The essay offers a novel interpretation of Hume’s notoriously thorny “Conclusion” to Book 1 of the Treatise of Human Nature that aims at reconciling Hume’s positive experimental science with his skepticism. I argue that Hume’s initial doubts are far less serious than they appear. I distinguish between the motivating forces of curiosity and ambition and Hume’s commitment to philosophical principles. Hume reveals his commitment to these principles after his dramatic epistemological crisis when he characterizes his “blind submission” to the senses and the understanding as the most perfect display of his “sceptical disposition and principles.” Hume’s sceptical principles, I argue, are essentially the principles guiding his experimental science. I offer an interpretation of Hume’s so-called “Title Principle” and how it fits within Hume’s “true scepticism.”