Health care providers (HCPs) with histories of adverse childhood experiences (ACEs) are at increased risk for burnout, which can threaten healthcare quality. This study examines the relation between ACEs and burnout among HCPs in primary care clinics at a safety-net hospital and whether this association is buffered by resilience. Sixty-seven HCPs (68.7% women; 44.8% White; Mage = 36.7 years, SDage = 9.8) recruited from a large, public U.S. healthcare system participated in an anonymous study assessing their ACE history, resilience, and burnout symptoms. ACE scores were positively correlated with burnout, r =.25, p =.048. A moderation analysis revealed main effects of ACEs, B = .17, SE = .07, p = .013, and resilience, B = −.34, SE = .08, p = .000, on HCP burnout, when controlling for years in healthcare. ACEs and resilience interacted to predict burnout, n = 55, B = −.11, SE=.05, p = .029. A positive relation was found between ACEs and burnout for HCPs who reported low, t = 3.21, p = .002, and average, t = 2.57, p = .013, resilience levels. Resilience appears to mitigate, or even prevent, burnout among HCPs, although it may be most helpful for those with ACE histories. Healthcare systems can build a more resilient workforce by offering routine, system-wide exposure to trauma-informed professional development or self-care opportunities to their HCPs.