This article examines the life and work of John Kennedy Toole, focusing onhis 1981 Pulitzer Prize winning novel A Confederacy of Dunces. Toole finished the novel in 1966 and, after failing torework his manuscript to his editor's satisfaction, he shelved the project.Following this, he displayed symptoms typical of paranoid schizophrenia andhe took his own life at the age of 31. In his novel, Toole parodies bothpsychoanalysis and the practice of psychiatry at the time, with a strongoverlap with the emerging perspectives critical of psychiatry popularised byfigures such as Szasz, Laing and Foucault. Toole's life and work haverelevance for psychiatrists interested in the relationship betweencreativity and mental illness, attitudes towards psychiatry in the 1960s,and the interplay between societal values and judgements of mentalhealth.