When is it justified to use opaque artificial intelligence (AI) output in medical decision-making? Consideration of this question is of central importance for the responsible use of opaque machine learning (ML) models, which have been shown to produce accurate and reliable diagnoses, prognoses, and treatment suggestions in medicine. In this article, I discuss the merits of two answers to the question. According to the Explanation View, clinicians must have access to an explanation of why an output was produced. According to the Validation View, it is sufficient that the AI system has been validated using established standards for safety and reliability. I defend the Explanation View against two lines of criticism, and I argue that within the framework of evidence-based medicine mere validation seems insufficient for the use of AI output. I end by characterizing the epistemic responsibility of clinicians and point out how a mere AI output cannot in itself ground a practical conclusion about what to do.

This article seeks to investigate the claim that South Georgia may have been first discovered in April 1675 by an English merchant called Antonio de la Roche. There are two unresolved questions: whether La Roche was the first to see the island, and whether the island that he saw was South Georgia. I introduce a third uncertainly by questioning whether Antonio de la Roche ever existed. He does not appear in the records of the French churches in London, and the sole source of his biography is the work of a fabricator, Francisco de Seyxas.

This article interrogates the concept of legal pluralism, as it currently tends to function within contemporary legal and historical scholarship. It argues that the concept of legal pluralism cannot ‘liberate’ positivist analytical legal theory from monist (municipal, state-centric, etc.) straightjackets, but rather itself presumes the primacy of centralized state-issued law—at the same time as masking that primacy within a pluralist discourse. The concept of legal pluralism should be properly understood—and analyzed—as part of the mythology of modern law, not as an alternative to it. The first two sections develop this argument via a critical tour of legal-pluralist historiography, focusing on 1986 to the present day. The final section then moves on to explore what is at stake for the pre-modern historian when they apply (modern) concept(s) of legal pluralism to try to explain the multiplicity of legal orders that they invariably encounter in their own source material.

This article takes up the short work of fiction Salam, written in Japanese in 2006 by Shirin Nezammafi, and deploys it as a primary source in the history of the Japanese present. Salam tells the tale of Layla, an Afghan migrant detained in and then expelled from Japan in 2001. The article argues that Salam exposes the unmaking of postcolonial Japan: if postcolonial Japan meant a territorial, sovereign nation-state built on hegemonic national myths, then now it is unsustainable. Salam calls to an inevitable if uncharted post-national, post-territorial future. To advance this argument, the article focuses on Nezammafi's treatment of three humanistic categories tied up with geopolitical territoriality: language, art, and gender. These categories, when associated with the nation-state, generate irony in Salam. That irony stems from the anachronism of nations: territorial nations, Japanese or otherwise, appear as past entities that have outlived their possibility.

There is much literature about the licensing of complement clauses by complement-taking predicates. However, less has been written about the licensing of adverbs in a complement clause. This article addresses the licensing of English evidential adverbs in complement clauses extracted from the NOW corpus. The article discusses three factors that determine the distribution of evidential adverbs in complement clauses. These are the nature of the evidential adverbs, the constraints of the complement clause and the anchor of the evidential adverb. To explore the role of these three factors, I adopt the hierarchical scopal theory of Functional Discourse Grammar (FDG). If a complement clause licenses the inclusion of the evidential adverb, then there is a match. Should there be no alignment between the complement clause and the adverb, there will be a mismatch. The results of the analysis of the data show that there are mostly matches, which occur with either a current speaker anchor or an actor anchor. Secondly, it appears that in cases of mismatches, there is always a current speaker. It thus appears that a current speaker anchor can override the constraints of the complement clause.

Human brain organoids (HBOs) are three-dimensional biological entities grown in the laboratory in order to recapitulate the structure and functions of the adult human brain. They can be taken to be novel living entities for their specific features and uses. As a contribution to the ongoing discussion on the use of HBOs, the authors identify three sets of reasons for moral concern. The first set of reasons regards the potential emergence of sentience/consciousness in HBOs that would endow them with a moral status whose perimeter should be established. The second set of moral concerns has to do with an analogy with artificial womb technology. The technical realization of processes that are typically connected to the physiology of the human body can create a manipulatory and instrumental attitude that can undermine the protection of what is human. The third set concerns the new frontiers of biocomputing and the creation of chimeras. As far as the new frontier of organoid intelligence is concerned, it is the close relationship of humans with new interfaces having biological components capable of mimicking memory and cognition that raises ethical issues. As far as chimeras are concerned, it is the humanization of nonhuman animals that is worthy of close moral scrutiny. A detailed description of these ethical issues is provided to contribute to the construction of a regulative framework that can guide decisions when considering research in the field of HBOs.

The study addresses the absence of a comprehensive institutional analysis framework in the academic literature on state-minority relations. It does so by employing a framework of analysis based on Skocpol’s analysis of structural factors and Ostrom’s multi-level institutional analysis to understand the processes of radical and incremental institutional change. The article is empirically grounded in a case study of Roma communities in Slovakia. More specifically, it maps and analyzes the evolution and change of institutional frameworks of state-minority relations in the context of Roma communities in Slovakia from the 1960s to 2020. Drawing from archival materials, interview findings, and document analysis, this article shows how post-socialist Slovakia radically redefined and diversified its institutional framework for Roma communities at different institutional levels, which subsequently continued to change at an incremental pace. Overall, the study aspires to offer a more dynamic institutional approach to the study of state-minority relations, which are currently dominated by more static regime- and rights-based approaches, and to contribute with a prospectively useful framework for understanding the developments of state-minority relations in the broader post-Soviet space and beyond.

Study abroad (SA) has long been regarded as a key component of internationalization efforts in higher education and much scholarship has investigated the practices and outcomes of SA from varied perspectives. More recently, scholars have paid growing attention to ways to increase the participation of historically marginalized students in SA, to design SA programs to meet those students’ needs, and to document their experiences abroad. Despite recent scholarship in these areas, relatively little research has employed an equity lens to address research on language-focused SA. This article puts forward language-focused SA as a possible venue to pursue equity and to provide quality education for all students, especially for historically underserved students. More specifically, we address three overarching questions: (1) What theoretical frameworks could be implemented to research SA through an equity lens?; (2) What methodological approaches could inform SA research with an equity lens?; and (3) What topics could be examined to research SA through an equity lens? Drawing on equity as a guiding principle, we discuss relevant research tasks that demonstrate specific ways to address these overarching questions in future research on language-focused SA.

The first “R” from animal research ethics prescribes the replacement of animal experiments with animal-free alternatives. However, the question of when an animal-free method qualifies as an alternative to animal experiments remains unresolved.

Drawing lessons from another debate in which the word “alternative” is central, the ethical debate on alternatives to germline genome editing, this paper develops a general account of when something qualifies as an alternative to something. It proposes three ethically significant conditions that technique, method, or approach X must meet to qualify as an alternative to Y: (1) X must address the same problem as Y, under an appropriate description of that problem; (2) X must have a reasonable chance of success, compared to Y, in solving the problem; and (3) X must not be ethically unacceptable as a solution. If X meets all these conditions, its relative advantages and disadvantages determine whether it is preferable, indifferent, or dispreferable as an alternative to Y.

This account is then applied to the question of whether animal-free research methods qualify as alternatives to animal research. Doing so breaks down the debate around this question into more focused (ethical and other) issues and illustrates the potential of the account.

This research note assesses participatory health governance practices for HIV and AIDS in Brazil. By extension, we also evaluate municipal democratic governance to public health outcomes. We draw from a unique dataset on municipal HIV/AIDS prevalence and participatory health governance from 2006–17 for all 5,570 Brazilian municipalities. We use negative binomial regression and coarsened exact matching with treatment effects to estimate the influence of community health governance institutions on HIV/AIDS prevalence. Municipalities with participatory health councils experience 14% lower HIV/AIDS prevalence than other municipalities, all else equal. Family Health Program coverage, municipal state capacity, and municipal per capita health spending are also associated with systematically lower HIV/AIDS prevalence. We conclude that participatory health governance may combat HIV and AIDS through municipal spending, education, and community mobilization. Municipal health councils can facilitate these strategies and offer opportunities for improving well-being around the world.

This article argues that the colonial government in India was shaped by changes in property law, race relations and other institutional interests that accompanied the political and economic restructuring of the colonial state. Therefore, the development of constitutionalism was the outcome of an interplay between institutional and professional interests and larger socio-economic and political forces. Against the backdrop of empire, constitutionalism in British India was defined by a specific form of allocation of powers between the executive (which also exercised legislative powers) and the high courts. The structure that developed as a result was a strong executive government, particularly in its exercise of power in local districts with formal judicial scrutiny introduced after 1861. The relationship between the executive and the judiciary in localities generated a series of conflicts and tensions, which were exacerbated by the expansion of the bureaucracy, the legal profession and gradual inclusion of Indians in the upper strata of governance. Taken together, these factors led to the development of a hybrid model of separation of powers in the Indian subcontinent, which seems to have stood the test of time in post-colonial countries of South Asia despite political elites having invested considerable resources on constitutional reform.

The paper aims to present a critical analysis of the phenomenon and notion of exceptionalism in bioethics. The authors demonstrate that exceptionalism pertains to phenomena that are not (yet) entirely familiar to us and could potentially bear risks regarding their regulation. After an overview of the state of the art, we briefly describe the origins and evolution of the concept, compared to exception and exclusion. In the second step, they look at the overall development debates on genetic exceptionalism, compared to other bioethical debates on exceptionalism, before presenting a detailed analysis of a specific case of early regulation of genetic screening. In the last part, the authors explain the historical background behind the connection between exceptionalism and exclusion in these debates. Their main conclusion is that while the initial stage of the discussion is shaped by the concept of exceptionalism and awareness of risks of exclusion, the later development centers around exceptions that are needed in detailed regulatory procedures.

Ronald P. Leow is Professor (Applied Linguistics) in the Department of Spanish and Portuguese and Language Program Director of Spanish Language Instruction at Georgetown University. He has initiated and published (over 100 articles and chapters) in several strands of research that include language curriculum development, research methodology, cognitive processes and depth of processing in language learning, (written and computerized) corrective feedback, textual enhancement, reactivity, and CALL. He has contributed to the field his 2015 Model of the L2 Learning Process in ISLA (in Explicit learning in the L2 classroom: A student-centered approach, Routledge) and his 2020 Feedback Processing Framework (in R. M. Manchón (Ed.), Writing and language learning. Advancing research agendas, John Benjamins) to provide a cognitive account for how L2 data and feedback are processed by L2 learners. His i10-index is 58 with over 6,500 citations.