1Bone, RA, Landrum, JT & Tarsis, SL (1985) Preliminary identification of the human macular pigment. Vision Res 25, 1531–1535.
2Landrum, JT & Bone, RA (2001) Lutein, zeaxanthin and the macular pigment. Arch Biochem Biophys 385, 28–40.
3Handelman, GJ, Dratz, EA, Reay, CC & Van Kuijk, JGM (1988) Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci 29, 850–855.
4Bone, RA, Landrum, JT, Hime, GW, Cains, A & Zamor, J (1993) Stereochemistry of the human macular carotenoids. Invest Ophthalmol Vis Sci 34, 2033–2040.
5Handelman, GJ, Snodderly, DM, Adler, AJ, Russett, MD & Dratz, EA (1992) Measurement of carotenoids in human and monkey retinas. Methods Enzymol 213, 220–230.
6O'Connell, E, Neelam, K, Nolan, JM, Au Eong, KG & Beatty, S (2006) Macular carotenoids and age-related maculopathy. Ann Acad Med Singapore 35, 821–830.
7Maoka, T, Arai, A, Sinuzu, M & Matsuno, T (1986) The first isolation of entiomeric and meso-zeaxanthin in nature. Comp Biochem Physiol B 83, 121–124.
8Khachik, F, de Moura, FF, Zhao, DY, Aebischer, CP & Bernstein, PS (2002) Transformations of selected carotenoids in plasma, liver, and ocular tissues of humans and in nonprimate animal models. Invest Ophthalmol Vis Sci 43, 3383–3392.
9Bone, RA, Landrum, JT, Friedes, CM, Gomez, MD & Kilburn, E (1997) Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res 64, 211–218.
10Johnson, EJ, Neuringer, M, Russell, RM, Schalch, W & Snodderly, DM (2005) Nutritional manipulation of primate retinas, III: effects of lutein or zeaxanthin supplementation on adipose tissue and retina of xanthophyll-free monkeys. Invest Ophthalmol Vis Sci 46, 692–702.
11Trumbo, PR & Ellwood, KC (2006) Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. Am J Clin Nutr 84, 971–974.
12Landrum, JT, Bone, RA, Joa, H, Kilburn, MD, Moore, LL & Sprague, KE (1997) A one year study of the macular pigment: the effect of 140 days of a lutein supplement. Exp Eye Res 65, 57–62.
13Bone, RA, Landrum, JT, Guerra, LH & Ruiz, CA (2003) Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J Nutr 133, 992–998.
14Hammond, BR Jr, Johnson, EJ, Russell, RM, Krinsky, NI, Yeum, KJ, Edwards, RB & Snodderly, DM (1997) Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci 38, 1795–1801.
15Bhosale, P, Larson, AJ, Frederick, JM, Southwick, K, Thulin, CD & Bernstein, PS (2004) Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye. J Biol Chem 279, 49447–49454.
16Snodderly, DM, Auran, JD & Delori, FC (1984) The macular pigment. II. Spatial distribution in primate retinas. Invest Ophthalmol Vis Sci 25, 674–685.
17Johansson, AS & Mannervik, B (2001) Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem 276, 33061–33065.
18Taylor, HR, West, S, Munoz, B, Rosenthal, FS, Bressler, SB & Bressler, NM (1992) The long-term effects of visible light on the eye. Arch Ophthalmol 110, 99–104.
19Sickel, W (1972) Retinal metabolism in dark and light. Handbk Sens Physiol 7, 667–727.
20Schalch, E (1992) Carotenoids in the retina – a review of their possible role in preventing or limiting damage caused by light and oxygen. In Free Radicals and Aging, pp. 280–298 [Emerit, I and Chance, B, editors]. Basel, Switzerland: Birkhauser Verlag.
21Foote, CS & Denny, RW (1968) Chemistry of singlet oxygen. VII. Quenching by β-carotene. Am Chem Soc J 90, 6233–6235.
22Burton, GW & Ingold, KU (1984) β-Carotene: an unusual type of lipid antioxidant. Science 224, 569–573.
23Chopra, M, Willson, RL & Thurnham, DI (1993) Free radical scavenging activity of lutein in vitro. In Proceedings of the New York Academy of Sciences Conference, pp. 246–249 [Canfield, LM, Olsonand, JA and Krinsky, NI, editors]. New York: New York Academy of Sciences.
24Malinow, MR, Feeney-Burns, L, Peterson, LH, Klein, ML & Neuringer, M (1980) Diet-related macular anomalies in monkeys. Invest Ophthalmol Vis Sci 19, 857–863.
25Dorey, CK, Toyoda, Y, Thompson, L, Garnett, KM, Sapunzatkis, M, Craft, NE, Nichols, C & Cheng, K (1997) Light-induced photoreceptor apoptosis is correlated with dietary and retinal levels of 3R,3′R-zeaxanthin. Invest Ophthalmol Vis Sci 38, Suppl., S355.
26Ciulla, TA, Curran-Celentano, J, Cooper, DA, Hammond, BR Jr, Danis, RP, Pratt, LM, Ricardi, KA & Filloon, TG (2001) Macula pigment optical density in a Midwestern sample. Ophthalmology 108, 730–737.
27Curran-Celentano, J, Hammond, BR Jr, Ciulla, TA, Cooper, DA, Pratt, LM & Danis, RB (2001) Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in a Midwest population. Am J Clin Nutr 74, 796–802.
28Mares-Perlman, JA, Fisher, AI, Klein, R, Palta, M, Block, G, Millen, AE & Wright, JD (2001) Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the Third National Health and Nutrition Examination Survey. Am J Epidemiol 153, 424–432.
29Nebeling, LC, Forman, MR, Graubard, BI & Snyder, RA (1997) Changes to carotenoid intake in the Unitied States: The 1987 and 1992 National Health interview surveys. J Am Diet Assoc 97, 991–996.
30Hartmann, D, Thurmann, PA, Spitzer, V, Schalch, W, Manner, B & Cohn, W (2004) Plasma kinetics of zeaxanthin and 3′-dehydro-lutein after multiple oral doses of synthetic zeaxanthin. Am J Clin Nutr 79, 410–417.
31van het Hof, KH, Brouwer, IA, West, CE, Haddeman, E, Steegers-Theunissen, RPM, van Dusseldorp, M, Weststrate, JA, Eskes, TKAB & Hautvast, JG (1999) Bioavailability of lutein from vegetables is 5 times higher than that of β-carotene. Am J Clin Nutr 70, 261–268.
32Castenmiller, JJ, West, CE, Linssen, JP, van het Hof, KH & Voragen, AG (1999) The food matrix of spinach is a limiting factor in determining the bioavailability of β-carotene and to a lesser extent of lutein in humans. J Nutr 129, 349–355.
33Roodenburg, AJC, Leenen, R, van het Hof, KH, Weststrate, JA & Tijburg, LB (2000) Amount of fat in the diet affects bioavailability of lutein esters but not α-carotene, β-carotene and vitamin E in humans. Am J Clin Nutr 71, 1187–1193.
34Tyssandier, V, Cardinault, N, Caris-Veyrat, C, Amiot, M-J, Grolier, P, Bouteloup, C, Azais-Braesco, V & Borel, P (2002) Vegetable-borne lutein, lycopene, and β-carotene compete for incorporation into chylomicrons, with no adverse effect on the medium-term (3-wk) plasma status of carotenoids in humans. Am J Clin Nutr 75, 526–534.
35Handelman, GJ, Nightingale, ZD, Lichtenstein, AH, Schaefer, EJ & Blumberg, JB (1999) Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. Am J Clin Nutr 70, 247–251.
36Surai, PF, Macpherson, A, Speake, BK & Sparks, NH (2000) Designer egg evaluation in a controlled trial. Eur J Clin Nutr 54, 298–305.
37Chung, H-Y, Rasmussen, HM & Johnson, EJ (2004) Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men. J Nutr 134, 1887–1893.
38Thurmann, PA, Schalch, W, Aebischer, C-P, Tenter, U & Cohn, W (2005) Plasma kinetics of lutein, zeaxanthin, and 3′-dehydro-lutein after multiple doses of a lutein supplement. Am J Clin Nutr 82, 88–97.
39Clark, RM, Herron, KL, Waters, D & Fernandez, ML (2006) Hypo- and hyperresponse to egg cholesterol predicts plasma lutein and beta-carotene concentrations in men and women. J Nutr 136, 601–607.
40Wenzel, AJ, Gerweck, C, Barbato, D, Nicolosi, RJ, Handelman, GJ & Curran-Celentano, J (2006) A 12-wk egg intervention increases serum zeaxanthin and macular pigment optical density in women. J Nutr 136, 2568–2573.
41Goodrow, EF, Wilson, TA, Houde, SC, Vishwanathan, R, Scollin, PA, Handelman, GJ & Nicolosi, RJ (2006) Consumption of one egg per day increases serum lutein and zeaxanthin concentrations in older adults without altering serum lipid and lipoprotein cholesterol concentrations. J Nutr 136, 2519–2524.
42Rock, CL, Swenseid, ME, Jacob, RA & McKee, RW (1992) Plasma carotenoid levels in human subjects fed a low carotenoid diet. J Nutr 122, 96–100.
43Burri, BJ, Neidlinger, TR & Clifford, AJ (2001) Serum carotenoid depletion follows first-order kinetics in healthy adult women fed naturally low carotenoid diets. J Nutr 131, 2096–2100.
44Khachik, F, Beecher, GR & Smith, JC Jr (1995) Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. J Cell Biochem 22, Suppl., 236–246.
45Bone, RA, Landrum, JT, Cao, Y, Howard, AN & Thurnham, DI (2006) Macular pigment response to a xanthophyll supplement of lutein, zeaxanthin and meso-zeaxanthin. Proc Nutr Soc 65, 105A.
46Thurnham, DI, Tremel, A & Howard, AN (2007) An intervention study in man with meso-zeaxanthin. Br J Nutr, .
47Trieschmann, M, Beatty, S, Nolan, JM, Hense, HW, Heimes, B, Austermann, U, Fobker, M & Pauleikhoff, D (2007) Changes in macular pigment optical density and serum concentrations of its constituent carotenoids following supplemental lutein and zeaxanthin: the LUNA study. Exp Eye Res 84, 718–728.
48Hickenbottom, SJ, Follett, JR, Lin, Y, Dueker, SR, Burri, BJ, Neidlinger, T & Clifford, AJ (2002) Variability in conversion of β-carotene to vitamin A in men as measured by using a double-tracer study design. Am J Clin Nutr 75, 900–907.
49Schiedt, K, Leuenberger, FJ, Vecchi, M & Glintz, E (1985) Absorption, retention and metabolic transformation of carotenoids in rainbow trout, salmon and chicken. Pure Appl Chem 57, 685–692.
51Granado, F, Olmedilla, B, Blanco, I & Rojas-Hidalgo, E (1996) Major fruit and vegetable contributors to the main serum carotenoids in the Spanish diet. Eur J Clin Nutr 50, 246–250.
52Granado, F, Olmedilla, B & Blanco, I (2004) Carotenoid depletion in serum of young type-1 diabetics fed low-carotenoid diets. Ann Nutr Metab 48, 251–258.
53Chang-Claude, JC (1990) Epidemiologic Study of Precancerous Lesions of the Oesophagus in Young Persons in a High-Incidence Area for the Oesophageal Cancer in China. Heidelberg: Heidelberg University.
54International Agency for Research on Cancer Working Group (1998) Carotenoids. Lyon: WHO IIARC.
55Thurnham, DI, Smith, E & Flora, PS (1988) Concurrent liquid-chromatographic assay of retinol, α-tocopherol, β-carotene, α-carotene, lycopene and β-cryptoxanthin in plasma with tocopherol acetate as internal standard. Clin Chem 34, 377–381.
56Sommerburg, O, Keunen, JEE, Bird, AC & van Kuijk, FJGM (1998) Fruits and vegetables that are sources of lutein and zeaxanthin: the macular pigment in the human eye. Br J Ophthalmol 82, 907–910.
57Leeson, S & Caston, L (2004) Enrichment of eggs with lutein. Poult Sci 83, 1709–1712.
58Ollilainen, V, Heinonen, MI, Linkola, EK, Varo, PT & Koivistoinen, PE (1989) Carotenoids and retinoids in Finnish foods: dairy products and eggs. J Dairy Sci 72, 2257–2265.
59Vuilleumier, J-P (1969) The “Roche Colour Fan” – an instrument for measuring yolk colour. Poult Sci 48, 226–227.
62Bone, RA, Landrum, JT, Cao, Y, Howard, AN & Alvarez-Calderon, F (2007) Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthin. Nutr Metabol 11, 1–8.
63Cantrell, A, McGarvey, DJ, Truscott, TG, Rancan, F & Böhm, F (2003) Singlet oxygen quenching by dietary carotenoids in a model membrane environment. Arch Biochem Biophys 412, 47–54.
64Nolan, JM, Stack, J, O'Connell, E & Beatty, S (2007) The relationships between macular pigment optical density and its constituent carotenoids in diet and serum. Invest Ophthalmol Vis Sci 48, 571–582.
65Eye Disease Case-Control (EDCC) Study Group (1993) Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol 111, 104–109.
66Seddon, AM, Ajani, UA, Sperduto, RD, et al. . (1994) Dietary carotenoids, vitamin A, C, and E, and advanced age-related macular degeneration. J Am Med Assoc 272, 1413–1420.
67Nolan, JM, Stack, J, O'Donovan, O, Loane, E & Beatty, S (2007) Risk factors for age-related maculopathy are associated with a relative lack of macular pigment. Exp Eye Res 84, 61–74.
68Thurnham, DI (1994) Carotenoids: functions and fallacies. Proc Nutr Soc 53, 77–87.
69Broekmans, WMR, Berendschot, TTJM, Klopping-Ketelaars, IAA, de Vries, AJ, Goldbohm, RA, Tijburg, LBM, Kardinaal, AFM & Van Poppel, G (2002) Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. Am J Clin Nutr 76, 595–603.
70Johnson, EJ, Hammond, BR Jr, Yeum, K-J, Qin, J, Wang, X-D, Castaneda, C, Snodderly, DM & Russell, RM (2000) Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. Am J Clin Nutr 71, 1555–1562.
71Bone, RA, Landrum, JT, Cao, Y, Howard, AN & Alvarez-Calderon, F (2007) Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthin. Nutr Metal (Lond) 4, 12, .
72Gale, CR, Hall, NF, Phillips, DIW & Martyn, CN (2003) Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci 44, 2461–2465.
73Hall, NF, Gale, CR, Syddall, H, Martyn, CN & Phillips, DIW (2002) Relation between size at birth and age-related macular degeneration. Invest Ophthalmol Vis Sci 43, 3641–3645.
74Vingerling, JR, Hofman, A, Grobbee, DE & de Jong, PT (1996) Age-related macular degeneration and smoking. The Rotterdam Study. Arch Ophthalmol 114, 1193–1196.
75Klein, R, Klein, BE & Moss, SE (1998) Relation of smoking to the incidence of age-related maculopathy. The Beaver Dam Eye Study. Am J Epidemiol 147, 103–110.
76Handelman, GJ, Snodderly, DM, Krinsky, NI, Russett, MD & Adler, AJ (1991) Biological control of primate macular pigment. Invest Ophthalmol Vis Sci 32, 257–267.
77Hammond, BR Jr, Curran-Celentano, J, Judd, S, Fuld, K, Krinsky, NI, Wooten, BR & Snodderly, DM (1996) Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. Vision Res 36, 2001–2012.
78Klein, R, Klein, BE, Jensen, SC & Meuer, SM (1997) The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology 104, 7–21.
79Age-Related Eye Disease Study Research Group (2000) Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: Age-Related Eye Disease Study Report Number 3. Ophthalmology 107, 2224–2232.
80Das, I (1985) Raised C-reactive protein levels in serum from smokers. Clin Chim Acta 153, 9–13.
81Northrop-Clewes, CA & Thurnham, DI (2007) Monitoring micronutrients in cigarette smokers. Clin Chim Acta 377, 14–38.
82Kritchevsky, SB, Bush, AJ, Pahor, M & Gross, MD (2000) Serum carotenoids and markers of inflammation in non-smokers. Am J Epidemiol 152, 1065–1071.
83Erlinger, TP, Guallar, E, Miller, ER, Stolzenberg-Solomon, R & Appel, LJ (2001) Relationship between systemic markers of inflammation and serum β-carotene levels. Arch Intern Med 161, 1903–1908.
84Seddon, AM, Gensler, G, Milton, RC, Klein, ML & Rifia, N (2004) Association between C-reactive protein and age-related macular degeneration. J Am Med Assoc 291, 704–710.