‘In an engaging and personal style, Henshall relates the stories of discovery and insight that have established microRNAs as key players in the cellular economy, conferring robustness and contextual sensitivity to the processes of life. He relates an accessible and enlightening history of the experiments and ideas in this important field, highlighting open questions along the way and the exciting prospects for therapeutic intervention. Fine-Tuning Life is a joy to read and will be a crucial resource for biomedical students and anyone interested in the subtle choreography of life and the thinking and practice of those who seek to reveal its logic.’
‘This book guides the reader along an accessible and lively journey into how the molecular genetic orchestra, essential for all our lives, is conducted across both health and disease. How we have reached this level of understanding is given “life” through considering the major players as people, as well as via their fundamental discoveries.’
‘David Henshall’s book is bravely aimed at two unrelated reader communities, presenting a real challenge to the author: science, medicine and pharmacology students and professionals who wish to update their know-how in this relatively new field, and naïve readers excited about novel developments in life sciences research. Dr Henshall conquers that challenge by clearly and methodically explaining the underlying scientific concepts to microRNAs’ functioning. He presents their discovery, their role in health and disease, and their potential to become novel therapeutic targets. The book explores the difficulties and achievements in microRNA research and their future use in novel therapeutics in a pandemic era where RNA-based therapies have now become realistic. This book is an enlightening read if you wish to learn how a new discovery can lead to realistic pharmacology prospects, and why there are no microRNA-targeted therapeutics in the current market. Recommended most warmly and with no hesitation.’
‘This book finally gives microRNAs the significance (credit) in human genetics they deserve – from their emerging role in the evolution of the human brain all the way to their prospects for the diagnosis and therapy of brain disorders. A must-read for the aspiring biology student and the established scientist alike.’
