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Stabilization in a chemotaxis system modelling T-cell dynamics with simultaneous production and consumption of signals

Published online by Cambridge University Press:  18 September 2024

Youshan Tao*
Affiliation:
School of Mathematical Sciences, CMA-Shanghai, Shanghai Jiao Tong University, Shanghai, P.R. China
Michael Winkler
Affiliation:
Institut für Mathematik, Universität Paderborn, Paderborn, Germany
*
Corresponding author: Youshan Tao; Email: taoys@sjtu.edu.cn
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Abstract

In a smoothly bounded domain $\Omega \subset \mathbb{R}^n$, $n\ge 1$, this manuscript considers the homogeneous Neumann boundary problem for the chemotaxis system

\begin{eqnarray*} \left \{ \begin{array}{l} u_t = \Delta u - \nabla \cdot (u\nabla v), \\[5pt] v_t = \Delta v + u - \alpha uv, \end{array} \right . \end{eqnarray*}
with parameter $\alpha \gt 0$ and with coincident production and uptake of attractants, as recently emphasized by Dallaston et al. as relevant for the understanding of T-cell dynamics.

It is shown that there exists $\delta _\star =\delta _\star (n)\gt 0$ such that for any given $\alpha \ge \frac{1}{\delta _\star }$ and for any suitably regular initial data satisfying $v(\cdot, 0)\le \delta _\star$, this problem admits a unique classical solution that stabilizes to the constant equilibrium $(\frac{1}{|\Omega |}\int _\Omega u(\cdot, 0), \, \frac{1}{\alpha })$ in the large time limit.

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Papers
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press