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Chap 9 - BENIGN FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS IN CHILDREN

Published online by Cambridge University Press:  01 March 2011

By
Markku Miettinen
Edited by
Markku Miettinen
Markku Miettinen
Affiliation:
Armed Forces Institute of Pathology, Washington DC
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Summary

Benign fibroblastic proliferations typical of children have here been divided into three categories: fasciitis and pseudotumors, fibromas and fibromatoses, and other benign fibrous proliferations. Among these are included a total of fifteen different clinicopathologic entities, which will be discussed here. These entities span a wide clinicopathologic and morphologic spectrum from non-neoplastic to neoplastic, with some examples of indeterminate conditions. Common to them all, however, is the potential for recurrence only, and none for metastasis. Some of these conditions can also occur in adults (e.g., calcifying fibrous tumor, calcifying aponeurotic fibroma, myofibroma). Conversely, many fibrous proliferations typically seen in adults also occur in children (e.g., nodular fasciitis, palmar, plantar and desmoid fibromatoses) – these are discussed in Chapter 8. Fibroblastic and myofibroblastic lesions of childhood with variable biologic potential are discussed in Chapter 10. Desmoid tumor is discussed in Chapter 8.

The terminology of some childhood fibrous tumors does not match the lesion type: some names are clearly misnomers and probably will be adjusted in the future. For example, the term fibromatosis has been historically applied to purely reactive, reparative processes such as fibromatosis colli, in addition to their main use for lesions with recurrence potential, such as desmoid. Similarly, some conditions classified as fibromas might be closer to fibromatosis in some respects. For example, calcifying aponeurotic fibroma tends to have diffuse infiltrative borders and significant potential for recurrence.

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Modern Soft Tissue Pathology
Tumors and Non-Neoplastic Conditions
 , pp. 255 - 284
Publisher: Cambridge University Press
Print publication year: 2010

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