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Chapter 14 - High Energy Forms: Employing the Spectrum of Energy as Surgical Adjuvants

from Section IV - The Surgeon’s Armamentarium

Published online by Cambridge University Press:  29 November 2025

Edited by
Benjamin Hartley ,
Philip E. Stieg ,
Rohan Ramakrishna  and
Michael L. J. Apuzzo
Benjamin Hartley
Affiliation:
Weill Cornell Medical Center
Philip E. Stieg
Affiliation:
Weill Cornell Medical College
Rohan Ramakrishna
Affiliation:
Weill Cornell Medical College
Michael L. J. Apuzzo
Affiliation:
Adjunct of Yale Medical School and Weill Cornell Medical College
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Neurosurgery
Beyond the Cutting Edge
 , pp. 269 - 332
Publisher: Cambridge University Press
Print publication year: 2025

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References

Clarke, RH, Horsley, SV. THE CLASSIC: On a Method of Investigating the Deep Ganglia and Tracts of the Central Nervous System (Cerebellum). Clin Orthop Relat Res. 2007;463:3–6. doi:10.1097/BLO.0b013e31814d4d99.CrossRefGoogle ScholarPubMed
Spiegel, EA, Wycis, HT, Marks, M, Lee, AJ. Stereotaxic Apparatus for Operations on the Human Brain. Science. 1947;106(2754):349–50. doi:10.1126/science.106.2754.349.CrossRefGoogle ScholarPubMed
Owen, H, Holder, D, Alonso, J, MacKay, R. Technologies for Delivery of Proton and Ion Beams for Radiotherapy. Int J Mod Phys A. 2014;29(14):1441002. doi:10.1142/S0217751X14410024.CrossRefGoogle Scholar
Tobiasj, CA, Lawrencej, H, Born, L, et al. Pituitary Irradiation with High-Energy Proton Beams A Preliminary Report. Cancer Res. 1958;18:19.Google Scholar
Leksell, L, Leksell, D, Schwebel, J. Stereotaxis and Nuclear Magnetic Resonance. J Neurol Neurosurg Psychiatry. 1985;48(1):14–18.10.1136/jnnp.48.1.14CrossRefGoogle ScholarPubMed
Gondi, V, Bauman, G, Bradfield, L, et al. Radiation Therapy for Brain Metastases: An ASTRO Clinical Practice Guideline. Pract Radiat Oncol. 2022;12(4):265–82. doi:10.1016/j.prro.2022.02.003.CrossRefGoogle ScholarPubMed
Brown, PD, Jaeckle, K, Ballman, KV, et al. Effect of Radiosurgery Alone vs Radiosurgery with Whole Brain Radiation Therapy on Cognitive Function in Patients with 1 to 3 Brain Metastases: A Randomized Clinical Trial. JAMA. 2016;316(4):401–9. doi:10.1001/jama.2016.9839.CrossRefGoogle Scholar
Aoyama, H, Shirato, H, Tago, M, et al. Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases: A Randomized Controlled Trial. JAMA. 2006;295(21):2483–91. doi:10.1001/jama.295.21.2483.CrossRefGoogle ScholarPubMed
Chang, EL, Wefel, JS, Hess, KR, et al. Neurocognition in Patients with Brain Metastases Treated with Radiosurgery or Radiosurgery Plus Whole-brain Irradiation: A Randomised Controlled Trial. Lancet Oncol. 2009;10(11):1037–44. doi:10.1016/S1470-2045(09)70263-3.CrossRefGoogle ScholarPubMed
Hong, AM, Fogarty, GB, Dolven-Jacobsen, K, et al. Adjuvant Whole-Brain Radiation Therapy Compared With Observation After Local Treatment of Melanoma Brain Metastases: A Multicenter, Randomized Phase III Trial. J Clin Oncol. 2019;37(33):3132–41. doi:10.1200/JCO.19.01414.CrossRefGoogle ScholarPubMed
Kocher, M, Soffietti, R, Abacioglu, U, et al. Adjuvant Whole-Brain Radiotherapy Versus Observation After Radiosurgery or Surgical Resection of One to Three Cerebral Metastases: Results of the EORTC 22952–26001 Study. J Clin Oncol. 2011;29(2):134–41. doi:10.1200/JCO.2010.30.1655.CrossRefGoogle ScholarPubMed
Yamamoto, M, Serizawa, T, Shuto, T, et al. Stereotactic Radiosurgery for Patients with Multiple Brain Metastases (JLGK0901): A Multi-institutional Prospective Observational Study. Lancet Oncol. 2014;15(4):387–95. doi:10.1016/S1470-2045(14)70061-0.CrossRefGoogle ScholarPubMed
Hughes, RT, Masters, AH, McTyre, ER, et al. Initial SRS for Patients With 5 to 15 Brain Metastases: Results of a Multi-Institutional Experience. Int J Radiat Oncol. 2019;104(5):1091–8. doi:10.1016/j.ijrobp.2019.03.052.CrossRefGoogle ScholarPubMed
Serizawa, T, Yamamoto, M, Higuchi, Y, et al. Local Tumor Progression Treated with Gamma Knife Radiosurgery: Differences Between Patients with 2–4 versus 5–10 Brain Metastases Based on an Update of a Multi-institutional Prospective Observational Study (JLGK0901). J Neurosurg. 2019;132(5):1480–9. doi:10.3171/2019.1.JNS183085.Google Scholar
Yamamoto, M, Serizawa, T, Higuchi, Y, et al. A Multi-institutional Prospective Observational Study of Stereotactic Radiosurgery for Patients With Multiple Brain Metastases (JLGK0901 Study Update): Irradiation-related Complications and Long-term Maintenance of Mini-Mental State Examination Scores. Int J Radiat Oncol. 2017;99(1):31–40. doi:10.1016/j.ijrobp.2017.04.037.CrossRefGoogle ScholarPubMed
Shuto, T, Akabane, A, Yamamoto, M, et al. Multiinstitutional Prospective Observational Study of Stereotactic Radiosurgery for Patients with Multiple Brain Metastases from Non–small Cell Lung Cancer (JLGK0901 study–NSCLC). J Neurosurg. 2018;129(Suppl1):86–94. doi:10.3171/2018.7.GKS181378.CrossRefGoogle ScholarPubMed
Yomo, S, Serizawa, T, Yamamoto, M, et al. The Impact of EGFR-TKI Use on Clinical Outcomes of Lung Adenocarcinoma Patients with Brain Metastases After Gamma Knife Radiosurgery: A Propensity Score-Matched Analysis Based on Extended JLGK0901 Dataset (JLGK0901-EGFR-TKI). J Neurooncol. 2019;145(1):151–7. doi:10.1007/s11060-019-03282-0.CrossRefGoogle ScholarPubMed
Higuchi, Y, Yamamoto, M, Serizawa, T, et al. Stereotactic Radiosurgery in Elderly Patients With Brain Metastases: Comparison with Non-elderly Patients Using Database of a Multi-institutional Prospective Observational Study (JLGK0901-Elderly). J Neurooncol. 2019;144(2):393–402. doi:10.1007/s11060-019-03242-8.CrossRefGoogle ScholarPubMed
Mahajan, A, Ahmed, S, McAleer, MF, et al. Post-operative Stereotactic Radiosurgery Versus Observation for Completely Resected Brain Metastases: A Single-centre, Randomised, Controlled, Phase 3 Trial. Lancet Oncol. 2017;18(8):1040–8. doi:10.1016/S1470-2045(17)30414-X.CrossRefGoogle ScholarPubMed
Souhami, L, Seiferheld, W, Brachman, D, et al. Randomized Comparison of Stereotactic Radiosurgery Followed by Conventional Radiotherapy with Carmustine to Conventional Radiotherapy with Carmustine for Patients with Glioblastoma Multiforme: Report of Radiation Therapy Oncology Group 93–05 Protocol. Int J Radiat Oncol Biol Phys. 2004;60(3):853–60. doi:10.1016/j.ijrobp.2004.04.011.CrossRefGoogle ScholarPubMed
Niranjan, A, Kano, H, Iyer, A, Kondziolka, D, Flickinger, JC, Lunsford, LD. Role of Adjuvant or Salvage Radiosurgery in the Management of Unresected Residual or Progressive Glioblastoma Multiforme in the Pre-bevacizumab Era. J Neurosurg. 2015;122(4):757–65. doi:10.3171/2014.11.JNS13295.CrossRefGoogle ScholarPubMed
Bunevicius, A, Pikis, S, Kondziolka, D, et al. Stereotactic Radiosurgery for Glioblastoma Considering Tumor Genetic Profiles: An International Multicenter Study. J Neurosurg. Published online November 5, 2021:1–9. doi:10.3171/2021.7.JNS211277.CrossRefGoogle Scholar
Cuneo, KC, Vredenburgh, JJ, Sampson, JH, et al. Safety and Efficacy of Stereotactic Radiosurgery and Adjuvant Bevacizumab in patients with Recurrent Malignant Gliomas. Int J Radiat Oncol Biol Phys. 2012;82(5):2018–24. doi:10.1016/j.ijrobp.2010.12.074.CrossRefGoogle ScholarPubMed
Park, KJ, Kano, H, Iyer, A, et al. Salvage Gamma Knife Stereotactic Radiosurgery Followed by Bevacizumab for Recurrent Glioblastoma Multiforme: A Case-Control Study. J Neurooncol. 2012;107(2):323–33. doi:10.1007/s11060-011-0744-9.CrossRefGoogle ScholarPubMed
Clark, GM, McDonald, AM, Nabors, LB, et al. Hypofractionated Stereotactic Radiosurgery with Concurrent Bevacizumab for Recurrent Malignant Gliomas: The University Of Alabama at Birmingham Experience. Neuro-Oncol Pract. 2014;1(4):172–7. doi:10.1093/nop/npu028.CrossRefGoogle ScholarPubMed
Santacroce, A, Walier, M, Régis, J, et al. Long-term Tumor Control of Benign Intracranial Meningiomas After Radiosurgery in a Series of 4565 Patients. Neurosurgery. 2012;70(1):32–9. doi:10.1227/NEU.0b013e31822d408a.CrossRefGoogle Scholar
Marchetti, M, Sahgal, A, De Salles, AAF, et al. Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline. Neurosurgery. 2020;87(5):879–90. doi:10.1093/neuros/nyaa169.CrossRefGoogle ScholarPubMed
Pikis, S, Bunevicius, A, Sheehan, J. Outcomes from Treatment of Asymptomatic Skull Base Meningioma with Stereotactic Radiosurgery. Acta Neurochir (Wien). 2021;163(1):83–8. doi:10.1007/s00701-020-04648-4.CrossRefGoogle ScholarPubMed
Sheehan, J, Pikis, S, Islim, AI, et al. An International Multicenter Matched Cohort Analysis of Incidental Meningioma Progression During Active Surveillance or After Stereotactic Radiosurgery: The IMPASSE Study. Neuro-Oncol. 2022;24(1):116–24. doi:10.1093/neuonc/noab132.CrossRefGoogle ScholarPubMed
Mantziaris, G, Pikis, S, Samanci, Y, et al. Stereotactic Radiosurgery Versus Active Surveillance for Asymptomatic, Skull-Based Meningiomas: An International, Multicenter Matched Cohort Study. J Neurooncol. 2022;156(3):509–18. doi:10.1007/s11060-021-03923-3.CrossRefGoogle ScholarPubMed
Pikis, S, Mantziaris, G, Samanci, Y, et al. Stereotactic Radiosurgery for Incidentally Discovered Cavernous Sinus Meningiomas: A Multi-institutional Study. World Neurosurg. 2022;158:e675–80. doi:10.1016/j.wneu.2021.11.037.CrossRefGoogle ScholarPubMed
Mantziaris, G, Pikis, S, Bunevicius, A, et al. Stereotactic Radiosurgery for Asymptomatic Petroclival Region Meningiomas: A Focused Analysis from the IMPASSE Study. Acta Neurochir (Wien). 2022;164(1):273–9. doi:10.1007/s00701-021-05056-y.CrossRefGoogle ScholarPubMed
Pikis, S, Mantziaris, G, Islim, AI, et al. Stereotactic Radiosurgery Versus Active Surveillance for Incidental, Convexity Meningiomas: A Matched Cohort Analysis from the IMPASSE Study. J Neurooncol. 2022;157(1):121–8. doi:10.1007/s11060-022-03953-5.CrossRefGoogle ScholarPubMed
Pikis, S, Mantziaris, G, Bunevicius, A, et al. Stereotactic Radiosurgery Compared With Active Surveillance for Asymptomatic, Parafalcine, and Parasagittal Meningiomas: A Matched Cohort Analysis From the IMPASSE Study. Neurosurgery. 2022;90(6):750–7. doi:10.1227/neu.0000000000001924.CrossRefGoogle ScholarPubMed
Milano, MT, Sharma, M, Soltys, SG, et al. Radiation-Induced Edema After Single-Fraction or Multifraction Stereotactic Radiosurgery for Meningioma: A Critical Review. Int J Radiat Oncol. 2018;101(2):344–57. doi:10.1016/j.ijrobp.2018.03.026.CrossRefGoogle ScholarPubMed
Wolf, A, Naylor, K, Tam, M, et al. Risk of Radiation-associated Intracranial Malignancy After Stereotactic Radiosurgery: A Retrospective, Multicentre, Cohort Study. Lancet Oncol. 2019;20(1):159–64. doi:10.1016/S1470-2045(18)30659-4.CrossRefGoogle ScholarPubMed
Shepard, MJ, Xu, Z, Kearns, K, et al. Stereotactic Radiosurgery for Atypical (World Health Organization II) and Anaplastic (World Health Organization III) Meningiomas: Results From a Multicenter, International Cohort Study. Neurosurgery. 2021;88(5):980–8. doi:10.1093/neuros/nyaa553.CrossRefGoogle ScholarPubMed
Vlachogiannis, P, Gudjonsson, O, Montelius, A, et al. Hypofractionated High-energy Proton-beam Irradiation is an Alternative Treatment for WHO grade I Meningiomas. Acta Neurochir (Wien). 2017;159(12):2391–400. doi:10.1007/s00701-017-3352-4.CrossRefGoogle Scholar
Halasz, LM, Bussière, MR, Dennis, ER, et al. Proton Stereotactic Radiosurgery for the Treatment of Benign Meningiomas. Int J Radiat Oncol Biol Phys. 2011;81(5):1428–35. doi:10.1016/j.ijrobp.2010.07.1991.CrossRefGoogle ScholarPubMed
Flickinger, JC, Kondziolka, D, Niranjan, A, Maitz, A, Voynov, G, Lunsford, LD. Acoustic Neuroma Radiosurgery with Marginal Tumor Doses of 12 to 13 gy. Int J Radiat Oncol. 2004;60(1):225–30. doi:10.1016/j.ijrobp.2004.02.019.CrossRefGoogle ScholarPubMed
Pikis, S, Mantziaris, G, Kormath Anand, R, et al. Stereotactic Radiosurgery for Koos Grade IV Vestibular Schwannoma: A Multi-institutional Study. J Neurosurg. Published online June 3, 2022:1–8. doi:10.3171/2022.4.JNS22203.CrossRefGoogle Scholar
Dumot, C, Pikis, S, Mantziaris, G, et al. Stereotactic Radiosurgery for Koos Grade IV Vestibular Schwannoma in Young Patients: A Multi-institutional Study. J Neurooncol. 2022;160(1):201–8. doi:10.1007/s11060-022-04134-0.CrossRefGoogle Scholar
Weber, DC, Chan, AW, Bussiere, MR, et al. Proton Beam Radiosurgery for Vestibular Schwannoma: Tumor Control and Cranial Nerve Toxicity. Neurosurgery. 2003;53(3):577–88. doi:10.1227/01.NEU.0000079369.59219.C0.CrossRefGoogle ScholarPubMed
Vernimmen, FJAI, Mohamed, Z, Slabbert, JP, Wilson, J. Long-term Results of Stereotactic Proton Beam Radiotherapy for Acoustic Neuromas. Radiother Oncol. 2009;90(2):208–12. doi:10.1016/j.radonc.2008.11.004.CrossRefGoogle ScholarPubMed
Kotecha, R, Sahgal, A, Rubens, M, et al. Stereotactic Radiosurgery for Non-functioning Pituitary Adenomas: Meta-analysis and International Stereotactic Radiosurgery Society Practice Opinion. Neuro-Oncol. 2020;22(3):318–32. doi:10.1093/neuonc/noz225.Google ScholarPubMed
Liščák, R, Vladyka, V, Marek, J, Šimonová, G, Vymazal, J. Gamma Knife Radiosurgery for Endocrine-inactive Pituitary Adenomas. Acta Neurochir (Wien). 2007;149(10):999–1006. doi:10.1007/s00701-007-1253-7.CrossRefGoogle ScholarPubMed
Ironside, N, Snyder, H, Xu, Z, et al. Effect of Distance from Target on Hypopituitarism After Stereotactic Radiosurgery for Pituitary Adenomas. J Neurooncol. 2022;158(1):41–50. doi:10.1007/s11060-022-04007-6.CrossRefGoogle ScholarPubMed
Pomeraniec, IJ, Kano, H, Xu, Z, et al. Early versus Late Gamma Knife Radiosurgery Following Transsphenoidal Surgery for Nonfunctioning Pituitary Macroadenomas: A Multicenter Matched-Cohort Study. J Neurosurg. 2017;129(3):648–57. doi:10.3171/2017.5.JNS163069.Google ScholarPubMed
Mantziaris, G, Pikis, S, Chytka, T, et al. Adjuvant Versus On-progression Gamma Knife Radiosurgery for Residual Nonfunctioning Pituitary Adenomas: A Matched-Cohort Analysis. J Neurosurg. Published online November 18, 2022:1–7. doi:10.3171/2022.10.JNS221873.CrossRefGoogle Scholar
Farnworth, MT, Yuen, KCJ, Chapple, KM, et al. Evolution of Postoperative Pituitary Adenoma Resection Cavities Assessed by Magnetic Resonance Imaging and Implications Regarding Radiotherapy Timing and Modality. Clin Imaging. 2022;82:110–16. doi:10.1016/j.clinimag.2021.11.004.CrossRefGoogle ScholarPubMed
Mathieu, D, Kotecha, R, Sahgal, A, et al. Stereotactic Radiosurgery for Secretory Pituitary Adenomas: Systematic Review and International Stereotactic Radiosurgery Society Practice Recommendations. J Neurosurg. 2022;136(3):801–12. doi:10.3171/2021.2.JNS204440.CrossRefGoogle ScholarPubMed
Wattson, DA, Tanguturi, SK, Spiegel, DY, et al. Outcomes of Proton Therapy for Patients With Functional Pituitary Adenomas. Int J Radiat Oncol. 2014;90(3):532–9. doi:10.1016/j.ijrobp.2014.06.068.CrossRefGoogle ScholarPubMed
Graffeo, CS, Sahgal, A, De Salles, A, et al. Stereotactic Radiosurgery for Spetzler-Martin Grade I and II Arteriovenous Malformations: International Society of Stereotactic Radiosurgery (ISRS) Practice Guideline. Neurosurgery. 2020;87(3):442–52. doi:10.1093/neuros/nyaa004.CrossRefGoogle Scholar
Rubin, BA, Brunswick, A, Riina, H, Kondziolka, D. Advances in Radiosurgery for Arteriovenous Malformations of the Brain. Neurosurgery. 2014;74:S50. doi:10.1227/NEU.0000000000000219.CrossRefGoogle ScholarPubMed
Kano, H, Flickinger, JC, Nakamura, A, et al. How to Improve Obliteration Rates During Volume-staged Stereotactic Radiosurgery for Large Arteriovenous Malformations. J Neurosurg. Published online July 1, 2018:1–8. doi:10.3171/2018.2.JNS172964.CrossRefGoogle Scholar
Starke, RM, Yen, CP, Ding, D, Sheehan, JP. A Practical Grading Scale for Predicting Outcome After Radiosurgery for Arteriovenous Malformations: Analysis of 1012 Treated Patients. J Neurosurg. 2013;119(4):981–7. doi:10.3171/2013.5.JNS1311.CrossRefGoogle ScholarPubMed
Ding, D, Starke, RM, Sheehan, JP. Radiosurgery for the Management of Cerebral Arteriovenous Malformations. Handb Clin Neurol. 2017;143:69–83. doi:10.1016/B978-0-444-63640-9.00007-2.Google ScholarPubMed
Russell, D, Peck, T, Ding, D, et al. Stereotactic Radiosurgery Alone or Combined with Embolization for Brain Arteriovenous Malformations: A Systematic Review and Meta-Analysis. J Neurosurg. 2018;128(5):1338–48. doi:10.3171/2016.11.JNS162382.CrossRefGoogle ScholarPubMed
Byun, J, Kwon, DH, Lee, DH, Park, W, Park, JC, Ahn, JS. Radiosurgery for Cerebral Arteriovenous Malformation (AVM): Current Treatment Strategy and Radiosurgical Technique for Large Cerebral AVM. J Korean Neurosurg Soc. 2020;63(4):415–26. doi:10.3340/jkns.2020.0008.CrossRefGoogle ScholarPubMed
Blomquist, E, Ronne-Engström, E, Borota, L, et al. Positive Correlation Between Occlusion Rate and Nidus Size of Proton Beam Treated Brain Arteriovenous Malformations (AVMs). Acta Oncol. 2016;55(1):105–12. doi:10.3109/0284186X.2015.1043023.CrossRefGoogle ScholarPubMed
Vernimmen, FJAI, Slabbert, JP, Wilson, JA, Fredericks, S, Melvill, R. Stereotactic Proton Beam Therapy for Intracranial Arteriovenous Malformations. Int J Radiat Oncol. 2005;62(1):44–52. doi:10.1016/j.ijrobp.2004.09.008.CrossRefGoogle ScholarPubMed
Tuleasca, C, Régis, J, Sahgal, A, et al. Stereotactic Radiosurgery for Trigeminal Neuralgia: A Systematic Review: International Stereotactic Radiosurgery Society Practice Guidelines. J Neurosurg. 2018;130(3):733–57. doi:10.3171/2017.9.JNS17545.Google Scholar
Pollock, BE, Phuong, LK, Gorman, DA, Foote, RL, Stafford, SL. Stereotactic Radiosurgery for Idiopathic Trigeminal Neuralgia. J Neurosurg. 2002;97(2):347–53. doi:10.3171/jns.2002.97.2.0347.CrossRefGoogle ScholarPubMed
Régis, J, Tuleasca, C, Resseguier, N, et al. Long-term Safety and Efficacy of Gamma Knife Surgery in Classical Trigeminal Neuralgia: A 497-Patient Historical Cohort Study. J Neurosurg. 2016;124(4):1079–87. doi:10.3171/2015.2.JNS142144.CrossRefGoogle ScholarPubMed
Kondziolka, D, Zorro, O, Lobato-Polo, J, et al. Gamma Knife Stereotactic Radiosurgery for Idiopathic Trigeminal Neuralgia: Clinical Article. J Neurosurg. 2010;112(4):758–65. doi:10.3171/2009.7.JNS09694.CrossRefGoogle Scholar
Zhao, ZF, Yang, LZ, Jiang, CL, Zheng, YR, Zhang, JW. Gamma Knife Irradiation-induced Histopathological Changes in the Trigeminal Nerves of Rhesus Monkeys. J Neurosurg. 2010;113(1):39–44. doi:10.3171/2010.1.jns091116.CrossRefGoogle ScholarPubMed
Pikis, S, Bunevicius, A, Donahue, J, et al. Diffusivity Metrics Three Months After Upfront Gamma Knife Radiosurgery for Trigeminal Neuralgia May Be Correlated with Pain Relief. World Neurosurg. 2021;153:e220–5. doi:10.1016/j.wneu.2021.06.086.CrossRefGoogle ScholarPubMed
Tohyama, S, Hung, P, Zhong, J, Hodaie, M. Early Postsurgical Diffusivity Metrics for Prognostication of Long-term Pain Relief After Gamma Knife Radiosurgery for Trigeminal Neuralgia. J Neurosurg. 2018;131(2):539–48. doi:10.3171/2018.3.JNS172936.Google ScholarPubMed
Gupta, A, Shepard, MJ, Xu, Z, et al. An International Radiosurgery Research Foundation Multicenter Retrospective Study of Gamma Ventral Capsulotomy for Obsessive Compulsive Disorder. Neurosurgery. 2019;85(6):808–16. doi:10.1093/neuros/nyy536.CrossRefGoogle ScholarPubMed
Rasmussen, SA, Noren, G, Greenberg, BD, et al. Gamma Ventral Capsulotomy in Intractable Obsessive-Compulsive Disorder. Biol Psychiatry. 2018;84(5):355–64. doi:10.1016/j.biopsych.2017.11.034.CrossRefGoogle ScholarPubMed
Kumar, KK, Appelboom, G, Lamsam, L, et al. Comparative Effectiveness of Neuroablation and Deep Brain Stimulation for Treatment-Resistant Obsessive-Compulsive Disorder: A Meta-analytic Study. J Neurol Neurosurg Psychiatry. 2019;90(4):469–73. doi:10.1136/jnnp-2018-319318.CrossRefGoogle ScholarPubMed
Spatola, G, Martinez-Alvarez, R, Martínez-Moreno, N, et al. Results of Gamma Knife Anterior Capsulotomy for Refractory Obsessive-Compulsive Disorder: Results in a Series of 10 Consecutive Patients. J Neurosurg. 2018;131(2):376–83. doi:10.3171/2018.4.JNS171525.Google Scholar
Martínez-Álvarez, R, Martínez-Moreno, N, Torres-Díaz, C, Lara-Almunia, M. SRS for OCD. In: Intracranial Stereotactic Radiosurgery. 3rd ed. CRC Press; 2021.Google Scholar
Samuel, N, Trifiletti, DM, Quinones-Hinojosa, A, Lunsford, LD, Sheehan, J. Stereotactic Radiosurgery Training Patterns Across Neurosurgical Programs: A Multi-national Survey. J Neurooncol. 2021;151(2):325–30. doi:10.1007/s11060-020-03670-x.CrossRefGoogle ScholarPubMed
Lad, M, Gupta, R, Raman, A, et al. Trends in Physician Reimbursements and Procedural Volumes for Radiosurgery Versus Open Surgery in Brain Tumor Care: An Analysis of Medicare Data from 2009 to 2018. J Neurosurg. 2021;136(1):97–108. doi:10.3171/2020.11.JNS202284.CrossRefGoogle ScholarPubMed
Sheehan, JP, Kavanagh, BD, Asher, A, Harbaugh, RE. Inception of a National Multidisciplinary Registry for Stereotactic Radiosurgery. J Neurosurg. 2016;124(1):155–62. doi:10.3171/2015.1.JNS142466.CrossRefGoogle ScholarPubMed

References

Atun, Rifat et al. Expanding global access to radiotherapy. Lancet Oncol. 16(10):1153–86.Google Scholar
Citrin, DE, Mitchell, JB. Altering the response to radiation: sensitizers and protectors. Semin Oncol. 2014 Dec;41(6):848–59. doi: 10.1053/j.seminoncol.2014.09.013. Epub 2014 Oct 7. PMID: 25499642; PMCID: PMC4270009.CrossRefGoogle ScholarPubMed
Barnett, GC, West, CM, Dunning, AM, Elliott, RM, Coles, CE, Pharoah, PD, Burnet, NG. Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Nat Rev Cancer. 2009 Feb;9(2):134–42. doi: 10.1038/nrc2587. Epub 2009 Jan 16. PMID: 19148183; PMCID: PMC2670578.CrossRefGoogle ScholarPubMed
Glide-Hurst, CK, Chetty, IJ. Improving radiotherapy planning, delivery accuracy, and normal tissue sparing using cutting edge technologies. J Thorac Dis. 2014 Apr;6(4):303–18. doi: 10.3978/j.issn.2072-1439.2013.11.10. PMID: 24688775; PMCID: PMC3968554.Google ScholarPubMed
Dimitrios Colevas, A. and others, For the Radiation Modifier Working Group of the National Cancer Institute. Development of investigational radiation modifiers. JNCI: J Natl Cancer Inst. 2003;95(9):646–51, https://doi.org/10.1093/jnci/95.9.646Google Scholar
Allison, RR. Radiobiological modifiers in clinical radiation oncology: current reality and future potential. Future Oncol. 2014 Dec;10(15):2359–79. doi: 10.2217/fon.14.174. PMID: 25525845.CrossRefGoogle ScholarPubMed
Gray, LH. Oxygenation in radiotherapy. I. Radiobiological considerations. Br J Radiol. 1957 Aug;30(356):403–6. doi: 10.1259/0007-1285-30-356-403. PMID: 13446401.CrossRefGoogle ScholarPubMed
Churchill-Davidson, I, Sanger, C, Thomlinson, RH. High pressure oxygen and radiotherapy. Lancet 1955;1:1091–5.Google Scholar
Gutin, PH, Wara, WM, Phillips, TL., Wilson, CB. Hypoxic cell radiosensitizers in the treatment of malignant brain tumors. Neurosurgery. 1980;6(5):567–76.Google ScholarPubMed
Wardman, P. Nitroimidazoles as hypoxic cell radiosensitizers and hypoxia probes: misonidazole, myths and mistakes. Br J Radiol. 2019 Jan;92(1093):20170915. doi: 10.1259/bjr.20170915. Epub 2018 Mar 20. PMID: 29303355; PMCID: PMC6435051.Google ScholarPubMed
Jeon, J, Lee, S, Kim, H, Kang, H, Youn, H, Jo, S, Youn, B, Kim, HY. Revisiting platinum-based anticancer drugs to overcome gliomas. Int J Mol Sci. 2021 May;22(10):5111. doi: 10.3390/ijms22105111. PMID: 34065991; PMCID: PMC8151298.CrossRefGoogle ScholarPubMed
Ferrari, B, Roda, E, Priori, EC, De Luca, F, Facoetti, A, Ravera, M, Brandalise, F, Locatelli, CA, Rossi, P, Bottone, MG. A new platinum-based prodrug candidate for chemotherapy and its synergistic effect with hadrontherapy: novel strategy to treat glioblastoma. Front Neurosci. 2021 Mar;15:589906. doi: 10.3389/fnins.2021.589906. PMID: 33828444; PMCID: PMC8019820.CrossRefGoogle ScholarPubMed
Wachsberger, PR, Lawrence, RY, Liu, Y, Rice, B, Daskalakis, C, Dicker, AP. Epidermal growth factor receptor mutation status and rad51 determine the response of glioblastoma to multimodality therapy with cetuximab, temozolomide, and radiation. Front Oncol. 2013 Feb;3:13. doi: 10.3389/fonc.2013.00013. PMID: 23383403; PMCID: PMC3563086.CrossRefGoogle ScholarPubMed
Stupp, R, Mason, WP, van den Bent, MJ, Weller, M, Fisher, B, Taphoorn, MJ, Belanger, K, Brandes, AA, Marosi, C, Bogdahn, U, Curschmann, J, Janzer, RC, Ludwin, SK, Gorlia, T, Allgeier, A, Lacombe, D, Cairncross, JG, Eisenhauer, E, Mirimanoff, RO; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005 Mar;352(10):987–96. doi: 10.1056/NEJMoa043330.Google Scholar
Niyazi, M, Harter, PN, Hattingen, E, Rottler, M, von Baumgarten, L, Proescholdt, M, Belka, C, Lauber, K, Mittelbronn, M. Bevacizumab and radiotherapy for the treatment of glioblastoma: brothers in arms or unholy alliance? Oncotarget. 2016 Jan;7(3):2313–28. doi: 10.18632/oncotarget.6320. PMID: 26575171; PMCID: PMC4823037.CrossRefGoogle ScholarPubMed
Omuro, A, Brandes, AA, Carpentier, AF, Idbaih, A, Reardon, DA, Cloughesy, T, Sumrall, A, Baehring, J, van den Bent, M, Bähr, O, Lombardi, G, Mulholland, P, Tabatabai, G, Lassen, U, Sepulveda, JM, Khasraw, M, Vauleon, E, Muragaki, Y, Di Giacomo, AM, Butowski, N, Roth, P, Qian, X, Fu, AZ, Liu, Y, Potter, V, Chalamandaris, AG, Tatsuoka, K, Lim, M, Weller, M. Radiotherapy combined with nivolumab or temozolomide for newly diagnosed glioblastoma with unmethylated MGMT promoter: An international randomized phase III trial. Neuro Oncol. 2023 Jan;25(1):123–34. doi: 10.1093/neuonc/noac099. PMID: 35419607; PMCID: PMC9825306.CrossRefGoogle ScholarPubMed
Hegi, ME, Diserens, AC, Gorlia, T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. New Engl J Med. 2005;352:997–1003.10.1056/NEJMoa043331CrossRefGoogle ScholarPubMed
Stupp, R, Hegi, ME, Mason, WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomized phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009; 10:459–66.10.1016/S1470-2045(09)70025-7CrossRefGoogle Scholar
Gilbert, MR, Wang, M, Aldape, KD, et al. Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial. J Clin Oncol 2013;31:4085–91.10.1200/JCO.2013.49.6968CrossRefGoogle ScholarPubMed
Zhuang, HQ, Bo, QF, Yuan, ZY, Wang, J, Zhao, LJ, Wang, P. The different radiosensitivity when combining erlotinib with radiation at different administration schedules might be related to activity variations in c-MET-PI3 K-AKT signal transduction. Onco Targets Ther. 2013 May;6:603–8. doi: 10.2147/OTT.S44505. PMID: 23745052; PMCID: PMC3671795.Google Scholar
Mellinghoff, IK, Wang, MY, Vivanco, I, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. New Engl J Med. 2005;353(19):2012–24.10.1056/NEJMoa051918CrossRefGoogle ScholarPubMed
Prados, MD, Chang, SM, Butowski, N, et al. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J Clin Oncol. 2009;27:579–84.10.1200/JCO.2008.18.9639CrossRefGoogle ScholarPubMed
Mathen, P, Rowe, L, Mackey, M, Smart, D, Tofilon, P, Camphausen, K. Radiosensitizers in the temozolomide era for newly diagnosed glioblastoma. Neurooncol Pract. 2020 Jun;7(3):268–76. doi: 10.1093/nop/npz057. Epub 2019 Nov 30. PMID: 32537176; PMCID: PMC7274183.Google ScholarPubMed
Matsui, JK, Perlow, HK, Ritter, AR, Upadhyay, R, Raval, RR, Thomas, EM, Beyer, SJ, Pillainayagam, C, Goranovich, J, Ong, S, Giglio, P, Palmer, JD. Small molecules and immunotherapy agents for enhancing radiotherapy in glioblastoma. Biomedicines. 2022 Jul;10(7):1763. doi: 10.3390/biomedicines10071763. PMID: 35885067; PMCID: PMC9313399.CrossRefGoogle ScholarPubMed
Sim, HW, Galanis, E, Khasraw, M. PARP inhibitors in glioma: a review of therapeutic opportunities. Cancers (Basel). 2022 Feb;14(4):1003. doi: 10.3390/cancers14041003. PMID: 35205750; PMCID: PMC8869934.CrossRefGoogle ScholarPubMed
Tancredi, A, Gusyatiner, O, Bady, P, Buri, MC, Lomazzi, R, Chiesi, D, Messerer, M, Hegi, ME. BET protein inhibition sensitizes glioblastoma cells to temozolomide treatment by attenuating MGMT expression. Cell Death Dis. 2022 Dec;13(12):1037. doi: 10.1038/s41419-022-05497-y. PMID: 36513631; PMCID: PMC9747918.CrossRefGoogle ScholarPubMed
Jenkins, EPW, Finch, A, Gerigk, M, Triantis, IF, Watts, C, Malliaras, GG. Electrotherapies for glioblastoma. Adv Sci (Weinh). 2021 Sep;8(18):e2100978. doi: 10.1002/advs.202100978. Epub 2021 Jul 22. PMID: 34292672; PMCID: PMC8456216.Google ScholarPubMed
Fabian, D, Guillermo Prieto Eibl, MDP, Alnahhas, I, Sebastian, N, Giglio, P, Puduvalli, V, Gonzalez, J, Palmer, JD. Treatment of glioblastoma (GBM) with the addition of tumor-treating fields (TTF): a review. Cancers (Basel). 2019 Feb;11(2):174. doi: 10.3390/cancers11020174. PMID: 30717372; PMCID: PMC6406491.CrossRefGoogle ScholarPubMed
Clontz, AD. Ketogenic therapies for glioblastoma: understanding the limitations in transitioning from mice to patients. Front Nutr. 2023 Mar;10:1110291. doi: 10.3389/fnut.2023.1110291. PMID: 36960210; PMCID: PMC10029602.CrossRefGoogle ScholarPubMed
Woolf, EC, Scheck, AC. The ketogenic diet for the treatment of malignant glioma. J Lipid Res. 2015 Jan;56(1):5–10. doi: 10.1194/jlr.R046797. Epub 2014 Feb 6. PMID: 24503133; PMCID: PMC4274070.CrossRefGoogle ScholarPubMed
Kut, C, Kleinberg, L. Radiotherapy, lymphopenia and improving the outcome for glioblastoma: a narrative review. Chin Clin Oncol. 2023 Feb;12(1):4. doi: 10.21037/cco-22-94. PMID: 36922353.CrossRefGoogle ScholarPubMed
Martikainen, M, Essand, M. Virus-based immunotherapy of glioblastoma. Cancers (Basel). 2019 Feb;11(2):186. doi: 10.3390/cancers11020186. PMID: 30764570; PMCID: PMC6407011.CrossRefGoogle ScholarPubMed
Storozynsky, QT, Agopsowicz, KC, Noyce, RS, Bukhari, AB, Han, X, Snyder, N, Umer, BA, Gamper, AM, Godbout, R, Evans, DH, Hitt, MM. Radiation combined with oncolytic vaccinia virus provides pronounced antitumor efficacy and induces immune protection in an aggressive glioblastoma model. Cancer Lett. 2023 May;562:216169. doi: 10.1016/j.canlet.2023.216169. Epub 2023 Apr 14. PMID: 37061120.CrossRefGoogle Scholar
Martinez-Velez, N, Marigil, M, García-Moure, M, Gonzalez-Huarriz, M, Aristu, JJ, Ramos-García, LI, Tejada, S, Díez-Valle, R, Patiño-García, A, Becher, OJ, Gomez-Manzano, C, Fueyo, J, Alonso, MM. Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models. Acta Neuropathol Commun. 2019 Apr;7(1):64. doi: 10.1186/s40478-019-0714-6. PMID: 31036068; PMCID: PMC6487528.CrossRefGoogle ScholarPubMed
Hainfeld, JF, Slatkin, DN, Smilowitz, HM. The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol. 2004;49(18):N309-N315. doi:10.1088/0031-9155/49/18/N09.CrossRefGoogle ScholarPubMed
Li, R, Wang, H, Liang, Q, Chen, L, Ren, J. Radiotherapy for glioblastoma: clinical issues and nanotechnology strategies. Biomater Sci. 2022 Feb;10(4):892–908. doi: 10.1039/d1bm01401 c. PMID: 34989724.CrossRefGoogle ScholarPubMed

References

Meng, Y., Hynynen, K. & Lipsman, N. Applications of focused ultrasound in the brain: from thermoablation to drug delivery. Nature Rev Neurol 17, 7–22 (2020).10.1038/s41582-020-00418-zCrossRefGoogle ScholarPubMed
Dubinsky, T. J., Cuevas, C., Dighe, M. K., Kolokythas, O. & Joo, H. H. High-intensity focused ultrasound: current potential and oncologic applications. AJR Am J Roentgenol 190, 191–9 (2008).10.2214/AJR.07.2671CrossRefGoogle ScholarPubMed
Izadifar, Z., Izadifar, Z., Chapman, D. & Babyn, P. An introduction to high intensity focused ultrasound: systematic review on principles, devices, and clinical applications. J Clin Med 9, 460 (2020).10.3390/jcm9020460CrossRefGoogle ScholarPubMed
Lipsman, N., Mainprize, T. G., Schwartz, M. L., Hynynen, K. & Lozano, A. M. Intracranial applications of magnetic resonance-guided focused ultrasound. Neurotherapeutics 11, 593–605 (2014).10.1007/s13311-014-0281-2CrossRefGoogle ScholarPubMed
Yoo, S., Mittelstein, D. R., Hurt, R. C., Lacroix, J. & Shapiro, M. G. Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification. Nature Commun 13, 1–13 (2022).10.1038/s41467-022-28040-1CrossRefGoogle ScholarPubMed
Nelson, E., Lindstrom, P. A. & Haymaker, W. Pathological effects of ultrasound on the human brain. A study of 25 cases in which ultrasonic irradiation was used as a lobotomy procedure. J Neuropathol Exp Neurol 18, 489–508 (1959).10.1097/00005072-195910000-00001CrossRefGoogle ScholarPubMed
MEYERS, R. et al. Early experiences with ultrasonic irradiation of the pallidofugal and nigral complexes in hyperkinetic and hypertonic disorders. J Neurosurg 16, 32–54 (1959).10.3171/jns.1959.16.1.0032CrossRefGoogle ScholarPubMed
Rosnitskiy, P. B., Vysokanov, B. A., Gavrilov, L. R., Sapozhnikov, O. A. & Khokhlova, V. A. Method for designing multielement fully populated random phased arrays for ultrasound surgery applications. IEEE Trans Ultrason Ferroelectr Freq Control 65, 630–7 (2018).10.1109/TUFFC.2018.2800160CrossRefGoogle ScholarPubMed
Asquier, N. et al. Blood–brain barrier disruption in humans using an implantable ultrasound device: quantification with MR images and correlation with local acoustic pressure. J Neurosurg 132, 875–83 (2019).Google ScholarPubMed
Gionso, M. et al. Focused ultrasound for brain diseases: a review of current applications and future perspectives. IRBM 44, 100790 (2023).10.1016/j.irbm.2023.100790CrossRefGoogle Scholar
Jagannathan, J. et al. High-intensity focused ultrasound surgery of the brain: Part 1 – A historical perspective with modern applications. Neurosurgery 64, 201–10 (2009).10.1227/01.NEU.0000336766.18197.8ECrossRefGoogle Scholar
Hynynen, K. MRI-guided focused ultrasound treatments. Ultrasonics 50, 221–9 (2010).10.1016/j.ultras.2009.08.015CrossRefGoogle ScholarPubMed
Bjartmarz, H. & Rehncrona, S. Comparison of accuracy and precision between frame-based and frameless stereotactic navigation for deep brain stimulation electrode implantation. Stereotact Funct Neurosurg 85, 235–42 (2007).10.1159/000103262CrossRefGoogle ScholarPubMed
Meng, Y. et al. Technical principles and clinical workflow of transcranial MR-guided focused ultrasound. Stereotact Funct Neurosurg 99, 329–42 (2021).10.1159/000512111CrossRefGoogle ScholarPubMed
Chen, K. T. et al. Neuronavigation-guided focused ultrasound for transcranial blood–brain barrier opening and immunostimulation in brain tumors. Sci Adv 7, (2021).Google ScholarPubMed
Medel, R. et al. Magnetic resonance guided focused ultrasound surgery: Part 2 – A review of current and future applications. Neurosurgery 71, 755 (2012).10.1227/NEU.0b013e3182672ac9CrossRefGoogle Scholar
Meng, Y. et al. Current and emerging brain applications of MR-guided focused ultrasound. J Ther Ultrasound 5, 1–9 (2017).10.1186/s40349-017-0105-zCrossRefGoogle ScholarPubMed
Hynynen, K. & MacDannold, N. MRI guided and monitored focused ultrasound thermal ablation methods: a review of progress. Int J Hyperthermia 20, 725–37 (2004).10.1080/02656730410001716597CrossRefGoogle ScholarPubMed
Jameel, A., Bain, P., Nandi, D., Jones, B. & Gedroyc, W. Device profile of exAblate Neuro 4000, the leading system for brain magnetic resonance guided focused ultrasound technology: an overview of its safety and efficacy in the treatment of medically refractory essential tremor. Expert Rev Med Devices 18, 429–37 (2021).10.1080/17434440.2021.1921572CrossRefGoogle ScholarPubMed
Jolesz, F. A., Hynynen, K., McDannold, N. & Tempany, C. MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery. Magn Reson Imaging Clin N Am 13, 545–60 (2005).10.1016/j.mric.2005.04.008CrossRefGoogle ScholarPubMed
Rivens, I., Shaw, A., Civale, J. & Morris, H. Treatment monitoring and thermometry for therapeutic focused ultrasound. Int J Hyperthermia 23, 121–39 (2007).10.1080/02656730701207842CrossRefGoogle ScholarPubMed
Martin, E., Jeanmonod, D., Morel, A., Zadicario, E. & Werner, B. High-intensity focused ultrasound for noninvasive functional neurosurgery. Ann Neurol 66, 858–61 (2009).10.1002/ana.21801CrossRefGoogle ScholarPubMed
Joutsa, J., Lipsman, N., Horn, A., Cosgrove, G. R. & Fox, M. D. The return of the lesion for localization and therapy. Brain 146, 3146–55 (2023).10.1093/brain/awad123CrossRefGoogle ScholarPubMed
Iorio-Morin, C., Hodaie, M. & Lozano, A. M. Adoption of focused ultrasound thalamotomy for essential tremor: why so much fuss about FUS? J Neurol Neurosurg Psychiatry 92, 549–54 (2021).10.1136/jnnp-2020-324061CrossRefGoogle ScholarPubMed
Boutet, A. et al. The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasound. J Neurosurg 132, 1785–91 (2019).Google ScholarPubMed
Schwartz, M. L. et al. Skull bone marrow injury caused by MR-guided focused ultrasound for cerebral functional procedures. J Neurosurg 130, 758–62 (2018).Google ScholarPubMed
Tierney, T. S. et al. Initial experience with magnetic resonance-guided focused ultrasound stereotactic surgery for central brain lesions in young adults. J Neurosurg 137, 760–7 (2022).10.3171/2021.10.JNS21416CrossRefGoogle ScholarPubMed
Yamaguchi, T. et al. Magnetic resonance–guided focused ultrasound ablation of hypothalamic hamartoma as a disconnection surgery: a case report. Acta Neurochir (Wien) 162, 2513–17 (2020).10.1007/s00701-020-04468-6CrossRefGoogle ScholarPubMed
Chang, K. W. et al. Safety and efficacy of magnetic resonance-guided focused ultrasound surgery with autofocusing echo imaging. Front Neurosci 14, 592763 (2021).10.3389/fnins.2020.592763CrossRefGoogle ScholarPubMed
Davidson, B. et al. Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials. Molec Psychiatry 25, 1946–57 (2020).10.1038/s41380-020-0737-1CrossRefGoogle ScholarPubMed
Behnsen, G. Über die Farbstoffspeicherung im Zentralnervensystem der weissen Maus in verschiedenen Alterszuständen. Zeitschr Zellforsch Mikroskopische Anatomie 4, 515–72 (1927).Google Scholar
Banks, W. A. From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery. Nature Rev Drug Discov 15, 275–92 (2016).10.1038/nrd.2015.21CrossRefGoogle ScholarPubMed
Terstappen, G. C., Meyer, A. H., Bell, R. D. & Zhang, W. Strategies for delivering therapeutics across the blood–brain barrier. Nature Rev Drug Discov 20, 362–83 (2021).10.1038/s41573-021-00139-yCrossRefGoogle ScholarPubMed
Xiong, B. et al. Strategies for structural modification of small molecules to improve blood-brain barrier penetration: a recent perspective. J Med Chem 64, 13152–73 (2021).10.1021/acs.jmedchem.1c00910CrossRefGoogle ScholarPubMed
Saraiva, C. et al. Nanoparticle-mediated brain drug delivery: overcoming blood–brain barrier to treat neurodegenerative diseases. J Control Release 235, 34–47 (2016).10.1016/j.jconrel.2016.05.044CrossRefGoogle ScholarPubMed
Wu, D. et al. The blood–brain barrier: structure, regulation, and drug delivery. Signal Transduct Target Ther 8, 1–27 (2023).Google ScholarPubMed
Li, J. et al. Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier. Adv Sci 8, 2101090 (2021).10.1002/advs.202101090CrossRefGoogle ScholarPubMed
Arvanitis, C. D., Ferraro, G. B. & Jain, R. K. The blood–brain barrier and blood–tumour barrier in brain tumours and metastases. Nature Rev Cancer 20, 26–41 (2019).10.1038/s41568-019-0205-xCrossRefGoogle ScholarPubMed
Darrow, D. P. Focused ultrasound for neuromodulation. Neurotherapeutics 16, 88 (2019).10.1007/s13311-018-00691-3CrossRefGoogle ScholarPubMed
Chen, S. et al. A review of bioeffects induced by focused ultrasound combined with microbubbles on the neurovascular unit. J Cerebr Blood Flow Metabol 42, 3 (2022).10.1177/0271678X211046129CrossRefGoogle ScholarPubMed
Lipsman, N. et al. Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound. Nature Commun 9, 1–8 (2018).10.1038/s41467-018-04529-6CrossRefGoogle ScholarPubMed
Gasca-Salas, C. et al. Blood–brain barrier opening with focused ultrasound in Parkinson’s disease dementia. Nature Commun 2021 12, 1–7 (2021).Google ScholarPubMed
Meng, Y. et al. Safety and efficacy of focused ultrasound induced blood–brain barrier opening, an integrative review of animal and human studies. J Control Release 309, 25–36 (2019).10.1016/j.jconrel.2019.07.023CrossRefGoogle ScholarPubMed
Sassaroli, E. & Hynynen, K. Cavitation threshold of microbubbles in gel tunnels by focused ultrasound. Ultrasound Med Biol 33, 1651–60 (2007).10.1016/j.ultrasmedbio.2007.04.018CrossRefGoogle ScholarPubMed
Pouliopoulos, A. N. et al. A clinical system for non-invasive blood–brain barrier opening using a neuronavigation-guided single-element focused ultrasound transducer. Ultrasound Med Biol 46, 73–89 (2020).10.1016/j.ultrasmedbio.2019.09.010CrossRefGoogle ScholarPubMed
Arvanitis, C. D., Livingstone, M. S., Vykhodtseva, N. & McDannold, N. Controlled ultrasound-induced blood-brain barrier disruption using passive acoustic emissions monitoring. PLoS One 7, 45783 (2012).10.1371/journal.pone.0045783CrossRefGoogle ScholarPubMed
Jones, R. M. et al. Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening. Theranostics 8, 2909 (2018).10.7150/thno.24911CrossRefGoogle ScholarPubMed
Meng, Y. et al. MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases. Sci Transl Med 13, (2021).10.1126/scitranslmed.abj4011CrossRefGoogle ScholarPubMed
Mainprize, T. et al. Blood-brain barrier opening in primary brain tumors with non-invasive MR-guided focused ultrasound: a clinical safety and feasibility study. Scientif Rep 9, 1–7 (2019).Google ScholarPubMed
Cao, Y. et al. Use of magnetic resonance imaging to assess blood–brain/blood–glioma barrier opening during conformal radiotherapy. J Clin Oncol 23, 4127–36 (2005).10.1200/JCO.2005.07.144CrossRefGoogle ScholarPubMed
Karakatsani, M. E., Blesa, J. & Konofagou, E. E. Blood–brain barrier opening with focused ultrasound in experimental models of Parkinson’s disease. Movement Disorders 34, 1252–61 (2019).10.1002/mds.27804CrossRefGoogle ScholarPubMed
LeWitt, P. A., Lipsman, N. & Kordower, J. H. Focused ultrasound opening of the blood–brain barrier for treatment of Parkinson’s disease. Move Disord 34, 1274–8 (2019).10.1002/mds.27722CrossRefGoogle ScholarPubMed
Gasca-Salas, C. et al. Blood–brain barrier opening with focused ultrasound in Parkinson’s disease dementia. Nature Commun 12, 1–7 (2021).10.1038/s41467-021-21022-9CrossRefGoogle ScholarPubMed
Abrahao, A. et al. First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nature Commun 10, 1–9 (2019).10.1038/s41467-019-12426-9CrossRefGoogle ScholarPubMed
Meng, Y. et al. MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors. Neuro Oncol 23, 1789–97 (2021).10.1093/neuonc/noab057CrossRefGoogle ScholarPubMed
Park, S. H. et al. One-year outcome of multiple blood–brain barrier disruptions with temozolomide for the treatment of glioblastoma. Front Oncol 10, 565579 (2020).10.3389/fonc.2020.01663CrossRefGoogle ScholarPubMed
Wei, H. J. et al. Focused ultrasound-mediated blood-brain barrier opening increases delivery and efficacy of etoposide for glioblastoma treatment. Int J Radiat Oncol Biol Phys 110, 539 (2021).10.1016/j.ijrobp.2020.12.019CrossRefGoogle ScholarPubMed
Meng, Y. et al. Putaminal recombinant glucocerebrosidase delivery with magnetic resonance-guided focused ultrasound in parkinson’s disease: a phase I study. Move Disord 37, 2134–9 (2022).10.1002/mds.29190CrossRefGoogle ScholarPubMed
’t Hart, E. et al. Radiosensitisation by olaparib through focused ultrasound delivery in a diffuse midline glioma model. J Control Release 357, 287–98 (2023).10.1016/j.jconrel.2023.03.058CrossRefGoogle Scholar
Meng, Y. et al. Current state of therapeutic focused ultrasound applications in neuro-oncology. J Neurooncol 156, 49–59 (2022).10.1007/s11060-021-03861-0CrossRefGoogle ScholarPubMed
Bonosi, L. et al. Sonodynamic therapy and magnetic resonance-guided focused ultrasound: new therapeutic strategy in glioblastoma. J Neuro-Oncol 163, 219–38 (2023).10.1007/s11060-023-04333-3CrossRefGoogle ScholarPubMed
Jagannathan, J. et al. High-intensity focused ultrasound surgery of the brain: part 1 – A historical perspective with modern applications. Neurosurgery 64(2), 201–10 (2009).10.1227/01.NEU.0000336766.18197.8ECrossRefGoogle Scholar
Baek, H. et al. Clinical intervention using focused ultrasound (FUS) stimulation of the brain in diverse neurological disorders. Front Neurol 9:13:880814 (2022).Google Scholar
Kook, G et al. Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography. Nature Microsyst Nanoengineer 9:45 (2023).Google ScholarPubMed
Rezai, A et al. Noninvasive hippocampal blood−brain barrier opening in Alzheimer’s disease with focused ultrasound. PNAS 117(17):9180–2 (2020).10.1073/pnas.2002571117CrossRefGoogle ScholarPubMed

References

Franzini, A, Moosa, S, Servello, D, Small, I, DiMeco, F, Xu, Z, et al. Ablative brain surgery: an overview. Int J Hyperthermia. 2019; 36(2):64–80.10.1080/02656736.2019.1616833CrossRefGoogle ScholarPubMed
Rosomoff, HL, Carroll, F. Reaction of neoplasm and brain to laser. Arch Neurol. 1966; 14(2):143–8.10.1001/archneur.1966.00470080027004CrossRefGoogle ScholarPubMed
Tew, JM, Jr., Tobler, WD. The laser: history, biophysics, and neurosurgical applications. Clin Neurosurg. 1983; 31:506–49.Google ScholarPubMed
Jain, KK. Lasers in neurosurgery: a review. Lasers Surg Med. 1983; 2(3):217–30.10.1002/lsm.1900020305CrossRefGoogle ScholarPubMed
Belykh, E, Yagmurlu, K, Martirosyan, NL, Lei, T, Izadyyazdanabadi, M, Malik, KM, et al. Laser application in neurosurgery. Surg Neurol Int. 2017; 8:274.Google ScholarPubMed
Leuthardt, EC, Duan, C, Kim, MJ, Campian, JL, Kim, AH, Miller-Thomas, MM, et al. Hyperthermic laser ablation of recurrent glioblastoma leads to temporary disruption of the peritumoral blood brain barrier. PLoS One. 2016; 11(2):e0148613.10.1371/journal.pone.0148613CrossRefGoogle ScholarPubMed
Keisari, Y. Tumor abolition and antitumor immunostimulation by physico-chemical tumor ablation. Front Biosci (Landmark Ed). 2017; 22(2):310–47.10.2741/4487CrossRefGoogle ScholarPubMed
Sutton, CH. Tumor hyperthermia in the treatment of malignant gliomas of the brain. Trans Am Neurol Assoc. 1971; 96:195–9.Google ScholarPubMed
Bown, SG. Phototherapy in tumors. World J Surg. 1983; 7(6):700–9.10.1007/BF01655209CrossRefGoogle ScholarPubMed
Sugiyama, K, Sakai, T, Fujishima, I, Ryu, H, Uemura, K, Yokoyama, T. Stereotactic interstitial laser-hyperthermia using Nd-YAG laser. Stereotact Funct Neurosurg. 1990; 54– 55:501–5.Google Scholar
Jolesz, FA, Bleier, AR, Jakab, P, Ruenzel, PW, Huttl, K, Jako, GJ. MR imaging of laser-tissue interactions. Radiology. 1988; 168(1):249–53.10.1148/radiology.168.1.3380968CrossRefGoogle ScholarPubMed
Tracz, RA, Wyman, DR, Little, PB, Towner, RA, Stewart, WA, Schatz, SW, et al. Magnetic resonance imaging of interstitial laser photocoagulation in brain. Lasers Surg Med. 1992; 12(2):165–73.10.1002/lsm.1900120209CrossRefGoogle ScholarPubMed
De Poorter, J, De Wagter, C, De Deene, Y, Thomsen, C, Stahlberg, F, Achten, E. Noninvasive MRI thermometry with the proton resonance frequency (PRF) method: in vivo results in human muscle. Magn Reson Med. 1995; 33(1):74–81.10.1002/mrm.1910330111CrossRefGoogle ScholarPubMed
Thomsen, S. Pathologic analysis of photothermal and photomechanical effects of laser-tissue interactions. Photochem Photobiol. 1991; 53(6):825–35.10.1111/j.1751-1097.1991.tb09897.xCrossRefGoogle ScholarPubMed
Kahn, T, Bettag, M, Ulrich, F, Schwarzmaier, HJ, Schober, R, Furst, G, et al. MRI-guided laser-induced interstitial thermotherapy of cerebral neoplasms. J Comput Assist Tomogr. 1994; 18(4):519–32.10.1097/00004728-199407000-00002CrossRefGoogle ScholarPubMed
Schwabe, B, Kahn, T, Harth, T, Ulrich, F, Schwarzmaier, HJ. Laser-induced thermal lesions in the human brain: short- and long-term appearance on MRI. J Comput Assist Tomogr. 1997; 21(5):818–25.10.1097/00004728-199709000-00031CrossRefGoogle Scholar
Missios, S, Bekelis, K, Barnett, GH. Renaissance of laser interstitial thermal ablation. Neurosurg Focus. 2015; 38(3):E13.10.3171/2014.12.FOCUS14762CrossRefGoogle ScholarPubMed
Tyc, R. Magnetic resonance-guided interstitial thermal therapy: historical perspectives and overview of the principles of LITT. In: Chiang, V, editor. Laser Interstitial Thermal Therapy in Neurosurgery: Springer International Publishing; 2020. p. 7.Google Scholar
Awad, AJ, Nguyen, HS, Arocho-Quinones, E, Doan, N, Mueller, W, Lew, SM. Stereotactic laser ablation of amygdala and hippocampus using a Leksell stereotactic frame. Neurosurg Focus. 2018; 44(VideoSuppl2):V1.10.3171/2018.4.FocusVid.17712CrossRefGoogle ScholarPubMed
Patel, NV, Mian, M, Stafford, RJ, Nahed, BV, Willie, JT, Gross, RE, et al. Laser interstitial thermal therapy technology, physics of magnetic resonance imaging thermometry, and technical considerations for proper catheter placement during magnetic resonance imaging-guided laser interstitial thermal therapy. Neurosurgery. 2016; 79 Suppl 1:S8–16.10.1227/NEU.0000000000001440CrossRefGoogle ScholarPubMed
D’Haese, PF, Pallavaram, S, Konrad, PE, Neimat, J, Fitzpatrick, JM, Dawant, BM. Clinical accuracy of a customized stereotactic platform for deep brain stimulation after accounting for brain shift. Stereotact Funct Neurosurg. 2010; 88(2):81–7.10.1159/000271823CrossRefGoogle ScholarPubMed
Patel, NV. Technical considerations for LITT: getting through the procedure. In: Chiang, V, editor. Laser Interstitial Thermal Therapy in Neurosurgery: Springer International Publishing; 2020. pp. 20–1.Google Scholar
Tovar-Spinoza, Z, Choi, H. MRI-guided laser interstitial thermal therapy for the treatment of low-grade gliomas in children: a case-series review, description of the current technologies and perspectives. Childs Nerv Syst. 2016; 32(10):1947–56.10.1007/s00381-016-3193-0CrossRefGoogle Scholar
Hooten, KG, Werner, K, Mikati, MA, Muh, CR. MRI-guided laser interstitial thermal therapy in an infant with tuberous sclerosis: technical case report. J Neurosurg Pediatr. 2018; 23(1):92–7.Google Scholar
Miller, BA, Salehi, A, Limbrick, DD, Jr., Smyth, MD. Applications of a robotic stereotactic arm for pediatric epilepsy and neurooncology surgery. J Neurosurg Pediatr. 2017; 20(4):364–70.10.3171/2017.5.PEDS1782CrossRefGoogle ScholarPubMed
Sneed, PK, Mendez, J, Vemer-van den Hoek, JG, Seymour, ZA, Ma, L, Molinaro, AM, et al. Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors. J Neurosurg. 2015; 123(2):373–86.10.3171/2014.10.JNS141610CrossRefGoogle ScholarPubMed
Ahluwalia, M, Barnett, GH, Deng, D, Tatter, SB, Laxton, AW, Mohammadi, AM, et al. Laser ablation after stereotactic radiosurgery: a multicenter prospective study in patients with metastatic brain tumors and radiation necrosis. J Neurosurg. 2018; 130(3):804–11.Google ScholarPubMed
Alattar, AA, Bartek, J, Jr., Chiang, VL, Mohammadi, AM, Barnett, GH, Sloan, A, et al. Stereotactic laser ablation as treatment of brain metastases recurring after stereotactic radiosurgery: a systematic literature review. World Neurosurg. 2019; 128:134–42.10.1016/j.wneu.2019.04.200CrossRefGoogle ScholarPubMed
Hong, CS, Deng, D, Vera, A, Chiang, VL. Laser-interstitial thermal therapy compared to craniotomy for treatment of radiation necrosis or recurrent tumor in brain metastases failing radiosurgery. J Neurooncol. 2019; 142(2):309–17.10.1007/s11060-019-03097-zCrossRefGoogle ScholarPubMed
Sujijantarat, N, Hong, CS, Owusu, KA, Elsamadicy, AA, Antonios, JP, Koo, AB, et al. Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases. J Neurooncol. 2020; 148(3):641–9.10.1007/s11060-020-03570-0CrossRefGoogle ScholarPubMed
Grabowski, MM, Srinivasan, ES, Vaios, EJ, Sankey, EW, Otvos, B, Krivosheya, D, et al. Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases. Neurooncol Adv. 2022; 4(1):vdac086.Google ScholarPubMed
Chan, M, Tatter, S, Chiang, V, Fecci, P, Strowd, R, Prabhu, S, et al. Efficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases. Neurooncol Adv. 2023; 5(1):vdad031.Google ScholarPubMed
Ostrom, QT, Cioffi, G, Waite, K, Kruchko, C, Barnholtz-Sloan, JS. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014–2018. Neuro Oncol. 2021; 23(12 Suppl 2):iii1–105.10.1093/neuonc/noab200CrossRefGoogle ScholarPubMed
Stupp, R, Hegi, ME, Mason, WP, van den Bent, MJ, Taphoorn, MJ, Janzer, RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009; 10(5):459–66.10.1016/S1470-2045(09)70025-7CrossRefGoogle Scholar
Stupp, R, Mason, WP, van den Bent, MJ, Weller, M, Fisher, B, Taphoorn, MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005; 352(10):987–96.10.1056/NEJMoa043330CrossRefGoogle ScholarPubMed
Lacroix, M, Abi-Said, D, Fourney, DR, Gokaslan, ZL, Shi, W, DeMonte, F, et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg. 2001; 95(2):190–8.10.3171/jns.2001.95.2.0190CrossRefGoogle ScholarPubMed
Sanai, N, Polley, MY, McDermott, MW, Parsa, AT, Berger, MS. An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg. 2011; 115(1):3–8.10.3171/2011.2.JNS10998CrossRefGoogle ScholarPubMed
Wilson, CB. Glioblastoma: the past, the present, and the future. Clin Neurosurg. 1992; 38:32–48.Google ScholarPubMed
Mohammadi, AM, Sharma, M, Beaumont, TL, Juarez, KO, Kemeny, H, Dechant, C, et al. Upfront magnetic resonance imaging-guided stereotactic laser-ablation in newly diagnosed glioblastoma: a multicenter review of survival outcomes compared to a matched cohort of biopsy-only patients. Neurosurgery. 2019; 85(6):762–72.10.1093/neuros/nyy449CrossRefGoogle ScholarPubMed
Ivan, ME, Mohammadi, AM, De Deugd, N, Reyes, J, Rodriguez, G, Shah, A, et al. Laser ablation of newly diagnosed malignant gliomas: a meta-analysis. Neurosurgery. 2016; 79 Suppl 1:S17–23.10.1227/NEU.0000000000001446CrossRefGoogle ScholarPubMed
Mohammadi, AM, Hawasli, AH, Rodriguez, A, Schroeder, JL, Laxton, AW, Elson, P, et al. The role of laser interstitial thermal therapy in enhancing progression-free survival of difficult-to-access high-grade gliomas: a multicenter study. Cancer Med. 2014; 3(4):971–9.10.1002/cam4.266CrossRefGoogle ScholarPubMed
Beaumont, TL, Mohammadi, AM, Kim, AH, Barnett, GH, Leuthardt, EC. Magnetic resonance imaging-guided laser interstitial thermal therapy for glioblastoma of the corpus callosum. Neurosurgery. 2018; 83(3):556–65.10.1093/neuros/nyx518CrossRefGoogle ScholarPubMed
Chaichana, KL, Jusue-Torres, I, Lemos, AM, Gokaslan, A, Cabrera-Aldana, EE, Ashary, A, et al. The butterfly effect on glioblastoma: is volumetric extent of resection more effective than biopsy for these tumors? J Neurooncol. 2014; 120(3):625–34.10.1007/s11060-014-1597-9CrossRefGoogle ScholarPubMed
Sloan, AE, Ahluwalia, MS, Valerio-Pascua, J, Manjila, S, Torchia, MG, Jones, SE, et al. Results of the NeuroBlate System first-in-humans phase I clinical trial for recurrent glioblastoma: clinical article. J Neurosurg. 2013; 118(6):1202–19.10.3171/2013.1.JNS1291CrossRefGoogle ScholarPubMed
Lee, I, Kalkanis, S, Hadjipanayis, CG. Stereotactic laser interstitial thermal therapy for recurrent high-grade gliomas. Neurosurgery. 2016; 79 Suppl 1:S24–34.10.1227/NEU.0000000000001443CrossRefGoogle ScholarPubMed
O’Halloran, PJ, Henry, J, Amoo, M, Kalyvas, A, Mohan, N, Zadeh, G, et al. LITTing up gliomas – is the future bright? World Neurosurg X. 2023; 17:100136.10.1016/j.wnsx.2022.100136CrossRefGoogle Scholar
de Groot JF, , Kim, AH, Prabhu, S, Rao, G, Laxton, AW, Fecci, PE, et al. Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma. Neurooncol Adv. 2022; 4(1):vdac040.Google ScholarPubMed
Wright, J, Chugh, J, Wright, CH, Alonso, F, Hdeib, A, Gittleman, H, et al. Laser interstitial thermal therapy followed by minimal-access transsulcal resection for the treatment of large and difficult to access brain tumors. Neurosurg Focus. 2016; 41(4):E14.10.3171/2016.8.FOCUS16233CrossRefGoogle ScholarPubMed
Man, J, Shoemake, JD, Ma, T, Rizzo, AE, Godley, AR, Wu, Q, et al. Hyperthermia sensitizes glioma stem-like cells to radiation by inhibiting AKT signaling. Cancer Res. 2015; 75(8):1760–9.10.1158/0008-5472.CAN-14-3621CrossRefGoogle ScholarPubMed
Sadler, RM. The syndrome of mesial temporal lobe epilepsy with hippocampal sclerosis: clinical features and differential diagnosis. Adv Neurol. 2006; 97:27–37.Google ScholarPubMed
Stereotactic Laser Ablation for Temporal Lobe Epilepsy [Internet]. 2016. Available from: classic.clinicaltrials.gov/ct2/show/NCT02844465.Google Scholar
Grobelny, BT. LITT in the treatment of adult epilepsy. In: Chiang, V, editor. Laser Interstitial Thermal Therapy in Neurosurgery: Springer International Publishing; 2020. p. 88.Google Scholar
Wu, C, Boorman, DW, Gorniak, RJ, Farrell, CJ, Evans, JJ, Sharan, AD. The effects of anatomic variations on stereotactic laser amygdalohippocampectomy and a proposed protocol for trajectory planning. Neurosurgery. 2015; 11 Suppl 2:345–56; discussion 56–7.Google Scholar
Jermakowicz, WJ, Kanner, AM, Sur, S, Bermudez, C, D’Haese, PF, Kolcun, JPG, et al. Laser thermal ablation for mesiotemporal epilepsy: analysis of ablation volumes and trajectories. Epilepsia. 2017; 58(5):801–10.10.1111/epi.13715CrossRefGoogle ScholarPubMed
Drane, DL, Willie, JT, Pedersen, NP, Qiu, D, Voets, NL, Millis, SR, et al. Superior verbal memory outcome after stereotactic laser amygdalohippocampotomy. Front Neurol. 2021; 12:779495.10.3389/fneur.2021.779495CrossRefGoogle ScholarPubMed
Lewis, EC, Weil, AG, Duchowny, M, Bhatia, S, Ragheb, J, Miller, I. MR-guided laser interstitial thermal therapy for pediatric drug-resistant lesional epilepsy. Epilepsia. 2015; 56(10):1590–8.10.1111/epi.13106CrossRefGoogle ScholarPubMed
Choi, SA, Kim, SY, Kim, H, Kim, WJ, Kim, H, Hwang, H, et al. Surgical outcome and predictive factors of epilepsy surgery in pediatric isolated focal cortical dysplasia. Epilepsy Res. 2018; 139:54–9.10.1016/j.eplepsyres.2017.11.012CrossRefGoogle ScholarPubMed
Willie, JT, Malcolm, JG, Stern, MA, Lowder, LO, Neill, SG, Cabaniss, BT, et al. Safety and effectiveness of stereotactic laser ablation for epileptogenic cerebral cavernous malformations. Epilepsia. 2019; 60(2):220–32.10.1111/epi.14634CrossRefGoogle ScholarPubMed
Thompson, SA, Kalamangalam, GP, Tandon, N. Intracranial evaluation and laser ablation for epilepsy with periventricular nodular heterotopia. Seizure. 2016; 41:211–16.10.1016/j.seizure.2016.06.019CrossRefGoogle ScholarPubMed
Benabid, AL, Chabardes, S, Torres, N, Piallat, B, Krack, P, Fraix, V, et al. Functional neurosurgery for movement disorders: a historical perspective. Prog Brain Res. 2009; 175:379–91.10.1016/S0079-6123(09)17525-8CrossRefGoogle ScholarPubMed
Weaver, FM, Follett, KA, Stern, M, Luo, P, Harris, CL, Hur, K, et al. Randomized trial of deep brain stimulation for Parkinson disease: thirty-six-month outcomes. Neurology. 2012; 79(1):55–65.10.1212/WNL.0b013e31825dcdc1CrossRefGoogle ScholarPubMed
McLaughlin, NCR, Lauro, PM, Patrick, MT, Pucci, FG, Barrios-Anderson, A, Greenberg, BD, et al. Magnetic resonance imaging-guided laser thermal ventral capsulotomy for intractable obsessive-compulsive disorder. Neurosurgery. 2021; 88(6):1128–35.10.1093/neuros/nyab050CrossRefGoogle ScholarPubMed
Tatsui, CE, Stafford, RJ, Li, J, Sellin, JN, Amini, B, Rao, G, et al. Utilization of laser interstitial thermotherapy guided by real-time thermal MRI as an alternative to separation surgery in the management of spinal metastasis. J Neurosurg Spine. 2015; 23(4):400–11.10.3171/2015.2.SPINE141185CrossRefGoogle Scholar
Tatsui, CE, Belsuzarri, TA, Oro, M, Rhines, LD, Li, J, Ghia, AJ, et al. Percutaneous surgery for treatment of epidural spinal cord compression and spinal instability: technical note. Neurosurg Focus. 2016; 41(4):E2.10.3171/2016.8.FOCUS16175CrossRefGoogle ScholarPubMed
Bastos, DCA, Vega, RA, Traylor, JI, Ghia, AJ, Li, J, Oro, M, et al. Spinal laser interstitial thermal therapy: single-center experience and outcomes in the first 120 cases. J Neurosurg Spine. 2020; 34(3):354–63.Google ScholarPubMed
Miretti, M, González Graglia, MA, Suárez, AI, Prucca, CG. Photodynamic therapy for glioblastoma: a light at the end of the tunnel. J Photochem Photobiol. 2023; 13:100161.10.1016/j.jpap.2023.100161CrossRefGoogle Scholar
Bettag, M, Ulrich, F, Schober, R, Furst, G, Langen, KJ, Sabel, M, et al. Stereotactic laser therapy in cerebral gliomas. Acta Neurochir Suppl (Wien). 1991; 52:81–3.10.1007/978-3-7091-9160-6_23CrossRefGoogle ScholarPubMed
Ascher, PW, Justich, E, Schrottner, O. Interstitial thermotherapy of central brain tumors with the Nd:YAG laser under real-time monitoring by MRI. J Clin Laser Med Surg. 1991; 9(1):79–83.10.1089/clm.1991.9.79CrossRefGoogle Scholar
Roux, FX, Merienne, L, Fallet-Bianco, C, Beuvon, F, Devaux, B, Leriche, B, et al. [Stereotaxic laser interstitial thermotherapy. A new alternative in the therapeutic management of some brain tumors]. Neurochirurgie. 1992; 38(4):238–44.Google ScholarPubMed
Sakai, T, Fujishima, I, Sugiyama, K, Ryu, H, Uemura, K. Interstitial laserthermia in neurosurgery. J Clin Laser Med Surg. 1992; 10(1):37–40.10.1089/clm.1992.10.37CrossRefGoogle ScholarPubMed
Reimer, P, Bremer, C, Horch, C, Morgenroth, C, Allkemper, T, Schuierer, G. MR-monitored LITT as a palliative concept in patients with high grade gliomas: preliminary clinical experience. J Magn Reson Imaging. 1998; 8(1):240–4.10.1002/jmri.1880080140CrossRefGoogle ScholarPubMed
Leonardi, MA, Lumenta, CB, Gumprecht, HK, von Einsiedel GH, , Wilhelm, T. Stereotactic guided laser-induced interstitial thermotherapy (SLITT) in gliomas with intraoperative morphologic monitoring in an open MR-unit. Minim Invasive Neurosurg. 2001; 44(1):37–42.10.1055/s-2001-13581CrossRefGoogle Scholar
Schwarzmaier, HJ, Eickmeyer, F, von Tempelhoff, W, Fiedler, VU, Niehoff, H, Ulrich, SD, et al. MR-guided laser-induced interstitial thermotherapy of recurrent glioblastoma multiforme: preliminary results in 16 patients. Eur J Radiol. 2006; 59(2):208–15.10.1016/j.ejrad.2006.05.010CrossRefGoogle ScholarPubMed
Carpentier, A, McNichols, RJ, Stafford, RJ, Guichard, JP, Reizine, D, Delaloge, S, et al. Laser thermal therapy: real-time MRI-guided and computer-controlled procedures for metastatic brain tumors. Lasers Surg Med. 2011; 43(10):943–50.10.1002/lsm.21138CrossRefGoogle ScholarPubMed
Carpentier, A, McNichols, RJ, Stafford, RJ, Itzcovitz, J, Guichard, JP, Reizine, D, et al. Real-time magnetic resonance-guided laser thermal therapy for focal metastatic brain tumors. Neurosurgery. 2008; 63(1 Suppl 1):ONS21-8; discussion ONS8-9.Google ScholarPubMed
Jethwa, PR, Lee, JH, Assina, R, Keller, IA, Danish, SF. Treatment of a supratentorial primitive neuroectodermal tumor using magnetic resonance-guided laser-induced thermal therapy. J Neurosurg Pediatr. 2011; 8(5):468–75.10.3171/2011.8.PEDS11148CrossRefGoogle ScholarPubMed
Carpentier, A, Chauvet, D, Reina, V, Beccaria, K, Leclerq, D, McNichols, RJ, et al. MR-guided laser-induced thermal therapy (LITT) for recurrent glioblastomas. Lasers Surg Med. 2012; 44(5):361–8.10.1002/lsm.22025CrossRefGoogle ScholarPubMed
Curry, DJ, Gowda, A, McNichols, RJ, Wilfong, AA. MR-guided stereotactic laser ablation of epileptogenic foci in children. Epilepsy Behav. 2012; 24(4):408–14.10.1016/j.yebeh.2012.04.135CrossRefGoogle ScholarPubMed
Rahmathulla, G, Recinos, PF, Valerio, JE, Chao, S, Barnett, GH. Laser interstitial thermal therapy for focal cerebral radiation necrosis: a case report and literature review. Stereotact Funct Neurosurg. 2012; 90(3):192–200.10.1159/000338251CrossRefGoogle ScholarPubMed

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