Language mixing is a common phenomenon in the language input of bilingual children. However, the relation between the frequency of parental language mixing and children’s language development remains unclear. The present study investigates the relation between language mixing as observed in daylong audio recordings (LENA) and as reported by parents in the questionnaire for Quantifying Bilingual Experience (Q-BEx) and children’s language outcomes in the majority and minority language. Participants were 52 3-to-5-year-old Polish-Dutch and Turkish-Dutch children in the Netherlands and Bayesian informative hypothesis evaluations were applied. In 14 out of 15 regression analyses, the LENA and Q-BEx measures yielded similar associations with children’s language outcomes. Parental language mixing was not related to majority language outcomes, but a negative relation was found with expressive vocabulary in the minority language. Longitudinal studies are needed to pinpoint the directionality of this negative relation.

Interpersonal psychotherapy (IPT) and antidepressant medications are both first-line interventions for adult depression, but their relative efficacy in the long term and on outcome measures other than depressive symptomatology is unknown. Individual participant data (IPD) meta-analyses can provide more precise effect estimates than conventional meta-analyses. This IPD meta-analysis compared the efficacy of IPT and antidepressants on various outcomes at post-treatment and follow-up (PROSPERO: CRD42020219891). A systematic literature search conducted May 1st, 2023 identified randomized trials comparing IPT and antidepressants in acute-phase treatment of adults with depression. Anonymized IPD were requested and analyzed using mixed-effects models. The prespecified primary outcome was post-treatment depression symptom severity. Secondary outcomes were all post-treatment and follow-up measures assessed in at least two studies. IPD were obtained from 9 of 15 studies identified (N = 1536/1948, 78.9%). No significant comparative treatment effects were found on post-treatment measures of depression (d = 0.088, p = 0.103, N = 1530) and social functioning (d = 0.026, p = 0.624, N = 1213). In smaller samples, antidepressants performed slightly better than IPT on post-treatment measures of general psychopathology (d = 0.276, p = 0.023, N = 307) and dysfunctional attitudes (d = 0.249, p = 0.029, N = 231), but not on any other secondary outcomes, nor at follow-up. This IPD meta-analysis is the first to examine the acute and longer-term efficacy of IPT v. antidepressants on a broad range of outcomes. Depression treatment trials should routinely include multiple outcome measures and follow-up assessments.

Bilinguals frequently switch between languages. The present study examined cued language switching (CLS) longitudinally in bilingual Turkish–Dutch children with (n = 11) and without (n = 30) developmental language disorder (DLD) in a three-wave design with one-year intervals. We studied effects of dominance, indexed by language proficiency and exposure, on overall switching performance and the costs associated with switching between languages. Results show limited evidence for overall costs associated with language switching (i.e., only mixing costs in reaction times [RTs]). Further, accuracy on CLS increased with increasing dominance in the trial language. Moreover, better performance, and larger switching costs, were found in the majority (Dutch) compared to the minority (Turkish) language. These results are discussed in light of the sociolinguistic context. As hypothesized, more errors, longer RTs and slightly larger mixing costs were observed in children with DLD, suggesting overall word retrieval difficulties and difficulties with cognitive control.

Despite its low prevalence, the potential diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT) should be at the forefront of a paediatric cardiologists mind in children with syncope during exercise or emotions. Over the years, the number of children with a genetic diagnosis of CPVT due to a (likely) pathogenic RYR2 variant early in life and prior to the onset of symptoms has increased due to cascade screening programmes. Limited guidance for this group of patients is currently available. Therefore, we aimed to summarise currently available literature for asymptomatic patients with a (likely) pathogenic RYR2 variant, particularly the history of CPVT and its genetic architecture, the currently available diagnostic tests and their limitations, and the development of a CPVT phenotype – both electrocardiographically and symptomatic – of affected family members. Their risk of arrhythmic events is presumably low and a phenotype seems to develop in the first two decades of life. Future research should focus on this group in particular, to better understand the development of a phenotype over time, and therefore, to be able to better guide clinical management – including the frequency of diagnostic tests, the timing of the initiation of drug therapy, and lifestyle recommendations.

In this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands Internet Collaboration (BIONIC). Across the Netherlands we collected data on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) lifetime MDD diagnosis in 132,850 Dutch individuals. Currently, N = 66,684 of these also have genomewide single nucleotide polymorphism (SNP) data. We initiated this project because the complex genetic basis of MDD requires large population-wide studies with uniform in-depth phenotyping. For standardized phenotyping we developed the LIDAS (LIfetime Depression Assessment Survey), which then was used to measure MDD in 11 Dutch cohorts. Data from these cohorts were combined with diagnostic interview depression data from 5 clinical cohorts to create a dataset of N = 29,650 lifetime MDD cases (22%) meeting DSM-5 criteria and 94,300 screened controls. In addition, genomewide genotype data from the cohorts were assembled into a genomewide association study (GWAS) dataset of N = 66,684 Dutch individuals (25.3% cases). Phenotype data include DSM-5-based MDD diagnoses, sociodemographic variables, information on lifestyle and BMI, characteristics of depressive symptoms and episodes, and psychiatric diagnosis and treatment history. We describe the establishment and harmonization of the BIONIC phenotype and GWAS datasets and provide an overview of the available information and sample characteristics. Our next step is the GWAS of lifetime MDD in the Netherlands, with future plans including fine-grained genetic analyses of depression characteristics, international collaborations and multi-omics studies.

The European Congenital Heart Surgeons Association (ECHSA) Congenital Database (CD) is the second largest clinical pediatric and congenital cardiac surgical database in the world and the largest in Europe, where various smaller national or regional databases exist. Despite the dramatic increase in interventional cardiology procedures over recent years, only scattered national or regional databases of such procedures exist in Europe. Most importantly, no congenital cardiac database exists in the world that seamlessly combines both surgical and interventional cardiology data on an international level; therefore, the outcomes of surgical and interventional procedures performed on the same or similar patients cannot easily be tracked, assessed, and analyzed. In order to fill this important gap in our capability to gather and analyze information on our common patients, ECHSA and The Association for European Paediatric and Congenital Cardiology (AEPC) have embarked on a collaborative effort to expand the ECHSA-CD with a new module designed to capture data about interventional cardiology procedures. The purpose of this manuscript is to describe the concept, the structure, and the function of the new AEPC Interventional Cardiology Part of the ECHSA-CD, as well as the potentially valuable synergies provided by the shared interventional and surgical analyses of outcomes of patients. The new AEPC Interventional Cardiology Part of the ECHSA-CD will allow centers to have access to robust surgical and transcatheter outcome data from their own center, as well as robust national and international aggregate outcome data for benchmarking. Each contributing center or department will have access to their own data, as well as aggregate data from the AEPC Interventional Cardiology Part of the ECHSA-CD. The new AEPC Interventional Cardiology Part of the ECHSA-CD will allow cardiology centers to have access to aggregate cardiology data, just as surgical centers already have access to aggregate surgical data. Comparison of surgical and catheter interventional outcomes could potentially strengthen decision processes. A study of the wealth of information collected in the database could potentially also contribute toward improved early and late survival, as well as enhanced quality of life of patients with pediatric and/or congenital heart disease treated with surgery and interventional cardiac catheterization across Europe and the world.

One approach to studying how children acquire language is to simulate language acquisition through computational modelling. Computational models implement theories of language acquisition and simulation outcomes can then be tested against existing real-world data or in new empirical research. It is more than ten years ago that Journal of Child Language published a special issue on the topic, edited and introduced by Brian MacWhinney (MacWhinney, 2010). Now is thus a good time to take stock of recent developments by bringing together a collection of articles that explore recent research and insights from computational modelling of child language acquisition.

This introduction begins with a brief overview of the three major factors shaping economic life and exchange in India, as laid out by contributions in the edited volume Rethinking Markets in Modern India: embedded exchange, contested jurisdiction, and pliable markets. The overarching logic of all the contributions is that markets in India must be understood as path dependent, that is, expressing a historical trajectory and specific, and changing, political and moral regimes. The remainder of this introduction discusses the origins of the distinction between ‘economy’ and ‘culture’ in the nationalist critiques of empire and how these critiques have led to a widespread moral ambivalence vis-à-vis the commercialization of everyday life in India that persists today across the political spectrum.

Sudden cardiac death is the most common mode of death during childhood and adolescence in hypertrophic cardiomyopathy, and identifying those individuals at highest risk is a major aspect of clinical care. The mainstay of preventative therapy is the implantable cardioverter-defibrillator, which has been shown to be effective at terminating malignant ventricular arrhythmias in children with hypertrophic cardiomyopathy but can be associated with substantial morbidity. Accurate identification of those children at highest risk who would benefit most from implantable cardioverter-defibrillator implantation while minimising the risk of complications is, therefore, essential. This position statement, on behalf of the Association for European Paediatric and Congenital Cardiology (AEPC), reviews the currently available data on established and proposed risk factors for sudden cardiac death in childhood-onset hypertrophic cardiomyopathy and current approaches for risk stratification in this population. It also provides guidance on identification of individuals at risk of sudden cardiac death and optimal management of implantable cardioverter-defibrillators in children and adolescents with hypertrophic cardiomyopathy.

Introduction

Guidelines have been formulated by the European Community (EC 1986) to cover housing conditions for laboratory animals. These guidelines are based essentially on common practice of housing laboratory animals and on limited data concerning relations between housing conditions and either animal growth or development of pathologies. Further information on this subject is required to optimize housing conditions of laboratory animals.

Are difficult decisions best made after a momentary diversion of thought? Previous research addressing this important question has yielded dozens of experiments in which participants were asked to choose the best of several options (e.g., cars or apartments) either after conscious deliberation, or after a momentary diversion of thought induced by an unrelated task. The results of these studies were mixed. Some found that participants who had first performed the unrelated task were more likely to choose the best option, whereas others found no evidence for this so-called unconscious thought advantage (UTA). The current study examined two accounts of this inconsistency in previous findings. According to the reliability account, the UTA does not exist and previous reports of this effect concern nothing but spurious effects obtained with an unreliable paradigm. In contrast, the moderator account proposes that the UTA is a real effect that occurs only when certain conditions are met in the choice task. To test these accounts, we conducted a meta-analysis and a large-scale replication study (N = 399) that met the conditions deemed optimal for replicating the UTA. Consistent with the reliability account, the large-scale replication study yielded no evidence for the UTA, and the meta-analysis showed that previous reports of the UTA were confined to underpowered studies that used relatively small sample sizes. Furthermore, the results of the large-scale study also dispelled the recent suggestion that the UTA might be gender-specific. Accordingly, we conclude that there exists no reliable support for the claim that a momentary diversion of thought leads to better decision making than a period of deliberation.