Alcohol withdrawal syndrome (AWS) is among the most severe components of alcohol dependence (AD). Severe AWS, especially complicated with seizures and delirium, was a common reason for medical complications and death. The introduction of benzodiazepines decreased but did not eliminate those risks. The definition of AWS evolved in different versions of Diagnostic and Statistical Manual for Mental Disorders (DSM) from having hand tremor plus one or more other symptoms in DSM-III-R to any two or more symptoms in DSM-IV, which was retained in the current version of DSM-5.

Comparing subgroups of individuals with AUD based on AWS symptoms profile to define phenotypes for investigation of biological underpinnings of AWS phenomenology and treatment response.

Treatment-seeking individuals diagnosed with DSM-IV alcohol dependence (AD; n=473; 35.5% females) were assessed with Psychiatric Research Interview for Substance and Mental Disorders (PRISM), Timeline Follow back (past 90 days) alcohol consumption, Penn Alcohol Craving Scale (PACS), Pittsburgh Sleep Quality Index (PSQI), Patient Health Questionnaire-9 (PHQ9), and General Anxiety Disorder-7 (GAD-7). Latent class analysis was used to classify subjects according to lifetime prevalence of AWS symptoms according to DSM-III-R or DSM-IV/5. Demographic and other clinical variables were compared among clusters by linear model ANOVA and chi-squared test.

Four clusters were identified: subjects with (1) no history of meeting any AWS criteria (n=50); (4) with complete number of AWS symptoms, meeting both DSM definitions (n=259); and two clusters of subjects with smaller number of AWS symptoms: (3) those meeting only DSM-IV/5 criteria (n=94) and (2) those also meeting DSM-III-R criteria (n=70). Compared to cluster 2, the Cluster 3 members had higher frequency of anxiety, insomnia, and restlessness during withdrawal. The clusters also differed in the total number of drinks (p=0.021), average drinks per drinking days (p=0.013), history of anxiety disorder (p=0.006), substance-induced depression (p=0.019), and higher scores of PSQI (p<0.001), PHQ9 (p<0.001), and GAD-7 (p<0.001) with a relative increase in frequency between clusters as follows 1<2<3<4. Group 4 also had the highest percentages of subjects with history of seizure, delirium or hallucinations.

Different definitions of AWS capture clusters of AD patients with different symptomatology, comorbidity and consumption patterns. Understanding of biological underpinnings behind those differences may guide improvement in personalized treatment selection.

None Declared

Delusional parasitosis is a psychotic disorder where individuals firmly believe they are infested with parasites despite no medical evidence. It can be primary or secondary, the latter being a symptom of other medical conditions like neurological diseases. Effective management requires collaboration between psychiatry and other specialties.

The evaluation of each patient with an interdisciplinary team increases adherence to treatment in patients with cancer and psychiatric illness.

Clinical history, complementary studies, and review of the literature on the case of a 66-year-old woman subjected to multiple dermatological treatments due to a sensation of body infestation. History of type 2 diabetes and diabetic neuropathy since 2021. In 2022, she was diagnosed with stage IIIA luminal B breast cancer and treated with surgery, chemotherapy, and radiotherapy. She is currently on adjuvant treatment with Anastrozole. The oncologist referred her due to the presence of psychotic symptoms. The General Health Questionnaire (GHQ-28), Functional Assessment of Cancer Therapy—General (FACT-G), and Positive and Negative Syndrome Scale (PANSS) were applied.

The patient presents with a psychotic disorder secondary to vascular pathology, manifested by delusions of infestation and sudden-onset hypodermic tactile hallucinations. Test results show a GHQ-28 score of 10/84, FACT score of 24/108, and PANSS score of 49 points. Although denying affective symptoms, anxiety, or cognitive impairment, neurological findings indicate decreased brain parenchyma, suggesting small vessel disease. Treatment includes Risperidone 1 mg once daily, along with therapeutic interventions such as psychoeducation and continued multidisciplinary monitoring by neurology for comprehensive disease management.

Evaluating psychotic symptoms requires assessing organic and non-organic factors. Neuroimaging aids diagnosing delusional parasitosis, improving treatment through interdisciplinary collaboration.

None Declared

Anorexia Nervosa (AN) is a complex psychiatric disorder often understood through a Western lens. This study explores AN in the Cambodian context, where the condition is not traditionally recognized, to uncover cultural and transcultural aspects of the illness.

This research aims to conduct an in-depth phenomenological exploration of AN cases in Cambodia, documenting the lived experiences of individuals and identifying cultural or transcultural elements within the universal description of AN.

Employing a qualitative research approach grounded in phenomenology, this study will involve in-depth interviews with Cambodian individuals experiencing AN. The data will be analyzed using both descriptive and interpretive phenomenological methods, ensuring the bracketing of researcher bias and fostering co-creation of interpretations.

Expected outcomes include a comprehensive phenomenological account of AN in Cambodia, shedding light on the lived experiences of individuals and potentially revealing unique cultural dimensions of the disorder. The study will contribute to the understanding of AN from a transcultural perspective, highlighting both universal and culturally specific aspects.

This research is anticipated to provide valuable insights into the phenomenology of AN in a non-Western context. The findings may have implications for clinical practice, research, and cross-cultural understanding of AN, emphasizing the importance of patient-centered approaches and the exploration of lived experiences in psychopathology.

S. Bora Grant / Research support from: International Exchange Award from the Renewing Phenomenological Psychopathology funded by the Wellcome Trust, R. Ngin: None Declared, S. Vilhem: None Declared

Digital phenotyping offers a valuable method for predicting and preventing nonsuicidal self-injury (NSSI) in daily life by providing objective, ecologically valid measurements at multiple time points. This approach quantifies an individual’s phenotype by capturing self-injury-related markers such as mood, step counts, and heart rate.

The aim of this study is to identify real-time predictors and to elucidate the dynamic trajectory of NSSI in individuals.

This study targets individuals in their 20s residing in South Korea who engaged NSSI on five or more days during the past year, and a total of 56 participants were included in the current study. Once participants were enrolled, active (e.g., ecological momentary assessment) and passive (e.g., heart rate, step count) data were collected via a smartphone app and wrist-worn wearables for 14 days. Initially, a random forest algorithm was employed to assess the relative importance of passive and active data in predicting NSSI thoughts. Subsequently, a multilevel logistic regression model was used to capture variability at both the within-person and between-person levels.

After inputting passive data into the random forest algorithm, the model demonstrated an accuracy of 0.619. Among the variables, walking stride had the highest importance score at 0.28, followed by heart rate (0.18) and heart rate variability (0.17). Subsequently, when analyzing the random forest algorithm with active variables, the model’s accuracy was found to be 0.666. In this case, anger toward others had the highest importance score at 0.26, followed by depression (0.22) and anger toward oneself (0.19). In a separate analysis using multilevel logistic regression models for each passive variable, none of the variables produced significant results in either the fixed or random effects analyses. However, when active variables were entered into separate multilevel logistic regression models, all emotional variables yielded significant results in the fixed effects analysis: depression (0.746, p < .001), anxiety (0.521, p < .001), anger toward oneself (0.475, p < .001), anger toward others (0.403, p < .001), loneliness (0.329, p < .001), and shame (0.557, p < .05). In contrast, none of the variables showed significant results in the random effects analysis.

The findings from this study could offer insights into novel mechanisms underlying the occurrence of self-injurious thoughts and their prediction in daily life. Additionally, this advanced approach may help identify optimal strategies for NSSI prevention and enable the delivery of personalized, real-time interventions.

None Declared

Despite rigorous evidence of the benefits, costs and savings and mentions in treatment guidance, cognitive remediation access is still sparse. Providers are often confused by disagreements about the strength of the benefits evidence, some think it is a game not a treatment and others do not consider that cognition should be a treatment target. These are all issues that were present in the literature at least ten years ago.

To identify the steps to widespread implementation of this beneficial intervention

Drawing on the literature and data from a large UK adaptive randomised control trial, we describe three: (i) the barriers and facilitators for the implementation into first episode services, (ii) cost effectiveness and (iii) training rollout and competency.

(i) Clinicians need to understand the relevance of cognition and be aware of effective interventions, (ii) Despite evidence of efficacy a therapist seems important for engagement and leads to cost effective therapy and (iii) online therapy can improve competencies for delivering cognitive therapy and but commitment to completing therapy is related to management commitment.

All the implementation issues can be overcome but we still need to understand the non-specific effects of cognitive remediation as well as the specific if we are to provide a formulation-based approach. Clinicians need to know that cognitive remediation is not “brain training” but is a holistic therapy that involves an active therapist providing motivation support, and who helps to mitigate the impact of cognitive difficulties through metacognition to develop awareness of cognitive approaches to problems.

T. Wykes Grant / Research support from: NIHR grant 2.2m

Globally, anxiety and depression are primary contributors to work disability and are associated with the mental and physical well-being of educators.Anxiety and depressive disorders result in poor mental health, great human misery, enormous loss in economic output and increased public health and economic burden.

To determine the prevalence and independent predictors of likely Generalized Anxiety Disorder (GAD) and likely Major Depressive Disorder (MDD) among teachers in Newfoundland and Labrador, Alberta, and Nova Scotia.

The study utilized a cross-sectional design. Educators in the three Canadian provinces completed an online survey after enrolling on the Wellness4Teachers program, a daily supportive text messaging program. Likely GAD and likely MDD among subscribers were respectively assessed using the Generalized Anxiety Disorder-7 scale and Patient Health Questionnaire-9. Data was analyzed with SPSS version 28.

Overall,763 out of the 1912 subscribers of the Wellness4Teachers program completed the survey, resulting in a 39.91% response rate. The prevalence of likely MDD was 55.7%, and likely GAD was 46.0%. Participants who experience high stress were 7.24 times more likely to experience MDD (OR = 7.24; 95% CI: 4.22–12.42) and 7.40 times more likely to experience GAD (OR = 7.40; 95% CI: 4.63–11.80) than those with mild to moderate stress. Again, participants with emotional exhaustion were 4.92 times more likely to experience MDD (OR = 4.92; 95% CI: 3.01–8.05) and 4.34 times more likely to experience GAD (OR = 4.34; 95% CI: 2.47–7.62) than those who did not. Similarly, respondents with low resilience were 3.01 times more likely to experience likely GAD compared to those with normal to high resilience (OR =3.01; 95% CI: 2.03-7.62). Sociodemographic and work-related variables did not independently predict the presence of likely GAD and likely MDD.

The current study reinforces the need for governments and policymakers in the education sector to implement appropriate and comprehensive mental health support programs to address the unique stressors faced by educators, reduce emotional exhaustion and improve resilience as a way to reduce anxiety and depression, promote their well-being and enhance the quality of educational delivery.

None Declared

Suicide involves not only patients but also families and communities, causing long-lasting effects on those who “survive”. The term “second victim” is used to define people who experience significant distress after a patient suicide (PS). For mental health professionals, PS could be considered an “occupational hazard”.

To assess the impact of patient death on psychiatric trainees and early career psychiatrists (ECPs), comparing PS to other causes of death.

Participants completed a socio-demographic section and a section about the experience of PS. Impact of event scale–revised version (IES-R) based on the last 7 days and the 7 days after the most recent patient death, Suicide Knowledge and Skills Questionnaire (SKSQ), the Impact of a Patient’s Suicide on Professional and Personal Lives Scale and the Maslach Burnout Inventory (MBI) were administered.

110 subjects were recruited from 23 European and 1 Asian countries. The mean age was 31.9 (SD=4.7). Most were trainees (66.4%, n=73), worked in a psychiatric ward (61.8%, n=68), and in general adult psychiatry (83.6%, n=92). Patient death was experienced by 51.8 % (n=57) of the participants. 17.3% (n=19) experienced a PS, 12.7% (n=14) experienced multiple PS, 13.6% (n=15) had patients who died both by suicide and other medical conditions, and 8.2% (n=9) had patients who died from other medical conditions. The most reported feelings were sadness, regret, guilt, helplessness and frustration. Among participants who experienced at least one PS, 89.7% (n=35) developed symptoms. The most common were increased awareness of risk (40.4%; n=19), low mood (34.0%; n=16), anxiety (32.6%; n=15) and lack of concentration (26.1%; n=12). 6.5% (n=3) experienced suicidal thoughts/passive death wishes, and 6.5% (n=3) received individual psychotherapy treatment for their symptomatology. Having experienced a patient loss influenced clinical practice in 33.3% (n=19) of the sample, with 10.5% (n=6) reporting the affliction of the ability to carry out clinical duties. 12.7% (n=14) considered changing careers, 10.5% (n=6) took sick leave, 57.8% (n=33) received helpful support from colleagues. However, 52.3% (n=30) felt they needed additional support. According to the total score of IES-R scored on the 7 days after the most recent patient death, 22.9% (n=11) of the sample who experienced at least one PS had a score indicating a risk of PTSD, compared to 22.2% (n=2) of participants who experienced other type of patient death. No difference in all scales was observed in those experienced PS rather than any other kind of patient death (p>0.05).

Our results confirm that PS affects the mental health of ECPs and psychiatric trainees, and impacts their daily lives. A larger sample should be collected to strengthen our results and better characterize the impact of these events.

None Declared

Stressful experiences and traumatic events are major contributors to the development of mood disorders, which affect about 8% of the global population. The interaction between stress, trauma, and mood disorders is multifaceted, involving neurobiological, psychological, and social factors. This study aims to analyze the prevalence, gender differences, and neurophysiological changes linked to these conditions, highlighting the importance of timely interventions for prevention and treatment.

To investigate how chronic stress and trauma contribute to the development of mood disorders, examine the impact of resilience factors, and explore the associated neurochemical and structural brain changes.

A review of literature was performed using psychiatric textbooks, clinical guidelines, and databases such as PubMed/MEDLINE, NCBI, PsycINFO, and Google Scholar. The analysis focused on studies published between 2016 and 2023, with search terms including “chronic stress”, “traum”, “mood disorders” and “resilience”.

An analysis of 30 studies revealed that 65% of individuals exposed to prolonged stress experience mood disorders. Trauma survivors have increased risk of developing depression, women 35% more likely to suffer from depression than men. In contrast, men show a 25% higher incidence of developing bipolar disorder following trauma. Resilience factors such as family support and psychological counseling can reduce the risk of mood disorders by 20%. Additionally, 35% of patients with mood disorders exhibit comorbidities such as PTSD or substance use disorders. Neurochemical changes include a 50% reduction in dopamine levels, while 40% of individuals show hippocampal atrophy linked to chronic stress.

Chronic stress and trauma are key factors in the onset of mood disorders, with distinct gender differences and significant neurobiological changes. Early intervention, focusing on resilience enhancement and psychosocial support, can reduce the long-term effects of stress and trauma, improving mental health outcomes.

None Declared

Women face a greater incidence of mental health issues than men, stemming from societal expectations, gender stereotypes, organizational structures that prioritize male leadership, and the need to balance work responsibilities with home life. Research indicates that women are twice as likely to suffer from depression, generalized anxiety disorder, and post-traumatic stress disorder (PTSD) compared to men. They are also more likely to battle eating disorders.

The authors will review the current literature on this topic.

43% of female executives experience burnout, compared to 31% of their male counterparts (Mc Kinsey 2024). Research is definitely needed to better understand the pathophysiology and socioeconomic mechanisms that drive sex-specific risk factors of psychological disorders in women. There is also an urgent need for studies that addressed the specific needs of women including insights around: the biological, life stage, socioeconomic, political and cultural factors associated with being female that have a significant impact on women’s mental health.

A mental health reform is necessary to prevent mental illnesses in women, provide specific care to vulnerable women and increase the overall well-being of women living with existing mental health conditions.

None Declared

Legalizing cannabis can yield significant benefits for public mental health by fostering harm reduction, promoting medical access, and mitigating societal stigma. While concerns about misuse exist, a well-regulated cannabis policy can outweigh these risks and provide a balanced approach to mental health promotion. 1. Harm Reduction through Regulation Prohibition often drives cannabis use into unregulated markets, where the lack of quality control increases risks of contamination with harmful substances. Legalization allows governments to regulate cannabis production, ensuring product safety and controlled potency. This can reduce incidents of adverse reactions, particularly those exacerbated by high-potency strains or toxic additives. A regulated market also discourages illicit activity, reducing exposure to dangerous drugs often sold alongside cannabis in black markets. 2. Promoting Medical Access and Mental Health Treatment Legalization enhances access to cannabis for therapeutic purposes, particularly for mental health conditions such as chronic pain and opens the door to explore the potential benefor for patents with anxiety and post-traumatic stress disorder (PTSD), and. Studies indicate that cannabinoids can alleviate symptoms of stress and anxiety when used responsibly and under medical supervision. By integrating cannabis into healthcare systems, individuals struggling with mental health disorders can benefit from a natural and potentially less addictive alternative to pharmaceuticals like opioids or benzodiazepines, which carry significant risks of dependency. 3. Addressing Stigma and Encouraging Open Dialogue Legalization reduces societal stigma associated with cannabis use, enabling more individuals to openly discuss their experiences and seek help for misuse if needed. Public health campaigns can then focus on education about responsible use, mental health implications, and support systems. Decriminalizing cannabis also reduces the disproportionate criminalization of marginalized groups, fostering a more inclusive and equitable approach to public health. 4. Potential to Reduce Alcohol and Opioid Use Research has suggested that legal cannabis availability is associated with reductions in alcohol and opioid consumption, substances that are more harmful to both physical and mental health. By providing a less harmful alternative for relaxation or pain management, cannabis legalization could mitigate the societal burden of these substances, including addiction and overdose crises. Conclusion While cannabis legalization requires careful regulation to mitigate risks like overuse or dependence, its potential benefits for public mental health are substantial. By reducing harm, enhancing medical access, and promoting a more informed and equitable societal approach, legalization represents a forward-thinking public health policy that prioritizes well-being over punitive enforcement.

None Declared

Eye-tracking technology is a sensitive and direct method of measuring social-cognitive abilities regardless of language, causing minimal cognitive strain and with the advantage of its passive presentation of stimuli to participants, which allows observation without requiring verbal interaction nor explicit responses.

Our aim was to study variations in social attention among adults diagnosed with ASD, ADHD, comorbid ASD and ADHD, and non-clinical individuals using eye-tracking technology.

We recruited a total of 80 participants over the age of 18 from the Psychiatric External Ward of Vall Hebron University Hospital, resulting in approximately 20 participants in each group. Social attention was assessed using vignettes from the Autism Diagnostic Observation Schedule-2 (ADOS-2).

Preliminary results revealed significant statistical differences among the groups in the variables analyzed, indicating that individuals with ASD display distinct patterns of visual attention toward Areas of Interest (AOIs) containing social information compared to the other groups. No differences were found in the duration of fixation on the characters’ eyes among the groups. However, participants diagnosed with ASD and ASD+ADHD tended to spend more time looking at regions with lower social information density, such as the characters’ hands in the third vignette.

These findings shed light on social attention profiles across clinical and non-clinical populations, indicating specific patterns associated particularly with ASD, and highlight the importance of considering multiple aspects of social cognition. By employing eye-tracking technology, this study provides valuable insights into the underlying mechanisms of social attention across different neurodevelopmental conditions. Furthermore, the lack of significant differences in eye fixation duration on the eyes among clinical groups challenges conventional beliefs regarding social attention deficits in ADHD compared to ASD.

Using objective measures like eye-tracking can enhance our understanding of these complex neurodevelopmental conditions, potentially aiding in diagnosis and guiding the development of targeted interventions to address social cognition challenges in populations with neurodevelopmental disorders.

Our findings may contribute to a better understanding of social attention differences between ASD, ADHD, comorbid ASD+ADHD, and non-clinical individuals, paving the way for the design of more tailored and effective interventions.

None Declared

Genetic testing has become an essential tool in managing psychiatric conditions among individuals with intellectual and developmental disabilities (IDD). The frequent presence of genetic syndromes within this population underscores the value of genetic insights for guiding personalized treatment. By integrating pharmacogenetics into care, clinicians enhance medication efficacy and reducing the likelihood of adverse effects.

This study aims to elucidate the role of genetic testing in identifying specific syndromes and psychiatric comorbidities in IDD, explore the application of pharmacogenetic insights to optimize psychiatric medication management, and highlight case examples that demonstrate how genetic insights influence treatment decisions.

A targeted literature review identified relevant studies on genetic syndromes linked to IDD, the impact of genetic testing in psychiatric care, and the application of pharmacogenetic data in guiding medication management. Key studies examined the pharmacogenetic profiles of individuals with IDD and their effects on treatment outcomes, focusing on findings that can inform personalized treatment strategies.

Fragile X syndrome (FXS), a prevalent genetic disorder among IDD populations, is associated with high rates of anxiety, ADHD, and autism spectrum disorder (ASD). Research shows that stimulant medications commonly used for ADHD may worsen agitation in individuals with FXS, making non-stimulant options or behavioral therapies preferable. Pharmacogenetic findings, such as variations in serotonin-related gene polymorphisms, have been linked to increased aggression and stereotypic behaviors in males with FXS, guiding clinicians toward selective serotonin reuptake inhibitors (SSRIs) or alternative behavioral approaches. In cases of DiGeorge syndrome (22q11.2 deletion syndrome), genetic testing identifies an increased risk for psychotic disorders, and genetic variants may affect drug metabolism. Findings from the IMPACT study, a Centre for Addiction and Mental Health (CAMH) project, highlight the benefits of tailoring medications based on genetic markers, such as CYP2D6 and CYP2C19 enzyme activity. These insights improve outcomes by reducing side effects like sedation and enhancing therapeutic efficacy, especially for IDD patients who may respond unpredictably to psychiatric medications.

Genetic testing is invaluable in the psychiatric management of individuals with IDD, offering insights that enable more personalized and effective treatment approaches. By identifying genetic syndromes and incorporating pharmacogenetic data into medication planning, clinicians can minimize adverse effects, tailor therapies, and improve patient outcomes. Ongoing research and broader access to pharmacogenetic testing are essential to further refine treatment protocols for the IDD population.

None Declared

Alcohol withdrawal syndrome (AWS) is not a common medical condition in general population however it affects patients with alcohol use disorder (AUD) and causes severe complications when diagnosed late or left untreated. Diazepam is a benzodiazepine, which is used to treat various diseases such as insomnia, anxiety, muscle spasm, pain and AWS. Compared to other benzodiazepines, diazepam is more efficient to prevent delirium and decrease withdrawal due to its long half-life. Diazepam is metabolised to its main metabolite nordiazepam with the enzymes expressed by CYP2C19 and CYP3A4 genes. It has been reported that metabolic activity of the enzymes encoded by CYP2C19 gene may be varied due to genetic polymorphisms leading a change in the efficiency of treatment via effecting the plasma level of drugs metabolised by CYP2C19.

The aim of this study is to investigate whether CYP2C19*17 gene polymorphism has an impact on plasma levels of diazepam and nordiazepam in the Turkish patients with AWS and under oral diazepam treatment.

The study included 50 male patients who were in withdrawal state and taking diazepam therapy. CYP2C19*17 polymorphism was determined by PCR-RFLP method. Plasma levels of diazepam (DZP) and nordiazepam (NDZP) were detected by HPLC.

Genotype frequencies were calculated as 66% for CC, 30% for CT and 4% for TT. Dose-normalized DZP and dose-normalized NDZP values were 0.049 μg/ml per mg/day and 0,056 μg/ml per mg/day, respectively. No statistical significance was observed in the levels of normalized DZP and NDZP when CC and CT+TT genotypes were compared (p= 0.073 and p=0.282, respectively).

The effect of CYP2C19*17 polymorphism on the plasma levels of DZP and NDZP following long term oral diazepam to treat patients with AWS was determined for the first time. With the help of current study, first data on Turkish population was obtained and may be useful for personalized therapy in the future.

This study was supported by Scientific and Technological Research Council of Turkey (TUBITAK) under the Grant Number 121C441. The authors thank to TUBITAK for their supports.

None Declared

Night shift work disrupts the natural circadian rhythms, leading to significant sleep disturbances that can adversely affect mental health. Nurses working these shifts often report higher levels of stress, anxiety, and depression compared to their day-shift counterparts.

This study aims to assess the prevalence of psycho-affective disorders among night-shift nurses.

Data were collected from a cross sectional study in the university hospitals of Sfax. We used a questionnaire exploring socio-demographic, professional data and pathological history. We evaluated absenteeism based on the number of days absent over the past year. Psychoaffective disorders were screened using the validated Arabic version of the Depression, Anxiety, and Stress Scale: DASS-21.

Our study included 114 nurses, with 65% being female. The mean age was 33.8 ans ± 7 years. Severe to very severe symptoms of depression, anxiety, and stress were found in 14%, 21%, and 18% of our participants, respectively. Among our workers, 58% reported being moderately satisfied at work. During the last 12 months, 68 nurses (59.6%) were absent for an average of 27.21 days ± 72.73 days. Significant associations were found between job satisfaction and severity of depression (p= 0.000), anxiety (p=0.027) and stress (p = 0.000). Absenteeism was significantly associated to depression (p=0.009, r=0.24), anxiety (p=0.014, r=0.23) and stress (p=0.35, r=0.19).

Psychoaffective disorders are common among paramedical staff working shifts in hospitals. It is essential to conduct screening consultations in occupational medicine to identify these disorders early on.

None Declared

Delusion of pregnancy is not common among patients suffering from schizophrenia, especially males. The reports in literature regarding this delusion are rare and not conclusive, particularly about its mechanisms. The psychopathology behind this particular condition may involve hormonal and biological ways.

Illustrate through a case report and a review of literature the causal relationship between delusion of pregnancy and hyperprolactinemia in a male with schizophrenia.

This case report involved a comprehensive evaluation of a patient presenting with delusion of pregnancy and hyperprolactinemia. We compared the clinical findings with the existent research after conducting a literature review on different databases such as Pubmed and the national library of medicine using the key words “delusion of pregnancy” “males” and “hyperprolactinemia”

A 30-year-old Tunisian man with a history of schizophrenia who has been of treatment for 6 months, presented to our department with auditory hallucinations, incoherent speech, and a delusion of pregnancy. The patient reported feeling fetal movements and believed a uterus had been implanted in his abdomen after receiving stem cell injections. Since it is the first time that our patient presents this delusion of pregnancy unlike his other relapses, we asked for a prolactinemia test and complete hormonal panel. His prolactin levels were elevated at 59.33 ng/ml (normal range: 15-25 ng/ml), compared to normal baseline levels in previous admissions. The hormonal screening revealed hypogonadotropic hypogonadism. The patient was treated with antipsychotics (haloperidol initially, then switched to clozapine) and sedatives to manage his symptoms and agitation. His prolactin levels were successfully managed with medication, returning to within the normal range (the second measurement being done 8 weeks after the switch to clozapine). The delusion of pregnancy resolved after several weeks of treatment with clozapine. The patient was discharged with ongoing outpatient care to monitor his schizophrenia and prolactin levels.

This case report highlights the association between delusion of pregnancy and hyperprolactinemia in a male patient with schizophrenia. The findings suggest the potential link between these two conditions. Further research is necessary to elucidate the underlying mechanisms and develop evidence-based clinical management.

None Declared

Studies shows a connection between hostility and the severity of psychopathological symptoms. When psychopathological symptoms (mainly depressive) are expressed, hostility towards one’s own “I”, other people, and generalized impersonal hostility in the form of a sense of injustice, ill will of the surrounding world, and a negative assessment of the subjective future are combined. the connection between hostility and a negative assessment of the future requires empirical confirmation.

The aim of the study was to analyze the connection between hostility and a negative assessment of the future.

N=37 people hospitalized in the clinic of the Mental Health Research Center (16 men and 21 women) with a diagnosis of schizophrenia and affective spectrum. Methods: SCL-90R, BPAQ-24 (Buss, Perry), All the subjects wrote a short essay “Me, others, the world”, attitude to the future was assessed by a group of answers in the modified Sentence Completion Test (Sacks, Levy). The subjects were divided into three subgroups: “positive expectations of the future” (N=16, mean age 24.87±8.20), “neutral future” (N=10, mean age 21.89±8.08), “negative assessment of the future” (N=11, mean age 21.45±4.82). The presence of a trend in changing parameters depending on the attitude to the future - Jonckheere-Terpstra Test, comparison of subgroups by parameters of qualitative assessment of the essay - Chi-Square Tests were used.

The analysis showed an increase in “hostility” (BPAQ-24) with a change in attitude to the future from negative to neutral and positive. With a negative attitude towards the future, there were the highest rates of “hostility” (24.82 ± 4.26, 17.60 ± 5.58, 16.40 ± 4.63, Std. J–Tstat. = -3.44, p = .001). It was revealed that negative expectations of the future are associated with the presence of problems in interpersonal relationships in the present, “Interpersonal Sensitivity” (SCL-90) is increased (10.82 ± 7.37, 7.00 ± 6.88, 4.87 ± 6.81, Std. J–Tstat. = -2.348, p = .019), individuals with high rates are distinguished by negative expectations regarding interpersonal interaction and any communications with other people. The analysis of the parameters of the qualitative analysis of the essays in the subgroups showed that only with a negative attitude towards the future there is a mention of the fragility and instability of the world (36%, p=.007), statistically more often mention the topic of suicide, death, “no place in this world” (80% compared to 16% and 22%, p=.049), the topic of “rejection” (p=.025), the frequency of expectation of a negative assessment of oneself by other people (, p=.004).

Results confirm the hypothesis about the relationship between hostility and a negative attitude towards the future and allow to assume that a common factor for both hostility and a negative attitude towards the future in mental pathology are problematic interpersonal relationships.

None Declared

The number of people exposed to trauma has increased due to disasters, epidemics, wars, and various man-made causes occurring worldwide- including Turkey. Therefore, the principles of trauma-informed care should be applied in all healthcare settings and incorporated into policies and institutional frameworks (Saunders et al., 2023; Greer, 2023; Huo et al., 2023). Although mental health professionals are experienced in the effects of trauma, a more systematic approach is required to enhance awareness of and achieve widespread trauma-informed care. In Turkey, there is no standardized guide or algorithm for providing care and treatment to trauma victims, and no guide has been developed to ensure a common understanding of care in approaching trauma among mental health professionals.

This study examined the knowledge, skills, and stance of professionals providing mental health services in Turkey regarding trauma-informed care, as well as their intervention skills related to trauma. This constitutes the first phase of the studies to establish a fundamentally trauma-informed care model in existing mental health settings.

The study was conducted with a cross-sectional design, and the convenience sampling method was used. The study population was mental health services professionals in Turkey. The participants were recruited by researchers through social media platforms, and only those accepting participation were included in the study. The study was completed with 197 participants who filled out the survey forms.The data were collected using the Trauma-Informed Care Scale and the Trauma Intervention Skills Scale through an online survey. The data were analyzed using Spearman correlation analysis, Mann Whitney U, and Kruskal Wallis tests.

More than half of the participants were unaware of the concept of trauma-informed care (55.3%), and only 14.2% felt competent in presenting this care model. In trauma-informed care scores, gender, age, and education level did not create a significant difference (p>0.05), while those who have received information about trauma-informed care during their years of education scored higher (p<0.05). Compared to other professionals, nurses had higher trauma-informed care scores, and psychologists had an augmented ability to intervene in trauma patients.

The results of the research indicated that while mental health professionals possess knowledge about trauma, they did not reach the desired level in developing attitudes towards trauma-informed care and feeling competent in this area. Trauma-informed care seemed more about providing information related to procedures performed in the clinic or ensuring that the patient was not traumatized during the procedure. Therefore, more studies are needed to evaluate TIC practices in the much-needed mental health field.

None Declared

Previous research has shown chronic pain to be more prevalent in individuals with psychiatric disorders, compared to the general population.

We performed a systematic review of studies relating to chronic pain in patients with schizophrenia (PWS), to explore its cause, prevalence and presentation.

Our search strategy yielded 4963 studies. Once duplicates were removed, and studies were screened according to our inclusion/exclusion criteria, 15 studies on chronic pain and quality of life (QOL) in PWS remained.

Our results showed that the prevalence of chronic pain in PWS was equal to, or greater than, healthy controls. Studies assessing chronic headaches specifically, found headaches to be more prevalent. Studies that compared chronic pain in PWS to individuals with other psychiatric disorders, such as depression or bipolar disorder, found PWS to have lower levels of pain. Pain intensity ranged from mild to moderate and was most frequently reported in the abdomen and head. The presence of pain was associated with anxiety, depression, psychotic symptoms, and older age. No clear links were found between chronic pain and patient gender, education, or wealth. QOL, particularly health-related QOL, was lower in patients with higher levels of pain, and such patients experienced greater functional impairment. However, when PWS performed self-assessments of QOL and health satisfaction, no difference was seen between individuals with and without pain.

These variations in pain perception may be due to disturbances in somatosensation, with PWS being internally more preocccupied. Specifically, computational models suggest this may be due to aberrant salience, where PWS attribute meaning or value to innocuous stimuli. Understanding the link between chronic pain and schizophrenia is essential as this may contribute to premature death. Further research is required to explore the link between comorbidities as a cause of chronic pain in PWS.

None Declared

A frequent developmental condition of inattention that may or may not be accompanied by hyperactivity is known as Attention Deficit Hyperactivity Disorder.1One’s inability to focus, excessive activity, and behavior that is inappropriate for their age, all of these traits are indicative of ADHD.2The data for Atomoxetine indicates that it is safe and effective in treating ADHD in children and teenagers3. For kids and teenagers with disruptive behaviors, ADHD, and developmental disorders, Risperidone may be a safe, effective medication. Numerous investigations have demonstrated the high effectiveness of risperidone4

To study the Efficacy of Atomoxetine alone vs. Atomoxtine with Antipsychotic (Risperidone) on ADHD children.

This follow-up study was carried out from January to June 2024 on 54 ADHD children (6–18 years old) who were receiving treatment at the psychiatry clinic at Al Hussian University Hospital in Cairo, Egypt. This study was authorized by the Al-Azhar Faculty of Medicine’s Ethical Committee. Following an explanation of the purpose of the study and the acquisition of verbal agreement, all children underwent semi-structured clinical interviews and were excluded from other psychiatric & medical conditions.

Based on the DSM IV criteria, ADHD has been diagnosed in all of the study children. Conner’s 2 test for ADHD, or SCID, was used for every child in the study. Implementing medicinal treatment for every child and monitoring their progress, who were divided into two groups. The first group, which consisted of 27 children diagnosed as ADHD children, received only Atomoxetine, independent of the kind of ADHD. In contrast, 27 recently diagnosed children with ADHD, irrespective of their kind of ADHD, received a combination of Atomoxetine and antipsychotic(Risperidone) medication in the second group.

SPSS 20.0 was employed. The qualitative data were expressed in terms of percentages and figures, and the significance of the outcomes was assessed at the 5% level.

When Atomoxetine was administered to 27 children, it demonstrated a moderate level of efficacy to 12 from 27 patients (44.4%) for all children with ADHD, regardless of type, but it significantly improved the inattention type of ADHD in 4 from 4 patients (100%).Given to 27 children, the combination of Atomoxetine and Risperidone demonstrated greater effect on 24 from 27 patients with (88.9%) for all ADHD children, and it showed a discernible improvement on 9 out of 9 with (100%) for ADHD hyperactivity type.

All types of ADHD are responsive to Atomoxetine or Atomoxetine / Antipsychotic (Risperidone) combination, But Atomoxetine effect is more on Attention deficit variant than other variants, while Antipsychotic (Risperidone) is more effective on hyperactivity and aggression.

None Declared

The Dark Tetrad of Personality includes factors commonly recognized as socially aversive. So far, they have been recognized as psychopathy, narcissism and Machiavellianism. Nowadays, sadism has also been included in the scope of dark personality traits. There are many tools for examining the Dark Triad of Personality, while tools dedicated to the Dark Tetrad are under development. One such tool is The Short Dark Tetrad scale (SD4) by Paulhus et al. (2021), which, due to its popularity, may enable cross-cultural research in the future.

The aim of the study was to assess the preliminary psychometric properties of the Short Dark Tetrad tool - Polish version (SD4-PL).

972 people with an average age of 34.39±11.09 SD years were recruited for the study. The 28-item Short Dark Tetrad scale (SD4) was translated into Polish (SD4 Pl) and used for a study. As part of the statistical analyses, a confirmatory factor analysis (CFA) was used, based on the structural equation modeling. The internal consistency of the tool was also assessed.

Confirmatory factor analysis (CFA) parameters turned out to be satisfactory. The original structure of the tool was maintained, which consists of four 7-item scales dedicated to psychopathy, narcissism, Machiavellianism and sadism. The obtained psychometric parameters turned out to be similar to the results obtained in several countries where the Short Dark Tetrad scale has already been introduced. Satisfactory measures confirming the reliability of the tool (Cronbach’s α) were also obtained, ranging between 0.68 and 0.79.

Short Dark Tetrad - Polish version (SD4-PL) presents satisfactory psychometric properties. By maintaining the original structure of the tool, it opens the possibility of examining its equivalence with other language versions and, in the future, the possibility of conducting international research focusing on factors such as psychopathy, narcissism, Machiavellianism and sadism.

None Declared