lower perceived community support, poor physical health, and low socioeconomic status. If income growth is a function of increased time spent in the United States, the unique pattern in income between the two RHS groups may reflect a “honeymoon period” that has previously been demonstrated in studies on migrants and culture shock (Maillet et al, APMH 2023; 50 563–575). Following this honeymoon period, however, lower income may predict worsened mental health in resettled refugees. These results support multi-factorial initiatives to support resettled refugees especially in areas of community interconnectedness, health and economic support.

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Pathological traits according to the dimensional diagnostic system for personality disorders include a certain set of emotional, cognitive and behavioral features. In different people, a certain trait manifests itself in a different behavioral form, while the same trait can manifest itself in several people similarly.

To analyze shoplifting in individuals with borderline personality disorder through pathological traits.

A non-systematized literature review was performed, with keywords: borderline personality disorder, shoplifting, and a case series was presented.

This is a series of three cases of people with borderline personality disorder, who were also assessed according to ICD 11 criteria with LPFS-BF 2.0, PSQ-11 and BPS. The first person is a female, 20 years old, a student, LPFS-BF 2.0 - 34, on PSQ-11 elevated values for all pathological traits, except for anankastia and BPS – 47. She is occasionally depressed and continuously abuses marijuana for a long period of time. The second person is the also female, age 21, student, LPFS-BF 2.0 - 31, on PSQ-11 elevated values for negative affectivity and disinhibition and BPS – 46. Occasionally has obsessive controlling and criticizing thoughts and several episodes of self-harm, incidental substance abuse. The third person is a 20-year-old male, unemployed, LPFS-BF 2.0 - 32, PSQ-11 elevated values for negative affectivity and disinhibition and BPS – 41. He is occasionally paranoid, has a history of self-harm and occasional excessive use of benzodiazepines. All three give information that they occasionally steal from markets and large stores, but they do not steal from people. As a reason for stealing, they cite a lack of funds at a given moment for a particular item they wanted, but also the need to steal, the inability to refrain and the excitement they feel at that moment.

Negative affectivity and disinhibition appear as common pathological traits in all three people. Disinhibition, characterized by impulsivity due to a rush of immediate emotions and thoughts, without thinking about the consequences and the need for immediate gratification, manifests itself in these individuals through shoplifting. Occasional shoplifting, without practice of other forms of stealing, is a disinhibitory phenomenon.

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Bipolar Disorder (BD) is a severe and chronic psychiatric condition, with complicated course and substantially reduce psychosocial functioning. Alterations in immune response are considered to be one of the major factors underlying the etiopathogenesis of BD, causing alterations in neurotransmitter systems, neuroendocrine systems, neurotrophic factors, and producing oxidative stress. Inflammatory cytokines have potential value for the clinical diagnosis and prognosis of BD.

The primary aim of the study was to assess the effect of disease course and clinical-characteristics on alterations of transforming growth factor-beta (TGF-beta), in BD.

This cross-sectional study included 82 patients with BD in remission. Multivariate linear regression with TGF-beta value as an outcome, and duration of illness, number of hospitalizations, residual symptoms estimated as Brief Psychiatric Rating Scale (BPRS) score, gender, and age, was used to produce the model.

The explored linear regression model was significant, explaining 39.4% of the variance (p<0.001). Higher TGF-beta was predicted by less previous hospitalizations (p<0.001) and lower BPRS score (0.034), while longer duration of illness was almost significant predictor (p=0.054). Age and gender showed no predictive effect in the model.

The study points out to the better course of BD characterized by less episodes and less residual symptoms in determining the TGF-beta levels, potentially creating a more favorable immunological state. The importance of neuroprotective and neurodegenerative balance of immune mediators, their interplay and relation to chronicity and severity of BD should be further explored.

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Manic episodes, a defining feature of bipolar disorder, are often triggered by significant psychosocial stressors. In Tunisia, marriage carries deep religious, societal, and familial significance, creating considerable pressure that may act as a precipitating factor for the onset of bipolar disorder. This case series presents three patients who experienced their first manic episode in the immediate aftermath of their wedding.

To highlight the role of marriage as a significant trigger for the first manic episodes in patients with no previous psychiatric history, within the specific socio-cultural context of Tunisia.

These case reports were compiled through clinical observations and interviews with the patients and their families. All three cases involved newlywed males who developed manic symptoms shortly after marriage, requiring hospitalization.

• - Case 1: A 30-year-old male with no personal or familial psychiatric history presented with manic symptoms 5 days after his wedding. Symptoms included expansive mood, irritability, insomnia, grandiose and persecutory delusions, hyperactivity, and logorrhea. He was hospitalized and treated with lithium and risperidone. After 3 weeks, he was discharged and has remained symptom-free for 1 month.

• - Case 2: A 33-year-old male with a paternal history of schizoaffective disorder developed mania the day after his wedding, following alcohol use and sleep deprivation. His symptoms included psychomotor agitation, destruction of objects, verbal aggression, logorrhea, tachyphemia, delusions of grandeur and persecution, insomnia, and hyperactivity. He was treated with clonazepam, lithium and haloperidol. Clonazepam was discontinued before discharge, and haloperidol after 3 months. He had been episode-free for 3 years, then he had a manic episode and was hospitalized for 2 weeks. Now he’s been symptom-free for 2 months

• - Case 3: A 31-year-old male with no personal or familial psychiatric history presented with manic symptoms 7 days after his wedding, including insomnia, expansive mood, grandiose delusions with auditory hallucinations (he believed God told him to have a son who would be the next prophet), hyperactivity, and logorrhea. He was treated with diazepam, lithium, and risperidone. He was discharged after 4 weeks, with diazepam discontinued before discharge and risperidone after 6 months. He has remained episode-free for 1 year.

These cases highlight the significant cultural pressures surrounding marriage in Tunisia, which can serve as a potent trigger for manic episodes in individuals without prior psychiatric history. Early identification and intervention with antipsychotics and mood stabilizers proved effective in all cases. These findings emphasize the importance of psychiatric vigilance in similar socio-cultural settings to manage the onset of bipolar disorder in response to life stressors.

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The Bible offers various insights into human struggles, including what can be interpreted today as mental illness. Although ancient texts do not explicitly refer to mental health using modern terminology, there are many accounts of emotional distress, depression, anxiety, and other psychological challenges. Throughout Scripture, several figures are portrayed grappling with deep sorrow, fear, and mental turmoil. These narratives provide spiritual reflections on suffering, healing, and divine intervention, shedding light on how biblical teachings have historically addressed human fragility.

To raises questions about how we can relate ancient wisdom to contemporary mental health issues, offering opportunities for spiritual growth, empathy, and care in our own lives.

A non-systematic review of the published literature was conducted using the Google Scholar database with the search terms “Bible” and “mental illness.” Articles were selected based on their relevance, and further information was obtained through direct consultation of biblical texts.

The prophet Elijah exhibits signs of reactive depression, triggered by stress after confronting the prophets of Baal and receiving a death threat from Jezebel (1 Kings 18:20-40). His symptoms—loss of appetite, isolation, low self-esteem, and hopelessness—are well-documented (1 Kings 19:3). God’s response (1 Kings 19:11-14) provides an example of care for depression, with affection, understanding, and patience.

James 5:15-18 references Elijah to highlight that depression can affect Christians, suggesting that illness, whether physical or spiritual, requires dialogue and support. James emphasizes God’s forgiveness, even if illness stems from sin, viewing depression as an organic condition in line with the holistic Jewish understanding. He advocates for confession and prayer as therapeutic (James 5:16), stressing that mercy triumphs over judgment.

Psalm 6:6-7 captures the deep despair of depression, showing the importance of seeking God amid mental anguish, which is often invisible to others.

The accounts of figures like Elijah and the reflections in Psalms demonstrate that conditions resembling modern definitions of depression and anxiety have long been acknowledged, albeit through the lens of ancient cultural and religious contexts. The compassionate care that God extends to Elijah, coupled with the guidance found in the New Testament, particularly in the book of James, underscores the importance of community and support in addressing mental health challenges.

By examining these stories, we gain a broader understanding of how faith communities have interpreted and coped with the complexities of mental illness - in light of their relationship with God.

These accounts present a holistic biblical view of depression, underscoring the need for empathy, spiritual care, and community support in mental health.

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Transitional care refers to the coordination and continuity of care between different healthcare locations or levels of care within the same facility, regardless of the patient’s age. Transition planning and management is therefore a key element in the organization and delivery of health services. Unfortunately, for many young people with mental health problems, transition is poorly planned, lacks coordination, and results in discontinuity of care. This is particularly true for intellectual disability, Autism Spectrum Disorder, and ADHD: as neurodevelopmental conditions, care typically begins at a young age with attendance at Child and Adolescent Mental Health Services (CAMHS), and the transition to Community Mental Health Services (CMHS) encounters numerous challenges.

A narrative review of the literature was conducted on the topic of transition from inception to January 26th, 2025. The following search string was used through PubMed, Web of Science, Scopus, and PsychInfo: (“Transitional Care” OR “Transition to Adult Care”) AND (“Neurodevelopmental Disorders” OR “Intellectual Disability” OR “Autistic Disorder” OR “Autism Spectrum Disorder”) AND (“Child and Adolescent Mental Health Services” OR “CAMHS” OR “Community Mental Health Centers”).

A total of 202 references were identified and screened considering titles and abstracts. After excluding papers not relevant to the topic and those that were unretrievable, 31 papers were included in the review. A significant majority of the included papers were qualitative studies based on focus groups and interviews conducted with family members and caregivers.

Findings reveal a lack of clarity and consistency regarding service availability for the conditions studied, possibly due to different eligibility criteria between child and adult mental health services, with variable service provision for young people with neurodevelopmental conditions (specifically, ASD, ADHD and ID). While high workloads and staff shortages were perceived to influence service thresholds and eligibility criteria, the lack of perceived severity by the CMHS often led to loss of follow-up.

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Multiple sclerosis (MS) is a chronic and progressive inflammatory autoimmune disease of the central nervous system. Beyond physical symptoms, it can cause various socio‐affective symptoms such as depression, anxiety, sleep disorders and loneliness, leading to a significant psychosocial burden.

This study aimed to identify factors contributing to loneliness in MS patients and to examine its associations with psychological distress, stigma, and resilience.

We conducted a nationwide cross-sectional study of patients with MS from October 2022 to January 2023. Data were collected using an online questionnaire, which included socio-demographic information, disease characteristics, experiences of social stigma, psychological distress, coping strategies, and perceived social support. Validated tools used were the Stigma Scale of Chronic Illness (SSCI-8), Kessler Psychological Distress Scale (K10), Brief Resilient Coping Scale (BRCS), and UCLA Loneliness Scale.

A total of 108 patients, 69.4% women, mean age 44.8 years, participated in the study. Higher loneliness scores were associated with greater psychological distress (p<0.001) and higher perceived stigma (p<0.001). Inversely, higher loneliness levels correlated with lower resilience (p<0.001). Patients living in small urban or rural areas reported higher levels of loneliness compared to those in large urban centers (p=0.002). Additionally, full-time employment (p=0.032) and better financial status (p = 0.025) were associated with reduced loneliness, while a family history of psychiatric illness was linked to higher loneliness (p=0.043).

This study reveals that loneliness is an important issue in MS patients and is associated with mental health problems, stigma and reduced coping resilience. Patients living in smaller urban areas, with poorer financial status, or a family history of psychiatric illness are particularly vulnerable. Addressing loneliness should be a priority in psychosocial interventions to improve quality of life. Future research with larger samples is recommended to confirm and extend these findings.

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Wilson disease is an autosomal recessive disorder that leads to defective copper metabolism. It manifests as neurologic, hepatic and psychiatric symptoms (Benhamla et al. Encephale 2007; 33(6):924–32). Through a case series of three family members, we emphasize the varied presentation of Wilson disease, and the need for investigation of metabolic causes of such symptoms especially in families with a history of consanguinity.

We aim to underscore the importance of considering metabolic causes of psychiatric symptoms, particularly when these symptoms cluster within families.

The cases are presented followed by an exploration of social context, gaps in existing literature, and suggestions for clinical practise.

Case 1: A 32-year-old male previously having received diagnoses of Treatment-Resistant Schizophrenia and Obsessive Compulsive Disorder over a period of 13 years presented with cognitive decline, delusions of persecution and reference, 2nd and 3rd person auditory hallucinations, preoccupation with cleaning and a significant decline in the ability to perform activities of daily living. Despite extensive psychiatric treatment, his symptoms worsened, raising suspicion for an underlying medical condition.

Case 2: A 16-year-old male, once a bright student, presented with progressive cognitive decline, poor working memory, social withdrawal, needing assistance with ADLs and sialorrhea for 2 years. These symptoms were initially misattributed to psychological stress and academic pressure, but the lack of response to treatment and worsening neurological signs of poor coordination raised suspicion for an organic cause. His eye exam was positive for Kayser Fleischer ring and his serum ceruloplasmin was below threshold level. This prompted a similar workup for his elder brother which was positive for Wilson disease.

Case 3: The mother of the aforementioned two patients, after witnessing her younger son’s decline, developed major depressive disorder with psychosis. Her symptoms started follwoing the stress of her children’s health problems and their lack of response to treatment.

Upon genetic counselling, the siblings of the first two patients revealed that they were both respectively engaged to be married to their first cousins and that their mother was adamant about these matches due to family traditions.

These cases underscore the need for a heightened suspicion of Wilson disease and other metabolic disorders in patients who belong to regions with high rates of consanguinity and have clustering of psychiatric disorders in their family. Further studies are needed to determine the true prevalence of Wilson disease in Pakistan which may be relatively high due to the common practise of cousin marriages (Zimbrean et al. Gen Hosp Psychiatry. 2014;36(1):53–62).

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The World Health Organization (WHO) defines adolescence as the developmental stage between childhood and adulthood, spanning ages 10 to 19. This period is characterized by significant physical, cognitive, and psychosocial growth.

This study aims to understand the clinical profile of adolescents hospitalized for the first time in the psychiatric department.

• - It’s a retrospective and descriptive study covering the files of patients who consulted the Avicenna Psychiatry department of Razi hospital aged under 18, during the year 2023.

• - The collection of anamnestic and clinical data was established using a pre-established form

Our study included 24 patients aged between 16 and 18 years, with a mean age of 17 years, comprising 13 males and 11 females.

Patients presented voluntarily in 42% of cases, were brought in by law enforcement in 25%, and were referred by a private psychiatrist in 17% of cases. The reasons for consultation were as follows: behavioral disturbances in 63% of cases, a suicide attempt in 21%, and incoherent statements in 8% of cases. 60% of cases used medication ingestion as the method during the suicide attempt. A family history of psychiatric disorders was found in 50% of cases, as well as a family history of suicide attempts in 13% of cases. Additionally, 71% of cases had prior follow-up with a private psychiatrist, 21%of cases had previously attempted suicide, and 33%of cases had personal somatic histories.

The onset of disturbances was progressive in 71% of patients. Upon hospitalization, anxious symptoms were noted in 25% of cases, while depressive symptoms with suicidal ideation were recorded in 29% of patients. hallucinations and delusions were noted in 50% of cases, and behavioral eccentricity was observed in 25% of cases.Instinctual disorders were present in 75% of cases, with sleep disturbances observed in 71%of cases, sexual disorders in 25%of cases, and appetite disorders in 13 %of cases.

Verbal hetero-aggression was identified in 83% of cases, while physical hetero-aggression was noted in 67%of cases. Self-harming behaviors were recorded in 48% of patients.

The diagnoses made according to DSM-5 criteria were distributed as follows: bipolar disorder in 29% of cases, schizophrenia in 17%of cases, and 13%of cases related to a life stage.

Adolescent psychiatric hospitalizations are rising, emphasizing the need to understand clinical characteristics of this population. This study analyzes clinical aspects of adolescents admitted to a psychiatric unit over one year. The findings aim to enhance treatment strategies and patient outcomes.

None Declared

Self-destructive behavior in depression is most often a pathological way of emotional self-regulation, but it may increase suicidal risk. In this regard, the identification of risk factors for self-destructive behavior is of practical importance.

The aim was to study hostility as risk factor self-destructive behavior in depression.

The study included 155 women from 16 to 25 years old (mean age 19,77) hospitalized with depression in a clinic of FSBSI MHRC. The Buss-Perry Aggression Questionnaire (BPAQ), the Symptom Checklist-90-reserved (SCL-90-R), the Physical Appearance Comparison Scale—Revised (PACS–R), the Body Investment Scale (BIS), anamnestic data about self-destructive behavior, a question to assess the level of autoaggression («Sometimes I deliberately injure myself » was measured on a Likert scale from 0 to 5) were used. ANOVA and Spearman’s rank correlation coefficient were used. To analyze the features associated with the level of hostility, the sample was divided into subgroups “with low hostility” (78 people, mean age 19.91) and “with high hostility” (77 people, mean age 19.6), according to the median value of the “Hostility” parameter of BPAQ - 23.

Correlation analysis showed a statistically significant relationship between the level of “Hostility” and the frequency of “deliberately injure” (r=0.19, p<0.05). Comparison of subgroups according to the parameters of SCL-90-R showed a higher level of psychopathologic symptomatology in the group with high hostility: SOM (1.11±0.80 in the “low hostility” group vs. 1.50±0.85 in the “high hostility” group at p=0.001), OC (1.60±0.87 vs. 2, 16±0.77 at p=0.000), INT (1.32±0.84 vs. 2.16±0.90 at p=0.000), DEP (1.73±0.98 vs. 2.27±0.87 at p=0.000), ANX (1.27±0.92 vs. 1.90±1.01 at p=0.000), HOS (0, 89±0.87 vs. 1.41±0.89 at p=0.000), PHOB (0.81±0.86 vs. 1.42±0.89 at p=0.000), PAR (0.74±0.65 vs. 1.43±0.84 at p=0.000), PSY (0.87±0.65 vs. 1, 26±0.78 at p=0.000), GSI (1.22±0.66 compared to 1.77±0.71 at p=0.000), PDSI (2.12±0.60 compared to 2.39±0.56 at p=.002), PSI (48.66±17.14 compared to 64.20±16.16 at p=0.000). BIS scores on the “body Investment subscale” (3.18±1.18 compared to 2.55±1.12 at p=0.001) on the total scale (3.38±0.58 compared to 3.15±0.54 at p=0.008) The PACS-R scale data demonstrate differences in the physical comparison parameter (2.02±1.37 versus 2.66±1.23 at p=0.002).

A higher level of hostility in depression in women with self-destructive behavior is associated with both a worse mental status and a stronger rejection of one’s body, manifested in a decreased concern for it and an increased need to compare oneself with others. This allows us to consider hostility as one of the markers of high risk of self-harming behavior in depression.

None Declared