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We report the radio continuum detection of well known Galactic Planetary Nebula (PN) NGC5189, observed at 943MHz during the Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) survey. Two detections of NGC5189 have been made during the survey, of better resolution than previous radio surveys. Both measurements of the integrated flux density are consistent with each other, at S943 MHz = 0.33 ± 0.03 Jy, and the spectral luminosity is L943 MHz = 8.89 × 1013 W m–2 Hz–1. Using available flux density measurements for radio-detections of NGC5189, we calculate a radio surface brightness at 1GHz and measure Σ1 GHz = 6.0 × 10–21 W m–2 Hz–1 sr–1, which is in the expected range for Galactic PNe. We measure an apparent size of 3.′4×2.′2 corresponding to physical diameters of 1.48 pc × 0.96 pc, and combine available radio observations of NGC5189 to estimate a spectral index of α = 0.12 ± 0.05. Hence, we agree with previous findings that NGC5189 is a thermal (free–free) emitting nebula. Additional measurements of the optical depth (τ = 0.00246) and electron density (Ne = 138 cm–3) support our findings that NGC5189 is optically thin at 943 MHz. Furthermore, the radio contours from the ASKAP–EMU image have been overlaid onto a Hubble Space Telescope (HST) Wide Field Camera 3 image, demonstrating that the radio morphology closely traces the optical. Notably, the contour alignment for the innermost region highlights the two envelopes of gas previously reported to be low-ionisation structures, which is considered a defining feature of post common–envelope PNe that surround a central Wolf-Rayet star.
We present the Evolutionary Map of the Universe (EMU) survey conducted with the Australian Square Kilometre Array Pathfinder (ASKAP). EMU aims to deliver the touchstone radio atlas of the southern hemisphere. We introduce EMU and review its science drivers and key science goals, updated and tailored to the current ASKAP five-year survey plan. The development of the survey strategy and planned sky coverage is presented, along with the operational aspects of the survey and associated data analysis, together with a selection of diagnostics demonstrating the imaging quality and data characteristics. We give a general description of the value-added data pipeline and data products before concluding with a discussion of links to other surveys and projects and an outline of EMU’s legacy value.
Background: Since 2018, several CGRP-targeted therapies have entered the migraine market, including eptinezumab. Minimal evidence exists evaluating the real-world effectiveness of switching from a subcutaneous to an intravenous anti-CGRP mAb. Methods: An observational, multi-site (n=4), US-based study, REVIEW evaluated real-world experiences of patients with chronic migraine (CM) treated with eptinezumab using a chart review, patient survey, and physician interviews. Adults (≥18 years) with a diagnosis of CM who had completed ≥2 consecutive eptinezumab infusion cycles were eligible. Results: Enrolled patients were primarily female (83%, 78/94), had a mean age of 49 years and a mean migraine diagnosis duration of 15.4 years. All patients (94/94) self-reported prior preventive therapy with 89% (84/94) reporting prior subcutaneous anti-CGRP mAb use (i.e., fremanezumab, galcanezumab, or erenumab). Regardless of prior exposure to a CGRP ligand or receptor blocker, the number of “good” days/month more than doubled following eptinezumab. Patients experienced a similar mean change in the number of “good” days/month regardless of the number and type of previous subcutaneous anti-CGRP mAb used. Conclusions: This real-world, patient survey showed that patients with prior exposure to subcutaneous anti-CGRP mAbs had high overall satisfaction with the effectiveness of eptinezumab treatment regardless of the number and type of previous therapies used.
Education of children about farm animal welfare could affect welfare standards, through influence on current and future purchasing of animal products, and improve general consideration for animals. Establishing success requires evaluation. Here, a farm animal educational event for 13 to 14 year-old schoolchildren, focusing on chicken biology, welfare and food labelling, was assessed. Alterations in knowledge, attitude and a proxy measure of behaviour towards animals and their welfare, key aspects expected to impact on animal welfare, were investigated using questionnaires. These key aspects were predicted to increase following event attendance and remain higher than in the non-attending control group three months later. Knowledge and positive behaviour towards specific poultry species increased significantly in attendees but, although remaining greater than pre-attendance, tended to diminish over time. Value afforded to animal life was unaffected by the event. Consideration of welfare needs was significantly greater overall in attendees than non-attendees, but appeared to be characteristic of children choosing to attend the event, rather than the event per se. Importance attributed to animal welfare followed a hierarchy from survival-relevant, eg freedom from hunger and thirst, to less critical needs, eg stimulation. The specific species under consideration had the most significant effect on attitudes; consistent with predictions based on perceptions of the animals’ ‘complexity’, cognitive ability, similarity to humans and use. Further investigation into the aetiology of attitude and potential barriers to attitude change is required to effect attitude change and determine whether attitude alteration could support maintenance of shifts in knowledge and behaviour.
Trifludimoxazin, a new protoporphyrinogen oxidase–inhibiting herbicide, is being evaluated for possible use as a soil-residual active herbicide treatment in cotton for control of small-seeded annual broadleaf weeds. Laboratory and greenhouse studies were conducted to compare vertical mobility and cotton tolerance of trifludimoxazin to flumioxazin and saflufenacil, which are two currently registered protoporphyrinogen oxidase–inhibiting herbicides for use in cotton, in three West Texas soils. Vertical soil mobility of trifludimoxazin was similar to flumioxazin in Acuff loam and Olton loam soils, but was more mobile than flumioxazin in the Amarillo loamy sand soil. The depth of trifludimoxazin movement after a 2.5-cm irrigation event ranged from 2.5 to 5.0 cm in all soils, which would not allow for crop selectivity based on herbicide placement, because ideal cotton seeding depth is from 0.6 to 2.54 cm deep. Greenhouse studies indicated that PRE treatments were more injurious than the 14 d preplant treatment when summarized across soils for the three herbicides (43% and 14% injury, respectively). No differences in visual cotton response or dry weight was observed after trifludimoxazin preplant as compared with the nontreated control within each of the three West Texas soils and was similar to the flumioxazin preplant across soils. On the basis of these results, a use pattern for trifludimoxazin in cotton may be established with the use of a more than 14-d preplant restriction before cotton planting.
Rotor Track and Balance (RTB) is an important part of regular helicopter maintenance. The ability to perform this service assessment during normal operations, rather than with a series of explicit RTB flights, would greatly reduce the time the vehicle is non-operational and the maintenance costs associated with these flights and adjustments. This paper presents a novel methodology for identifying the RTB-related flight regimes, using a minimal number of vibration signals and comparing these to repeatable and stable characteristic vibration profiles. The technique is stable, with an 81% success in correct identification of the flight regime, when applied to a whole flight with a number of unknown regime events. The method can be run in real time, making it an effective way of identifying periods of flight that are suitable for RTB measurements. A new technique for visually representing any real-time flight signal, such as vibration, is also presented.