1Liu, CX, Xiao, PG. Recent advances on ginseng research in China. J. Ethnopharmacol. 1992; 36: 27–38.
2Gillis, CN. Panax ginseng pharmacology: A nitric acid link? Biochem. Pharmacol. 1997; 54: 1–8.
3Attele, AS, Wu, JA, Yuan, CS. Ginseng pharmacology. Biochem. Pharmacol. 1999; 58: 1685–93.
4Vogler, BK, Hittler, MH, Ernst, E.The efficacy of ginseng. A systematic review of randomised clinical trials. Eur. J. Clin. Pharmacol. 1999; 55: 567–75.
5Lee, YS, Chung, IS, Lee, IR, Kim, KH, Hong, WS, Yun, YS. Activation of multiple effector pathways of immune system by the antineoplastic immunostimulator acid polysaccharide ginsan, isolated from Panax ginseng. Anticancer Res. 1997; 17: 323–31.
6Kim, K, Lee, YS, Jung, IS, et al. Acidic polysaccharide from Panax ginseng, ginsan, induces TH-1 cell and macrophage cytokines and generates LAK cells in synergy with IL-2. Planta Med. 1998; 64: 110–15.
7Ma, YC, Zhu, J, Luo, L, et al. . A comparative evaluation of ginsenosides in commercial ginseng products and tissue culture samples using HPLC. J. Herb Spices Med. Plants 1995; 3, 41–50.
8Li, TSC, Mazza, G, Cottrell, AC, Gao, L.Ginsenosides in roots and leaves of American ginseng. J. Agric. Food Chem. 1996; 44: 717–20.
9Yuan, C-S, Wu, JA, Lowell, T, Gu, M.Gut and brain effects of American ginseng root on brainstem neuronal activities in rats. Am. J. Chin. Med. 1998; 26: 47–55.
10Mizuno, M, Yamada, J, Terai, H, Kozukue, N, Lee, YS, Tsuchida, H.Differences in immunomodulating effects between wild and cultured Panax ginseng. Biochem. Biophys. Res. Commun. 1994; 200: 1672–8.
11Marasco, C, Vargas Ruiz, R, Salas Villagomez, A, Begona Infante, C.Double blind study of a multivitamin complex supplemented with ginseng extract. Drugs Exp. Clin. Res. 1998; 22: 323–9.
12Zuin, M, Attezzati, ZM, Camisasca, M, Riebenfield, D, Podda, M.Effects of a preparation containing a standardized ginseng extract combined with trace elements and multi-vitamins against hepatotoxin-induced chronic liver disease in the elderly. J. Int. Med. Res. 1987; 15: 276–81.
13Takino, Y, Odani, T, Hisayuki, T, Hayashi, T.Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. I. Quantitative analysis of ginsenoside Rg1 in rats. Chem. Pharm. Bull. 1982; 30: 2196–210.
14Kajiwara, H, Hewmming, AM, Hirano, H.Evidence of metal binding activities of pentadecapeptid from Panax ginseng. J. Chromatogr. 1996; 687: 443–8.
15Hasegawa, H, Sung, J-H, Benno, Y.Role of human intestinal prevotella oris in hydrolyzing ginseng saponins. Planta Med. 1997; 63: 436–40.
16Lee, BH, Lee, SJ, Hui, JH, Lee, S, Huh, JD, Moon, CK. In vitro antigenotoxic activity of novel ginseng saponin metabolites formed by intestinal bacteria. Planta Med. 1998; 64: 500–3.
17Brekham, II, Dardymov, IV. New substances of plant origin, which increase non-specific resistance. Annu. Rev. Pharmacol. 1969; 9: 419–30.
18Pieralisi, G, Ripari, P, Vecchiet, L.Effects of standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals and trace elements on physical performance during exercise. Clin. Ther. 1991; 13: 373–82.
19Brahrke, MS, Morgan, WP. Evaluation of the ergogenic properties of ginseng. Sports Med. 1984; 18: 229–48.
20Hassan-Samira, MM, Attia Attia, M, Allam, M, Elwan, O.Effect of the standardized ginseng extract G115 on the metabolism and electrical activity of the rabbit's brain. J. Int. Med. Res. 1985; 13: 342–8.
21Kirchdorfer, AM. Clinical trials with the standardized ginseno-side concentrate G115. In: Chang, HN, Yeung, HW, Tso, WW, Koo, A, eds. Advances in Chinese Medicinal Materials Research. Singapore: World Scientific Publishers, 1985: 529–42.
22Wang, L, Lee, T.Effect of ginseng saponins on exercise performance in non-trained rats. Planta Med. 1998; 64: 130–3.
23Cherdrungsi, P, Rungroeng, D.The effects of standardized extract and exercise training on aerobic and anaerobic exercise capacities in humans. Korean J. Ginseng Sci. 1995; 19: 93–100.
24Engels, HJ, Said, JM, Wirth, JC. Failure of chronic ginseng supplementation to affect work performance and energy metabolism in healthy adult females. Nutr. Res. 1996; 16: 1295–1305.
25Morris, AC, Jacobs, I, McLellan, TM, Klugerman, A, Wanga, LCH, Zamecnik, J.No ergogenic effect of ingestion. Int. J. Sport Nutr. 1996; 6: 263–71.
26Herman, J, Engels, HJ, Wirth, J.No ergogenic effects of ginseng (Panax ginseng C.A. Meyer) during graded maximal exercise aerobic exercise. J. Am. Diet. Assoc. 1997; 97: 1110–15.
27Fulder, SJ. Ginseng and the hypothalamic-pituitary control of stress. Am. J. Chin. Med. 1981; 9: 112–18.
28Hiai, S, Yokoyama, H, Oura, H, Kawashima, Y.Evaluation of corticosterone-secretion-inducing activities of ginsenosides and their prosapogenins and sapogenins. Chem. Pharm. Bull. 1983; 31: 168–74.
29Lee, YJE, Chung, K, Lee, YH, Lee, B, Huh, B, Lee, SK. Ginsenoside-Rg1, one of the major active molecules from Panax ginseng, is a functional ligand of glucocorticoid receptor. Mol. Cell. Endocrinol. 1997; 113: 135–40.
30Hiai, S, Yokoyama, H, Oura, H.Features of ginseng saponin induced corticosterone release. Endocrinol. Jpn. 1979; 26: 737–40.
31Waki, I, Kyo, H, Yasuda, M, Kimura, M.Effects of hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals. J. Pharmacobio-dynamics. 1982; 5: 547–9.
32Sotaniemi, EA, Haapakoski, E, Rautio, A.Ginseng therapy in non-insulin dependent diabetic patients. Diabetes Care 1995; 18, 1373–5.
33Yuan, YV, Kitts, DD. Endogenous antioxidants. Role of antioxidant enzymes in biological systems. In: Shahidi, F, ed. Natural Antioxidants: Chemistry, Health Effects and Applications. Champaign, IL: AOCS Press, 1996: 258–70.
34Deng, HL, Zhang, JT. Anti-lipid peroxidative effect of ginsenoside Rb1 and Rg1. Chin. Med. J. 1991; 104: 395–8.
35Rimar, S, Lee-Mengel, M, Gillis, CN. Pulmonary protective vasodilating effects of a standardized Panax ginseng preparation following artificial gastric digestion. Pulm. Pharmacol. 1996; 9: 205–9.
36Voces, J, Alvarez, AI, Vila, L, Ferrando, A, Cabral de Oliveria, C, Prieto, JG. Effects of administration of the standardized Panax ginseng extract G-115 on hepatic antioxidant function after exhaustive exercise. Comp. Biochem. Physiol. 1999; 123: 175–84.
37Jeong, TC, Kim, HJ, Park, JI, et al. . Protective effects of red ginseng saponins against carbon tetrachloride-induced hepatotoxicity in Sprague-Dawley rats. Planta Med. 1997; 63: 136–40.
38Li, Y, Zhao, XJ. Effects of panaxadiol saponins on the contents of serum enzymes, lipid peroxides and SOD in hemorrhagic shock dogs. Chin. J. Pathophysiol. 1989; 5: 539–44.
39Hui-Ling, D, Jun-Tian, Z.Anti-lipid peroxidative effect of ginsenoside Rb1 and Rg2. Chin. Med. J. 1991; 104: 395–8.
40Kim, YH, Park, KH, Rho, HM. Transcriptional activation of the Cu/Zn superoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng. J. Biol. Chem. 1996; 271: 24539–43.
41Zhang, YG, Liu, TP. Protective effects of total saponins of Panax ginseng on ischemia-reperfusion injury in rat brains. Chin. J. Pharmacol. Toxicol. 1994; 8: 7–12.
42Chen, X, Gillis, CN. Effect of free radicals on pulmonary vascular response to acetylcholine. J. Appl. Physiol. 1991; 71: 821–5.
43Kim, HY, Chen, X, Gillis, CN. Ginsenosides protect pulmonary vascular endothelium against free radical-induced injury. Biochem. Biophys. Res. Commun. 1992; 189: 670–6.
44Yuan, C-S, Attele, AS, Wu, JA, Lowell, TK, Gu, Z, Lin, Y.Panax quinquefolium L. inhibits thrombin-induced endothelin release in vitro. Am. J. Chin. Med. 1999; 27: 331–8.
45Wink, DA, Hanbauer, I, Krishna, MC, DeGraft, W, Ganson, J, Mitchell, JB. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. Proc. Natl. Acad. Sci. 1993; 90: 9813–17.
46Kang, SY, Schini-Kerth, VB, Kim, ND. Ginsenosides of the protopanaxatriol group causes endothelium-dependent relaxation in the rat aorta. Life Sci. 1995; 56: 1577–86.
47Peng, CF, Li, YJ, Li, YJ, Deng, HW. Effects of ginsenosides on vasodilator nerve actions in the rat perfused mesentery are mediated by nitric oxide. J. Pharm. Pharmacol. 1995; 47: 614–17.
48Maffei-Facino, R, Carini, R, Aldini, G, Berti, F, Rossoni, G.Panax ginseng administration in the rat prevents myocardial ischemia-reperfusion damage induced by hyperbaric oxygen: evidence for an antioxidant intervention. Planta Med. 1999; 65: 614–19.
49Abuja, PM, Murkovic, M, Pfannhauser, W.Antioxidant and prooxidant activities of elderberry (Sambucus nigra) extract in low-density lipoprotein oxidation. J. Agric. Food Chem. 1998; 46: 4091–6.
50Wang, H, Cao, G, Prior, RL. Oxygen radical absorbing capacity of anthocyanins. J. Agric. Food Chem. 1997; 45: 304–9.
51Kitts, DD, Yuan, YV, Wijewickreme, AN, Thompson, LU. Antioxidant activity of the flaxseed lignan secoisolaiciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Mol. Cell. Biochem. 1999; 202: 91–100.
52Hu, C, Kitts, DD. Studies on the antioxidant activity of echinacea root extract. J. Agric. Food Chem. 2000; 48: 466–72.
53Zhang, D, Yasuda, Y, Yu, P.Ginseng extract scavenges hydroxyl radical and protects unsaturated fatty acids from decomposition caused by iron-mediated lipid peroxidation Free Radical. Biol. Med. 1996; 20: 145–50.
54Kitts, DD, Wijewickreme, AN, Hu, C.Antioxidant properties of a North American ginseng extract. Mol. Cell. Biochem. 2000; 203: 1–10.
55Huong, NTT, Matsumoto, K, Kasai, R, Yamosaka, K, Watanabe, H.In vitro antioxidant activity of vietnamese ginseng saponin and its components. Biol. Pharm. Bull. 1998; 21: 978–81.
56Zhong, GG, Qi, H, Zhao, CY, Jiang, Y.Comparative observation on the influence of 11 ginsenoside monomers on the free radical contents of myocardiocytes with the electron spin resonance method Acta. Biochem. Biophys. Sin. 1993; 25: 667–71.
57Mei, B, Wang, YF, Wu, JX, Chen, WZ. Protective effects of ginsenosides on oxygen free radical induced damages of cultured vascular endothelial cells in vitro Acta. Pharm. Sin. 1994; 29: 801–8.
58Suh, DY, Han, YN, Han, BH. Malitol, an antioxidant component of Korean red ginseng shows little prooxidant activity. Arch. Pharm. Res. 1996; 19: 112–15.
59Juurlink, BNJ. Management of oxidative stress in the CNS: The many roles of glutathione. Neurotoxicity Res. 1999; 1: 119–40.
60Coteller, N, Bernier, JL, Henichart, JP, Catteau, JP, Gaydou, E, Wallet, JC. Scavenger and antioxidant properties of ten synthetic flavones Free Radical. Biol. Med. 1992; 13: 211–19.
61Ko, FN, Cheng, ZJ, Lin, CN, Teng, CM. Scavenger and antioxidant properties of prenylflavones isolated from Artocarpus heterophyllus Free Radical. Biol. Med. 1998; 25: 166–8.
62Hess, FG, Parent, RA, Stevens, KR, Cox, GE, Becci, PJ. Effect of subchronic feeding of ginseng extract G-115 in beagle dogs Food. Chem. Toxicol. 1983; 21: 95–7.
63Siegel, RK. Ginseng abuse syndrome: Problems with the panacea. JAMA 1979; 241, 1614–15.
64The German Commission E Monographs. Translated into English: Blumenthal, M, Hall, T, Rister, R, eds. Klein, S, Rister, R, transl. Austin, TX: American Botanical Council, 1996.
65Klepser, TB, Klepser, ME. Unsafe herbal therapies. Am. J. Health System. Pharm. 1999; 56, 125.
66Awang, DVC. Maternal use of ginseng and neonatal androgenization. [Letter, comment]. JAMA 1991; 265, 1828.
67Palmer, BV, Montgomery, ACV, Monteiro, JCMP. Ginseng and mastalgia. BMJ 1978; 6122, 1284.
68Jones, BD, Runkis, AM. Interaction of ginseng with phenelzine. J. Clin. Psychopharmacol. 1987; 7: 201–2.
69Janetzky, K, Morreale, AP. Probable interactions between warfarin and ginseng. Am. J. Health Syst. Pharm. 1997; 54: 692–3.
70Awang, DVC. The anti-stress potential of North American ginseng (Panax quinquefolius L.). J. Herbs, Spices Med. Plants 1998; 62, 87–91.
71Mahoney, JR, Graft, E.Role of alpha-tocopherol, ascorbic acid, citric acid and EDTA as oxidants in model systems. J. Food Sci. 1986; 51: 1293–6.
72Aruoma, OI, Evans, PJ, Kaur, H, Sutcliffe, L, Halliwell, B.An evaluation of the antioxidant and potential prooxidant properties of food additives and trolox C, vitamin E and probucol. Free Radical Res. Commun. 1990; 10: 143–57.
73Biaglow, JE, Manevich, Y, Uckin, F, Held, KD. Quantitation of hydroxyl radicals produced by radiation and copper-linked oxidation of ascorbate by 2-deoxy-D-ribose method. Free Radical Biol. Med. 1997; 22: 1129–38.
74Laughton, ML, Halliwell, PL, Evans, PL, Hoult, JRS. Antioxidant and prooxidant actions of the plant phenolics, quercetin, gossypol and myricetin. Biochem. Pharmacol. 1989; 38: 2859–65.
75Roedig-Penman, A, Gordon, MH. Antioxidant properties of catechins and green tea extracts in model food emulsions. J. Agric. Food Chem. 1997; 45: 4267–70.
76Halliwell, B, Grootveld, M, Gutteridge, B.Methods for the measurement of hydroxyl radicals in biochemical systems. Deoxyribose degradation and aromatic hydroxylation. Methods Biochem. Anal. 1987; 33: 59–87.
77Ueda, J, Saito, N, Shimazu, Y, Ozawa, T.A comparison of scavenging abilities of antioxidants against hydroxyl radicals. Arch. Biochem. Biophys. 1996; 333: 377–84.
78Cui, J, Garle, M, Bjorkhem, I, Eneroth, P.What do commercial ginseng preparations contain? Lancet 1994; 344, 134.
79Choi, SW, Cho, EH, Chi, SY. 1995; Ginsenosides activate DNA polymerase from bovine placenta. Life Sci. 1994; 57: 1359–65.
80Tachikawa, E, Kudo, K, Kashimoto, T.Ginseng saponins reduce acetylcholine-evoked Na+ influx and catecholamine secretion in bovine adrenal chromaffin cells. J. Pharmacol. Exp. Ther. 1995; 273: 629–36.
81See, DM, Broumand, N, Sahl, L, Tills, JG. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficient syndrome patients. Immunopharmacology 1997; 35, 229–35.
82Kenarova, B, Neychev, H, Hadijiivariova, C, Petkov, VD. Immunomodulatory activity of ginsenoside Rg1 from Panax ginseng. Jpn. J. Pharmacol. 1990; 54: 447–54.
83Ro, JY, Ahn, YS, Kim, KH. Inhibitory effect of ginsenoside on the mediator release of the guinea pig mast cells activated by specific antigen-antibody reactions. Int. J. Immunopharmacol. 1998; 20: 625–41.
84Lui, J, Zhang, JT. Immunoregulatory effects of ginsenoside Rg1 in aged rats. Yao Hsueh Hsueh Pao-Acta Pharm. Sin. 1995; 30: 818–23.
85Lui, J, Wang, S, Liu, H, Yang, L, Nan, G.Stimulatory effect of saponin from Panax ginseng on immune function of lymphocytes in the elderly. Mech. Ageing Dev. 1995; 83: 43–53.
86Matsunaga, H, Katano, M, Yamamoto, H, Mori, M, Takata, K.Studies on the panaxatriol of Panax ginseng C.A. Meyer. Isolation, determination and antitumour activity. Chem. Pharm. Bull. 1989; 37: 1281–91.
87Duda, RB, Zhong, Y, Navas, V, Li, MZC, Toy, BR, Alavarez, JG. American ginseng and breast cancer therapeutic agents synergistically inhibit MCF-7 breast cancer cell growth. J. Surg. Oncol. 1999; 72: 230–9.
88Tode, T, Kikuchi, Y, Kita, T, Hirata, J, Imaizumi, I, Nagata, I.Inhibitory effects by oral administration of ginsenoside Rh2 on the growth of human ovarian cancer cells in nude mice. J. Cancer Res. Clin. Oncol. 1993; 120: 24–6.
89Zhu, JH, Takeshita, T, Kitagawa, I, Morimorto, K.Suppression of the formation of sister chromatid exchanges by low concentrations of ginsenoside Rh2 in human blood lymphocytes. Cancer. Res. 1995; 55: 1221–3.
90Wakabaayashi, C, Murakami, K, Hasegawa, H, Murata, J, Saiki, I.An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumour cells. Biochem. Biophys. Res. Commun. 1998; 246: 725–30.
91Oh, M, Choi, YH, Choi, SH. Antiproliferating effects of ginsenoside Rh2 on MCF-& human breast cancer cells. Int. J. Oncol. 1999; 14: 869–75.
92Kim, T-H, Lee, Y-S, Cho, C-K, Park, S, Choi, S-Y, Yoo, S-Y. Protective effect of ginseng on radiation-induced DNA double strand breaks and repair in murine lymphocytes. Cancer Biother. Radiopharm. 1996; 11: 267–72.
93Mochizuki, M, Yoo, YC, Maatsuzawa, K.Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20 (S)-ginsenoside-Rg3, of red ginseng. Biol. Pharm. Bull. 1995; 18: 1197–1202.
94Yun, TK. Experimental and epidemiological evidence of the cancer-preventative effects of Panax ginseng. C.A. Meyer Nutr. Rev. 1996; 54, S71–81.
95Yun, T-K, Choi, SY. Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int. J. Epidemiol. 1998; 27: 359–64.
96Zhang, Y, Xu, XU, Jiang, YP. Effects of ginsenosides on myocardial ischemia/re-perfusion damage in open heart surgery patients. Med. J. China 1994; 74, 626–8.
97Lee, J-H, Park, H-J. Effects of lipophilic fraction from Korean red ginseng on platelet aggregation and blood coagulation in rats fed with corn oil and beef tallow diet. Korean J. Ginseng Sci. 1995; 19: 206–11.
98Chen, X.Cardiovascular protection by ginsenosides and their nitric oxide releasing action. Clin. Exp. Pharmacol. Physiol. 1996; 23: 728–32.
99Huang, YS. Effect of ginsenosides Rb1 and Rg1 on lipid peroxidation of rat in vitro. Chung Kuo I Shueh Ko Hsueh Yuan Hsueh Pao 1989; 11, 460–2.
100Kim, J-S, Kim, K-W, Choi, K-J. Screening of active components of red ginseng saponin Korean. J. Ginseng Sci. 1996; 20: 173–8.
101Chang, MS, Choi, KJ, Rho, HM. Effect of the contents of ratio of panaxadiol ginsenosides extracted from compartments of ginseng on the transcription of Cu/Zn superoxide dismutase gene. J. Ginseng Res. 1999; 23: 44–9.