First psychotic episodes (FPE) have a significant impact not only on the individual who experiences them but also on their close environment, particularly their family. The onset of a FPE typically occurs in the early twenties, a stage of life where individuals are planning and developing their adult life project. The changes in family dynamics following a FPE are part of the recovery process and are considered a prognostic factor for recovery.

Since the beginning of the Comprehensive Care Program for First Psychotic Episodes, a weekly support group for families has been conducted. The group is open, lasts 90 minutes.The group has an open theme and is co-facilitated. Participants may attend after starting the psychoeducation workshop for FPE and can continue attending even after the patient has been discharged from the facility.

The aim is to analyze the predominant family figures, age range, and gender, as well as the main themes that arise and concern the families of patients with first psychotic episodes.

A retrospective study with a mixed-method approach (qualitative and quantitative) is proposed, based on the narrative records collected during the weekly sessions from 2023 until June 2024.

The average attendance is 10.7 participants per group, mostly women (80%). The range age is from 18 to 70 years, with and average of 58 years. In terms of the roles concerning the patient: parents (95%), siblings (5%), with no representation of partners during the period analysed.

The predominant themes identified from the analysis of the collected verbatims include: guilt regarding the onset of the illness; the timing of recovery and managing the sense of urgency from the institution, the family, and the patient; regression in relational family dynamics; caregivers’ fear of their own death; shame and stigma; the traumatic experience of hospitalization; the distinction between behaviors associated with personality versus the illness; the rupture with identity; the fear of relapse and suicide.

Families highlight the role of the group as an emotional support, an improvement in communication strategies and bonding with the sick relative, better capacity for mentalization, and managing their own anxieties and emotions related to guilt and self-care.

The onset of a FPE generally affects the entire family system. Past conflicts and regressive attachment dynamics are activated. Communication based on guilt harms the elements of the system. Family support groups play a crucial role in the recovery process and in helping to establish new dynamics that promote the well-being and autonomy of both the patient and caregivers. The group stands out as a source of hope, which is the main healing factor. Additionally, participants report gaining healthy coping tools and reducing their experience of isolation and stigma.

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Autism Spectrum Disorder (ASD) is a developmental condition that modifies how a person perceives their surroundings, communicates and interacts with others. Autistic individuals often experience executive dysfunction, impaired social cognition, likewise differences in perception and information processing that can make it challenging to describe their internal sense of gender and gender-related needs. This case report presents the therapeutic journey of a young man diagnosed with Asperger Syndrome who entered dynamic supportive psychotherapy to address social and emotional challenges, likewise identity issues.

This poster aims to explore the clinical complexities arising from the presence of gender neurodivergence in individuals with ASD and its impact on their presentation, assessment and management. It seeks to highlight the unique challenges faced by autistic individuals in navigating gender identity, emphasizing the need for tailored clinical approaches.

A descriptive case report of a patient with ASD and gender neurodivergence, drawing on clinical records, patient interviews and psychotherapy sessions, psychological assessment and a non-systematic review of relevant literature.

A case report presentation of a 29-year-old man diagnosed with Asperger syndrome during adolescence. Due to adaptation difficulties and anxiety he started seeing a child’s psychiatrist and then transferred to an adult setting. He had intermittent visits to a community mental health service initially and, over the last two years, attended biweekly psychotherapy sessions at our hospital. Early psychological assessments revealed challenges with social interactions, confused and bizarre thinking patterns, identity diffusion, and a tendency for ruminative self-reflection. Treatment was interrupted at the end of 2023 due to a psychotic episode with dissociative phenomena, leading to the introduction of antipsychotics. After stabilization, psychotherapy resumed. During the course of therapy, conversations revealed a complex narrative around gender identity, including reflections on multiple genders and gender fluidity.

This case highlights the intersection of neurodiversity and gender identity, illustrating how individuals on the autism spectrum may experience and navigate gender in unique ways. The therapeutic process explored gender fluidity as an evolving self-concept, emphasizing the importance of inclusive approaches in psychotherapy. The report underscores the need for mental health professionals to be attuned to diverse expressions of gender identity within neurodivergent populations and advocates for flexible therapeutic frameworks that accommodate both neurodiversity and gender diversity.

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There is very little information about the mental health status of people with disabilities in Iran, while monitoring the status of this index is very necessary to properly address problems, design appropriate interventions, and evaluate the impact of interventions.

in this regard, this study investigated the prevalence of mental disorders among adults with physical and sensory disabilities in Sanandaj City, Iran.

This descriptive-analytical and cross-sectional study was conducted on people with physical and sensory (sight, hearing and speech) disabilities over 18 years of age in Sanandaj city in 2023. A two-part questionnaire was used in order to collect data in this study. The first part consisted of age, sex, type of disability, basic health insurance status, supplementary health insurance, education, employment status, and economic status (wealth assets). The second part included Goldberg’s 28-item questionnaire (GHQ-28) that was used as a screen tool for mental disorders. Data were analyzed using STATA software version 16.0 (Stata Corp, College Station, TX, USA.)

Finally A total of 607 people (response rate: 99%) participated in this study that 317 were men (52.2%) and 290 were women (47.8%). The prevalence of mental disorders suspicion was 56.7% (344 people) and its prevalence based on the severity of the disorder was 29.7% mild, 16.6% moderate and 10.4% severe. Results indicated that over 56% of participants were suspected of having a mental disorder, with the most common being depression and anxiety. Females, younger participants, the unemployed, those without supplementary health insurance, and those from lower economic classes had significantly higher odds of mental disorder suspicion. An uneven distribution was observed, with a disproportionate concentration among the lower economic status group.

The findings highlight a high prevalence of suspected mental disorders among people with disabilities and inequalities in gender, age, employment, insurance coverage, and socioeconomic status. Addressing mental health needs is crucial through targeted screening, prevention programs, and promoting access to appropriate services for this vulnerable population.

Disabled individuals, Disability, Mental health, Psychiatric disorders, Psychology, Health inequality, Iran.

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People living with schizophrenia (PLWS) face one of the most significant health equality gaps in Europe. Their life expectancy is 15–20 years shorter than that of the general population, mainly because they are affected at an earlier age by preventable physical illnesses, but encounter barriers in accessing adequate care. PLWS did not benefit from prevention campaigns for cardiovascular, oncologic, or metabolic risk. Antipsychotics might add to the cardiometabolic risk and represent a further reason for monitoring and treating emergent conditions. Notwithstanding international guidance papers or national guidelines, PLWS do not receive adequate screening and treatment.

This presentation will summarize national and international efforts to reduce this health equality gap, illustrating the minimum screening procedures and several interventions that can be integrated into schizophrenia treatment to improve health outcomes of PLWS.

A. Mucci Consultant of: Angelini, Gedeon. Richter Bulgaria, Janssen Pharmaceuticals, Lundbeck, Otsuka Pharmaceutical, Pfizer, Pierre Fabre, Rovi. Pharma and Boehringer Ingelheim

The science-to-practice gap in psychotherapy is a prominent topic of discussion that hinders the seamless integration of research findings into clinical settings. This divide seems, among others, to stem from conflicting views on the practical relevance of evidence-based mental health (EBMH).

This study aims to provide a comprehensive overview of the existing narratives that define the science-to-practice gap, develop an inclusive definition that reflects the complexities of this issue, and identify the factors influencing and strategies for mitigating this gap.

We conducted a systematic literature review with a qualitative, thematic synthesis approach including 131 articles. Themes were identified and synthesized to outline the science-to-practice gap. Additionally, we included a historical analysis to examine how the prevalence of certain codes and themes has evolved over time, reflecting shifts in the academic and clinical landscape.

Based on our findings, we refined the definition of the science-to-practice gap, capturing its multifaceted nature. Key themes influencing this gap include the educational background of psychotherapists, orientation towards specific psychotherapeutic schools, and personal inclinations of psychotherapists. Contextual factors such as institutional support and incentives for employing EBMH were also found to be positive influences. However, critiques regarding the rigidity of research methodologies and their applicability to diverse clinical scenarios were prevalent, with observable variances in thematic emphasis over the decades. Strategies identified for bridging the gap emphasized increased dialogue and collaboration between researchers and practitioners.

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This work sets the stage for future research that should prioritize the clinical perspective on evidence usefulness, broaden the research focus beyond intervention efficacy, and validate diverse methodologies. By proposing practice-focused research guidelines and emphasizing the need for robust dialogue between science and practice, we aim to enhance the applicability of research findings in clinical settings. Ultimately, our findings advocate for policies that facilitate the exchange of ideas and experiences, aiming to bridge the gap between scientific evidence and psychotherapeutic practice effectively.

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Attention deficit disorder with or without hyperactivity (ADHD) is a neurodevelopmental disorder. It represents the most common psychiatric disorder in pediatric population. Children with ADHD can experience academic and social difficulties, as well as psychological complications.

The objective was to determine the prevalence rate and the clinical profile of children with ADHD symptoms in the governorate of Monastir (Tunisia) and to study the comorbid symptoms.

We carried out a cross-sectional study, applying the Strengths and Difficulties Questionnaire (SDQ) scale and the short versions of Conners 3 to parents and teachers of 435 school children in a sample of 18 public and private schools randomly selected from 6 delegations in the governorate of Monastir.

The prevalence of ADHD symptoms was 12% of which 51.9% were boys and 48.1% were girls. The average age was 9.8 [9.2;10.4] years.

We found a predominance of the inattentive form with a frequency of 57.7% compared to the impulsive-hyperactive and combined forms which have a frequency of 17.3% and 25% respectively.

In 40% of the ADHD group, an emotional disorder was found, and in 54% of cases there were behavioral disorders, with a statistically significant difference. Relationship problems rise to 74%, but with no statistically significant difference.

The prevalence of ADHD symptoms in the governorate of Monastir is similar to the rate found in other parts of the world. Identifying predisposing factors helps early intervention, which in turn reduces the psychosocial impact of this disorder.

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The high symptom burden of lung cancer, coupled with the emotional strain of diagnosis and treatment, often leads to disrupted sleep patterns and heightened levels of anxiety and depression.

The aim of this study was to assess the prevalence and severity of insomnia in patients with primary bronchopulmonary cancers, and to explore its relationship with anxiety and depression.

This was a cross-sectional, descriptive and analytical study conducted among patients followed up for bronchopulmonary cancer at the palliative care unit in the pneumology and allergology department of the Hedi Chaker University Hospital in Sfax. The questionnaire used included patients’ sociodemographic characteristics, clinical and treatment data. Sleep disturbance was assessed using the insomnia severity index (ISI) and psychological distress using the Hospital Anxiety and Depression Scale (HADS).

A total of 49 patients participated, with a mean age of 61,8 years, the majority being male (85,7%). The disease duration was less than one year in 61,2% of cases, and 59,2% of patients had stage IV lung cancer, with tumor progression observed in 32,7%.

Mild to moderate insomnia affected 49% of the patients.

The mean anxiety score was 7,08 (SD = 3,6), with a prevalence of anxiety observed in 4,1% of patients. The mean depression score was 6,92 (SD = 3,4), and 34,7% of patients exhibited signs of depression.

A significant association was found between insomnia and depression (p=0,005), but no significant relationship was observed between insomnia and anxiety (p=0,14).

The relationship between sleep disturbance and psychological distress highlights the need for comprehensive management that addresses both physical symptoms and mental health in this population. Early identification and intervention for insomnia and depression in lung cancer patients may enhance their overall well-being and quality of life.

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Lung cancer remains one of the leading causes of cancer-related morbidity and mortality worldwide. Despite being a crucial treatment, chemotherapy often brings a range of side effects that can significantly impact the overall quality of life of the patients.

To evaluate the quality of life (QoL) in lung cancer patients undergoing chemotherapy.

The sample consisted of 49 lung cancer patients undergoing chemotherapy at the Pneumology and Allergology Department of the Hedi Chaker University Hospital in Sfax. The questionnaire used included patients’ sociodemographic characteristics, cancer and treatment data, and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire 30-item version (EORTC QLQ-C30).

The mean age of the patients surveyed was 61,8 years, with a male predominance (85,7%). The most frequently reported functional signs of lung cancer were dyspnea (36,7%), cough (34,7%) and chest pain (20,4%). Disease duration was less than 1 year in 61,2% of the cases, and 59,2% were classified as stage IV. Tumor progression occurred in 32,7% of cases. Of the patients, 20,4% were on a single chemotherapy agent, while 79.6% were on a combination regimen.

According to QLQ-C30, the mean global QoL score was 61,24 ± 24,5 for the entire sample. Physical functioning and role functioning were the most affected on the functional scale, while fatigue and appetite loss were the most frequent symptoms.

The findings indicate that lung cancer patients undergoing chemotherapy experience significant challenges to their quality of life, particularly in physical functioning and symptom management. These results highlight the critical need for integrating routine QoL assessments into clinical practice to better address patients’ needs and improve supportive care.

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Ketamine is widely recognized for its dissociative anesthetic properties, particularly in procedural sedation and severe pain management among children, adolescents, and young adults. Despite its noted applications, research investigating ketamine’s impact on mood and suicidality within this specific demographic remains limited. This retrospective review seeks to address this gap by characterizing ketamine usage and psychiatric comorbidities in Treatment-resistant depression (TRD).

This review aims to provide an initial assessment of the safety and efficacy of esketamine in adolescents suffering from TRD with concurrent comorbidities such as GAD and SUD, and infer common drug-drug interactions that may arise from utilizing esketamine in adolescents. This preliminary overview will contribute valuable insights toward optimizing treatment strategies for this vulnerable population.

This systematic review evaluates the evidence for ketamine use in children with treatment-resistant mood disorders. Two to four authors independently screened studies and extracted data on safety, tolerability, and efficacy. We searched two electronic databases for English-language studies on the therapeutic effects and side effect profiles of ketamine in youth aged 14-23 with treatment-resistant mood disorders, including those with treatment-resistant depression (with and without psychotic features) and bipolar disorder.

Recent studies, including a randomized, midazolam-controlled trial, indicate that IV ketamine can effectively reduce depressive symptoms in adolescents with treatment-resistant depression (TRD), with mild and manageable side effects like dissociation. No serious adverse events or instances of misuse were reported.

In conclusion, esketamine has demonstrated effectiveness in treating treatment-resistant depression. Additionally, when combined with SSRIs, esketamine improves depressive symptoms in TRD patients, irrespective of their anxiety status. These findings highlight the potential of esketamine as a valuable treatment option for this challenging patient population. Future research will focus on optimizing dosing, exploring complementary therapies such as cognitive behavioral therapy (CBT), and identifying biomarkers for response, while considering the unique risks to the developing adolescent brain.

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Adversity in adolescence, including peer victimisation, is associated with substance misuse in young adults, particularly in vulnerable individuals like sexual minorities. However, the potential developmental mechanisms underlying this association are yet to be fully understood.

This study will empirically investigate the relationship between childhood adversity and addictive behaviours in young adulthood (i.e., drug use). In particular, we will examine the possible moderating role of sexual identity and orientation on drug use problems.

A total of 329 adults (aged 18 to 35 years old) were recruited into the study and included in the final analysis. Of the 329 participants, 93 identified as being a sexual minority (26.16%). A large majority of participants were women (N = 278 / 78.1%) with a mean age of 20.3 years old (SD = 3.5) and a diverse distribution of ethnicities reflective of metropolitan Australia. All participants completed an online battery of demographic, self-report, and behavioural measures. A multiple regression using Hayes’ PROCESS macro for SPSS was conducted.

Overall, both identifying as being a sexual minority (b = .51, p <. 05) and reporting greater peer victimisation during childhood (b = .17, p <. 01) predicted greater levels of drug use in adulthood. Over and above the independent effects of sexual orientation and peer victimisation, being a sexual minority who also experienced a high level of peer victimisation were together predictive of more pronounced drug use in adulthood (b = .25, p <. 05).

Identifying as being a sexual minority as well as reporting greater peer victimisation in childhood were independently predictive of potential risky drug use in adulthood. This is in keeping with theories of the role of chronic stress in the development of potentially harmful behavioural, coping mechanisms. Consistent with our hypothesis, these effects were magnified when they occurred in combination, such that sexual minorities were more susceptible to the effects of peer victimisation on later drug use. Findings from the current study contribute to the identification of a possible modifiable adolescent risk factors – that is, peer victimisation - in driving increased substance misuse in sexual minority groups, which have significant implications for targeted public health strategies for these vulnerable individuals.

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People with psychotic-like experiences (PLE) have slow movements and uncontrolled movements, which are indicative of transition to psychotic disorders afterwards. Earlier research has reported that rhythmic auditory stimulation (RAS) is a promising therapeutic technique for movement abnormalities in people in the psychosis continuum. However, the small sample size was a major limitation in earlier research and restricted result generalizability.

This study was to increase the sample size and examine if faster RAS induced faster movements and less uncontrolled movements at both hands in people with PLE.

A total of 55 right-handed people with PLE (age: 20.51±2.50 years; 28 females) and 55 age- and gender-matched right-handed healthy controls (age: 20.53±3.10 years; 24 females) were recruited. Participants used the index finger to perform the alternate touching task for each hand when the motion capture system recorded the movement procedure. They were required to follow each beat of RAS with the normal tempo (100% of the fastest movement tempo without RAS) and the fast tempo (110% of the fastest movement tempo), the order of which was counterbalanced, when performing the alternate touching task. Kinematic variables were calculated to reflect severity of slow movements and uncontrolled movements in participants.

Two-way analysis of variance showed no interaction between groups and RAS in right-hand and left-hand kinematic values. People with PLE had slow movements at both hands and uncontrolled movements at the right hand. Faster RAS induced faster movements and less uncontrolled movements at both hands in people with PLE.

The major contribution of this study was to use a relatively large sample size to demonstrate effectiveness of faster RAS on inducing faster movements and less uncontrolled movements at both hands in people with PLE and thus increase result generalizability. Given that movement abnormalities are initial signs in the psychosis continuum and risk factors of transition to psychotic disorders, when healthcare practitioners design early intervention for movement problems in people with PLE, incorporating RAS in therapy is suggested.

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Involuntary hospitalization of a patient with a mental disorder is defined as admission to an inpatient unit without consent. Literature suggests that severe involuntarily admitted patients often present in crisis situations, receive less pharmacologic intervention and therapy, and exhibit poorer prognostic outcomes, such as an increased risk of readmission. Despite being a lifesaving treatment, involuntary admissions can also be stigmatizing, undermine the long-term therapeutic relationship and reduce adherence to care. In this context, little research has been conducted to evaluate how switching a patient’s hospitalization from involuntary to voluntary may impact health outcomes, such as psychiatric decompensation.

To compare the risk of hospital readmission of patients who switched to voluntary hospitalization with those who remain under involuntary hospitalization, and to analyze their sociodemographic characteristics and prognostic outcomes.

An observational retrospective study will be conducted using administrative and clinical data of patients who were involuntary admitted to inpatient psychiatry of Unidade Local de Saúde São João. All involuntary hospitalizations spanning from January 1, 2022, and December 31, 2022, will be categorized into two groups: patients who switch to voluntary hospitalization or patients that maintained involuntary hospitalization. Data registered in medical records within one year after the index hospitalization will be assessed (whether structured data or free-text). Descriptive, univariate, and multivariate analyses will be performed.

For both groups, sociodemographic and clinical variables will be described and compared, as well as the number of previous admissions, their legal status and the presence of previous ambulatory involuntary treatment. Administrative data on patient’s hospitalization, such as the length of stay, medical treatment and procedures performed, and the orientation received after discharge will also be compared. Additionally, prognosis outcomes, including readmissions, length of stay of readmissions and legal status of readmission will be analyzed.

We expect to elucidate the impact of switching involuntary hospitalized patients to voluntary status on prognosis outcomes. Through this comparative analysis, we hope to provide evidence supporting the prioritization of voluntary treatment whenever feasible.

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This paper presents a descriptive analysis of common data collected across 11 independent studies in the National Research Mentoring Network (NRMN) from 2019 to 2024, focusing on participant demographics and participation in training programs prior to NRMN.

Analyses focused on data from 6,197 survey responses collected primarily at baseline. Descriptive analyses examined participants’ demographic characteristics (gender, combined race/ethnicity, disability, parent/guardian education, and career stage) and participation in training programs prior to NRMN.

The majority of respondents were female (70%). Most respondents identified as White (46%), Black (23%), Asian (18%), and Hispanic (17%). Most respondents (91%) did not report a disability. In terms of career stage, 55% were undergraduates. Sixty-three percent reported that their parent or guardian had completed a bachelor’s degree. Regarding participation in training programs prior to NRMN, 60% had participated in mentor training, and 62% reported involvement in research training activities such as workshops, field experiences, and conferences. Patterns of participation in prior mentorship or research program varied across demographic characteristics.

The NRMN common data reveal the backgrounds of over 6,000 participants engaged in mentorship intervention studies across the biomedical workforce. The dataset includes participants from diverse demographics and career stages with varying levels of participation in prior mentor training and exposure to research training programs. This extensive dataset provides a valuable opportunity to explore the long-term impact of mentorship on the biomedical workforce in future research.

Psychiatric emergencies represent a significant challenge for healthcare systems due to their impact on patients, families and also healthcare professionals. These emergencies often arise in crisis situations, requiring immediate and appropriate intervention. Effective management not only involves stabilizing the patient but attending to psychosocial factors and continuity of treatment. In recent years, there has been an increase in the demand for psychiatric emergency services attributed to various factors; this underscores the need to analyze the patterns of these emergencies in order to optimize available resources and improve patient care.

The present study provides information regarding demographic and clinical characteristics of the patients treated. The main goal is to identify trends, risk factors, and opportunities for improving critical situations management as well as and the effectiveness of procedures implemented in primary and specialized care.

Currently there is no standardized method for collecting data on urgent psychiatric care, thus depending on the specific methodology of each center. In our hospital, a written request from the General Emergency department (where patients are initially received and attended) is mandatory; without it, patients are not assessed. Therefore, there is a reliable computerized record of daily attendances, data that has been collected retrospectively on a weekly basis until the study period is completed (June, July, and August 2024).

The following items have been studied: time of request, age, sex, patient origin, reason for the request, prior follow-up, management in emergencies, and discharge referral. Telephone calls for specific consultations have not been included in the record or considered psychiatric care as such.

There is a wealth of cross-referenced data that can be obtained form the collected information. In our opinion, the most interesting ones are those regarding referral reasons and discharging plans according to sex as well as age groups.

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The main conclusions are:

1. (1) More than 55% of patients present voluntarily, which could be interpreted as a positive indicator of mental health awareness, although it may also indicate a lack of prior support to prevent these crises.

2. (2) Of the patients assessed, 64.3% are discharged and 22.1% are admitted, with a low rate of service abandonment (1.8%). 64.3% of the total number had prior follow-up, suggesting effective ongoing care.

3. (3) More than 56% of the attendances received are women. It is essential to investigate whether this gender difference is due to a greater predisposition to seek help or differences in the incidence of psychiatric disorders.

4. (4) Regarding the reason of consultation, there is a high prevalence of suicidal ideation without prior intoxication (22.1%), reflecting the importance of preventive strategies in mental health and early crisis intervention.

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In psychopathology, a dualistic approach often refers to the conceptual separation of the mind and body as distinct entities, which can influence how mental disorders are classified and diagnosed. This separation may lead to biased judgments and contribute to the stigmatization of mental health conditions. It can also encourage alternative conceptualizations of mental health disorders and promote new methods of classifying mental health issues beyond traditional biomedical or behavioral frameworks.

The goal of our research was to examine the impact of psychiatrists’ and psychologists’ dualistic perspectives on the biological model of depression using the PLS-SEM model.

This cross-sectional study carried out in the Republic of Croatia in 2018, involved 238 participants, comprising 122 psychiatrists and 116 psychologists. We applied the Maudsley Attitude Questionnaire to examine the preferences of psychiatrists and psychologists in choosing the biological model of depression. Their dualistic perspectives were assessed using the Stanovich Mind-Body Dualism Scale. In the PLS-SEM modeling, dualism and monism were observed as exogenous latent variables in the model, and their impact on the biological model, which represents the endogenous latent variable, was analyzed. All model indicators are reflective.

Psychiatrists (M = 14.71, SD = 2.27) and psychologists (M = 13.77, SD = 2.69) predominantly support the biological model out of Harlands’ 8 models of mental disorders in defining depression. The PLS-SEM initial reflective model is significant (p = 0.002) even though the fit indices provided mixed results. The GFI (0.963) and SRMR (0.059) suggested a good or acceptable fit, but the CFI (0.862) and RMSEA (0.095) indicated that the model requires further refinement. The R² value revealed that the model explained 61.3% of the variance in the endogenous variables.

Mental health professionals prefer the biological approach in explaining the etiology, classification, research, and treatment of depression. Supporting a dualistic perspective had a significant negative total effect (p < 0.05) on the choice of the biological model of depression.

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Health Related Quality of Life (HRQOL) is a key outcome in the treatment of patients with psychosis. It is considered Patients should assess their HRQOL through PROMs. This subjective assessment could be combined with other sources of information

The aims of the present study are to evaluate HRQOL and other related variables in a sample of Spanish schizophrenia spectrum patients, who start treatment in a Rehabilitation Unit and to evaluate if there are improvements in HRQOL and in these variables after receiving a rehabilitation treatment

A sample of 127 of schizophrenia or schizoaffective disorders patients were included in the study (Table 1). These patients started a multi-professional treatment in a Rehabilitation Service. Patients have been evaluated twice – at the beginning and treatment end. Patients have assessed their general and specific HRQOL with the EUROQOL-5D-5L and SQLS-R4 scales. Professionals have evaluated main symptoms of psychosis SSPI, general functioning (objective QOL) PSP and basic and instrumental Daily activities VAVDI. Frequencies in the demographic, clinical and questionnaire scores were calculated. Changes in the questionnaires between the two assessments (Wilcoxon and Chi Square tests) (Table 1).

HRQOL scores were moderate in the EQ-5D-5L health and SQLS-R4 factors and total score (M=37.9; ST=20.9) in the first assessment, and high in the EQ-5D-5L value. The PSP score (objective QOL) at the first assessment shows notable difficulties. Significant changes HRQOL improvement were found in the EQ5D5L health, in the SQLS-R4 factors and total score (effect size range between .35-.39 small effect). General functioning (PSP) scores improved (effect size .68, middle effect) and Daily activities (0.34 small effect). A significant reduction in symptoms was observed in the total SSPI score, especially in negative symptoms, and anxiety/depression, with the effect size being particularly large (Table 2).

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These results of the present study outcomes have shown an improvement in both the perceived subjective and objective quality of life of patients. It seems patients and professional may have different criteria to evaluate HRQOL. The relevance of integrating patients’ HRQOL assessment into intervention strategies for the treatment of serious mental disorders is highlighted.

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Pro-inflammatory mediators inhibit drug metabolism and transport. Detailed knowledge is lacking on the mechanism and extent of alterations in olanzapine pharmacokinetics during acute inflammatory states accompanying infections.

To quantify the extent of systemic and brain exposure to olanzapine in a murine model of endotoxemia compared to a non-endotoxemia model.

Acute endotoxemia model was established in C57BL/6N mice intraperitonealy injected with 5 mg/kg Escherichia coli lipopolysaccharide (LPS). On Day 2 following LPS administration, LPS-injected mice and saline-treated controls were given single doses of olanzapine orally (p.o.) or intravenously (i.v.) or desmethylolanzapine (DMO) i.v. Concentrations and unbound fractions of olanzapine and DMO were measured in plasma samples and brain homogenates. Moreover, plasma biochemistry parameters and mRNA expression patterns were evaluated of pro-inflammatory cytokines, selected phase I and II drug-metabolizing enzymes and transporters in the liver, ileum and brain.

Following p.o. olanzapine, the areas under the concentration-time curve (AUC) for olanzapine and DMO in the plasma were increased 3.8-fold and 2.6-fold (P<0.05) in LPS-injected mice vs. controls. The AUC for olanzapine in the brain homogenate was 5.2-fold higher (P<0.05). Brain DMO was hardly detectable in both groups. The penetration ratios (Kp,brain) of 8.5 and 6.3 confirmed that LPS increased the passage of olanzapine into the brain. Expression of mRNAs was decreased in the liver of CYP1A2 and UGT1a1/1a5 enzymes and Abcb1a, Bsep and Ntcp transporters and of ileal Abcb1a, whereas Abcb1a and Abcb1b in the brain and inflammatory cytokines and chemokines mRNAs in the liver were upregulated.

Investigation of olanzapine pharmacokinetics in endotoxemia mice clearly indicates a considerable increase in systemic and brain concentrations of the drug after oral administration. Further studies should clarify whether or not the inflammation-induced inhibition of metabolism and efflux transport results in brain overexposure to the drug and adverse effects in accutely infected patients treated with oral olanzapine.

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The corpus callosum (CC) is essential for interhemispheric communication, and its abnormal integration is central to the neurobiology of schizophrenia (SCZ). SCZ patients have a 10-fold higher risk of cannabis use disorder (CUD) and about 20-35% show a lack or poor response to antipsychotics and are defined as treatment-resistant schizophrenia (TRS) Until now, no study has analyzed the morphology of the CC in TRS compared to healthy controls (HC) and non-TRS patients with and without CUD.

The aim of the study is to assess whether the diagnosis of psychosis, the response to antipsychotic treatment, and CUD can influence the volume of the CC. To achieve this, we used an innovative artificial intelligence program applied to MRI, which provides structural information on a single subject.

We included 20 HC and 48 SCZ patients, of whom 14 were affected by TRS and 34 were non-TRS. Among the non-TRS group, 20 had CUD comorbidity (non-TRS-CUD+) and 14 did not have CUD (non-TRS-CUD-). All were assessed cross-sectionally through the Neurological Evaluation Scale, the Brief Assessment of Cognition in Schizophrenia, the Positive And Negative Syndrome Scale. We assessed them cross-sectionally using psychometric tools, cognitive tests. All patients underwent a brain MRI 1.5 T, for white matter volume group analysis, and MRI applied to Artificial Intelligence (MRI-AI-Pixyl.Neuro) for single-subjects analysis.

TRS was associated with higher PANSS total score (fig. 1) and neurological soft signs (fig. 2) and lower negative symptoms (trend) than non-TRS groups. The TRS group performs worse in the Tower of London task compared to non-TRS and HC groups. Only the condition of TRS is associated with a significantly smaller CC volume (64.28%) compared to HCs and non-TRS patients (Fig. 3). Only one patient from the non-TRS-CUD- group showed a reduction in the volume of the CC like TRS patients.

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TRS is associated with more severe general and negative symptoms, NSS, and cognitive dysfunctions and with a significantly smaller CC volume, demonstrating the role of this structure in the pathogenesis of TRS and probably in executive function impairment. Is conceivable that TRS has unique evolution and course characteristics, and that continuous cannabis use for 6.95 years is probably not sufficient to cause the structural alterations typical of TRS.

The MRI-AI applied to a single subject has shown reliable results, confirmed by classical group analysis, and represents a revolutionary tool for identifying potential neuroradiological biomarkers of disease, enabling quick TRS diagnosis in clinical practice, faster clozapine treatment following TRIPP guidelines, and easy application using only a standard volumetric sequence without post-scan analysis.

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Older people’s complex healthcare needs require the development of integrated mental and physical health services. The College of Psychiatrists of Ireland’s Faculty of Psychiatry of Old Age (POA) is in the process of drafting a position statement on the integration of POA with other services for older people such as the Integrated Care Program for Older People (ICPOP). ICPOP provides geriatric multi-disciplinary treatment in the community. In January 2024, the Clare Psychiatry of Later Life (POLL) team set up a novel consult liaison (CL) service with our local colleagues ICPOP colleagues.

The authors aim to describe a novel model of care for our newly developed ICPOP CL service. It may be of interest to other POLL teams who wish to expand their CL service to include their local ICPOP services or other community services. We also evaluated: referral patterns to the Clare POLL CL service, the number of referrals from the ICPOP CL service in its first six months, and key patient characteristics of ICPOP CL referrals compared to inpatient CL referrals.

The model of care for our novel ICPOP CL clinic is described in detail. Patients were discussed at integrated multidisciplinary meetings. Cases brought by ICPOP for discussion with POLL could result in advice, a consult in a designated ICPOP CL clinic, or a referral for joint care. Joint teaching sessions were also arranged.

71.25 % (n=57, n=80) of referrals from Ennis General were for POLL CL. Conversely, CL referrals made up 21.43 % (n=81, n=378) of referrals to the Clare POLL service overall. ICPOP CL referrals made up 31.58% (n=18, n=57) of the POLL CL referrals over six months and made up 10% (n=18, n=180) of overall referrals to the Clare POLL service for the same period. Of these 18 ICPOP CL referrals, only four (22.22%) required joint care. Seven patients were referred by POLL to ICPOP for joint care over the same period. Patient characteristics were summarized by table 1.

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The authors present a service integration initiative between a local POLL and ICPOP service, which they believe was mutually beneficial to both services and the patients they serve. The characteristics of patients referred to POLL from the new integration with ICPOP resemble other community referrals, as opposed to inpatient CL referrals.

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Medical improvisation, or HPTI (Health Professional Training Improv), enhances critical skills in healthcare professionals. These skills include communication, empathy, time pressure management, and creative problem-solving. Our presentation aims to showcase a practical application of HPTI, demonstrating its relevance and effectiveness in mental health training.

In this presentation, we will demonstrate our training method, including a short session with exercises adapted to healthcare professions. The session is divided into four parts. Each part is designed to maximize engagement and learning, with debriefing sessions to clarify teaching objectives and foster reflective practice.

Warm-Up Exercises: Physical and vocal exercises to optimize communication and awareness. Improvisation Techniques: Exercises focused on mastering emotions and various forms of communication, allowing participants to explore their strengths and limitations. Medical Scenario Applications: Short clinical scenarios to emphasize the cognitive and affective dimensions of empathy. Review of Existing Workshops and Research: Presentation of current workshops and research to encourage further exploration and application in training. Each part includes a debriefing session to clarify teaching objectives, develop a reflective approach, and identify areas for improvement.

For our ongoing comparative study we have implemented the following questionnaires for our training participants: IUS (uncertainty intolerance scale) and Acceptance and Action Questionnaire-II (AAQII). A total of 50 students participated in our research in both countries.

Hungarian training participants included medical school students in Hungary and fourth-year speech therapy students in France and included professional scenarios based on stress and emotion management, interdisciplinary collaboration and collaboration with the patient, and communication, with debriefing on their performance. The data is currently being collected.

Applied improvisation through HPTI offers a valuable approach to improving mental health training. By enhancing communication, empathy, and problem-solving skills, healthcare professionals can provide better patient care and navigate their roles more effectively. Our presentation demonstrates these techniques and encourages their integration into regular training programs.

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