The world faces an era of ‘permacrisis’, marked by overlapping challenges such as climate change, conflicts, economic instability, and recurrent disease outbreaks, which disrupt health systems and deepen inequalities. Primary Health Care (PHC) is vital for addressing immediate health needs and social determinants, fostering resilience, and promoting equity during such crises. This opinion piece highlights PHC’s unique role in ensuring essential services, reducing barriers to care, and integrating health with broader social and environmental policies. In conflict-affected and climate-impacted regions, PHC supports community resilience, promotes health equity, and adapts to systemic shocks. Investing in PHC infrastructure, empowering community health workers, early disease detection, promoting climate-adaptive health practices and delivering integrated care can advance health for all. PHC offers a sustainable pathway to resilient health systems capable of navigating the complexities of a rapidly changing world.