This study examines how university curriculum reforms that increase course selection flexibility influence entrepreneurial outcomes. Departing from traditional emphasis on educational attainment, we explore how institutional changes in education shape entrepreneurial tendencies among alumni. Leveraging a reform that removed constraints on course selection at a major university, we find that increased educational choice significantly fosters entrepreneurship. Our analysis reveals partial support for the moderating effects of individual, family, and spatial factors: the positive impact of these reforms is contingent on the type of electives and courses taken, with stronger effects observed among alumni with entrepreneurial parents, those born in urban areas, and those from higher socioeconomic backgrounds. These groups leverage specific course patterns to align their educational choices with entrepreneurial aspirations, enhancing their likelihood of pursuing entrepreneurial ventures. However, these findings also underscore the potential for educational reforms to exacerbate inequalities, disproportionately benefiting those with preexisting advantages. By integrating insights on institutional changes, course-taking patterns, and individual moderators, this study advances understanding of the interplay between education and entrepreneurship, offering implications for designing more equitable educational policies.