Medical Implications of Biofilms

doi:10.1017/CBO9780511546297

Human tissues often support large, complex microbial communities growing as biofilms that can cause a variety of infections. As a result of an increased use of implanted medical devices, the incidence of these biofilm-associated diseases is increasing: the non-shedding surfaces of these devices provide ideal substrata for colonisation by biofilm-forming microbes. The consequences of this mode of growth are far-reaching. As microbes in biofilms exhibit increased tolerance towards antimicrobial agents and decreased susceptibility to host defence systems, biofilm-associated diseases are becoming increasingly difficult to treat. Not surprisingly, therefore, interest in biofilms has increased dramatically. The application of microscopic and molecular techniques has revolutionised our understanding of biofilm structure, composition, organisation, and activities, resulting in important advances in the prevention and treatment of biofilm-related diseases. The purpose of this book, which was first published in 2003, is to bring these advances to the attention of clinicians and medical researchers.

Review of the hardback:‘… a real pleasure to read … suitable for both clinicians and medical researchers. the wide range of topics covered makes this work a perfect review for those interested in medically related biofilms.’

Source: ASM News

Review of the hardback:'… a valuable reference both for biofilm aficionados and anyone, including final-year undergraduates, with an interest in infectious diseases.'

Source: Microbiology Today

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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Preface
pp vii-viii
- By Michael Wilson, Professor of Microbiology in the Faculty of Clinical Sciences, University College London, Deirdre Devine, Senior Lecturer in Microbiology, Leeds Dental Institute, University of Leeds
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List of Contributors
pp ix-xiv
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PART ONE - INTRODUCTORY CHAPTERS
pp 1-2
- By Michael Wilson, Professor of Microbiology in the Faculty of Clinical Sciences, University College London, Deirdre Devine, Senior Lecturer in Microbiology, Leeds Dental Institute, University of Leeds
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1 - Biofilm-Dependent Regulation of Gene Expression
pp 3-17
- By Philippe Lejeune, Laboratoire de Microbiologie et Génétiquè, Institut National des Sciences Appliquées de Lyon, Lyon, France
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2 - Quorum Sensing and Microbial Biofilms
pp 18-35
- By Teresa R. de Kievit, Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada, Barbara H. Iglewski, Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
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3 - Antimicrobial Agents and Biofilms
pp 36-56
- By Michael R. W. Brown, Department of Pharmacy and Pharmacology, University of Bath, Bath, UK, Anthony W. Smith, Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
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PART TWO - BIOFILMS ON PROSTHETIC DEVICES
pp 57-58
- By Michael Wilson, Professor of Microbiology in the Faculty of Clinical Sciences, University College London, Deirdre Devine, Senior Lecturer in Microbiology, Leeds Dental Institute, University of Leeds
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4 - Animal Models of Orthopaedic Implant Infection
pp 59-85
- By Yuehuei H. An, Orthopaedic Research Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA, Christopher M. Hill, Orthopaedic Research Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA, Richard J. Friedman, Orthopaedic Research Laboratory, Medical University of South Carolina, Charleston, South Carolina, USA
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5 - Intravascular-Catheter-Related Infections
pp 86-109
- By Hend A. Hanna, Department of Infectious Diseases, Infection Control and Employee Health, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA, Issam Raad, Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
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6 - Molecular Basis of Biofilm Formation by Staphylococcus epidermidis
pp 110-135
- By Christine Heilmann, Institute of Medical Microbiology, University of Münster, Muenster, Germany
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7 - Biofilm Complications of Urinary Tract Devices
pp 136-170
- By Sean P. Gorman, School of Pharmacy, Medical Biology Centre, Queen's University of Belfast, Belfast, UK, David S. Jones, School of Pharmacy, Medical Biology Centre, Queen's University of Belfast, Belfast, UK
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PART THREE - ORAL BIOFILMS
pp 171-172
- By Michael Wilson, Professor of Microbiology in the Faculty of Clinical Sciences, University College London, Deirdre Devine, Senior Lecturer in Microbiology, Leeds Dental Institute, University of Leeds
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8 - Novel Microscopic Methods to Study the Structure and Metabolism of Oral Biofilms
pp 173-188
- By David J. Bradshaw, Bioscience Department, Quest International, Ashford, Kent, UK, Philip D. Marsh, Department of Oral Microbiology, Leeds Dental Institute, Leeds, UK
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9 - Oral Streptococcal Genes That Encode Biofilm Formation
pp 189-211
- By C. Y. Loo, Boston University, Goldman School of Dental Medicine, Department of Paediatric Dentistry, Boston, Massachusetts, USA
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10 - Gene Expression in Oral Biofilms
pp 212-228
- By Robert A. Burne, Department of Oral Biology, University of Florida, Gainesville, Florida, USA, Yi-Ywan M. Chen, Department of Oral Biology, University of Florida, Gainesville, Florida, USA, Yunghua Li, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada, Samir Bhagwat, Department of Medicine, University of Rochester, Rochester, New York, USA, Zezhang Wen, Department of Oral Biology, University of Florida, Gainesville, Florida, USA
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PART FOUR - BIOFILMS ON SHEDDING SURFACES
pp 229-230
- By Michael Wilson, Professor of Microbiology in the Faculty of Clinical Sciences, University College London, Deirdre Devine, Senior Lecturer in Microbiology, Leeds Dental Institute, University of Leeds
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11 - Dissection of the Genetic Pathway Leading to Multicellular Behaviour in Salmonella enterica Serotype Typhimurium and Other Enterobacteriaceae
pp 231-261
- By Ute Römling, Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm, Sweden, Werner Bokranz, Department of Cell Biology, Gesellschaft für Biotechnologische Forschung, Braunschweig, Germany, Ulrich Gerstel, Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm, Sweden, Heinrich Lünsdorf, Department of Microbiology, Gesellschaft für Biotechnologische Forschung, Braunschweig, Germany, Manfred Nimtz, Department of Structural Biology, Gesellschaft für Biotechnologische Forschung, Braunschweig, Germany, Wolfgang Rabsch, National Reference Centre for Salmonellae and Other Enteric Pathogens, Robert-Koch-Institut, Wernigerode, Germany, Helmuth Tschäpe, National Reference Centre for Salmonellae and Other Enteric Pathogens, Robert-Koch-Institut, Wernigerode, Germany, Xhavit Zogaj, Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm, Sweden
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12 - Bacterial Growth on Mucosal Surfaces and Biofilms in the Large Bowel
pp 262-286
- By S. Macfarlane, MRC Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, UK, G. T. Macfarlane, MRC Microbiology and Gut Biology Group, University of Dundee, Ninewells Hospital Medical School, Dundee, UK
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13 - Pseudomonas aeruginosa Biofilms in Lung Infections
pp 287-310
- By Kimberly K. Jefferson, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA, Gerald B. Pier, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
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Index
pp 311-314
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Medical Implications of Biofilms

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Contents

Frontmatter
pp i-iv

Contents
pp v-vi

Preface
pp vii-viii

List of Contributors
pp ix-xiv

PART ONE - INTRODUCTORY CHAPTERS
pp 1-2

1 - Biofilm-Dependent Regulation of Gene Expression
pp 3-17

2 - Quorum Sensing and Microbial Biofilms
pp 18-35

3 - Antimicrobial Agents and Biofilms
pp 36-56

PART TWO - BIOFILMS ON PROSTHETIC DEVICES
pp 57-58

4 - Animal Models of Orthopaedic Implant Infection
pp 59-85

5 - Intravascular-Catheter-Related Infections
pp 86-109

6 - Molecular Basis of Biofilm Formation by Staphylococcus epidermidis
pp 110-135

7 - Biofilm Complications of Urinary Tract Devices
pp 136-170

PART THREE - ORAL BIOFILMS
pp 171-172

8 - Novel Microscopic Methods to Study the Structure and Metabolism of Oral Biofilms
pp 173-188

9 - Oral Streptococcal Genes That Encode Biofilm Formation
pp 189-211

10 - Gene Expression in Oral Biofilms
pp 212-228

PART FOUR - BIOFILMS ON SHEDDING SURFACES
pp 229-230

11 - Dissection of the Genetic Pathway Leading to Multicellular Behaviour in Salmonella enterica Serotype Typhimurium and Other Enterobacteriaceae
pp 231-261

12 - Bacterial Growth on Mucosal Surfaces and Biofilms in the Large Bowel
pp 262-286

13 - Pseudomonas aeruginosa Biofilms in Lung Infections
pp 287-310

Index
pp 311-314

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Medical Implications of Biofilms

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