Sir James Jeans Always says what he means; He is really perfectly serious About the Universe being Mysterious. E. Clerihew Bentley (1875–1956) Punch, vol. 196, issue 5100, p. 39 [1939 Jan 11]

Section 10.1 discusses patients with aMCI. These patients have long-term memory deficits due to atrophy of medial temporal lobe regions. Within a few years of being diagnosed with aMCI, about half of these individuals are diagnosed with AD, the topic of Section 10.2. Section 10.3 focuses on patients with mTBI, who typically perform normally on working memory tasks but have increased fMRI activity within the lateral prefrontal cortex and the parietal cortex. In Section 10.4, patients with mTLE are considered. These patients can elect to have a region in their medial temporal lobe removed to reduce the frequency of their seizures. Section 10.5 discusses patients with TGA; these patients have a sudden onset of amnesia that lasts for less than 24 hours and is caused by a small temporary lesion to a specific subregion of the hippocampus.

I’m trying to relax, but it’s hard. Ryuichi Sakamoto (1952–2023) New York Times interview, 2017 Apr 22

How, given the murder of those demanding a more representative political system at Peterloo in 1819, did more Britons, at home and in the colonies, get to vote by 1885?

Section 9.1 reviews the brain regions that have been associated with attention, which include sensory processing regions in addition to lateral prefrontal cortex and parietal cortex control regions. These regions are similar to the regions that have been associated with working memory and long-term memory. In Section 9.2, the brain regions associated with imagery are reviewed, which also include sensory processing regions, the lateral prefrontal cortex, and the parietal cortex, similarly to working memory. Section 9.3 details the regions of the brain associated with language processing, which include the left inferior lateral prefrontal cortex and the left posterior lateral temporal cortex; these regions are of relevance to multiple types of memory. Section 9.4 considers brain regions associated with emotion and their role in memory. Section 9.5 touches on a relatively new line of research that considers the role of memory in decision-making.

How did religious and political debates that had only recently generated violent conflicts become relatively peaceably conducted in growing numbers of publications and clubs?

How did social democracy seed new forms of politics that came of age in the global revolts of 1968, exposing its contradictions and compromised foundations, and hastening its demise after 1976?

Working memory refers to actively holding information in mind during a relatively short period of time, typically seconds. During working memory paradigms, information is actively kept in mind during the delay period. Working memory has been associated with activity in the lateral prefrontal cortex, the parietal cortex, and sensory processing regions. Section 8.1 details the brain regions that store the contents of working memory during the delay period. In Section 8.2, the evidence is evaluated that claims to link working memory with the hippocampus. Section 8.3 considers the brain timing commonly associated with working memory. In Section 8.4, brain activity associated with working memory that oscillates at particular frequencies is considered, which primarily includes alpha activity and gamma activity. In Section 8.5, changes in brain activity are highlighted that have been linked to training-related increases in working memory capacity.

This chapter focuses on long-term memory in animals, which relates to the research conducted with humans. Section 11.1 shows that rats, cats, and monkeys have the same medial temporal lobe organization as humans. The perirhinal cortex is associated with item memory, the parahippocampal cortex is associated with context memory, and the hippocampus is associated with binding item information and context information. In Section 11.2, long-term potentiation in the hippocampus is discussed. Section 11.3 reviews evidence for memory replay in rats, which refers to reactivation of the same brain regions in the same or the reverse temporal sequence that were activated during a previous event. In Section 11.4, time cells in the rat hippocampus are discussed. Section 11.5 considers the behavioral evidence and the brain evidence that indicates animals have episodic memory. This has proven to be a controversial topic because animals cannot tell us whether or not they “remember.”

Ships that pass in the night, and speak each other in passing, Only a signal shown and a distant voice in the darkness; So on the ocean of life we pass and speak one another, Only a look and a voice, then darkness again and a silence. Henry Wadsworth Longfellow (1807–1882)

A Frenchman who arrives in London, will find Philosophy, like every Thing else, very much chang’d there… In France, ’tis the Pressure of the Moon that causes the Tides; but in England ’tis the Sea that gravitates toward the Moon. Letters Concerning the English Nation [1733] Letter XIV: On Descartes and Sir Isaac Newton, Voltaire (1694–1778)