Hostname: page-component-77c78cf97d-lphnv Total loading time: 0 Render date: 2026-04-25T15:29:33.847Z Has data issue: false hasContentIssue false
  • English
  • Français

Natural bioactive substances in milk and colostrum: effects on the arterial blood pressure system

Published online by Cambridge University Press:  09 March 2007

Susan M. Groziak  and
G. D. Miller
Susan M. Groziak
Affiliation:
National Dairy Council, Dairy Management Inc. 10255 W. Higgins, Suite 900, Rosemont, IL 60018, USA
G. D. Miller*
Affiliation:
National Dairy Council, Dairy Management Inc. 10255 W. Higgins, Suite 900, Rosemont, IL 60018, USA
*
*Corresponding author: G.D. Miller, fax 847 803 2077, email gregorym@rosedmi.com
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the 'Save PDF' action button.

High blood pressure is a significant public health problem worldwide which is associated with increased risk of cardiovascular disease, stroke, and renal disease. The development of this disease is influenced by genetic and environmental factors. The results of many studies have linked increased consumption of milk and milk products with lower blood pressure and reduced risk of hypertension. The intake of several minerals found in milk has been demonstrated to have an inverse relationship with blood pressure. Peptides formed during the digestion of milk proteins have also been demonstrated to have a blood pressure lowering effect. Other components in milk that have been examined for their effects on blood pressure have been less promising. More recent data indicate that a dietary pattern that is low in fat, with fruits, vegetables, and low fat dairy products can significantly reduce blood pressure and lower risk of developing high blood pressure.

Keywords

MilkBlood pressureElectrolytesMineralsPeptidesDietCalcium

Information

Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue S1 , November 2000 , pp. 119 - 125
Copyright
Copyright © The Nutrition Society 2000

References

Abubakar, A, Saito, T, Kitazawa, H, Kawai, Y & Itoh, T (1998) Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. Journal of Dairy Science 81, 3131–3138.CrossRefGoogle ScholarPubMed
Ackley, S, Barrett-Connor, E & Suarez, L (1983) Dairy products, calcium, and blood pressure. American Journal of Clinical Nutrition 38, 457–461.CrossRefGoogle ScholarPubMed
Altura, B, Altura, B, Gebrewold, A, Ising, H & Gunther, T (1984) Magnesium deficiency and hypertension, correlation between magnesium deficient diets and microcirculatory changes in situ. Science 223, 1315–1317.CrossRefGoogle ScholarPubMed
Appel, L, Moore, T, Obarzanek, E, Vollmer, W, Svetkey, L, Sacks, F, Bray, G, Vogt, T, Cutler, J, Windhauser, M, Lin, P & Karanj, N (1997) A clinical trial of the effects of dietary patterns on blood pressure. New England Journal of Medicine 336, 1117–1124.CrossRefGoogle ScholarPubMed
Berthelot, A & Esposito, J (1983) Effects of dietary magnesium on the development of hypertension in the spontaneously hypertensive rat. Journal of the American College of Nutrition 4, 343–353.CrossRefGoogle Scholar
Brancati, F, Appel, L, Seidler, A & Whelton, P (1996) Effect of potassium supplementation on blood pressure in African Americans on a low-potassium diet. Archives of Internal Medicine 156, 61–67.CrossRefGoogle ScholarPubMed
Brussard, J, van Raaij, J, Stasse-Wolthuis, M, Katan, M & Hautvast, J (1981) Blood pressure and diet in normotensive volunteers: absence of an effect of dietary fiber, protein, or fat. American Journal of Clinical Nutrition 34, 2023–2029.CrossRefGoogle Scholar
Cappuccio, FP, Elliott, P, Allender, PS, Pryer, J, Follman, DA & Cutler, JA (1995) The epidemiological association between dietary calcium intake and blood pressure: a meta-analysis of published data. American Journal of Epidemiology 142, 935–945.CrossRefGoogle ScholarPubMed
Chiang, M, Kimura, S & Fujimot, H (1989) Effect of dietary eicosapentaenoic acid on plasma lipids and platelet function in stroke-prone spontaneously hypertensive rat. International Journal for Vitamin & Nutrition Research 60, 142–149.Google Scholar
Cutler, J & Brittain, E (1990) Calcium and blood pressure: an epidemiologic perspective. American Journal of Hypertension 3, 137S-146S.CrossRefGoogle ScholarPubMed
Davda, R (1995) Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C-independent mechanism. Hypertension 26, 764–770.CrossRefGoogle ScholarPubMed
Davey Smith, G & Phillips, A (1996) Inflation in epidemiology: the proof and measurement of association between two things. British Medical Journal 312, 1659–1661.CrossRefGoogle Scholar
Dwyer, J, Li, L, Dwyer, K, Curtin, L & Feinleib, M (1996) Dietary calcium, alcohol, and incidence of treated hypertension in the NHANES I epidemiologic followup study. American Journal of Epidemiology 144, 828–838.CrossRefGoogle Scholar
Fiat, A-M, Migliore-Samour, D, Jolles, P, Drouet, L, Bal, Dit, Sollier, C & Caen, J (1993) Biologically active peptides from milk proteins with emphasis on two examples concerning antithrombotic and immunomodulating activities. Journal of Dairy Science 76, 301–310.CrossRefGoogle ScholarPubMed
Frohlich, E, Chien, Y & Pegram, B (1993) Relationship between dietary sodium intake, hemodynamics, and cardiac mass in SHR and WKY rats. American Journal of Physiology 264, R30-R34.Google ScholarPubMed
Garcia-Palmieri, M, Costas, R, Cruz-Vidal, M, Sorlie, P, Tillotson, J & Havlik, R (1984) Milk consumption, calcium intake and decreased hypertension in Puerto Rico: Puerto Rico Heart Health Program Study. Hypertension 6, 322–328.CrossRefGoogle ScholarPubMed
Gibson, R & Kneebone, G (1981) Fatty acid composition of human colostrum and mature breast milk. American Journal of Clinical Nutrition 34, 252–257.CrossRefGoogle ScholarPubMed
Griffith, LE, Guyatt, GH, Cook, RJ, Bucher, HC & Cook, DJ (1999) The influence of dietary and nondietary calcium supplementation on blood pressure: an updated metaanalysis of randomized controlled trials. American Journal of Hypertension 12, 84–92.CrossRefGoogle ScholarPubMed
Grobbee, D, Hackeng, W, Birkenhager, J & Hofman, A (1988) Raised plasma intact parathyroid hormone concentrations in young people with mildly raised blood pressure. British Medical Journal 296, 814–816.CrossRefGoogle ScholarPubMed
Haddy, F (1991) Roles of sodium, potassium, calcium, and natriuretic factors in hypertension. Hypertension 18, 179.CrossRefGoogle ScholarPubMed
Hanneman, R (1996) Intersalt: hypertension rise with age revisited. British Medical Journal 312, 1283–1284.CrossRefGoogle ScholarPubMed
Hatton, DC, Coste, S, McCarron, DA, Yue, Q, Harrison-Hohner, J & Reller, M (1998) Prenatal calcium supplementation lowers blood pressure in children. American Journal of Hypertension 11, 15A.CrossRefGoogle Scholar
Ikeda, K, Mochizuki, S, Nara, Y, Horie, R & Yamori, Y (1987) Effect of milk protein and fat intake on blood pressure and the incidence of cerebrovascular diseases in strokeprone spontaneously hypertensive rats (SHRSP). Journal of Nutritional Science and Vitaminology 33, 31–36.CrossRefGoogle ScholarPubMed
International Dairy Foods Association (1995) Health claim concerning the role of adequate dietary intake of calcium in reducing the risk of hypertension (Prepared by The Weinberg Group, Inc.).Google Scholar
Joffres, M, Reed, D & Yano, K (1987) Relationship of magnesium intake and other dietary factors to blood pressure: the Honolulu Heart Study. American Journal of Clinical Nutrition 45, 469–475.CrossRefGoogle ScholarPubMed
Kotchen, T & McCarron, D (1998) Dietary electrolytes and blood pressure: a statement for healthcare professionals from the American Heart Association Nutrition Committee. Circulation 98, 613–617.CrossRefGoogle Scholar
Kristal-Boneh, E, Froom, P, Harari, G & Ribak, J (1997) Hypertension 30, 1289–1294.CrossRefGoogle Scholar
Kurtz, T, Portale, A & Morris, R (1986) Evidence for a difference in vitamin D metabolism between spontaneously hypertensive and Wistar-Kyoto rats. Hypertension 8, 1015–1020.CrossRefGoogle ScholarPubMed
Lebrun, I, Lebrum, F, Henriques, O, Carmona, A, Juliano, L & Camargo, A (1995) Isolation and characterization of a new bradykinin potentiatin octapeptide from gamma-casein. Canadian Journal of Physiology and Pharmacology 73, 85–91.CrossRefGoogle Scholar
Life Sciences Research Office, Federation of American Societies for Experimental Biology (1995) Prepared for the Interagency Board for Nutrition Monitoring and Related Research. Third Report on Nutrition Monitoring in the United States: Vol. 1. Washington, DC: US Government Printing Office.Google Scholar
Linas, S (1991) The role of potassium in the pathogenesis and treatment of hypertension. Kidney International 39, 771.CrossRefGoogle ScholarPubMed
Lind, L, Pollare, A, Hvarfner, A, Lithell, H, Sorensen, O & Ljunghall, S (1989) Long-term treatment with active vitamin D (alphacalcidiol) in middle-age men with impaired glucose tolerance: effects on insulin secretion and sensitivity, glucose tolerance and blood pressure. Diabetes Research 11, 141–147.Google Scholar
McCarron, D, Pingree, P, Rubin, R, Gaucher, S, Molitch, M & Krutzik, S (1980) Enhanced parathyroid function in essential hypertension: a homeostatic response to a urinary calcium leak. Hypertension 2, 163–168.CrossRefGoogle ScholarPubMed
Marcoux, S, Brisson, J & Fabia, J (1991) Calcium intake from dairy products and supplements and the risks of preeclampsia and gestational hypertension. American Journal of Epidemiology 133, 1266–1272.CrossRefGoogle ScholarPubMed
Maruyama, S, Mitachi, H, Awaja, J, Kurono, M, Tomizaka, N & Suzuki, H (1987) Angiotensin I-converting enzyme inhibitory activity of the C-terminal hexapeptide of aSl-casein. Agricultural Biology and Chemistry 51, 2557.Google Scholar
Meisel, H (1997) Biochemical properties of regulatory peptides derived from milk proteins. Biopoly 43, 119–128.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
Merke, J, Hofman, W, Goldschmidt, D & Ritz, E (1987) Demonstration of 1,25(OH)2 vitamin D3 receptors and actions in vascular smooth muscle cells in vitro. Calcified Tissue International 41, 112–114.CrossRefGoogle ScholarPubMed
Midgley, J, Matthew, A, Greenwood, C & Logan, A (1996) Effect of reduced dietary sodium on blood pressure: a meta-analysis of randomized controlled trials. Journal of the American Medical Association 275, 1590–1597.CrossRefGoogle ScholarPubMed
Miller, GD, Jarvis, J & McBean, L (1999) Dairy foods and hypertension Handbook of Dairy Foods and Nutrition. Boca Raton: CRC Press.CrossRefGoogle Scholar
Miller, GD, DiRienzo, DD, Reusser, ME & McCarron, DA (2000) Benefits of dairy product consumption on blood pressure in humans: a summary of the biomedical literature. Journal of the American College of Nutrition 19, 147S-163S.CrossRefGoogle ScholarPubMed
Moers, A & Schrezenmeir, J (1996) Palmitic acid but not stearic acid inhibits NO-production in endothelial cells. Diabetes 105, 78–80.Google Scholar
Montgomery, P, Patton, S, Huston, G & Josephson, R (1987) Gel electrophoretic analysis of proteins in human milk and colostrum. Comparative Biochemistry and Physiology 86, 635–639.Google ScholarPubMed
Morris, RC, Sebastian, A, Forman, A, Tanaka, M & Schmidlin, O (1999) Normotensive salt sensitivity: effects of race and dietary potassium. Hypertension 33, 18–23.CrossRefGoogle ScholarPubMed
Nakamura, Y, Masuda, O & Takano, T (1996) Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats. Bioscience Biotechnology and Biochemistry 60, 488–489.CrossRefGoogle ScholarPubMed
Nakamura, Y, Nyamamoto, N, Sakai, K & Takano, T (1995) Antihypertensive effect of sour milk and peptides isolated from it that are inhibitors to angiotensin I-converting enzyme. Journal of Dairy Science 78, 1253–1257.CrossRefGoogle ScholarPubMed
National Institutes of Health (1997) Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. NIH Publication No 98–4080.Google Scholar
Paolisso, G & Barbagallo, M (1997) Hypertension, diabetes, mellitus, and insulin resistance. The role of intracelluar magnesium. American Journal of Hypertension 10, 346–355.CrossRefGoogle Scholar
Resnick, L & Laragh, J (1984) Short-term effects of 1,25-dihydroxyvitamin D3 on blood pressure in essential hypertension. Kidney International 26, 206.Google Scholar
Resnick, L, Nicholson, J & Laragh, L (1986) Calcium metabolism in essential hypertension: relationship to altered renin system activity. Federation Proceedings 45, 2739.Google ScholarPubMed
Reusser, M & McCarron, D (1994) Micronutrient effects on blood pressure regulation. Nutrition Reviews 52, 367–375.CrossRefGoogle ScholarPubMed
Sacks, F, Willet, WC, Smith, A, Brown, LE, Rosner, B & Moore, TJ (1998) Effect on blood pressure of potassium, calcium, and magnesium in women with low habitual intake. Hypertension 31, 131–138.CrossRefGoogle ScholarPubMed
Saravia, M, Ackerman, R, Murphy, N, Berman, S & McMurray, D (1983) Effect of maternal nutritional status on immunological substances in human colostrum and milk. American Journal of Clinical Nutrition 37, 632–640.Google Scholar
Schlimme, E & Meisel, H (1995) Bioactive peptides derived from milk proteins. Structural, physiological and analytical aspects. Die Nahrung 39, 1–20.CrossRefGoogle ScholarPubMed
Simons-Morton, D, Hunsberger, S, Van Horn, L, Barton, B, Robson, A, McMahon, R, Muhonen, L, Kwiterovich, P, Lasser, N, Kimm, S & Greenlick, M (1997) Nutrient intake and blood pressure in the Dietary Intervention Study in Children. Hypertension 29, 930–936.CrossRefGoogle ScholarPubMed
Sowers, J, Zemel, M, Zemel, P, Beck, F, Walsh, M & Zawada, E (1988) Salt sensitivity in Blacks. Salt intake and natriuretic substances. Hypertension 12, 485–490.CrossRefGoogle ScholarPubMed
Sowers, M, Wallace, R, Hollis, B & Lemke, J (1988) Relationship between 1.23-dihydroxyvitamin D and blood pressure in a geographically defined population. American Journal of Clinical Nutrition 48, 1053–1056.CrossRefGoogle Scholar
Stumpf, W (1990) Steroid hormones and the cardiovascular system: direct actions of estradiol, progesterone, testosterone, gluco and mineralocorticoids, and soltriol (vitamin D) on central nervous regulatory and peripheral tissues. Experientia 46, 112–114.CrossRefGoogle Scholar
Sullivan, J (1991) Salt-sensitivity: definition, conception, methodology, and long-term issues. Hypertension 17, 173–174.CrossRefGoogle ScholarPubMed
Svetkey, LP, Simons-Morton, D, Vollmer, WM, Appel, LJ, Conlin, PR, Ryan, DH, Ard, J & Kennedy, BM (1999) Effects of dietary patterns on blood pressure: subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Archives of Internal Medicine 159, 285–293.CrossRefGoogle ScholarPubMed
Taubes, G (1998) The (political) science of salt. Science 281, 898–901.CrossRefGoogle ScholarPubMed
Teschemacher, H & Koch, G (1991) Opioids in the milk. Endocrine Regulations 25, 147–150.Google ScholarPubMed
The INTERSALT Cooperative Research Group (1988) Intersalt: An International Study of Electrolyte Excretion and Blood Pressure: results for 24-hour urinary sodium and potassium excretion. British Medical Journal 297, 319–328.CrossRefGoogle Scholar
The Trials of Hypertension Prevention Collaborative Research group (1997) Effects of weight loss and sodium reduction intervention on blood pressure and hypertension incidence in overweight people with high-normal blood pressure: the Trials of Hypertension Prevention, Phase II. Archives of Internal Medicine 157, 657–667.CrossRefGoogle Scholar
Van Beresteyn, E, Schaafsma, G & de Waard, H (1986) Oral calcium and blood pressure: a controlled intervention trial. American Journal of Clinical Nutrition 44, 883–888.CrossRefGoogle ScholarPubMed
Whelton, P, He, J, Cutler, J, Brancati, F, Appel, L, Follmann, D & Klag, M (1997) Effects of oral potassium on blood pressure: meta-analysis of randomized controlled clinical trials. Journal of the American Medical Association 277, 1624–1632.CrossRefGoogle ScholarPubMed
Witteman, J, Willett, W, Stampfer, M, Colditz, G, Sacks, F, Speizer, F, Rosner, B & Hennekens, D (1989) A prospective study of nutritional factors and hypertension among U.S. women. Circulation 80, 1320–1327.CrossRefGoogle Scholar
Yamamoto, N (1997) Antihypertensive peptides derived from food proteins. Biopoly 43, 129–134.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Yamamoto, N, Akino, A & Takano, T (1994) Antihypertensive effects of peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. Journal of Dairy Science 77, 917–922.CrossRefGoogle ScholarPubMed
Young, E, McCarron, D & Morris, C (1990) Calcium regulating hormones in essential hypertension. Importance of gender. American Journal of Hypertension 3, 161S-166S.CrossRefGoogle ScholarPubMed
Zemel, M (1997) Dietary pattern and hypertension: the DASH study. Nutrition Reviews 55, 303–398.CrossRefGoogle ScholarPubMed
Zemel, M, Bedford, B, Zemel, P, Marwah, PO & Sowers, J (1998) Altered cation transport in noninsulindependent diabetic hypertension: effects of dietary calcium. Journal of Hypertension 6, 228–230.CrossRefGoogle Scholar
Zemel, P, Zemel, M, Urberg, M, Douglas, F, Geiser, R & Sowers, J (1997) Metabolic and hemodynamic effects of magnesium supplementation in patients with essential hypertension. American Journal of Clinical Nutrition 51, 665–669.CrossRefGoogle Scholar