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Non-linear biphasic mixture model: Existence and uniqueness results

Published online by Cambridge University Press:  18 September 2024

Meraj Alam
Affiliation:
Department of Mathematics, Ecole Centrale School of Engineering, Mahindra University, Hyderabad, 500043, Telangana, India
Adrian Muntean
Affiliation:
Department of Mathematics and Computer Science, Karlstad University, Karlstad, 651 88, Sweden
Raja Sekhar G P*
Affiliation:
Department of Mathematics, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, 721302, India
*
Corresponding author: Raja Sekhar G P; Email: rajas@iitkgp.ac.in
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Abstract

This paper is concerned with the development and analysis of a mathematical model that is motivated by interstitial hydrodynamics and tissue deformation mechanics (poro-elasto-hydrodynamics) within an in-vitro solid tumour. The classical mixture theory is adopted for mass and momentum balance equations for a two-phase system. A main contribution of this study is we treat the physiological transport parameter (i.e., hydraulic resistivity) as anisotropic and heterogeneous, thus the governing system is strongly coupled and non-linear. We derived a weak formulation and then formulated the equivalent fixed-point problem. This enabled us to use the Galerkin method, and the classical results on monotone operators combined with the well-known Schauder and Banach fixed-point theorems to prove the existence and uniqueness of results.

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Type
Papers
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Copyright
© The Author(s), 2024. Published by Cambridge University Press
Figure 0

Figure 1. Geometry of the problem.

Figure 1

Table 1. Dimensionless poro-elasto-hydrodynamics parameters corresponding to tumour tissue with their value range.