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Plant polyphenols: are they the new magic bullet?

  • Garry G. Duthie (a1), Peter T. Gardner (a1) and Janet A. M. Kyle (a1)
  • DOI:
  • Published online: 01 March 2007

Epidemiological evidence suggests that diets rich in fruit and vegetables decrease the risk of premature mortality from major clinical conditions, including cancer and heart disease. However, it is not yet clear which components or combination of components in fruit and vegetables are protective and what is their mechanism of action. Such scientific uncertainty does not seem to inhibit the marketing of a huge range of plant-based concoctions, promoted as ‘magic bullets’ for optimum health. For example, the purported health-giving properties of plant polyphenols represent a case in which enthusiastic marketing claims may far exceed the current scientific evidence. Even when good experimental evidence exists, results need to be interpreted with caution in relation to human health benefits, as polyphenols may have limited bioavailability and may also be extensively metabolised. In addition, some polyphenols can be toxic and mutagenic in some cell culture systems. Until more is known about the activity and metabolic fate of polyphenols in the body, it would be better for the consumer to increase fruit and vegetable intake, and also to be wary of claims that these compounds are a panacea for good health.

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*Corresponding author: Dr Garry G. Duthie, fax +44 1224 710000,
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PT Gardner , DB McPhail & GG Duthie (1997) Electron spin resonance spectroscopic assessment of the antioxidant potential of teas in aqueous and organic media. Journal of the Science of Food and Agriculture 76, 257262.

JB Harborne (1994) The Flavonoids: Advances in Research Since 1986. London: Chapman & Hall.

W Lutz , W Sanderson & S Scherbov (1997) Doubling of world population unlikely. Nature 387, 803805.

W Mullen , BA Graf , ST Caldwell , RC Hartley , GG Duthie , CA Edwards , MEJ Lean & A Crozier (2003) Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radio-counting and tandem mass spectrometry following oral ingestion of [2–14C]quercetin-4'-glucoside. Journal of Agricultural and Food Chemistry 50, 69026909.

GS Omenn , GE Goodman & MD Thornquist , (1996) Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 334, 11501155.

J Peterson & J Dwyer (1998) Flavonoids: Dietary occurrence and biochemical activity. Nutrition Research 18, 19952018.

J Rapola , J Virtamo & S Ripatti (1997) Randomised trial of alphatocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 349, 17151720.

C Rice-Evans (2001) Flavonoid antioxidants. Current Medicinal Chemistry 8, 797807.

C Williams (1995) Healthy eating: clarifying advice about fruit and vegetables. British Medical Journal 310, 14531455.

G Williamson , AJ Day , GW Plumb & D Coteau (2000) Human metabolic pathways of dietary flavonoids and cinnamates. Biochemical Society Transactions 28, 1622.

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