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Attachment security moderates the link between adverse childhood experiences and cellular aging

Published online by Cambridge University Press:  12 December 2017

Or Dagan ,
Arun Asok ,
Howard Steele ,
Miriam Steele  and
Kristin Bernard
Or Dagan*
Affiliation:
New School for Social Research
Arun Asok
Affiliation:
Columbia University Howard Hughes Medical Institute
Howard Steele
Affiliation:
New School for Social Research
Miriam Steele
Affiliation:
New School for Social Research
Kristin Bernard
Affiliation:
Stony Brook University
*
Address correspondence and reprint requests to: Or Dagan, Department of Psychology, New School for Social Research, 80 Fifth Avenue, New York, NY 10003; E-mail: dagao968@newschool.edu.
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Abstract

Exposure to childhood adversity has been linked to accelerated telomere shortening, a marker of cellular aging and an indicator of physical health risk. In the current study, we examined whether adult attachment representation moderated the association between childhood adversity and telomere length. Participants included 78 young adults (M age = 20.46, SD = 1.57), who reported on their exposure to adverse childhood experiences (ACE) and were administered the Adult Attachment Interview, which was coded for attachment state of mind. Relative telomere length was assayed from buccal cells. Multiple regression analyses revealed a significant interaction between attachment state of mind and ACE in predicting telomere length. Whereas the association between number of ACE and telomere length was nonsignificant for secure–autonomous, r (50) = –.15, p = .31, and insecure–preoccupied young adults, r (9) = –.15, p = .71, there was a strong negative association between number of ACE and telomere length for insecure–dismissing young adults, r (19) = –.59, p = .007. This study is novel in demonstrating that attachment may affect biological resilience following childhood adversity, contributing to the growing literature about the role of the quality of early caregiving experiences and their representations in shaping biological processes and physical health.

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Type
Regular Articles
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Development and Psychopathology , Volume 30 , Issue 4 , October 2018 , pp. 1211 - 1223
Copyright
Copyright © Cambridge University Press 2017 

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References

Afifi, T. O., & MacMillan, H. L. (2016). Resilience following child maltreatment: A review of protective factors resilience following child maltreatment. Canadian Journal of Psychiatry, 56, 266–272. doi:10.1016/j.chiabu.2005.11.015 10.1016/0145-2134(96)00062-2Google Scholar
Ainsworth, M. D. S., Blehar, S., Waters, E., & Wall, S. (1978). Patterns of attachment: A psychological study of the Strange Situation. Hillsdale, NJ: Erlbaum.Google Scholar
Ammaniti, M., van IJzendoorn, M. H., Speranza, A. M., & Tambelli, R. (2000). Internal working models of attachment during late childhood and early adolescence: An exploration of stability and change. Attachment and Human Development, 2, 328–346. doi:10.1080/14616730010001587Google Scholar
Asok, A., Bernard, K., Roth, T. L., Rosen, J. B., & Dozier, M. (2013). Parental responsiveness moderates the association between early-life stress and reduced telomere length. Development and Psychopathology, 25, 577–585. doi:10.1017/S0954579413000011Google Scholar
Bahm, N. I. G., Simon-Thomas, E. R., Main, M., & Hesse, E. (2017). Unresolved loss, a risk factor for offspring, predicts event-related potential responses to death-related imagery. Developmental Psychology, 53, 191–199. doi:10.1037/dev0000255Google Scholar
Bakaysa, S. L., Mucci, L. A., Slagboom, P. E., Boomsma, D. I., Mcclearn, G. E., Johansson, B., & Pedersen, N. L. (2007). Telomere length predicts survival independent of genetic influences. Aging Cell, 6, 769–774. doi:10.1111/j.1474-9726.2007.00340.xGoogle Scholar
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2009). The first 10,000 Adult Attachment Interviews: Distributions of adult attachment representations in clinical and non-clinical groups. Attachment and Human Development, 11, 223–263. doi:10.1080/14616730902814762Google Scholar
Barger, S. D., & Cribbet, M. R. (2016). Social support sources matter: Increased cellular aging among adults with unsupportive spouses. Biological Psychology, 115, 43–49. doi:10.1016/j.biopsycho.2016.01.003Google Scholar
Barnett, D., Manly, J. T., & Cicchetti, D. (1993). Defining child maltreatment: The interface between policy and research. In Cicchetti, D. & Toth, S. L. (Eds.), Advances in applied developmental psychology (Vol. 8, pp. 7–73). Norwood, NJ: Ablex.Google Scholar
Beijersbergen, M. D., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., & Juffer, F. (2008). Stress regulation in adolescents: Physiological reactivity during the adult attachment interview and conflict interaction. Child Development, 79, 1707–1720. doi:10.1111/j.1467-8624.2008.01220.xGoogle Scholar
Bernard, K., & Dozier, M. (2010). Examining infants’ cortisol responses to laboratory tasks among children varying in attachment disorganization: Stress reactivity or return to baseline? Developmental Psychology, 46, 1771–1778. doi:10.1037/a0020660Google Scholar
Bowlby, J. (1982). Attachment and loss: Retrospect and prospect. American Journal of Orthopsychiatry, 52, 664–678. doi:10.1111/j.1939-0025.1982.tb01456.xGoogle Scholar
Brody, G. H., Yu, T., Beach, S. R. H., & Philibert, R. A. (2015). Prevention effects ameliorate the prospective association between nonsupportive parenting and diminished telomere length. Prevention Science, 16, 171–180. doi:10.1007/s11121-014-0474-2Google Scholar
Carlson, E. A. (1998). A prospective longitudinal study of attachment disorganization/disorientation. Child Development, 69, 1107–1128. doi:10.2307/1132365Google Scholar
Cassidy, J., Jones, J. D., & Shaver, P. R. (2013). Contributions of attachment theory and research: A framework for future research, translation, and policy. Development and Psychopathology, 25, 1415–1434. doi:10.1017/S0954579413000692Google Scholar
Cawthon, R., Smith, K., O'Brien, E., Sivatchenko, A., & Kerber, R. (2003). Association between telomere length in blood and mortality in people aged 60 years or older. Lancet, 361, 393–395. doi:10.1016/S0140-6736(03)12384-7Google Scholar
Charuvastra, A., & Cloitre, M. (2009). Social bonds and posttraumatic stress disorder. Annual Review of Psychology, 59, 301–328. doi:10.1146/annurev.psych.58.110405.085650.SocialGoogle Scholar
Chen, E., Miller, G. E., Kobor, M. S., & Cole, S. W. (2011). Maternal warmth buffers the effects of low early-life socioeconomic status on pro-inflammatory signaling in adulthood. Molecular Psychiatry, 16, 729–737. doi:10.1038/mp.2010.53Google Scholar
Cicchetti, D., & Blender, J. A. (2006). A multiple-levels-of-analysis perspective on resilience: Implications for the developing brain, neural plasticity, and preventive interventions. Annals of the New York Academy of Sciences, 1094, 248–258. doi:10.1196/annals.1376.029Google Scholar
Cicchetti, D., & Toth, S. (2005). Child maltreatment. Annual Review of Clinical Psychology, 1, 409–437. doi:10.1146/annurev.clinpsy.1.102803.144029Google Scholar
Coan, J. A., Schaefer, H. S., & Davidson, R. J. (2006). Lending a hand of the neural response to threat. Psychological Science, 17, 1032–1039. doi:10.1111/j.1467-9280.2006.01832.xGoogle Scholar
Collins, N. L., & Feeney, B. C. (2000). A safe haven: An attachment theory perspective on support seeking and caregiving in intimate relationships. Journal of Personality and Social Psychology, 78, 1053–1073. doi:10.1037/0022-3514.78.6.1053Google Scholar
Cyr, C., Euser, E. M., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2010). Attachment security and disorganization in maltreating and high-risk families: A series of meta-analyses. Development and Psychopathology, 22, 87–108. doi:10.1017/S0954579409990289Google Scholar
Donovan, A. O., Epel, E., Lin, J., Wolkowitz, O., Cohen, B., Metzler, T., … Thomas, C. (2012). Childhood trauma associated with short leukocyte telomere length in post-traumatic stress disorder. Biological Psychiatry, 70, 465–471. doi:10.1016/j.biopsych.2011.01.035.childhoodGoogle Scholar
Dozier, M., & Kobak, R. R. (1992). Psychophysiology in attachment interviews: Converging evidence for deactivating strategies. Child Development, 63, 1473–1480. doi:10.1111/1467-8624.ep9308195014Google Scholar
Dozier, M., Meade, E. B., & Bernard, K. (2014). Attachment and Biobehavioral Catch-Up: An intervention for parents at risk of maltreating their infants and toddlers. In Timmer, S. & Urquiza, A. (Eds.), Evidence-based approaches for the treatment of child maltreatment (pp. 43–59). New York: Springer.Google Scholar
Dube, S. R., Felitti, V. J., Dong, M., Chapman, D. P., Giles, W. H., & Anda, R. F. (2003). Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: The adverse childhood experiences study. Pediatrics, 111, 564–572. doi:10.1542/peds.111.3.564Google Scholar
Dykas, M. J., & Cassidy, J. (2011). Attachment and the processing of social information across the life span: Theory and evidence. Psychological Bulletin, 137, 19–46. doi:10.1037/a0021367Google Scholar
Ehrlich, K., Miller, G. E., & Chen, E. (2016). Childhood adversity and adult physical health. In Cicchetti, D. (Ed.), Developmental psychopathology (3rd ed., pp. 1–42). Hoboken, NJ: Wiley.Google Scholar
Ehrlich, K. B., Miller, G. E., Jones, J. D., & Cassidy, J. (2016). Attachment and psychoneuroimmunology. In Cassidy, J. & Shaver, P. R. (Eds.), Handbook of attachment: Theory, research, and clinical applications (3rd ed., pp. 180–201). New York: Guilford Press.Google Scholar
Ehrlich, K. B., Ross, K. M., Chen, E., & Miller, G. E. (2016). Testing the biological embedding hypothesis: Is early life adversity associated with a later proinflammatory phenotype? Development and Psychopathology, 28, 1273–1283. doi:10.1017/S0954579416000845Google Scholar
Eisenberger, N. I., Master, S. L., Inagaki, T. K., Taylor, S. E., Shirinyan, D., Lieberman, M. D., & Naliboff, B. D. (2011). Attachment figures activate a safety signal-related neural region and reduce pain experience. Proceedings of the National Academy of Sciences, 108, 11721–11726. doi:10.1073/pnas.1108239108Google Scholar
Epel, E. S., Lin, J., Wilhelm, F. H., Wolkowitz, O. M., Cawthon, R., Adler, N. E., … Blackburn, E. H. (2006). Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology, 31, 277–287. doi:10.1016/j.psyneuen.2005.08.011Google Scholar
Evans, G. W., Kim, P., Ting, A. H., Tesher, H. B., & Shannis, D. (2007). Cumulative risk, maternal responsiveness, and allostatic load among young adolescents. Developmental Psychology, 43, 341–351. doi:10.1037/0012-1649.43.2.341Google Scholar
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., … Marks, J. S. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The adverse childhood experiences (ACE) study. American Journal of Preventive Medicine, 14, 245–258. doi:10.1016/S0749-3797(98)00017-8Google Scholar
Fisher, P. A., & Chamberlain, P. (2000). Multidimensional treatment foster care: A program for intensive parenting, family support, and skill building. Journal of Emotional and Behavioral Disorders, 8, 155–164. doi:10.1177/106342660000800303Google Scholar
Gadalla, S. M., Cawthon, R., Giri, N., Alter, B. P., & Savage, S. A. (2010). Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes. Aging, 2, 867–874. doi:10.18632/aging.100235Google Scholar
George, C., Kaplan, N., & Main, M. (1984). Adult Attachment Interview. Unpublished manuscript, University of California, Berkeley.Google Scholar
Gotlib, I. H., LeMoult, J., Colich, N. L., Foland-Ross, L. C., Hallmayer, J., Joormann, J., … Wolkowitz, O. M. (2014). Telomere length and cortisol reactivity in children of depressed mothers. Molecular Psychiatry, 20, 615–620. doi:10.1038/mp.2014.119Google Scholar
Gross, J. J., & John, O. P. (2003). Individual differences in two emotion regulation processes: Implications for affect, relationships, and well-being. Journal of Personality and Social Psychology, 85, 348–362. doi:10.1037/0022-3514.85.2.348Google Scholar
Gunnar, M. R., & Quevedo, K. (2007). The neurobiology of stress and development. Annual Review of Psychology, 58, 145–173. doi:10.1146/annurev.psych.58.110405.085605Google Scholar
Haydon, K. C., Roisman, G. I., Owen, M. T., Booth-Laforce, C., & Cox, M. J. (2014). VII. Shared and distinctive antecedents of adult attachment interview state-of-mind and inferred-experience dimensions. Monographs of the Society for Research in Child Development, 79, 108–125. doi:10.1111/mono.12116Google Scholar
Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B. (2010). Neurobiological and psychiatric consequences of child abuse and neglect. Developmental Psychobiology, 52, 671–690. doi:10.1002/dev.20494Google Scholar
Hesse, E. (2016). The Adult Attachment Interview: Protocol, method of analysis, and empirical studies: 1985–2015. In Cassidy, J. & Shaver, P. R. (Eds.), Handbook of attachment: Theory, research, and clinical applications (3rd ed., pp. 553–597). New York: Guilford Press.Google Scholar
Hesse, E., & Main, M. (2006). Frightened, threatening, and dissociative parental behavior: Theory and associations with parental Adult Attachment Interview status and infant disorganization. Development and Psychopathology, 18, 309–343. doi:10.1017/S0954579406060172Google Scholar
Honig, L. S., Kang, M. S., Schupf, N., Lee, J. H., & Mayeux, R. (2012). Association of shorter leukocyte telomere repeat length with dementia and mortality. Archives of Neurology, 69, 1332–1339. doi:10.1001/archneurol.2012.1541Google Scholar
Humphreys, K. L., Esteves, K., Zeanah, C. H., Fox, N. A., Nelson, C. A., & Drury, S. S. (2016). Accelerated telomere shortening: Tracking the lasting impact of early institutional care at the cellular level. Psychiatry Research, 246, 95–100. doi:10.1016/j.psychres.2016.09.023Google Scholar
Jacobvitz, D., Curran, M., & Moller, N. (2002). Measurement of adult attachment: The place of self-report and interview methodologies. Attachment and Human Development, 4, 207–215. doi:10.1080/14616730210154225Google Scholar
Joubert, D., Webster, L., & Hackett, R. K. (2012). Unresolved attachment status and trauma-related symptomatology in maltreated adolescents: An examination of cognitive mediators. Child Psychiatry and Human Development, 43, 471–483. doi:10.1007/s10578-011-0276-8Google Scholar
Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience & Biobehavioral Reviews, 35, 2–16. doi:10.1016/j.neubiorev.2009.10.002Google Scholar
Kananen, L., Surakka, I., Pirkola, S., Suvisaari, J., Lönnqvist, J., Peltonen, L., … Hovatta, I. (2010). Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLOS ONE, 5, 1–7. doi:10.1371/journal.pone.0010826Google Scholar
Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011). Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosomatic Medicine, 73, 16–22. doi:10.1097/PSY.0b013e31820573b6Google Scholar
Kimura, M., Hjelmborg, J. V. B., Gardner, J. P., Bathum, L., Brimacombe, M., Lu, X., … Christensen, K. (2008). Telomere length and mortality: A study of leukocytes in elderly danish twins. American Journal of Epidemiology, 167, 799–806. doi:10.1093/aje/kwm380Google Scholar
Kroenke, C. H., Epel, E., Adler, N., Bush, N. R., Obradovic, J., Lin, J., … Boyce, W. T. (2011). Autonomic and adrenocortical reactivity and buccal cell telomere length in kindergarten children. Psychosomatic Medicine, 73, 533–540. doi:10.1097/PSY.0b013e318229acfcGoogle Scholar
Lin, J., Epel, E., & Blackburn, E. (2012). Telomeres and lifestyle factors: Roles in cellular aging. Mutation Research—Fundamental and Molecular Mechanisms of Mutagenesis, 730, 85–89. doi:10.1016/j.mrfmmm.2011.08.003Google Scholar
Ma, H., Zhou, Z., Wei, S., Liu, Z., Pooley, K. A., Dunning, A. M., … Wei, Q. (2011). Shortened telomere length is associated with increased risk of cancer: A meta-analysis. PLOS ONE, 6. doi:10.1371/journal.pone.0020466Google Scholar
Madigan, S., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., Moran, G., Pederson, D. R., & Benoit, D. (2006). Unresolved states of mind, anomalous parental behavior, and disorganized attachment: A review and meta-analysis of a transmission gap. Attachment and Human Development, 8, 89–111. doi:10.1080/14616730600774458Google Scholar
Main, M. (2000). The organized categories of infant, child, and adult attachment: Flexible vs. inflexible attention under attachment-related stress. Journal of the American Psychoanalytic Association, 48, 1055–1096. doi:10.1177/00030651000480041801Google Scholar
Main, M., Kaplan, N., & Cassidy, J. (1985). Security in infancy, childhood, and adulthood: A move to the level of representation. Monographs of the Society for Research in Child Development, 50, 66–104. doi:10.2307/3333827Google Scholar
Main, M., & Solomon, J. (1990). Procedures for identifying disorganized/disoriented infants during the Ainsworth Strange Situation. In Greenberg, M., Cicchetti, D., & Cummings, M. (Eds.), Attachment in the preschool years (pp. 121–160). Chicago: University of Chicago Press.Google Scholar
Matthews, K. A., & Gallo, L. C. (2011). Psychological perspectives on pathways linking socioeconomic status and physical health. Annual Review of Psychology, 62, 501–530. doi:10.1146/annurev.psych.031809.130711Google Scholar
McEwen, B. S., Gray, J. D., & Nasca, C. (2015). Redefining neuroendocrinology: Stress, sex and cognitive and emotional regulation. Journal of Endocrinology, 226, T67–T83. doi:10.1530/JOE-15-0121Google Scholar
Melchior, M., Moffitt, T. E., Milne, B. J., Poulton, R., & Caspi, A. (2007). Why do children from socioeconomically disadvantaged families suffer from poor health when they reach adulthood? A life-course study. American Journal of Epidemiology, 166, 966–974. doi:10.1093/aje/kwm155Google Scholar
Miga, E. M., Hare, A., Allen, J. P., & Manning, N. (2010). The relation of insecure attachment states of mind and romantic attachment styles to adolescent aggression in romantic relationships. Attachment and Human Development, 12, 463–481. doi:10.1080/14616734.2010.501971Google Scholar
Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137, 959–997. doi:10.1037/a0024768Google Scholar
Monnat, S. M., & Chandler, R. F. (2015). Long-term physical health consequences of adverse childhood experiences. Sociological Quarterly, 56, 723–752. doi:10.1111/tsq.12107Google Scholar
Murphy, A., Steele, M., Dube, S. R., Bate, J., Bonuck, K., Meissner, P., … Steele, H. (2014). Adverse childhood experiences (ACEs) questionnaire and Adult Attachment Interview (AAI): Implications for parent child relationships. Child Abuse and Neglect, 38, 224–233. doi:10.1016/j.chiabu.2013.09.004Google Scholar
Neigh, G. N., Gillespie, C. F., & Nemeroff, C. B. (2009). The neurobiological toll of child abuse and neglect. Trauma, Violence, and Abuse, 10, 389–410. doi:10.1177/1524838009339758Google Scholar
Nusslock, R., & Miller, G. E. (2016). Early-life adversity and physical and emotional health across the lifespan: A neuroimmune network hypothesis. Biological Psychiatry, 80, 23–32. doi:10.1016/j.biopsych.2015.05.017Google Scholar
O'Donovan, A., Lin, J., Dhabhar, F. S., Wolkowitz, O., Tillie, J. M., Blackburn, E., & Epel, E. (2009). Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain, Behavior, and Immunity, 23, 446–449. doi:10.1016/j.bbi.2008.11.006Google Scholar
Pierrehumbert, B., Torrisi, R., Ansermet, F., Borghini, A., & Halfon, O. (2012). Adult attachment representations predict cortisol and oxytocin responses to stress. Attachment and Human Development, 14, 453–476. doi:10.1080/14616734.2012.706394Google Scholar
Pollak, S. D. (2008). Mechanisms linking early experience and the emergence of emotions: Illustrations from the study of maltreated children. Current Directions in Psychological Science, 17, 370–375. doi:10.1111/j.1467-8721.2008.00608.xGoogle Scholar
Price, L. H., Kao, H. T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013). Telomeres and early-life stress: An overview. Biological Psychiatry, 73, 15–23. doi:10.1016/j.biopsych.2012.06.025Google Scholar
Puterman, E., & Epel, E. (2012). An intricate dance: Life experience, multisystem resiliency, and rate of telomere decline throughout the lifespan. Social and Personality Psychology Compass, 6, 807–825. doi:10.1111/j.1751-9004.2012.00465.xGoogle Scholar
Puterman, E., Gemmill, A., Karasek, D., Weir, D., Adler, N. E., Prather, A. A., & Epel, E. S. (2016). Lifespan adversity and later adulthood telomere length: Findings from the nationally representative U.S. Health and Retirement Study. Psychological and Cognitive Sciences, 3, E6335–E6342. doi:10.1073/pnas.1525602113Google Scholar
Ravitz, P., Maunder, R., Hunter, J., Sthankiya, B., & Lancee, W. (2010). Adult attachment measures: A 25-year review. Journal of Psychosomatic Research, 69, 419–432. doi:10.1016/j.jpsychores.2009.08.006Google Scholar
Repetti, R. L., Taylor, S. E., & Seeman, T. E. (2002). Risky families: Family social environments and the mental and physical health of offspring. Psychological Bulletin, 128, 330–366. doi:10.1037//0033-2909.128.2.330Google Scholar
Ridout, K. K., Levandowski, M., Ridout, S. J., Gantz, L., Goonan, K., Palermo, D., … Tyrka, A. R. (2017). Early life adversity and telomere length: A meta-analysis. Molecular Psychiatry. Advance online publication. doi:10.1038/mp.2017.26Google Scholar
Roisman, G. I., Padrón, E., Sroufe, L. A., & Egeland, B. (2002). Earned–secure attachment status in retrospect and prospect. Child Development, 73, 1204–1219. doi:10.1111/1467-8624.00467/abstractGoogle Scholar
Roisman, G. I., Tsai, J. L., & Chiang, K.-H. S. (2004). The emotional integration of childhood experience: Physiological, facial expressive, and self-reported emotional response during the adult attachment interview. Developmental Psychology, 40, 776–789. doi:10.1037/0012-1649.40.5.776Google Scholar
Salpea, K. D., Talmud, P. J., Cooper, J. A., Maubaret, C. G., Stephens, J. W., Abelak, K., & Humphries, S. E. (2010). Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation. Atherosclerosis, 209, 42–50. doi:10.1016/j.atherosclerosis.2009.09.070Google Scholar
Scheidt, C. E., Waller, E., Malchow, H., Ehlert, U., Becker-Stoll, F., Schulte-Mönting, J., & Lücking, C. H. (2000). Attachment representation and cortisol response to the adult attachment interview in idiopathic spasmodic torticollis. Psychotherapy and Psychosomatics, 69, 155–162.Google Scholar
Schuengel, C., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (1999). Frightening maternal behavior linking unresolved loss and disorganized infant attachment. Journal of Consulting and Clinical Psychology, 67, 54–63. doi:10.1080/02646839808404575Google Scholar
Shalev, I. (2013). Early life stress and telomere length: Investigating the connection and possible mechanisms: A critical survey of the evidence base, research methodology and basic biology. Bioessays, 34, 943–952. doi:10.1002/bies.201200084Google Scholar
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013). Stress and telomere biology: A lifespan perspective. Psychoneuroendocrinology, 38, 1835–1842. doi:10.1016/j.psyneuen.2013.03.010Google Scholar
Shalev, I., Moffitt, T. E., Sugden, K., Williams, B., Houts, R. M., Danese, A., … Caspi, A. (2013). Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: A longitudinal study. Molecular Psychiatry, 18, 576–581. doi:10.1038/mp.2012.32Google Scholar
Shaver, P. R., & Mikulincer, M. (2007). Adult attachment strategies and the regulation of emotion. In Gross, J. J. (Ed.), Handbook of emotion regulation (pp. 446–465). New York: Guilford Press.Google Scholar
Shonkoff, J. P., Boyce, W. T., & McEwen, B. S. (2009). Neuroscience, molecular biology, and the childhood roots of health disparities. Journal of the American Medical Association, 301, 2252–2259. doi:10.1001/jama.2009.754Google Scholar
Shonkoff, J. P., Garner, A. S., Siegel, B. S., Dobbins, M. I., Earls, M. F., Garner, A. S., … Wood, D. L. (2012). The lifelong effects of early childhood adversity and toxic stress. Pediatrics, 129, e232–e246. doi:10.1542/peds.2011-2663Google Scholar
Simpson, J. A., Collins, W. A., Tran, S., & Haydon, K. C. (2007). Attachment and the experience and expression of emotions in romantic relationships: A developmental perspective. Journal of Personality and Social Psychology, 92, 355–367. doi:10.1037/0022-3514.92.2.355Google Scholar
Simpson, J. A., Rholes, W. S., & Nelligan, J. S. (1992). Support seeking and support giving within couples in an anxiety-provoking situation: The role of attachment styles. Journal of Personality and Social Psychology, 62, 434–446. doi:10.1037/0022-3514.62.3.434Google Scholar
Srivastava, S., Tamir, M., McGonigal, K. M., John, O. P., & Gross, J. J. (2009). The social costs of emotional suppression: A prospective study of the transition to college. Journal of Personality and Social Psychology, 96, 883–897. doi:10.1037/a0014755Google Scholar
Steele, R. D., Waters, T. E. A., Bost, K. K., Vaughn, B. E., Truitt, W., Waters, H. S., … Roisman, G. I. (2014). Caregiving antecedents of secure base script knowledge: A comparative analysis of young adult attachment representations. Developmental Psychology, 50, 2526–2538. doi:10.1037/a0037992Google Scholar
Taylor, S. E. (2010). Mechanisms linking early life stress to adult health outcomes. Proceedings of the National Academy of Sciences, 107, 8507–8512. doi:10.1073/pnas.1003890107Google Scholar
Taylor, S. E., Eisenberger, N. I., Saxbe, D., Lehman, B. J., & Lieberman, M. D. (2006). Neural responses to emotional stimuli are associated with childhood family stress. Biological Psychiatry, 60, 296–301. doi:10.1016/j.biopsych.2005.09.027Google Scholar
Thomas, P., O'Callaghan, N. J., & Fenech, M. (2008). Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mechanisms of Ageing and Development, 129, 183–190. doi:10.1016/j.mad.2007.12.004Google Scholar
Tomiyama, A. J., O'Donovan, A., Lin, J., Puterman, E., Lazaro, A., Chan, J., … Epel, E. (2012). Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length. Physiology & Behavior, 106, 40–45. doi:10.1016/j.physbeh.2011.11.016Google Scholar
Treboux, D., Crowell, J. A., & Waters, E. (2004). When “new” meets “old”: Configurations of adult attachment representations and their implications for marital functioning. Developmental Psychology, 40, 295–314. doi:10.1037/0012-1649.40.2.295Google Scholar
Tyrka, A. R., Price, L. H., Kao, H. T., Porton, B., Marsella, S. A., & Carpenter, L. L. (2010). Childhood maltreatment and telomere shortening: Preliminary support for an effect of early stress on cellular aging. Biological Psychiatry, 67, 531–534. doi:10.1016/j.biopsych.2009.08.014Google Scholar
von Zglinicki, T., Serra, V., Lorenz, M., Saretzki, G., Lenzen-Grossimlighaus, R., Gessner, R., … Steinhagen-Thiessen, E. (2000). Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible risk factor? Laboratory Investigation, 80, 1739–1747. doi:10.1038/labinvest.3780184Google Scholar
Waters, E., & Cummings, E. M. (2000). A secure base from which to explore close relationships. Child Development, 71, 164–172. doi:10.1111/1467-8624.00130Google Scholar
West, M., Adam, K., Spreng, S., & Rose, S. (2001). Attachment disorganization and dissociative symptoms in clinically treated adolescents. Canadian Journal of Psychiatry, 46, 627–631. doi:10.1177/070674370104600707Google Scholar
Willeit, P., Willeit, J., Mayr, A., Weger, S., Oberhollenzer, F., Brandstätter, A., … Kiechl, S. (2010). Telomere length and risk of incident cancer and cancer mortality. Journal of the American Medical Association, 304, 69–75. doi:10.1001/jama.2010.897Google Scholar
Wong, L. S. M., Huzen, J., De Boer, R. A., Van Gilst, W. H., Van Veldhuisen, D. J., & Van Der Harst, P. (2011). Telomere length of circulating leukocyte subpopulations and buccal cells in patients with ischemic heart failure and their offspring. PLOS ONE, 6, e23118. doi:10.1371/journal.pone.0023118Google Scholar
Yang, Z., Huang, X., Jiang, H., Zhang, Y., Liu, H., Qin, C., … Ju, Z. (2009). Short telomeres and prognosis of hypertension in a Chinese population. Hypertension, 53, 639–645. doi:10.1161/hypertensionaha.108.123752Google Scholar
Zee, R. Y. L., Castonguay, A. J., Barton, N. S., Germer, S., & Martin, M. (2010). Mean leukocyte telomere length shortening and type 2 diabetes mellitus: A case-control study. Translational Research, 155, 166–169. doi:10.1016/j.trsl.2009.09.012Google Scholar
Zhang, C., Chen, X., Li, L., Zhou, Y., Wang, C., & Hou, S. (2015). The association between telomere length and cancer prognosis: Evidence from a meta-analysis. PLOS ONE, 10, 1–17. doi:10.1371/journal.pone.0133174Google Scholar