1Doll, R, Peto, R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Journal of the National Cancer Institute 1981; 66: 1191–308.
3World Cancer Research Fund. Food, Nutrition, and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research, 1997.
4COMA. Nutritional Aspects of the Development of Cancer (Report of the Working Group on Diet and Cancer of the Committee on Medical Aspects of Food and Nutrition Policy). London: The Stationery Office, 1998.
5Armstrong, B, Doll, R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. International Journal of Cancer 1975; 15: 617–31.
6International Agency for Research on Cancer. Cancer: Causes, Occurrence and Control. IARC Scientific Publications No. 100. Lyon: IARC,1990.
7FerIay, J, Bray, P, Pisani, P, Parkin, DM. Globocan 2000: Cancer incidence, mortality and prevalence worldwide, Version 1.0. IARC CancerBase No. 5. http://www-dep.iarc.fr/globocan/globocan.html (accessed 11 3, 2001).
8Giovannucci, E, Stampfer, MJ, Colditz, GA, et al. A comparison of prospective and retrospective assessments of diet in the study of breast cancer. American Journal of Epidemiology 1993; 137: 502–11.
9Willett, WC. Nutritional Epidemiology. New York: Oxford University Press, 1998.
10International Agency for Research on Cancer. Principles of Chemoprevention. IARC Scientific Publications No. 139. Lyon: IARC, 1996.
11Parkin, DM, Bray, F, Ferlay, J, Pisani, P. Estimating the world cancer burden: Globocan 2000. International Journal of Cancer 2001; 94: 153–6.
12International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. vol. 44. Alcohol drinking. Lyon: IARC, 1988.
13Brown, LM, Swanson, CA, Gridley, G, et al. Adenocarcinoma of the esophagus: role of obesity and diet. Journal of the National Cancer Institute 1995; 87: 104–9.
14Cheng, KK, Sharp, L, McKinney, PA, et al. A case-control study of oesophageal adenocarcinoma in women: a preventable disease. British Journal of Cancer 2000; 83: 127–32.
15International Agency for Research on Cancer. Overweight and lack of exercise linked to increased cancer risk. IARC Handbooks of Cancer Prevention. vol. 6. Geneva: World Health Organisation, 2002.
16World Health Organisation: International Agency for Research on Cancer. Cancer: Causes, Occurrence and Control. Lyon: IARC, 1990.
17Steinmetz, KA, Potter, JD. Vegetables, fruit, and cancer prevention: a review. Journal of the American Dietetic Association 1996; 96: 1027–39.
18Sharp, L, Chilvers, CE, Cheng, KK, et al. Risk factors for squamous cell carcinoma of the oesophagus in women: a case-control study. British Journal of Cancer 2001; 85: 1667–70.
19Blot, WJ, Li, JY, Taylor, PR, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/ mineral combinations, cancer incidence, and disease-specific mortality in the general population. Journal of the National Cancer Institute 1993; 85: 1483–92.
20Li, JY, Taylor, PR, Li, B, et al. Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. Journal of the National Cancer Institute 1993; 85: 1492–8.
21Yu, MC. Nasopharyngeal carcinoma: epidemiology and dietary factors. In: O'Neill, IK, Chen, J, Bartsch, H, eds. Relevance to Human Cancer of N-nitroso Compounds, Tobacco Smoke and Mycotoxins. IARC Scientific Publications No. 105. Lyon: 1ARC, 1991, 39–47.
22International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol 56. Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. Lyon: IARC,1993.
23Doll, R, Peto, R. Epidemiology of cancer. In: Weatherall, DJ, Ledingham, JGG, Warrell, DA, eds. Oxford Textbook of Medicine. Oxford: Oxford University Press, 1996, 197–221.
25Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001; 49: 347–53.
26Palli, D. Epidemiology of gastric cancer: an evaluation of available evidence. Journal of Gastroenterology 2000; 35(Suppl. 12): 84–9.
27McCullough, ML, Robertson, AS, Jacobs, EJ, Chao, A, Calle, EE, Thun, MJ. A prospective study of diet and stomach cancer mortality in United States men and women. Cancer Epidemiology Biomarkers & Prevention 2001; 10: 1201–5.
28Botterweck, AA, van den Brandt, PA, Goldbohm, RA. A prospective cohort study on vegetable and fruit consumption and stomach cancer risk in The Netherlands. American Journal of Epidemiology 1998; 148: 842–53.
29Correa, P, Fontham, ET, Bravo, JC, et al. Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy. Journal of the National Cancer Institute 2000; 92: 1881–8.
30Cummings, JH, Bingham, SA. Diet and the prevention of cancer. British Medical Journal 1998; 317: 1636–40.
31Hardman, AE. Physical activity and cancer risk. Proceeding of the Nutrition Society 2001; 60: 107–13.
32Gooderham, NJ, Murray, S, Lynch, AM, et al. Assessing human risk to heterocyclic amines. Mutation Research 1997; 376: 53–60.
33Kazerouni, N, Sinha, R, Hsu, CH, Greenberg, A, Rothman, N. Analysis of 200 food items for benzo[a]pyrene and estimation of its intake in an epidemiologic study. Food Chemistry and Toxicology 2001; 39: 423–36.
34Bingham, SA, Pignatelli, B, Pollock, JR, et al. Does increased endogenous formation of N -nitroso compounds in the human colon explain the association between red meat and colon cancer? Carcinogenesis 1996; 17: 515–23.
35Lund, EK, Wharf, SG, Fairweather-Tait, SJ, Johnson, IT. Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers. American Journal of Clinical Nutrition 1999; 69: 250–5.
36Norat, T, Lukanova, A, Ferrari, P, Riboli, E. Meat consumption and colorectal cancer risk: a dose–response meta-analysis of epidemiological studies. International Journal of Cancer 2002; 98: 241–56.
37Key, TJ, Fraser, GE, Thorogood, M, et al. Mortality in vegetarians and non-vegetarians: a collaborative analysis of 8300 deaths among 76,000 men and women in five prospective studies. Public Health Nutrition 1998; 1: 33–41.
38Howe, GR, Aronson, KJ, Benito, E, et al. The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies. Cancer Causes & Control 1997; 8: 215–28.
39Burkitt, DP. Related disease—related cause? Lancet 1969; 2: 1229–31.
40La Vecchia, C. Diet and human cancer: a review. European Journal of Cancer Prevention 2001; 10: 177–81.
41Hague, A, Elder, DJ, Hicks, DJ, Paraskeva, C. Apoptosis in colorectal tumour cells: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate. International Journal of Cancer 1995; 60: 400–6.
42Nagengast, FM, Grubben, MJ, van Munster, IP. Role of bile acids in colorectal carcinogenesis. European Journal of Cancer 1995; 31A: 1067–70.
43Potter, JD, Steinmetz, K. Vegetables, fruit and phytoestrogens as preventive agents. In: Stewart, BW, McGregor, D, eds. Principles of Chemoprevention. IARC Scientific Publication No. 139. Lyon: 1ARC, 1996, 61–90.
44Jacobs, DRJ, Marquart, L, Slavin, J, Kushi, LH. Whole-grain intake and cancer: an expanded review and meta-analysis. Nutrition and Cancer 1998; 30: 85–96.
45Bueno De Mesquita, HB, Ferrari, P, Riboli, E, on behalf of EPIC. Plant?foods and the risk of colorectal cancer in Europe: preliminary findings IARC Scientific Publications Series. 2002; 156: 89–95.
46Fuchs, CS, Giovannucci, EL, Colditz, GA, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. New England Journal of Medicine 1999; 340: 169–76.
47Michels, KB, Edward, G, Joshipura, KJ, et al. Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. Journal of the National Cancer Institute 2000; 92: 1740–52.
48Schatzkin, A, Lanza, E, Corle, D, et al. Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. New England Journal of Medicine 2000; 342: 1149–55.
49Alberts, DS, Martinez, ME, Roe, DJ, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians' Network. New England Journal of Medicine 2000; 342: 1156–62.
50Bonithon-Kopp, C, Kronborg, O, Giacosa, A, Rath, U, Faivre, J. Calcium and fibre supplementation in prevention of colorectal adenoma recurrence: a randomised intervention trial. European Cancer Prevention Organisation Study Group. Lancet 2000; 356: 1300–6.
51Terry, P, Giovannucci, E, Michels, KB, et al. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. Journal of the National Cancer Institute 2001; 93: 525–33.
52McKeown-Eyssen, G. Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?. Cancer Epidemiology Biomarkers & Prevention 1994; 3: 687–95.
53Franceschi, S, Dal Maso, L, Augustin, L, et al. Dietary glycemic load and colorectal cancer risk. Annals of Oncology 2001; 12: 173–8.
54Giovannucci, E, Rimm, EB, Ascherio, A, Stampfer, MJ, Colditz, GA, Willett, WC. Alcohol, low-methionine, low-folate diets, and risk of colon cancer in men. Journal of the National Cancer Institute 1995; 87: 265–73.
55Glynn, SA, Albanes, D, Pietinen, P, et al. Alcohol consumption and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes & Control 1996; 7: 214–23.
56Giovannucci, E, Stampfer, MJ, Colditz, GA, et al. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Annals of Internal Medicine 1998; 129: 517–24.
57Choi, SW, Mason, JB. Folate and carcinogenesis: an integrated scheme. Journal of Nutrition 2000; 130: 129–32.
58Potter, JD. Colorectal cancer: molecules and populations. Journal of the National Cancer Institute 1999; 91: 916–32.
59Blount, BC, Mack, MM, Wehr, CM, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proceedings of the National Academy of Sciences of the United States of America 1997; 94: 3290–5.
60Ma, J, Stampfer, MJ, Christensen, B, et al. A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. Cancer Epidemiology Biomarkers & Prevention 1999; 8: 825–9.
61Sesink, AL, Termont, DS, Kleibeuker, JH, Van Der Meer, R. Red meat and colon cancer: dietary haem-induced colonic cytotoxicity and epithelial hyperproliferation are inhibited by calcium. Carcinogenesis 2001; 22: 1653–9.
62Baron, JA, Beach, M, Mandel, JS, et al. Calcium supplements and colorectal adenomas. Polyp Prevention Study Group. Annals of the New York Academy of Sciences 1999; 889: 138–45.
63International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol 59. Lyon: IARC, 1994.
64Saracco, G. Primary liver cancer is of multifactorial origin: importance of hepatitis B virus infection and dietary aflatoxin. Journal of Gastroenterology and Hepatology 1995; 10: 604–8.
65Michaud, DS, Giovannucci, E, Willett, WC, Colditz, GA, Stampfer, MJ, Fuchs, CS. Physical activity, obesity, height, and the risk of pancreatic cancer. Journal of the American Medical Association 2001; 286: 921–9.
66Bjelke, E. Dietary vitamin A and human lung cancer. International Journal of Cancer 1975; 15: 561–5.
67Hennekens, CH, Buring, JE, Manson, JE, et al. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. New England Journal of Medicine 1996; 334: 1145–9.
68Omenn, GS, Goodman, GE, Thornquist, MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 1996; 334: 1150–5.
69The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New England Journal of Medicine 1994; 330: 1029–35.
70Feskanich, D, Ziegler, RG, Michaud, DS, et al. Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. Journal of the National Cancer Institute 2000; 92: 1812–23.
71Voorrips, LE, Goldbohm, RA, Verhoeven, DT, et al. Vegetable and fruit consumption and lung cancer risk in the Netherlands Cohort Study on diet and cancer. Cancer Causes & Control 2000; 11: 101–15.
72Key, TJ, Verkasalo, PK, Banks, E. Epidemiology of breast cancer. Lancet Oncology 2001; 2: 133–40.
73Collaborative Group on Hormonal Factors in Breast Cancer. Breastfeeding and breast cancer: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50,302 women with breast cancer and 96,973 women without the disease. Lancet 2002; 360: 187–95.
74Collaborative group on hormonal factors in breast cancer. Alcohol, tobacco and breast cancer-collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. British Journal of Cancer 2002; 87: 1234–45.
75Dorgan, JF, Baer, DJ, Albert, PS, et al. Serum hormones and the alcohol-breast cancer association in postmenopausal women. Journal of the National Cancer Institute 2001; 93: 710–5.
76Sellers, TA, Kushi, LH, Cerhan, JR, et al. Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology 2001; 12: 420–8.
77Smith-Warner, SA, Spiegelman, D, Adami, HO, et al. Types of dietary fat and breast cancer: a pooled analysis of cohort studies. International Journal of Cancer 2001; 92: 767–74.
78Wu, AH, Pike, MC, Stram, DO. Meta-analysis: dietary fat intake, serum estrogen levels, and the risk of breast cancer. Journal of the National Cancer Institute 1999; 91: 529–34.
79Holmes, MD, Spiegelman, D, Willett, WC, et al. Dietary fat intake and endogenous sex steroid hormone levels in postmenopausal women. Journal of Clinical Oncology 2000; 18: 3668–76.
80Key, TJ, Allen, NE. Nutrition and breast cancer. The Breast 2001; 10(Suppl. 3): 9–13.
81Smith-Warner, SA, Spiegelman, D, Yaun, SS, et al. Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies. Journal of the American Medical Association 2001; 285: 769–76.
82Bergstrom, A, Pisani, P, Tenet, V, Wolk, A, Adami, HO. Overweight as an avoidable cause of cancer in Europe. International Journal of Cancer 2001; 91: 421–30.
83Key, TJ, Pike, MC. The dose–effect relationship between ‘unopposed’ oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk. British Journal of Cancer 1988; 57: 205–12.
84International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol 64. Human Papillomaviruses. Lyon: IARC, 1995.
85Banks, E, Beral, V, Reeves, G. The epidemiology of epithelial ovarian cancer: a review. International Journal of Gynecological Cancer 1997; 425–38.
86Schuurman, AG, van den Brandt, PA, Dorant, E, Goldbohm, RA. Animal products, calcium and protein and prostate cancer risk in The Netherlands Cohort Study. British Journal of Cancer 1999; 80: 1107–13.
87Chan, JM, Stampfer, MJ, Ma, J, Gann, PH, Gaziano, JM, Giovannucci, EL. Dairy products, calcium, and prostate cancer risk in the Physicians' Health Study. American Journal of Clinical Nutrition 2001; 74: 549–54.
88Michaud, DS, Augustsson, K, Rimm, EB, Stampfer, MJ, Willett, WC, Giovannucci, E. A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes & Control 2001; 12: 557–67.
89Heinonen, OP, Albanes, D, Virtamo, J, et al. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. Journal of the National Cancer Institute 1998; 90: 440–6.
90Clark, LC, Dalkin, B, Krongrad, A, et al. Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial. British Journal of Urology 1998; 81: 730–4.
91Kristal, AR, Cohen, JH. Invited commentary: tomatoes, lycopene, and prostate cancer. How strong is the evidence? American Journal of Epidemiology 2000; 151: 124–7.
92Eaton, NE, Reeves, GK, Appleby, PN, Key, TJ. Endogenous sex hormones and prostate cancer: a quantitative review of prospective studies. British Journal of Cancer 1999; 80: 930–4.
93Gann, PH, Hennekens, CH, Ma, J, Longcope, C, Stampfer, MJ. Prospective study of sex hormone levels and risk of prostate cancer. Journal of the National Cancer Institute 1996; 88: 1118–26.
94Chan, JM, Stampfer, MJ, Giovannucci, E, et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998; 279: 563–6.
95Stattin, P, Bylund, A, Rinaldi, S, et al. Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins and prostate cancer risk: a prospective study. Journal of the National Cancer Institute 2000; 92: 1910–7.
96Allen, NE, Appleby, PN, Davey, GK, Key, TJ. Hormones and diet: low insulin-like growth factor-I but normal bioavailable androgens in vegan men. British Journal of Cancer 2000; 83: 95–7.
97Heaney, RP, McCarron, DA, Dawson-Hughes, B, et al. Dietary changes favorably affect bone remodeling in older adults. Journal of the American Dietetic Association 1999; 99: 1228–33.
98Zeegers, MP, Goldbohm, RA, van den Brandt, PA. Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiology Biomarkers & Prevention 2001; 10: 1121–8.
99Michaud, DS, Spiegelman, D, Clinton, SK, Rimm, EB, Willett, WC, Giovannucci, EL. Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort. Journal of the National Cancer Institute 1999; 91: 605–13.
100Bergstrom, A, Hsieh, CC, Lindblad, P, Lu, CM, Cook, NR, Wolk, A. Obesity and renal cell cancer—a quantitative review. British Journal of Cancer 2001; 85: 984–90.
101International Agency for Research on Cancer. IARC Handbooks of Cancer Prevention. Vol 6. Weight Control and Physical Activity. Lyon: IARC, 2002.
102Giovannucci, E. Insulin and colon cancer. Cancer Causes & Control 1995; 6: 164–79.
103Willett, WC. Is dietary fat a major determinant of body fat? American Journal of Clinical Nutrition 1998; 67: 556S–62S.
104Giovannucci, E, Clinton, SK. Tomatoes, lycopene, and prostate cancer. Proceedings of the Society for Experimental Biology and Medicine 1998; 218: 129–39.
105International Agency for Research in Cancer. Acrylamide. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 1994; 60: 389–433.
106Tarake, E, Rydberg, P, Karlsson, P, Eriksson, S, Törnqvist, M. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. Journal of Agricultural and Food Chemistry 2002; 50: 4998–5006.
107Mottram, DS, Wedzicha, BL, Dodson, AT. Food chemistry: acrylamide is formed in the Maillard reaction. Nature 2002; 419: 448–9.
108Stadler, RH, Blank, I, Varga, N, et al. Food chemistry: acrylamide from Maillard reaction products. Nature 2002; 419: 449–50.
109Food and Agriculture Organization/ World Health Organization. FAO/WHO Consultation on the Health Implications or Acrylamide in Food: Summary Report. Geneva: WHO, 2002.
110Shaw, I, Thomson, B. Acrylamide food risk. Lancet 2003; 361: 434.
111Mucci, LA, Dickman, PW, Steineck, G, Adami, H-O, Augustsson, K. Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. British Journal of Cancer 2003; 88: 84–9.