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Exploration of biomarkers for total fish intake in pregnant Norwegian women

  • Anne Lise Brantsæter (a1), Margaretha Haugen (a1), Yngvar Thomassen (a2), Dag G Ellingsen (a2), Trond A Ydersbond (a3), Tor-Arne Hagve (a4) (a5), Jan Alexander (a1) and Helle Margrete Meltzer (a1)...
Abstract
AbstractObjective

Few biomarkers for dietary intake of various food groups have been established. The aim of the present study was to explore whether selenium (Se), iodine, mercury (Hg) or arsenic may serve as a biomarker for total fish and seafood intake in addition to the traditionally used n-3 fatty acids EPA and DHA.

Design

Intake of fish and seafood estimated by an FFQ was compared with intake assessed by a 4 d weighed food diary and with biomarkers in blood and urine.

Setting

Validation study in the Norwegian Mother and Child Cohort Study (MoBa).

Subjects

One hundred and nineteen women.

Results

Total fish/seafood intake (median 39 g/d) calculated with the MoBa FFQ was comparable to intake calculated by the food diary (median 30 g/d, rS = 0·37, P < 0·001). Erythrocyte DHA and blood Hg, Se and arsenic concentrations were positively correlated with intake of fish and seafood, but the association for DHA was weakened by the widespread use of supplements. The main finding was the consistent positive association between the intake of fish/seafood and blood arsenic concentration. In multivariate analyses, blood arsenic was associated with blood Hg and fish and seafood intake. In these models, arsenic turned out to be the best indicator of intake of fish and seafood, both totally and in subgroups of fish/seafood intake.

Conclusions

While DHA reflected the intake of fatty fish and n-3 PUFA supplements, blood arsenic concentration also reflected the intake of lean fish and seafood. Blood arsenic appears to be a useful biomarker for total fish and seafood intake.

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Corresponding author
*Corresponding author: Email anne.lise.brantsaeter@fhi.no
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10. KR Mahaffey , RP Clickner & CC Bodurow (2004) Blood organic mercury and dietary mercury intake: National Health and Nutrition Examination Survey, 1999 and 2000. Environ Health Perspect 112, 562570.

15. SY Hess , MB Zimmermann , T Torresani , H Burgi & RF Hurrell (2001) Monitoring the adequacy of salt iodization in Switzerland: a national study of school children and pregnant women. Eur J Clin Nutr 55, 162166.

16. I Thorsdottir , BE Birgisdottir , S Halldorsdottir & RT Geirsson (2004) Association of fish and fish liver oil intake in pregnancy with infant size at birth among women of normal weight before pregnancy in a fishing community. Am J Epidemiol 160, 460465.

17. IB Helland , L Smith , K Saarem , OD Saugstad & CA Drevon (2003) Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children’s IQ at 4 years of age. Pediatrics 111, e39e44.

18. JR Hibbeln , JM Davis , C Steer , P Emmett , I Rogers , C Williams & J Golding (2007) Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study. Lancet 369, 578585.

19. P Magnus , LM Irgens , K Haug , W Nystad , R Skjaerven & C Stoltenberg (2006) Cohort profile: The Norwegian Mother and Child Cohort Study (MoBa). Int J Epidemiol 35, 11461150.

20. HM Meltzer , AL Brantsæter , TA Ydersbond , J Alexander & M Haugen (2008) Methodological challenges when monitoring the diet of pregnant women in a large study: experiences from the Norwegian Mother and Child Cohort Study (MoBa). Matern Child Nutr 4, 1427.

21. AL Brantsæter , M Haugen , J Alexander & HM Meltzer (2008) Validity of a new food frequency questionnaire for pregnant women in the Norwegian Mother and Child Cohort Study (MoBa). Matern Child Nutr 4, 2843.

24. AL Brantsæter , M Haugen , TA Hagve , L Aksnes , SE Rasmussen , K Julshamn , J Alexander & HM Meltzer (2007) Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa). Ann Nutr Metab 51, 146154.

25. DG Ellingsen , L Dubeikovskaya , K Dahl , M Chashchin , V Chashchin , E Zibarev & Y Thomassen (2006) Air exposure assessment and biological monitoring of manganese and other major welding fume components in welders. J Environ Monit 8, 10781086.

30. TI Halldorsson , HM Meltzer , I Thorsdottir , V Knudsen & SF Olsen (2007) Is high consumption of fatty fish during pregnancy a risk factor for fetal growth retardation? A study of 44,824 Danish pregnant women. Am J Epidemiol 166, 687696.

32. BM Margetts & M Nelson (1997) Design Concepts in Nutritional Epidemiology. Oxford: Oxford University Press.

33. BJ Fuhrman , M Barba , V Krogh (2006) Erythrocyte membrane phospholipid composition as a biomarker of dietary fat. Ann Nutr Metab 50, 95102.

34. K Mina , L Fritschi & M Knuiman (2007) A valid semiquantitative food frequency questionnaire to measure fish consumption. Eur J Clin Nutr 61, 10231031.

35. M Brustad , T Braaten & E Lund (2004) Predictors for cod-liver oil supplement use – the Norwegian Women and Cancer Study. Eur J Clin Nutr 58, 128136.

36. M Haugen , AL Brantsæter , J Alexander & HM Meltzer (2008) Dietary supplements contribute substantially to the total nutrient intake in pregnant Norwegian women. Ann Nutr Metab 52, 272280.

37. MA Williams , IO Frederick , C Qiu , LJ Meryman , IB King , SW Walsh & TK Sorensen (2006) Maternal erythrocyte omega-3 and omega-6 fatty acids, and plasma lipid concentrations, are associated with habitual dietary fish consumption in early pregnancy. Clin Biochem 39, 10631070.

38. R Matorras , L Perteagudo , P Sanjurjo & JI Ruiz (1999) Intake of long chain ω3 polyunsaturated fatty acids during pregnancy and the influence of levels in the mother on newborn levels. Eur J Obstet Gynecol Reprod Biol 83, 179184.

40. A Hjartaker & E Lund (1998) Relationship between dietary habits, age, lifestyle, and socio-economic status among adult Norwegian women. The Norwegian Women and Cancer Study. Eur J Clin Nutr 52, 565572.

42. H Frey , B Rosenlund , K Try & L Theodorsen (1993) Urinary excretion of iodine in Norway. In Iodine Deficiency in Europe, pp. 297300 [F Delange, editor]. New York: Plenum Press.

43. AL Brantsæter , M Haugen , K Julshamn , J Alexander & HM Meltzer (2009) Evaluation of urinary iodine excretion as a biomarker for intake of milk and dairy products in pregnant women in the Norwegian Mother and Child Cohort Study (MoBa). Eur J Clin Nutr 63, 347354.

45. KA Bjornberg , M Vahter , KP Grawe & M Berglund (2005) Methyl mercury exposure in Swedish women with high fish consumption. Sci Total Environ 341, 4552.

46. SE Schober , TH Sinks , RL Jones (2003) Blood mercury levels in US children and women of childbearing age, 1999–2000. JAMA 289, 16671674.

48. KA Bjornberg , M Vahter , K Petersson-Grawe (2003) Methyl mercury and inorganic mercury in Swedish pregnant women and in cord blood: influence of fish consumption. Environ Health Perspect 111, 637641.

49. E Oken , KP Kleinman , WE Berland , SR Simon , JW Rich-Edwards & MW Gillman (2003) Decline in fish consumption among pregnant women after a national mercury advisory. Obstet Gynecol 102, 346351.

51. J Burger & M Gochfeld (2004) Mercury in canned tuna: white versus light and temporal variation. Environ Res 96, 239249.

52. RS Rasmussen & MT Morrissey (2007) Effects of canning on total mercury, protein, lipid, and moisture content in trawl-caught albacore tuna (Thunnus alalunga). Food Chem 101, 11301135.

53. B Lehmann , E Ebeling & C Alsen-Hinrichs (2001) Kinetics of arsenic in human blood after a fish meal. Gesundheitswesen 63, 4248.

54. HM Meltzer , A Maage , TA Ydersbond , E Haug , E Glattre & H Holm (2002) Fish arsenic may influence human blood arsenic, selenium, and T4:T3 ratio. Biol Trace Elem Res 90, 8398.

55. RM Brown , D Newton , CJ Pickford & JC Sherlock (1990) Human metabolism of arsenobetaine ingested with fish. Hum Exp Toxicol 9, 4146.

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Public Health Nutrition
  • ISSN: 1368-9800
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