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Determining the relationship between dietary carbohydrate intake and insulin resistance

  • Neville H. McClenaghan (a1)

Insulin resistance underlies type 2 diabetes, CVD and the metabolic syndrome, driven by changes in diet, lifestyle, energy over–consumption and obesity. Nutritional recommendations for insulin resistance remain an area of controversy, particularly the quantity and types of dietary carbohydrate. The present review gives an overview of insulin resistance, its relationship to impaired insulin secretion and the metabolic syndrome, research methodologies used to measure insulin action and the epidemiological and intervention studies on the relationship between dietary carbohydrate and insulin resistance. Epidemiological studies provide little evidence to suggest that total dietary carbohydrate predicts risk of type 2 diabetes, and high–carbohydrate, high–fibre diets with low–glycaemic index (GI) may even contribute to diabetes prevention. Despite inherent limitations associated with techniques used to measure insulin resistance and dietary assessment, most intervention studies reveal an increase in glucose tolerance or insulin sensitivity with high–carbohydrate, low–fat diets in non–diabetic and diabetic individuals. When energy is restricted the source or reduced content of carbohydrate does not appear to be as important as fat for body weight. Thus, low energy intake is key to weight loss and augmentation of insulin sensitivity. Given this, widespread adoption of popular low–carbohydrate high–fat diets highlights the necessity to evaluate dietary interventions regarding safety and metabolic effects. While current evidence supports FAO/WHO recommendations to maintain a high–carbohydrate diet with low–GI foods, the relationships between carbohydrate and insulin sensitivity remains an important research area. Emerging technologies should further enhance understanding of gene–diet interactions in insulin resistance, providing useful information for future nutrition policy decisions.

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Corresponding author: Dr Neville H. McClenaghan, fax +44 28 7032 4965, email
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Abdel-Wahab, YH, O'Harte, FP, Ratcliff, H, McClenaghan, NH, Barnett, CR & Flatt, PR (1996) Glycation of insulin in the islets of Langerhans of normal and diabetic animals. Diabetes 45, 14891496.
Abraira, C & Derler, J (1988) Large variations of sucrose in constant carbohydrate diets in type II diabetes. American Journal of Medicine 84, 193200.
Anderson, JW (1977) Effect of carbohydrate restriction and high carbohydrates diets on men with chemical diabetes. American Journal of Clinical Nutrition 30, 402408.
Anderson, JW, Herman, RH & Zakim, D (1973) Effect of high glucose and high sucrose diets on glucose tolerance of normal men. American Journal of Clinical Nutrition 26, 600607.
Anonymous (1997) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20, 11831197.
Archer, SL, Liu, K, Dyer, AR, Ruth, KJ, Jacobs, DR Jr, Van Horn, L, Hilner, JE & Savage, PJ (1998) Relationship between changes in dietary sucrose and high density lipoprotein cholesterol: the CARDIA study. Coronary Artery Risk Development in Young Adults. Annals of Epidemiology 8, 433438.
Astrup, A (2001) Healthy lifestyles in Europe: prevention of obesity and type II diabetes by diet and physical activity. Public Health Nutrition 4, 499515.
Astrup, A, Meinert Larsen, T, Harper, A (2004) Atkins and other low–carbohydrate diets: hoax or an effective tool for weight loss? Lancet 364, 897899.
Bantle, JP, Laine, DC & Thomas, JW (1986) Metabolic effects of dietary fructose and sucrose in types I and II diabetic subjects. JAMA 256, 32413246.
Bantle, JP, Swanson, JE, Thomas, W & Laine, DC (1992) Metabolic effects of dietary fructose in diabetic subjects. Diabetes Care 15, 14681476.
Bantle, JP, Swanson, JE, Thomas, W & Laine, DC (1993) Metabolic effects of dietary sucrose in type II diabetic subjects. Diabetes Care 16, 13011305.
Beard, JC, Bergman, RN, Ward, WK & Porte, D (1986) The insulin sensitivity index in non–diabetic man: correlation between clamp–derived and IVGTT–derived values. Diabetes 35, 362369.
Beck-Nielsen, H (1999) General characteristics of the insulin resistance syndrome: prevalence and heritability. European Group for the Study of Insulin Resistance (EGIR). Drugs 58, Suppl. 1, 710.
Beck-Nielsen, H, Pedersen, O & Lindskov, HO (1980) Impaired cellular insulin binding and insulin sensitivity induced by high–fructose feeding in normal subjects. American Journal of Clinical Nutrition 33, 273278.
Behall, KM & Howe, JC (1995) Effect of long–term consumption of amylose vs amylopectin starch on metabolic variables in human subjects. American Journal of Clinical Nutrition 61, 334340.
Bergman, RN, Ider, YZ, Bowden, CR & Cobelli, C (1979) Quantitative estimation of insulin sensitivity. American Journal of Physiology 236, E667E677.
Bergman, RN, Prager, R, Volund, A & Olefsky, JM (1989) Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycaemic glucose clamp. Journal of Clinical Investigation 79, 790800.
Bessesen, DH (2001) The role of carbohydrates in insulin resistance. Journal of Nutrition 131, 2782S2786S.
Bisschop, PH, de Metz, J, Ackermans, MT, Endert, E, Sauerwein, HP, Romijn, JA (2001) Dietary fat content alters insulin–mediated glucose metabolism in healthy men. American Journal of Clinical Nutrition 73, 554559.
Bjorntorp, P (1997) Body fat distribution, insulin resistance, and metabolic diseases. Nutrition 13, 795803.
Blundell, JE & MacDiarmid, JI (1997) Fat as a risk factor for overconsumption: satiation, satiety, and patterns of eating. Journal of the American Dietetics Association 97, Suppl., S63S69.
Boeing, H, Weisgerber, UM, Jeckel, A, Rose, HJ & Kroke, A (2000) Association between glycated hemoglobin and diet and other lifestyle factors in a nondiabetic population: cross-sectional evaluation of data from the Potsdam cohort of the European Prospective Investigation into Cancer and Nutrition Study. American Journal of Clinical Nutrition 71, 11151122.
Bonora, E, Moghetti, P, Zancanaro, C, Cigolini, M, Cacciatori, V, Corgnati, A & Muggeo, M (1989) Estimates of in vivo insulin action in man: comparison of insulin tolerance test with euglycaemic and hyperglycaemic glucose clamp studies. Journal of Clinical Endocrinology and Metabolism 68, 374378.
Borkman, M, Campbell, LV, Chisholm, DJ & Storlien, LH (1991) Comparison of the effects on insulin sensitivity of high carbohydrate and high fat diets in normal subjects. Journal of Clinical Endocrinology and Metabolism 72, 432437.
Bossetti, BM, Kocher, LM, Moranz, JF & Falko, JM (1984) The effects of physiologic amounts of simple sugars on lipoprotein, glucose, and insulin levels in normal subjects. Diabetes Care 7, 309312.
Brand, JC, Colagiuri, S, Crossman, S, Allen, A, Roberts, DC & Truswell, AS (1991) Low–glycemic index foods improve long–term glycemic control in NIDDM. Diabetes Care 14, 95101.
Brand-Miller, J, Wolever, TMS, Colagirui, S & Foster-Powell, K (1999) The Glucose Revolution: The Authoritative Guide to the Glycaemic Index. New York: Marlowe.
Bravata, DM, Sanders, L, Huang, J, Krumholz, HM, Olkin, I, Gardner, CD & Bravata, DM (2003) Efficacy and safety of low–carbohydrate diets: a systematic review. JAMA 289, 18371850.
Brunzell, JD, Lerner, RL, Hazzard, WR, Porte, D Jr & Bierman, EL (1971) Improved glucose tolerance with high carbohydrate feeding in mild diabetes. New England Journal of Medicine 284, 521524.
Brunzell, JD, Lerner, RL, Porte, D Jr & Bierman, EL (1974) Effect of a fat free, high carbohydrate diet on diabetic subjects with fasting hyperglycemia. Diabetes 23, 138142.
Brynes, AE, Mark, EC, Ghatei, MA, Dornhorst, A, Morgan, LM, Bloom, SR & Frost, GS (2003) A randomised four-intervention crossover study investigating the effect of carbohydrates on daytime profiles of insulin, glucose, non–esterified fatty acids and triacylglycerols in middle-aged men. British Journal of Nutrition 89, 207218.
Bundred, P, Kitchiner, D & Buchan, I (2001) Prevalence of overweight and obese children between 1989 and 1998: population–based series of cross–sectional studies. British Medical Journal 10, 326328.
Buyken, AE, Toeller, M, Heitkamp, G, Irsigler, K, Holler, C, Santeusanio, F, Stehle, P & Fuller, JH (2000) Carbohydrate sources and glycaemic control in type 1 diabetes mellitus. Diabetic Medicine 17, 351359.
Calle-Pascual, AL, Gomez, V, Leon, E & Bordiu, E (1988) Foods with a low glycemic index do not improve glycemic control of both type 1 and type 2 diabetic patients after one month of therapy. Diabete et Metabolisme 14, 629633.
Chakravarthy, MV & Booth, FW (2004) Eating, exercise, and ‘thrifty’ genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases. Journal of Applied Physiology 96, 310.
Chen, M, Bergman, RN, Porte, D Jr (1988) Insulin resistance and beta–cell dysfunction in aging: the importance of dietary carbohydrate. Journal of Clinical Endocrinology and Metabolism 67, 951957.
Chiasson, JL, Liljenquist, JE, Lacy, WW, Jennings, JS & Cherrington, AD (1977) Gluconeogenesis: methodological approaches. Federation Proceedings 36, 229235.
Choudhary, P (2004) Review of dietary recommendations for diabetes mellitus. Diabetes Research and Clinical Practice 65, S9S15.
Colagiuri, S, Miller, JJ & Edwards, RA (1989) Metabolic effects of adding sucrose and aspartame to the diet of subjects with noninsulin–dependent diabetes mellitus. American Journal of Clinical Nutrition 50, 474478.
Colditz, GA, Manson, JE, Stampfer, MJ, Rosner, B, Willett, WC & Speizer, FE (1992) Diet and risk of clinical diabetes in women. American Journal of Clinical Nutrition 55, 10181023.
Coulston, AM, Hollenbeck, CB, Donner, CC, Williams, R, Chiou, YA & Reaven, GM (1985) Metabolic effects of added dietary sucrose in individuals with noninsulin–dependent diabetes mellitus (NIDDM). Metabolism: Clinical and Experimental 34, 962966.
Coulston, AM, Hollenbeck, CB, Swislocki, AL, Chen, YD & Reaven, GM (1987) Deleterious metabolic effects of high–carbohydrate, sucrose–containing diets in patients with non–insulin–dependent diabetes mellitus. American Journal of Medicine 82, 213220.
Crapo, PA & Kolterman, OG (1984) The metabolic effects of 2–week fructose feeding in normal subjects. American Journal of Clinical Nutrition 39, 525534.
Crapo, PA, Kolterman, OG & Henry, RR (1986) Metabolic consequence of two–week fructose feeding in diabetic subjects. Diabetes Care 9, 111119.
Cummings, JH & Englyst, HN (1987) Fermentation in the human large intestine and the available substrates. American Journal of Clinical Nutrition 45, Suppl., 12431255.
Cutler, DL, Gray, CG, Park, SW, Hickman, MG, Bell, JM & Kolterman, OG (1995) Low–carbohydrate diet alters intracellular glucose metabolism but not overall glucose disposal in exercise–trained subjects. Metabolism 44, 12641270.
DeFronzo, RA (1997) Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Reviews 5, 177269.
DeFronzo, RA & Ferrannini, E (1991) Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diabetes Care 14, 173194.
DeFronzo, RA, Tobin, JD & Andres, R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. American Journal of Physiology 237, E214E223.
Del Prato, S (1999) Measurement of insulin resistance in vivo. Drugs 58, Suppl. 1, 36.
Ehtisham, S, Barrett, TG & Shaw, NJ (2000) Type 2 diabetes in UK children: an emerging problem. Diabetic Medicine 17, 867871.
Ferrannini, E & Mari, A (1998) How to measure insulin sensitivity. Journal of Hypertension 16, 895906.
Feskens, EJ, Bowles, CH & Kromhout, D (1991) Carbohydrate intake and body mass index in relation to the risk of glucose intolerance in an elderly population. American Journal of Clinical Nutrition 54, 136140.
Feskens, EJ & Kromhout, D (1989) Cardiovascular risk factors and the 25 year incidence of diabetes mellitus in middle–aged men. The Zutphen Study. American Journal of Epidemiology 130, 11011108.
Feskens, EJ & Kromhout, D (1990) Habitual dietary intake and glucose tolerance in euglycaemic men: the Zutphen Study. International Journal of Epidemiology 19, 953959.
Feskens, EJ, Virtanen, SM, Rasanen, L, Tuomilehto, J, Stengard, J, Pekkanen, J, Nissinen, A & Kromhout, D (1995) Dietary factors determining diabetes and impaired glucose tolerance. A 20–year follow–up of the Finnish and Dutch cohorts of the Seven Countries Study. Diabetes Care 18, 11041112.
Finegood, DT, Hramiak, IM & Dupre, J (1990) A modified protocol for estimation of insulin sensitivity with minimal model glucose kinetics in patients with insulin-dependent diabetes. Journal of Clinical Endocrinology and Metabolism 70, 15381549.
Flatt, PR (1992) Nutrient Regulation of Insulin Secretion. London: Portland Press.
Fontvieille, AM, Acosta, M, Rizkalla, SW, Bornet, F, David, P, Letanoux, M, Tchobroutsky & Slama, G (1988) A moderate switch from high to low glycaemic–index foods for 3 weeks improves the metabolic control of type I (IDDM) diabetic subjects. Diabetes, Nutrition and Metabolism – Clinical and Experimental 1, 139143.
Fontvieille, AM, Rizkalla, SW, Penfornis, A, Acosta, M, Bornet, FRJ & Slama, G (1992) The use of low glycaemic index foods improves metabolic control of diabetic patients over five weeks. Diabetic Medicine 9, 444450.
Ford, ES & Mokdad, AH (2001) Fruit and vegetable consumption and diabetes mellitus incidence among US adults. Preventative Medicine 32, 3339.
Franz, M (2001) Carbohydrate and diabetes: is the source or the amount of more importance? Current Diabetes Reports 1, 177186.
Frost, G, Keogh, B, Smith, D, Akinsanya, K & Leeds, A (1996) The effect of low–glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary heart disease. Metabolism 45, 669672.
Frost, G, Leeds, A, Trew, G, Margara, R & Dornhorst, A (1998) Insulin sensitivity in women at risk of coronary heart disease and the effect of a low glycemic diet. Metabolism 47, 12451251.
Frost, G, Wilding, J & Beecham, J (1994) Dietary advice based on the glycaemic index improves dietary profile and metabolic control in type 2 diabetic patients. Diabetic Medicine 11, 397401.
Fukagawa, NK, Anderson, JW, Hageman, G, Young, VR & Minaker, KL (1990) High–carbohydrate, high–fiber diets increase peripheral insulin sensitivity in healthy young and old adults. American Journal of Clinical Nutrition 52, 524528.
Garg, A (2004) Regional adiposity and insulin resistance. Journal of Clinical Endocrinology and Metabolism 89, 42064210.
Garg, A, Grundy, SM & Unger, RH (1992) Comparison of effects of high and low carbohydrate diets on plasma lipoproteins and insulin sensitivity in patients with mild NIDDM. Diabetes 41, 12781285.
Garvey, WT, Huecksteadt, TP, Matthaei, S & Olefsky, JM (1988) Role of glucose transporters in the cellular insulin resistance of type II non–insulin–dependent diabetes mellitus. Journal of Clinical Investigation 81, 15281536.
Gittelsohn, J, Wolever, TM, Harris, SB, Harris-Giraldo, R, Hanley, AJ & Zinman, B (1998) Specific patterns of food consumption and preparation are associated with diabetes and obesity in a Native Canadian community. Journal of Nutrition 128, 541547.
Goff, LM, Frost, GS, Hamilton, G, Thomas, EL, Dhillo, WS, Dornhorst, A & Bell, JD (2003) Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids. British Journal of Nutrition 89, 365374.
Green, SM, Wales, JK, Lawton, CL & Blundell, JE (2000) Comparison of high–fat and high-carbohydrate foods in a meal or snack on short–term fat and energy intakes in obese women. British Journal of Nutrition 84, 521530.
Grigoresco, C, Rizkalla, SW, Halfon, P, Bornet, F, Fontvieille, AM, Bros, M, Dauchy, F, Tchobroutsky, G & Slama, G (1988) Lack of detectable deleterious effects on metabolic control of daily fructose ingestion for 2 months in NIDDM patients. Diabetes Care 11, 546550.
Haffner, S & Cassells, HB (2003) Metabolic syndrome – a new risk factor of coronary heart disease? Diabetes Obesity and Metabolism 5, 359370.
Hales, CN & Barker, DJ (2001) The thrifty phenotype hypothesis. British Medical Bulletin 60, 520.
Hallfrisch, J, Ellwood, KC, Michaelis, OE, Reiser, S, O'Dorisio, TM, Prather, ES (1983) Effects of dietary fructose on plasma glucose and hormone responses in normal and hyperinsulinemic men. Journal of Nutrition 113, 18191826.
Harano, Y, Ohgaku, S, Hidaka, H, Haneda, K, Kikkawa, R, Shigeta, Y & Abe, H (1977) Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. Journal of Clinical Endocrinology and Metabolism 45, 11241127.
Henderson, L, Gregory, J, Irving, K & Swan, G (2003) The National Diet and Nutrition Survey: Adults aged 19–24 Years, vol. 2, Energy, protein, carbohydrate, fat and alcohol intake. London, UK: HM Stationery Office.
Hermans, MP, Levy, JC, Morris, RJ & Turner, RC (1999) Comparison of insulin sensitivity tests across a range of glucose tolerance from normal to diabetes. Diabetologia 42, 678687.
Herrmann, TS, Bean, ML, Black, TM, Wang, P & Coleman, RA (2001) High glycemic index carbohydrate diet alters the diurnal rhythm of leptin but not insulin concentrations. Experimental Biology and Medicine 226, 10371044.
Himsworth, HP (1936) Diabetes mellitus: its differentiation into insulin-sensitive and insulin–insensitive types. Lancet i, 127130.
Hirst, S, Phillips, DIW, Vines, SK, Clark, PM & Hales, CN (1993) Reproducibility of the short insulin tolerance test. Diabetic Medicine 10, 839842.
Hjollund, E, Pedersen, O, Richelsen, B, Beck-Nielsen, H & Sorensen, NS (1983) Increased insulin binding to adipocytes and monocytes and increased insulin sensitivity of glucose transport and metabolism in adipocytes from non–insulin–dependent diabetics after a low–fat/high–starch/high–fiber diet. Metabolism 32, 10671075.
Hodge, AM, Montgomery, J, Dowse, GK, Mavo, B, Watt, T & Zimmet, PZ (1996) A case–control study of diet in newly diagnosed NIDDM in the Wanigela people of Papua New Guinea. Diabetes Care 19, 457462.
Home, PD (1988) The OGTT: gold that does not shine. Diabetic Medicine 5, 313314.
Howe, JC, Rumpler, WV & Behall, KM (1996) Dietary starch composition and level of energy intake alter nutrient oxidation in ‘carbohydrate–sensitive’ men. Journal of Nutrition 126, 21202129.
Hu, FB, van Dam, RM & Liu, S (2001) Diet and risk of type 2 diabetes: the role of types of fat and carbohydrate. Diabetologia 44, 805811.
Hughes, VA, Fiatarone, MA, Fielding, RA, Ferrara, CM, Elahi, D & Evans, WJ (1995) Long–term effects of a high–carbohydrate diet and exercise on insulin action in older subjects with impaired glucose tolerance. American Journal of Clinical Nutrition 62, 426433.
Hunter, SJ, Boyd, AC, O'Harte, FP, McKillop, AM, Wiggam, MI, Mooney, MH, McCluskey, JT, Lindsay, JR, Ennis, CN, Gamble, R, Sheridan, B, Barnett, CR, McNulty, H, Bell, PM & Flatt, PR (2003) Demonstration of glycated insulin in human diabetic plasma and decreased biological activity assessed by euglycaemic–hyperinsulinemic clamp technique in humans. Diabetes 52, 492498.
Janket, SJ, Manson, JE, Sesso, H, Buring, JE & Liu, S (2003) A prospective study of sugar intake and risk of type 2 diabetes in women. Diabetes Care 26, 10081015.
Jarvi, AE, Karlstrom, BE, Granfeldt, YE, Bjorck, IE, Asp, NG & Vessby, BO (1999) Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low–glycemic index diet in type 2 diabetic patients. Diabetes Care 22, 1018.
Jellish, WS, Emanuele, MA & Abraira, C (1984) Graded sucrose/carbohydrate diets in overtly hypertriglyceridemic diabetic patients. American Journal of Medicine 77, 10151022.
Jenkins, DJ, Wolever, TM, Taylor, RH, Barker, H, Fielden, H, Baldwin, JM, Bowling, AC, Newman, HC, Jenkins, AL & Goff, DV (1981) Glycemic index of foods: a physiological basis for carbohydrate exchange. American Journal of Clinical Nutrition 34, 362366.
Jenkins, DJ, Wolever, TM, Vuskan, V, Brighenti, F, Cunnane, SC, Rao, AV, Jenkins, AL, Buckley, G, Patten, R & Singer, W (1989) Nibbling versus gorging: metabolic advantages of increased meal frequency. New England Journal of Medicine 321, 929934.
Jensen, MD & Johnson, CM (1996) Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women. Metabolism 45, 662666.
Jeppesen, J, Schaaf, P, Jones, C, Zhou, MY, Chen, YD & Reaven, GM (1997) Effects of low–fat, high–carbohydrate diets on risk factors for ischemic heart disease in postmenopausal women. American Journal of Clinical Nutrition 65, 10271033.
Kahn, HA, Herman, JB, Medalie, JH, Neufeld, HN, Riss, E & Goldbourt, U (1971) Factors related to diabetes incidence: a multivariate analysis of two years observation on 10,000 men. The Israel Ischemic Heart Disease Study. Journal of Chronic Disease 23, 617629.
Kaiser, N, Leibowitz, G & Nesher, R (2003) Glucotoxicity and beta–cell failure in type 2 diabetes mellitus. Journal of Pediatric Endocrinology and Metabolism 16, 522.
Kalergis, M, Pacaud, D & Yale, JF (1998) Attempts to control the glycaemic response to carbohydrate in diabetes mellitus: overview and practical implications. Canadian Journal of Diabetes Care 22, 2029.
Kashiwagi, A, Mott, D, Bogardus, C, Lillioja, S, Reaven, GM & Foley, JE (1985) The effects of short–term overfeeding on adipocyte metabolism in Pima Indians. Metabolism 34, 364370.
Katz, A, Nambi, SS, Mather, K, Baron, AD, Follmann, DA, Sullivan, G & Quon, MJ (2000) Quantitative insulin sensitivity check index (QUICKI): a simple, accurate method for assessing insulin sensitivity in humans. Journal of Clinical Endocrinology and Metabolism 85, 24012410.
Keen, H, Thomas, BJ, Jarrett, RJ & Fuller, JH (1979) Nutrient intake, adiposity, and diabetes. British Medical Journal 1, 655658.
Kiens, B & Richter, EA (1996) Types of carbohydrate in an ordinary diet affect insulin action and muscle substrates in humans. American Journal of Clinical Nutrition 63, 4753.
Kitano, H, Oda, K, Kimura, T, Matsuoka, Y, Csete, M, Doyle, J & Muramatsu, M (2004) Metabolic syndrome and robustness tradeoffs. Diabetes 53, Suppl. 3, S6S15.
Kirk, T, Crombie, N & Cursiter, M (2000) Promotion of dietary carbohydrate as an approach to weight maintenance after initial weight loss: a pilot study. Journal of Human Nutrition and Dietetics 13, 277285.
Koivisto, VA, Yki-Jarvinen, H (1993) Fructose and insulin sensitivity in patients with type 2 diabetes. Journal of Internal Medicine 233, 145153.
Lindquist, CH, Gower, BA & Goran, MI (2000) Role of dietary factors in ethnic differences in early risk of cardiovascular disease and type 2 diabetes. American Journal of Clinical Nutrition 71, 725732.
Lovejoy, JC (2002) The influence of dietary fat on insulin resistance. Current Diabetes Reports 2, 435440.
Lungren, H, Bengtsson, C, Blohme, O, Isaksson, B, Lapidus, L, Lenner, RA, Saaek, A & Winther, E (1989) Dietary habits and incidence of non–insulin–dependent diabetes mellitus in a population study of women in Gothenburg, Sweden. American Journal of Clinical Nutrition 49, 708712.
Luscombe, ND, Noakes, M & Clifton, PM (1999) Diets high and low in glycemic index versus high monounsaturated fat diets: effects on glucose and lipid metabolism in NIDDM. European Journal of Clinical Nutrition 53, 473478.
McClenaghan, NH & Flatt, PR (1999 a) Engineering cultured insulin–secreting pancreatic B–cell lines. Journal of Molecular Medicine 77, 235243.
McClenaghan, NH & Flatt, PR (1999 b) Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin–secreting cell lines. Diabetes Obesity and Metabolism 1, 137150.
Mann, J (2004) Free sugars and human health: sufficient evidence for action? Lancet 363, 10681070.
Manolio, TA, Savage, PJ, Burke, GL, Hilner, JE, Kiu, K, Orchard, TJ, Sidney, S & Oberman, A (1991) Correlates of fasting insulin levels in young adults: the CARDIA study. Journal of Clinical Epidemiology 44, 571578.
Marshall, JA, Bessesen, DH & Hamman, RF (1997) High saturated fat and low starch and fibre are associated with hyperinsulinaemia in a non-diabetic population: the San Luis Valley Diabetes Study. Diabetologia 40, 430438.
Marshall, JA, Hamman, RF & Baxter, J (1991) High-fat, low–carbohydrate diet and the etiology of non–insulin–dependent diabetes mellitus: the San Luis Valley Diabetes Study. American Journal of Epidemiology 134, 590603.
Marshall, JA, Hoag, S, Shetterly, S & Hamman, RF (1994) Dietary fat predicts conversion from impaired glucose tolerance to NIDDM. The San Luis Valley Diabetes Study. Diabetes Care 17, 5056.
Matthews, DR, Hosker, JP, Rudenski, AS, Naylor, BA, Treacher, DF & Turner, RC (1985) Homeostasis model assessment: insulin resistance and beta–cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412419.
Medalie, JH, Papier, C, Herman, JB, Goldbourt, U, Tamir, S, Neufeld, HN & Riss, E (1974) Diabetes mellitus among 10,000 adult men. I. Five–year incidence and associated variables. Israel Journal of Medical Sciences 10, 681697.
Meyer, KA, Kushi, LH, Jacobs, DR Jr, Slavin, J, Sellers, TA & Folsom, AR (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. American Journal of Clinical Nutrition 71, 921930.
Montonen, J, Knekt, P, Jarvinen, R, Aromaa, A & Reunanen, A (2003) Whole–grain and fiber incidence of type 2 diabetes. American Journal of Clinical Nutrition 77, 622629.
Mooy, JM, Grootenhuis, PA, de Vries, H, Valkenburg, HA, Bouter, LM, Kostense, PJ & Heine, RJ (1995) Prevalence and determinants of glucose intolerance in a Dutch Caucasian population. The Hoorn Study. Diabetes Care 18, 12701273.
National Institutes of Health (1995) Diabetes in America, 2nd ed. Bethesda, MD: National Institutes of Health publication no. 951468.
Orban, T, Landaker, E, Ruan, Z, Cordeman, T, Weitgasser, R, Bonner-Weir, S, Jackson, R & Patti, ME (2001) High fructose diet preserves b–cell mass and prevents diabetes in NOD mice: a potential role for increased IRS–2 expression. Metabolism 50, 13691376.
Parillo, M & Riccardi, G (2004) Diet composition and the risk of type 2 diabetes: epidemiological and clinical evidence. British Journal of Nutrition 92, 719.
Parillo, M, Rivellese, AA, Ciardullo, AV, Capaldo, B, Giacco, A, Genovese, S & Riccardi, G (1992) A high-monounsaturated–fat/low–carbohydrate diet improves peripheral insulin sensitivity in non–insulin–dependent diabetic patients. Metabolism 41, 13731378.
Pessin, JE & Saltiel, AR (2000) Signalling pathways in insulin action: molecular targets of insulin resistance. Journal of Clinical Investigation 106, 165169.
Peterson, DB, Lambert, J, Gerring, S, Darling, P, Carter, RD, Jelfs, R & Mann, JI (1986) Sucrose in the diet of diabetic patients – just another carbohydrate? Diabetologia 29, 216220.
Pi-Sunyer, FX (2002) Glycemic index and disease. American Journal of Clinical Nutrition 76, 290S298S.
Pickup, JC & Williams, G (2003) The Textbook of Diabetes, 3rd ed. Oxford, UK: Blackwell Science Limited.
Polonsky, KS, Sturis, J & Bell, JI (1996) Non-insulin dependent diabetes mellitus: a genetically programmed failure of the beta cell to compensate for insulin resistance. New England Journal of Medicine 334, 777783.
Raben, A, Holst, JJ, Madsen, J & Astrup, A (2001) Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high–fat diet in normal–weight never–obese and postobese women. American Journal of Clinical Nutrition 73, 177189.
Reiser, S, Bickard, MC, Hallfrisch, J, Michaelis, OE & Prather, ES (1981 a) Blood lipids and their distribution in lipoproteins in hyperinsulinemic subjects fed three different levels of sucrose. Journal of Nutrition 111, 10451057.
Reiser, S, Bohn, E, Hallfrisch, J, Michaelis, OE, Keeney, M & Prather, ES (1981 b) Serum insulin and glucose in hyperinsulinemic subjects fed three different levels of sucrose. American Journal of Clinical Nutrition 34, 23482358.
Reiser, S, Hallfrisch, J, Fields, M, Powell, A, Mertz, W, Prather, ES & Canary, JJ (1986) Effects of sugars on indices of glucose tolerance in humans. American Journal of Clinical Nutrition 43, 151159.
Reiser, S, Powell, AS, Scholfield, DJ, Panda, P, Fields, M & Canary, JJ (1989) Day–long glucose, insulin, and fructose responses of hyperinsulinemic and nonhyperinsulinemic men adapted to diets containing either fructose or high–amylose cornstarch. American Journal of Clinical Nutrition 50, 10081014.
Rosell, MS, Hellenius, ML, de Faire, UH& Johansson, GK (2003) Associations between diet and the metabolic syndrome vary with the validity of dietary intake data. American Journal of Clinical Nutrition 78, 8490.
Ruderman, N, Chisholm, D, Pi-Sunyer, X & Schneider, S (1998) The metabolically obese, normal–weight individual revised. Diabetes 47, 699713.
Saad, MF, Anderson, RL, Laws, A, Watanabe, RM, Kades, WW, Chen, YD, Sands, RE, Pei, D, Savage, PJ & Bergman, RN (1994) A comparison between the minimal model and the glucose clamp in the assessment of insulin sensitivity across the spectrum of glucose tolerance. Diabetes 43, 11141121.
Salmeron, J, Ascherio, A, Rimm, EB, Colditz, GA, Spiegelman, D, Jenkins, DJ, Stampfer, MJ, Wing, AL & Willett, WC (1997 a) Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care 20, 545550.
Salmeron, J, Manson, JE, Stampfer, MJ, Colditz, GA, Wing, AL & Willett, WC, (1997 b) Dietary fiber, glycemic load, and risk of non–insulin–dependent diabetes mellitus in women. Journal of the American Medical Association 277, 472477.
Sevak, L, McKeigue, PM & Marmot, MG (1994) Relationship of hyperinsulinemia to dietary intake in south Asian and European men. American Journal of Clinical Nutrition 59, 10691074.
Shen, SW, Reaven, GM & Farquar, JW (1970) Comparison of impedance to insulin–mediated glucose uptake in normal subjects and in subjects with latent diabetes. Journal of Clinical Investigation 49, 21512160.
Steele, R (1959) Influences of glucose loading and injected insulin on hepatic glucose output. Annals of the New York Academy of Sciences 82, 420430.
Stevens, J, Ahn, K, Juhaeri, PH, Houston, D, Steffan, L & Couper, PH (2002) Dietary fiber intake and glycemic index and incidence of diabetes in African–American and white adults. Diabetes Care 10, 17151721.
Storlien, LH, Baur, LA, Kriketos, AD, Pan, DA, Cooney, GJ, Jenkins, AB, Calvert, GD & Campbell, LV (1996) Dietary fats and insulin action. Diabetologia 39, 621631.
Storlien, LH, Higgins, JA, Thomas, TC, Brown, MA, Wang, HQ, Huang, XF & Else, PL (2000) Diet composition and insulin action in animal models. British Journal of Nutrition 83, Suppl. 1, S85S90.
Sunehag, AL, Toffolo, G, Treuth, MS, Butte, NF, Cobelli, C, Bier, DM & Haymond, MW (2002) Effects of dietary macronutrient content on glucose metabolism in children. Journal of Clinical Endocrinology and Metabolism 87, 51685178.
Swinburn, BA, Boyce, VL, Bergman, RN, Howard, BV & Bogardus, C (1991) Deterioration in carbohydrate metabolism and lipoprotein changes induced by modern, high fat diet in Pima Indians and Caucasians. Journal of Clinical Endocrinology and Metabolism 73, 156165.
Thomsen, C, Rasmussen, O, Christiansen, C, Pedersen, E, Vesterlund, M, Storm, H, Ingerslev, J & Hermansen, K (1999) Comparison of the effects of a monounsaturated fat diet and a high carbohydrate diet on cardiovascular risk factors in first degree relatives to type–2 diabetic subjects. European Journal of Clinical Nutrition 53, 818823.
Thorburn, AW, Crapo, PA, Griver, K, Wallace, P & Henry, RR (1990) Long–term effects of dietary fructose on carbohydrate metabolism in non–insulin–dependent diabetes mellitus. Metabolism: Clinical and Experimental 39, 5863.
Tsihlias, EB, Gibbs, AL, McBurney, MI & Wolever, TM (2000) Comparison of high– and low–glycemic–index breakfast cereals with monounsaturated fat in the long–term dietary management of type 2 diabetes. American Journal of Clinical Nutrition 72, 439449.
Tsunehara, CH, Leonetti, DL & Fujimoto, WY (1990) Diet of second–generation Japanese–American men with and without non–insulin–dependent diabetes. American Journal of Clinical Nutrition 52, 731738.
Turner, JL, Bierman, EL, Brunzell, JD & Chait, A (1979) Effect of dietary fructose on triglyceride transport and glucoregulatory hormones in hypertriglyceridemic men. American Journal of Clinical Nutrition 32, 10431050.
Vermunt, SH, Pasman, WJ, Schaafsma, G & Kardinaal, AF (2003) Effects of sugar intake on body weight: a review. Obesity Reviews 4, 9199.
Vessby, B (2000) Dietary fat and insulin action in humans. British Journal of Nutrition 83, Suppl. 1, S91S96.
Vidon, C, Boucher, P, Cachefo, A, Peroni, O, Diraison, F & Beylot, M (2001) Effects of isoenergetic high–carbohydrate compared with high–fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism. American Journal of Clinical Nutrition 73, 878884.
Wallace, TM & Matthews, DR (2002) The assessment of insulin resistance in man. Diabetic Medicine 19, 527534.
Weyer, C, Bogardus, C, Mott, DM & Pratley, R (1999) The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Journal of Clinical Investigation 104, 787794.
White, MF (2003) Insulin receptor signalling and regulation. In The Textbook of Diabetes, 3rd ed., pp. 14.114.17 [JC, Pickup and G, Williams, editors]. Oxford, UK: Blackwell Science Limited.
Willett, W, Manson, J & Liu, S (2002) Glycemic index, glycemic load, and the risk of type 2 diabetes. American Journal of Clinical Nutrition 7, Suppl., 274S280S.
Williams, DEM, Prevost, AT, Whichelow, MJ, Cox, BD, Day, NE & Wareham, NJ (2000) A cross–sectional study of dietary patterns with glucose intolerance and other features of the metabolic syndrome. British Journal of Nutrition 83, 257266.
Wolever, TM (2000) Dietary carbohydrates and insulin action in humans. British Journal of Nutrition 83, Suppl. 1, S97S102.
Wolever, TM, Hamad, S, Gittelsohn, J, Gao, J, Hanley, AJ, Harris, SB & Zinman, B (1997) Low dietary fiber and high protein intakes associated with newly diagnosed diabetes in a remote aboriginal community. American Journal of Clinical Nutrition 66, 14701474.
Wolever, TM & Mehling, C (2002) High–carbohydrate–low–glycaemic index dietary advice improves glucose disposition index in subjects with impaired glucose tolerance. British Journal of Nutrition 87, 477487.
Wolever, TM & Mehling, C (2003) Long–term effect of varying the source or amount of dietary carbohydrate on postprandial plasma glucose, insulin, triacylglycerol, and free fatty acid concentrations in subjects with impaired glucose tolerance. American Journal of Clinical Nutrition 77, 612621.
Wolever, TMS, Jenkins, DJA, Vuksan, V, Jenkins, AL, Wong, GS & Josse, RG (1992) Beneficial effect of low–glycemic index diet in overweight NIDDM subjects. Diabetes Care 15, 562564.
Yang, EJ, Kerver, JM, Park, YK, Kayitsinga, J, Allison, DB & Song, WO (2003) Carbohydrate intake and biomarkers of glycemic control among adults: the third National Health and Nutrition Examination Survey. American Journal of Clinical Nutrition 77, 14261433.
Yang, Y, Youn, JH & Bergman, RN (1987) Modified protocols improve insulin sensitivity estimation using the minimal model. American Journal of Physiology 253, E595E602.
Yki-Jarvinen, H (1992) Glucose toxicity. Endocrine Reviews 13, 415431.
Yu, C, Chen, Y, Cline, GW, Zhang, D, Zong, H, Wang, Y, Bergeron, R, Kin, JK, Cushman, SW, Cooney, GJ, Atcheson, B, White, MF, Kraegen, EW & Shulman, GI (2002) Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate–1 (IRS–1)–associated phosphatidylinositol 3–kinase activity in muscle. Journal of Biological Chemistry 277, 5023050236.
Zierler, K (1961) Theory of the use of arteriovenous concentration differences for measuring metabolism in steady and non–steady states. Journal of Clinical Investigation 40, 21112125.
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Nutrition Research Reviews
  • ISSN: 0954-4224
  • EISSN: 1475-2700
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